File - Developing Anaesthesia
... Rivaroxaban (trade name in Australia “Xarelto”), is a drug from a novel class of noncoumarin anticoagulants, (loosely known as NOACs or “New Oral Anticoagulants”) which is an orally active direct Factor Xa inhibitor. It offers some significant therapeutic advantages over warfarin, but is more proble ...
... Rivaroxaban (trade name in Australia “Xarelto”), is a drug from a novel class of noncoumarin anticoagulants, (loosely known as NOACs or “New Oral Anticoagulants”) which is an orally active direct Factor Xa inhibitor. It offers some significant therapeutic advantages over warfarin, but is more proble ...
Aspirin Resistance in Cardiovascular Disease
... Low dose aspirin started immediately after MI prevents reinfarction and reduce mortality. Use with or with out Heparin Clopidogrel/Ticlopidine are alternatives ...
... Low dose aspirin started immediately after MI prevents reinfarction and reduce mortality. Use with or with out Heparin Clopidogrel/Ticlopidine are alternatives ...
Legal Drugs
... and small intestine cancer. Pregnancy: Physical defects can develop in a fetus in association with high levels of alcohol consumption during pregnancy. Alcohol crosses the placental barrier and can stunt fetal growth or weight, create distinctive facial stigmata, damage neurons and brain structure ...
... and small intestine cancer. Pregnancy: Physical defects can develop in a fetus in association with high levels of alcohol consumption during pregnancy. Alcohol crosses the placental barrier and can stunt fetal growth or weight, create distinctive facial stigmata, damage neurons and brain structure ...
Effects of oral contraceptives - Microgynon and Primolut
... Oral contraceptives (OCs) are drugs taken orally for the prevention of pregnancy. Around 100 million women throughout the world now use the drugs. (kay et al., 1974; Kuhl & Goethe, 1990; CHPE, 1984). The oral contraceptives: Microgynon a combined pill (0.15mg levonorgestrel and 0.03mg ethinylestradi ...
... Oral contraceptives (OCs) are drugs taken orally for the prevention of pregnancy. Around 100 million women throughout the world now use the drugs. (kay et al., 1974; Kuhl & Goethe, 1990; CHPE, 1984). The oral contraceptives: Microgynon a combined pill (0.15mg levonorgestrel and 0.03mg ethinylestradi ...
SUMMARY OF PRODUCT CHARACTERISTICS 4 CLINICAL
... Corticosteroids: increased risk of gastrointestinal ulceration or bleeding (see section 4.4). Digoxin, Digitoxin: Concurrent therapy with Feldene and digoxin, or Feldene and digitoxin, did not affect the plasma levels of either drug. Diuretics: Non-steroidal anti-inflammatory drugs may cause sodium, ...
... Corticosteroids: increased risk of gastrointestinal ulceration or bleeding (see section 4.4). Digoxin, Digitoxin: Concurrent therapy with Feldene and digoxin, or Feldene and digitoxin, did not affect the plasma levels of either drug. Diuretics: Non-steroidal anti-inflammatory drugs may cause sodium, ...
Medicines Over the Counter and Dosing
... short period of time, although there are a growing number of studies in children that find no significant difference in symptomatic relief when compared with placeboes. More troubling is that despite their wide use and sales, there is simply no good evidence to suggest that these agents do anything ...
... short period of time, although there are a growing number of studies in children that find no significant difference in symptomatic relief when compared with placeboes. More troubling is that despite their wide use and sales, there is simply no good evidence to suggest that these agents do anything ...
Letairis
... Decreases in hemoglobin concentration and hematocrit have followed administration of other endothelin receptor antagonists and were observed in clinical studies with Letairis. These decreases were observed within the first few weeks of treatment with Letairis, and stabilized thereafter. The mean dec ...
... Decreases in hemoglobin concentration and hematocrit have followed administration of other endothelin receptor antagonists and were observed in clinical studies with Letairis. These decreases were observed within the first few weeks of treatment with Letairis, and stabilized thereafter. The mean dec ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These
... the breastfed infant, or the effects of the drug on milk production. Animal studies have shown, however, that ivabradine is present in rat milk [see Data]. Because of the potential risk to breastfed infants from exposure to Corlanor, breastfeeding is not recommended. ...
