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Developmental roles of Rhomboid proteases
Developmental roles of Rhomboid proteases

... the ligand-processing cassette, which of the three elements in this group is normally limiting? Expression of Spi and Star appears to be ubiquitous. Presumably, in the absence of Rhomboid the Spi/Star complex fails to reach the plasma membrane. Thus, the Spi precursor is protected from fortuitous cl ...
Cytokinesis is blocked in mammalian cells transfected with
Cytokinesis is blocked in mammalian cells transfected with

Science Lesson Plan Biology 111/112 Unit 1 – The Cell Cell
Science Lesson Plan Biology 111/112 Unit 1 – The Cell Cell

... No, the membrane can choose what goes across. It is selectively permeable. What would be the function of the cell membrane in relation to our factory model? Students should work together to generate a model. One example would be the security system, which allows some people entrance but not others. ...
Document
Document

... ATTACHEMENT = fibronectin and α2 microglobulin . Promotes cell – substrate interaction. CARRIER = albumin and transferrin. albumin carry lipids and vitamins and transferrin carry iron in bioavailable forms. ...
Chapter 7: A View of the Cell
Chapter 7: A View of the Cell

... van Leeuwenhoek saw in water. Others, like the plants and animals with which you are most familiar, are multicellular, or made up of many cells. 2. The cell is the basic unit of structure and organization of organisms. Although organisms such as humans, dogs, and trees can become very large and comp ...
In Vitro Cytotoxicity of Oxide Nanoparticles: Comparison
In Vitro Cytotoxicity of Oxide Nanoparticles: Comparison

... cells (see Supporting Information for details) was tested using two different assays: The total cell culture activity was spectroscopically measured as the total mitochondrial activity using the selective conversion of a formazan-type dye from its leukoform to the active dye (MTT test, see Supportin ...
Cell Cycle Control in Arabidopsis
Cell Cycle Control in Arabidopsis

... and † Laboratoire AssocieU de l’Institut National de la Recherche Agronomique (France), UniŠersiteit Gent, K. L. Ledeganckstraat 35, B-9000 Gent, Belgium Received : 30 October 1995 Accepted : 8 February 1996 ...
NNF1 is an essential yeast gene required for proper spindle
NNF1 is an essential yeast gene required for proper spindle

... for nuclear envelope proteins. The antisera recognized several proteins by immunoblot analysis and was used to screen a yeast λgt11 expression library. Several positive clones were isolated, including one that contained part of an ORF with 201 amino acids (Fig. 1). We named this gene NNF1 (necessary ...
A natural anti-T-cell receptor monoclonal antibody protects against
A natural anti-T-cell receptor monoclonal antibody protects against

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Cell division and leaf morphogenesis - Development

... can occur by cell division-independent means (Kaplan, 1992), with modulation of cell wall extensibility being a prime candidate as an alternative mechanism to cell division as the driving or restraining force for morphogenesis (Fleming et al., 1997; Pien et al., 2001a). However, the experiments so f ...
The Plant Cell - Gunawardena Lab
The Plant Cell - Gunawardena Lab

... after the conversion of chloroplasts to gerontoplasts (Simeonova et al., 2000; Thomas et al., 2003). The early disruption of the large central vacuole characterizes the third cytological variant of PCD (Fukuda, 2000). In this form, the vacuole sequesters lytic enzymes such as nucleases and proteases ...
Mapping functional regions of the segment
Mapping functional regions of the segment

... properties. Several features of the Krox-20 protein are represented: zinc fingers, acidic, basic and proline-rich regions. The positions of the extremities of the different deletions are indicated along the wild-type sequence. The 'M' within Krox-20/2ER zinc fingers symbolize the double amino acid m ...
An indelible lineage marker for Xenopus using a
An indelible lineage marker for Xenopus using a

... identical in all embryos. This constraint does not apply to GFP.RN3, which can be viewed in living cells. We have followed the descendants of single injected blastomeres, by viewing the same living embryos over several days. When GFP.RN3 mRNA is injected into only one blastomere of a 2-cell egg, the ...
The FRA1 kinesin contributes to cortical microtubule
The FRA1 kinesin contributes to cortical microtubule

... synthesized in the Golgi and then delivered to the extracellular space through the secretory system. Atypically, cellulose microfibrils are synthesized de novo at the plasma membrane by cellulose synthase (CESA) complexes, although the CESA complexes themselves are thought to be assembled in the Gol ...
Unicellular Organisms
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... The main groups of unicellular organisms are bacteria, protozoa, unicellular algae, and unicellular fungi or yeasts. Each species is unique. They can be interesting to study because of their intricate and beautiful patterns. Some are sensitive to light. They may move toward it or away from it. They ...
Macromomycin, an Inhibitor of the Membrane Function of Tumor Cells
Macromomycin, an Inhibitor of the Membrane Function of Tumor Cells

