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cathepsin-d is required for the growth of fibroblasts in - HAL
cathepsin-d is required for the growth of fibroblasts in - HAL

... dimensional (3D) matrices and in vivo in athymic nude mice (Rochefort and LiaudetCoopman, 1999; Glondu et al., 2001). Immunohistochemical studies indicated that cath-D, independently of its proteolytic activity, stimulates not only cancer cell proliferation by an autocrine and/or intracrine mechani ...
Musculoskeletal
Musculoskeletal

... • Periosteum: produces reactive bone if stimulated (causes Codman’s triangle, sunburst, or onion skin patterns on X-ray) • Osteoblasts, contain alkaline phosphate, become osteocytes, produce osteoid (like collagen) which becomes mineralised as bone (fibres are at first irregular - woven - later beco ...
Unit 2-3 Review
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... 3. Organisms show adaptation. 4. Organisms respond to changes in the environment. 5. Organisms grow and develop. 6. Organisms maintain homeostasis 7. Organisms Reproduce ...
6 systems biology of cell organization
6 systems biology of cell organization

... activities of cells are controlled by many proteins that are generally known as regulatory proteins. As described next, some of these proteins regulate genes in the cell nucleus, while others regulate the functions of other proteins. 2. Gene and protein regulation cause the proteome to be dynamic. I ...
as a PDF
as a PDF

... from the oviduct and upregulated during the blastocyst stage (E3.5). The extraembryonic endoderm layer is formed during this stage and in the presence of LIF (Shen and Leder, 1992). In agreement with this, previous studies have demonstrated that aggregated ES cells can give rise to primitive endoder ...
Sexual Reproduction in Higher Plants I: Fertilization and Zygotic
Sexual Reproduction in Higher Plants I: Fertilization and Zygotic

... recognize each other and how the embryogenesis program is initiated are two important questions. Although this process has been studied extensively in animals using the model organisms such as fly, nematode and mouse (for review, see Zurita et al. 2008), the knowledge in plants is rather descriptive ...
Chapter 1 The Study of Life/ Chapter 2
Chapter 1 The Study of Life/ Chapter 2

... 5. Describe the function of enzymes, including how enzymesubstrate specificity works, in biochemical reactions - describe the effect of enzymes on the activation of energy needed for chemical reactions to take place. - Define a catalyst - List examples and describe the name of several enzymes. 7. Ex ...
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... molecule approaches, arguably better termed ‘in cellulo’ approaches if one is observing single individual cells to discriminate from investigations on multicellular organisms (excepting single-celled organisms such as bacteria which can be described in both contexts), add significant insight not onl ...
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Full-Text PDF

... genetics, immuno-binding/cytochemical labeling, high resolution microscopy and spectroscopy have recently provided significant insight into deciphering the complexities of the plant cell wall [1–6]. The current, yet rapidly evolving, working model of the cell wall is one of a fibrous composite of po ...
The perichromatin region of the plant cell nucleus is the area with
The perichromatin region of the plant cell nucleus is the area with

... Allium cepa (Cui and Moreno Dı́az de la Espina 2003), but its role in the functioning of the splicing system has not been determined to date. The eukaryotic spliceosome contains SR proteins in addition to snRNAs. They are characterised by the presence of one or two RNA-binding domains of the RRM typ ...
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BLM 2-30, Compare the Events of Meiosis and Mitosis Key Meiosis I

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Genetically Engineered Cell Lines: Characterisation and

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Penium margaritaceum: A Unicellular Model Organism for

The plant cytoskeleton: its significance in plant
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A Heat Shows of Two Shock-resistant Mutant of Saccharomyces

... Cells of the mutant are approximately 1,000-fold more resistant to lethal heat shock than those of the parental strain. Tetrad analysis indicates that phenotypes revealed by this mutant segregated together in the ratio 2+:2 - from heterozygotes constructed with the wild-type strain of the opposite m ...
Chapter 8: Cellular Transport and the Cell Cycle
Chapter 8: Cellular Transport and the Cell Cycle

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The D-Type Alfalfa Cyclin Gene cycMs4 Complements

... Cyclins are key regulators of the cell cycle in all eukaryotes. In alfalfa, we have previously isolated three 6-type cyclins. The closely related c y c M s l and cycMs2 genes are expressed primarily during the G2 and M phases and are most likely mitotic cyclins; expression of the cycMs3 gene is indu ...
Mechanics of the Cvtoskeleton
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Heart Valve Tissue Engineering: Concepts, Approaches, Progress
Heart Valve Tissue Engineering: Concepts, Approaches, Progress

... exposed to the same mechanical environment. These differences suggest a unique phenotype of VEC not mimicked by vascular cells and could have implications for cardiovascular cell biology and cell-source considerations for tissue-engineered heart valves. Moreover, different transcriptional profiles a ...
B6A-8 - De Anza
B6A-8 - De Anza

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... Caloric value depends on • amount energy per gram HOW, WHY?? • fats have more than carbs or proteins • HIGH Caloric value!!! ...
Cellular polarity, mitotic synchrony and axes of
Cellular polarity, mitotic synchrony and axes of

... with respect to the morphogenetic furrow (Wolff and Ready, 1991). The link between this process and embryonic polarity is that furrow progression is controlled by segment polarity genes, in particular hedgehog (hh) (Ma et al., 1993). Normal furrow progression requires the induction of hh expression ...
Characterization of clonogenic multiple myeloma cells
Characterization of clonogenic multiple myeloma cells

... unclear whether MM plasma cells have the proliferative capacity required for the initiation, maintenance, and progression of clinical disease. On the other hand, cells phenotypically resembling mature B cells and sharing immunoglobulin gene sequences and idiotype specificity with MM plasma cells hav ...
The Differentiation of Contact Cells and Isolation
The Differentiation of Contact Cells and Isolation

... is maintained through the rows of isolation cells. We observed no isotropic layer in isolation cells after deposition of secondary walls (Fig. 5 B). Chafe (1974) reported that isolation cells of Populus tremuloides formed secondary walls and isotropic layers, all of which became lignified, within a ...
Electronic Student Book Chapter 1
Electronic Student Book Chapter 1

... In 1999, there were reports in the northeastern United States of unusually high numbers of dead birds. Similar reports were released in southern Ontario in 2001. Microbiologists, who study cells, examined the bird carcasses to find out what was happening. They studied blood and tissue samples under ...
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Extracellular matrix



In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by cells that provides structural and biochemical support to the surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest.The plant ECM includes cell wall components, like cellulose, in addition to more complex signaling molecules. Some single-celled organisms adopt multicelluar biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances (EPS).
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