A genome-wide resource of cell cycle and cell shape genes of
... delayed in cell cycle progression because they continue to grow but fail to divide and thus become elongated. However, not all genes required for the cell cycle show a long cell phenotype when deleted. For example, genes encoding checkpoint proteins that are not required during a normal cell cycle m ...
... delayed in cell cycle progression because they continue to grow but fail to divide and thus become elongated. However, not all genes required for the cell cycle show a long cell phenotype when deleted. For example, genes encoding checkpoint proteins that are not required during a normal cell cycle m ...
machen2006
... mediators in BAL fluids showing that increased inflammation in CF followed bacterial infections (5). Recent studies using terminal restriction fragment length polymorphism profiling of sputum from both adult (149) and pediatric (148) CF patients have shown many (⬎40) bacterial species that have not ...
... mediators in BAL fluids showing that increased inflammation in CF followed bacterial infections (5). Recent studies using terminal restriction fragment length polymorphism profiling of sputum from both adult (149) and pediatric (148) CF patients have shown many (⬎40) bacterial species that have not ...
20. A Cellular Adventure
... Lysosome: Well, it may not be the best job, but some organelle has got to do it. Just imagine if no one picked up your garbage? Just think of me as a trash collector, except I eat this stuff. Yum, yum. Ryan: So all you do is travel around the cell and digest worn-out organelles, debris, and ingest p ...
... Lysosome: Well, it may not be the best job, but some organelle has got to do it. Just imagine if no one picked up your garbage? Just think of me as a trash collector, except I eat this stuff. Yum, yum. Ryan: So all you do is travel around the cell and digest worn-out organelles, debris, and ingest p ...
Identification of a Second Collagen-Like
... desorption/ionization time-of-flight mass spectrometry (MS) and the carbohydrate components by gas chromatography-mass spectrometry and tandem mass spectrometry. Spore-specific sugars were also demonstrated to be components of BclB. as demonstrated by monoclonal antibody labeling. The peptide backbo ...
... desorption/ionization time-of-flight mass spectrometry (MS) and the carbohydrate components by gas chromatography-mass spectrometry and tandem mass spectrometry. Spore-specific sugars were also demonstrated to be components of BclB. as demonstrated by monoclonal antibody labeling. The peptide backbo ...
appearance and function of endogenous peroxidase in fetal rat thyroid
... tain the dark cytochemical reaction product . A number of small vesicular inclusions lying along the peripheral borders of the cells also contain the reaction product (Fig . 7) . Although the origin of these inclusions cannot always be ascertained, many of them have been identified as cross-sectione ...
... tain the dark cytochemical reaction product . A number of small vesicular inclusions lying along the peripheral borders of the cells also contain the reaction product (Fig . 7) . Although the origin of these inclusions cannot always be ascertained, many of them have been identified as cross-sectione ...
lysosomes in skeletal muscle tissue
... group has a higher proportion of acid ribonuclease, ß-glucuronidase, and arylsulftase ; the equilibrium density can be shifted by dextran-500 and Triton WR-1339 . It is suggested that this group of lysosomes is derived from macrophages and other connective tissue cells, whereas the former group repr ...
... group has a higher proportion of acid ribonuclease, ß-glucuronidase, and arylsulftase ; the equilibrium density can be shifted by dextran-500 and Triton WR-1339 . It is suggested that this group of lysosomes is derived from macrophages and other connective tissue cells, whereas the former group repr ...
MAIT Cells Precursor Derivatives Activating Mouse Derived Riboflavin
... Although MAIT cell TCRs use preferential Vb segments, mutagenesis of individual residues within the CDRb regions indicates that the TCRb-chain of the MAIT cell TCRs did not play an important role in Ag reactivity, consistent with the lack of TCRb constraints (12, 15). Altogether, the structural data ...
... Although MAIT cell TCRs use preferential Vb segments, mutagenesis of individual residues within the CDRb regions indicates that the TCRb-chain of the MAIT cell TCRs did not play an important role in Ag reactivity, consistent with the lack of TCRb constraints (12, 15). Altogether, the structural data ...
Control of pathfinding by the avian trunk neural crest
... the sclerotome has dispersed. Finally, other neural crest cells may enter the sclerotome by migrating along the ventral root motor fibres that also course through the anterior somite (see below). Some of the crest cells migrate between the neural tube and somite opposite the posterior half of a somi ...
... the sclerotome has dispersed. Finally, other neural crest cells may enter the sclerotome by migrating along the ventral root motor fibres that also course through the anterior somite (see below). Some of the crest cells migrate between the neural tube and somite opposite the posterior half of a somi ...
Solid-Phase Synthesis, Characterization, and Cellular Activities of
... been utilized as the “solid-phase” for direct synthesis of peptides on its surface,24,25 we sought out a different approach that would allow for selective binding of ND within any peptide. More specifically, we considered attachment of NDs following traditional solid-phase peptide synthesis, where t ...