... as intact cells. Dead cells were estimated by staining with nigrosine solution (0.2% in PBS). Preparation of MCR-1311 (8, 14). Two mg of MCR were dissolved in 0.5 ml of 0.16 M NaCl:0.2 M borate buffer, pH 8, and 1 ml of water was added to the solution. The pH was adjusted to 8 by addition of 2 drops ...
Paul M. Nurse - Nobel Lecture
Paul M. Nurse - Nobel Lecture

... the cell cycle by Murdoch Mitchison in the 1950s (Mitchison 1971). It is a cylindrically shaped cell, 12–15 µm length and 3–4 µm diameter, typically eukaryotic and yet with a genome of less than 5000 genes (Wood, Gwilliam et al. 2002). Murdoch used fission yeast to study how cells grow during the ce ...
The Fundamental Unit of Life
The Fundamental Unit of Life

... Answer: Functional segments of DNA are called genes. 38. What is the function of chromatin material? Answer: The function of chromatin material is whenever the cell is about to divide, the chromatin material gets organised into chromosomes. 39. What are the main roles of nucleus? Answer: The nucleu ...
A Long Twentieth Century of Review the Cell
A Long Twentieth Century of Review the Cell

... around the same time, Kolliker realized that early embryonic cleavage represented a series of cell divisions producing cells that eventually became differentiated into various tissues and organs (for a great near contemporary account of cell work at this time, see Wilson, 1925). This idea was extend ...
Galluzzi et al., 2007. Cell Death and Differentition 14:1237-1266
Galluzzi et al., 2007. Cell Death and Differentition 14:1237-1266

... either the inner or the outer mitochondrial membrane) is routinely assessed to identify cells irreversibly committed to death which have not yet acquired an apoptotic phenotype.15,16 Finally, activation of the autophagic process according to a precise sequence of molecular events (formation of autop ...
Formation of the leading edge boundary
Formation of the leading edge boundary

... phosphatase that negatively regulates the kinase activity of JNK. This negative feedback provides one mechanism with which to control the level of signaling through the JNK pathway (Martin-Blanco et al., 1998). Another mechanism could involve limited activation of the pathway initially. ...
When Cells Become Organelle Donors
When Cells Become Organelle Donors

... pretreated with glycated collagen type I, which induces lysosomal dysfunction, the fraction of cells participating in lysosomal exchange doubles. Interestingly, the increase is driven entirely by lysosomal transfer in one direction, from the EPC to the HUVEC (34). Under some conditions, cell stress ...
Key concepts -- Lecture 5 IB 168: Spring 2006 Polypodiales
Key concepts -- Lecture 5 IB 168: Spring 2006 Polypodiales

... The vast majority of ferns (~3% of tracheophytes); treated in 25-50 families A well-supported monophyletic group. Worldwide in distribution; most diverse in tropics (where high humidity; equable climate year-round and through time). Ancient (date back to Paleozoic) but most modern fern diversity ("h ...
STAINING
STAINING

... Mycolic acid is a waxy substance that gives acid-fast cells a higher .for this differential stain affinity for the primary stain and resistance to decolorization by an acid alcohol solution. A variety of acid-fast staining procedures are employed, two of which are the ZiehlNeelsen (ZN) method and th ...
Stem Cells of the Adult Olfactory Epithelium
Stem Cells of the Adult Olfactory Epithelium

... including basal cells, olfactory sensory neurons (OSNs), nonneuronal supporting or sustentacular (Sus) cells, and Bowman duct/gland assemblies (3). The peripheral olfactory system is readily accessible and can be safely biopsied with minimal discomfort or risk, thereby offering a unique glimpse of a ...
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Cellular differentiation



In developmental biology, cellular differentiation isa cell changes from one cell type to another. Most commonly this is a less specialized type becoming a more specialized type, such as during cell growth. Differentiation occurs numerous times during the development of a multicellular organism as it changes from a simple zygote to a complex system of tissues and cell types. Differentiation continues in adulthood as adult stem cells divide and create fully differentiated daughter cells during tissue repair and during normal cell turnover. Some differentiation occurs in response to antigen exposure. Differentiation dramatically changes a cell's size, shape, membrane potential, metabolic activity, and responsiveness to signals. These changes are largely due to highly controlled modifications in gene expression and are the study of epigenetics. With a few exceptions, cellular differentiation almost never involves a change in the DNA sequence itself. Thus, different cells can have very different physical characteristics despite having the same genome.A cell that can differentiate into all cell types of the adult organism is known as pluripotent. Such cells are called embryonic stem cells in animals and meristematic cells in higher plants. A cell that can differentiate into all cell types, including the placental tissue, is known as totipotent. In mammals, only the zygote and subsequent blastomeres are totipotent, while in plants many differentiated cells can become totipotent with simple laboratory techniques. In cytopathology, the level of cellular differentiation is used as a measure of cancer progression. ""Grade"" is a marker of how differentiated a cell in a tumor is.
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