... been utilized as the “solid-phase” for direct synthesis of peptides on its surface,24,25 we sought out a different approach that would allow for selective binding of ND within any peptide. More specifically, we considered attachment of NDs following traditional solid-phase peptide synthesis, where t ...
Introduction-to-OBO - Buffalo Ontology Site
... Problems with Orthogonality • what if researchers need purpose-built ontologies to meet their own specific needs? • OBO Foundry provides orthogonal reference ontologies, so that they can as far as possible build their application ontologies using terms composed as cross-products • thereby avoid sil ...
... Problems with Orthogonality • what if researchers need purpose-built ontologies to meet their own specific needs? • OBO Foundry provides orthogonal reference ontologies, so that they can as far as possible build their application ontologies using terms composed as cross-products • thereby avoid sil ...
Detergent-Insoluble Membrane Compartment CD20 Required for Its
... or lysine, and the nonspecific protease proteinase K to treat intact Raji B cells as described in Materials and Methods. There is no trypsin digest site present in the putative loop between TM1 and TM2, and four sites in the hydrophilic region between TM3 and TM4. Therefore, the presence of an extra ...
... or lysine, and the nonspecific protease proteinase K to treat intact Raji B cells as described in Materials and Methods. There is no trypsin digest site present in the putative loop between TM1 and TM2, and four sites in the hydrophilic region between TM3 and TM4. Therefore, the presence of an extra ...
A Cellular Adventure
... Lysosome: Yeah, I do get very full. Sometimes I feel like I’m going to burst. All of the organelles mumble “Oh, no… don’t burst!” Ryan: Well, what’s wrong with that? Lysosome: Remember when I said that I was full of digestive enzymes? Ryan: Yeah, but what does that have to do with anything? Lysosom ...
... Lysosome: Yeah, I do get very full. Sometimes I feel like I’m going to burst. All of the organelles mumble “Oh, no… don’t burst!” Ryan: Well, what’s wrong with that? Lysosome: Remember when I said that I was full of digestive enzymes? Ryan: Yeah, but what does that have to do with anything? Lysosom ...
Dynamical remodeling of the during tumor growth vascular network K. Bartha
... Start with a small tumor (e.g. Eden cluster of TCs) O2 concentration field is produced by circulated vessels GF (Growth Factor) concentration field is produced by viable TCs TCs proliferate if local O2 conc. is sufficient (TC = Tumor Cell) ECs proliferate when GF conc. is sufficient (EC = Endothelia ...
... Start with a small tumor (e.g. Eden cluster of TCs) O2 concentration field is produced by circulated vessels GF (Growth Factor) concentration field is produced by viable TCs TCs proliferate if local O2 conc. is sufficient (TC = Tumor Cell) ECs proliferate when GF conc. is sufficient (EC = Endothelia ...
1 - Utrecht University Repository
... the cell with the cell environment. Integrins mediate cell adhesion to extracellular matrix (ECM) proteins and to other cells. Integrins are connected to the cytoskeleton, and regulate several signal transduction pathways. In this way, they control many cellular processes, including adhesion, migrat ...
... the cell with the cell environment. Integrins mediate cell adhesion to extracellular matrix (ECM) proteins and to other cells. Integrins are connected to the cytoskeleton, and regulate several signal transduction pathways. In this way, they control many cellular processes, including adhesion, migrat ...
NF-κB
... LUBAC is recruited to the CD40 receptor-signaling complex in response to stimulation, and the CD40-induced canonical NF-κB activation,is attenuated in B cells derived from cpdm and HOIL-1L-/- mice Furthermore, the ablation of HOIP in a B cell line impaired CD40 signaling and abolished the recruitme ...
... LUBAC is recruited to the CD40 receptor-signaling complex in response to stimulation, and the CD40-induced canonical NF-κB activation,is attenuated in B cells derived from cpdm and HOIL-1L-/- mice Furthermore, the ablation of HOIP in a B cell line impaired CD40 signaling and abolished the recruitme ...
Shape and position of the node and notochord along
... the node was preserved. For example, the cilia emanating from the ventral surface of these inverted nodes were positioned toward the posterior region of nodal cells (Fig. 1A9,B9, Fig. 2), and the presumptive notochordal cells were always seen coming out of the anterior-facing side of the node (Figs ...
... the node was preserved. For example, the cilia emanating from the ventral surface of these inverted nodes were positioned toward the posterior region of nodal cells (Fig. 1A9,B9, Fig. 2), and the presumptive notochordal cells were always seen coming out of the anterior-facing side of the node (Figs ...
Taxol-stabilized Microtubules Can Position the
... positioning, with a subpopulation of relatively stable microtubules interacting with the equatorial cortex to promote furrow formation, and dynamic microtubules at the polar regions helping to suppress ectopic furrowing (Canman et al., 2003). Therefore, microtubule dynamics, rather than their locati ...
... positioning, with a subpopulation of relatively stable microtubules interacting with the equatorial cortex to promote furrow formation, and dynamic microtubules at the polar regions helping to suppress ectopic furrowing (Canman et al., 2003). Therefore, microtubule dynamics, rather than their locati ...
Regulated protein degradation controls PKA function and cell
... that CulA, FbxA, and RegA are found in a complex in vivo, and formation of this complex is dependent on the MAP kinase ERK2, which is also required for PKA function. We propose that CulA and FbxA regulate multicellular development by targeting RegA for degradation via a pathway that requires ERK2 fu ...
... that CulA, FbxA, and RegA are found in a complex in vivo, and formation of this complex is dependent on the MAP kinase ERK2, which is also required for PKA function. We propose that CulA and FbxA regulate multicellular development by targeting RegA for degradation via a pathway that requires ERK2 fu ...
Gene Section MAPRE1 (Microtubule-associated protein, RP/EB family, member 1)
... EB1 is important in spindle positioning within the cell. This is thought to be due to its effects on astral microtubule dynamic instability. In budding yeast, EB1 also plays a role in positioning the mitotic spindle through the bud neck. In this case, it is through microtubule dynamics as well direc ...
... EB1 is important in spindle positioning within the cell. This is thought to be due to its effects on astral microtubule dynamic instability. In budding yeast, EB1 also plays a role in positioning the mitotic spindle through the bud neck. In this case, it is through microtubule dynamics as well direc ...
Role of glypican 4 in the regulation of convergent extension
... Xnot), ventral (Xvent-1), dorsal (Xgsc) and neural markers (Xen2), we found that embryos injected dorsally with Xgly4Mo exhibited defects in the positioning and morphology of the mesoendodermal and neural tissues, although they expressed normal levels of specific marker genes (Fig. 4C; data not show ...
... Xnot), ventral (Xvent-1), dorsal (Xgsc) and neural markers (Xen2), we found that embryos injected dorsally with Xgly4Mo exhibited defects in the positioning and morphology of the mesoendodermal and neural tissues, although they expressed normal levels of specific marker genes (Fig. 4C; data not show ...
Peptide Repertoire Class I Molecule Q10 Binds a Classical The
... The biological properties of the nonclassical class I MHC molecules secreted into blood and tissue fluids are not currently understood. To address this issue, we studied the murine Q10 molecule, one of the most abundant, soluble class Ib molecules. Mass spectrometry analyses of hybrid Q10 polypeptid ...
... The biological properties of the nonclassical class I MHC molecules secreted into blood and tissue fluids are not currently understood. To address this issue, we studied the murine Q10 molecule, one of the most abundant, soluble class Ib molecules. Mass spectrometry analyses of hybrid Q10 polypeptid ...
Full Text - The International Journal of Developmental Biology
... animal’s unique body-plan. While gastrulation has been studied extensively in classic model systems such as flies, worms, and vertebrates, less is known about gastrulation at a mechanistic level in other taxa. Surprisingly, one particularly neglected group constitutes a major branch of animals: the ...
... animal’s unique body-plan. While gastrulation has been studied extensively in classic model systems such as flies, worms, and vertebrates, less is known about gastrulation at a mechanistic level in other taxa. Surprisingly, one particularly neglected group constitutes a major branch of animals: the ...
RIBOSOME-INACTIVATING PROTEINS: A Plant Perspective
... inactivates the ribosome, thereby blocking its further participation in protein synthesis. RIPs are widely distributed among different plant genera and within a variety of different tissues. Recent work has shown that enzymatic activity of at least some RIPs is not limited to site-specific action on ...
... inactivates the ribosome, thereby blocking its further participation in protein synthesis. RIPs are widely distributed among different plant genera and within a variety of different tissues. Recent work has shown that enzymatic activity of at least some RIPs is not limited to site-specific action on ...
118 - University of Oxford
... unsolved problems in developmental biology. Mathematical modelling has been a useful tool in this process, as it provides a framework in which to study the outcome of proposed interactions and can make experimentally testable predictions. In this paper we outline the biological background of these p ...
... unsolved problems in developmental biology. Mathematical modelling has been a useful tool in this process, as it provides a framework in which to study the outcome of proposed interactions and can make experimentally testable predictions. In this paper we outline the biological background of these p ...
Examination of the role of signal transduction and oxidative stress in
... Mossman et al, 1983). Cells containing mutations in key proto-oncogenes or tumour suppressor genes may exhibit a ‘response modification’, freeing them from normal growth controls or changing their response to external signals such as growth factors (Cerutti, 1988; Cerutti, 1989). Promotion and progr ...
... Mossman et al, 1983). Cells containing mutations in key proto-oncogenes or tumour suppressor genes may exhibit a ‘response modification’, freeing them from normal growth controls or changing their response to external signals such as growth factors (Cerutti, 1988; Cerutti, 1989). Promotion and progr ...
Extracellular matrix
In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by cells that provides structural and biochemical support to the surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest.The plant ECM includes cell wall components, like cellulose, in addition to more complex signaling molecules. Some single-celled organisms adopt multicelluar biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances (EPS).