... the breastfed infant, or the effects of the drug on milk production. Animal studies have shown, however, that ivabradine is present in rat milk [see Data]. Because of the potential risk to breastfed infants from exposure to Corlanor, breastfeeding is not recommended. ...
diuretics
... following would be LEAST harmful in a patient with severe hyperkalemia A. Amiloride ...
... following would be LEAST harmful in a patient with severe hyperkalemia A. Amiloride ...
Slide 1
... Equol producers have many health benefits Ausio is in a strong position to develop S-equol ...
... Equol producers have many health benefits Ausio is in a strong position to develop S-equol ...
STEP ONE- Nurse or GP
... There is no place now for oral bronchodilators- tablets or syrup. No ‘niche’ exists for their use- in children little benefit from bronchodilators under 2 and most mums should manage a spacer and inhaler with or without a mask. A plastic cup can be useful in an emergency and less threatening than a ...
... There is no place now for oral bronchodilators- tablets or syrup. No ‘niche’ exists for their use- in children little benefit from bronchodilators under 2 and most mums should manage a spacer and inhaler with or without a mask. A plastic cup can be useful in an emergency and less threatening than a ...
Coagulation
... (risk depends on both the INR and patient factors) Contraindicated in pregnancy - teratogenic effects, crosses placenta risk foetal haemorrhage Warfarin induced skin necrosis - paradoxical local thrombosis - increased in patients with protein C or S deficiency ...
... (risk depends on both the INR and patient factors) Contraindicated in pregnancy - teratogenic effects, crosses placenta risk foetal haemorrhage Warfarin induced skin necrosis - paradoxical local thrombosis - increased in patients with protein C or S deficiency ...
Table 17. Specific Drug Information for ER/LA Opioid
... Titrate using a minimum of 1- to 2-day intervals. Hepatic impairment: start with one-third to one-half the usual dosage. Renal impairment (creatinine clearance <60 mL/min): start with onehalf the usual dosage. Consider use of other analgesics in patients who have difficulty swallowing or have unde ...
... Titrate using a minimum of 1- to 2-day intervals. Hepatic impairment: start with one-third to one-half the usual dosage. Renal impairment (creatinine clearance <60 mL/min): start with onehalf the usual dosage. Consider use of other analgesics in patients who have difficulty swallowing or have unde ...
Slide 1 - Texas Tech University Health Sciences Center
... drugs which cause an altered sensory perception without losing consciousness Monoamine reuptake inhibition NMDA (N-Methyl-D-aspartic acid) antagonism Sigma opioid receptor: PCP associates with extremely high ...
... drugs which cause an altered sensory perception without losing consciousness Monoamine reuptake inhibition NMDA (N-Methyl-D-aspartic acid) antagonism Sigma opioid receptor: PCP associates with extremely high ...
Equianalgesic Dosing of Opioids for Pain Management
... Equianalgesic Dosing of Opioids for Pain Management Equianalgesic doses contained in this chart are approximate, and should be used only as a guideline. Dosing must be titrated to individual response. There is often incomplete cross-tolerance among these drugs. It is, therefore, recommended to begin ...
... Equianalgesic Dosing of Opioids for Pain Management Equianalgesic doses contained in this chart are approximate, and should be used only as a guideline. Dosing must be titrated to individual response. There is often incomplete cross-tolerance among these drugs. It is, therefore, recommended to begin ...
Can Topical and Oral NSAIDs Be Combined for
... Patients with moderate to severe musculoskeletal pain may experience suboptimal relief despite the use of a nonsteroidal anti-inflammatory drug (NSAID). Patients seeking additional pain relief may inquire about the use of topical NSAID therapy in addition to oral NSAID therapy. Currently, no guideli ...
... Patients with moderate to severe musculoskeletal pain may experience suboptimal relief despite the use of a nonsteroidal anti-inflammatory drug (NSAID). Patients seeking additional pain relief may inquire about the use of topical NSAID therapy in addition to oral NSAID therapy. Currently, no guideli ...
Lamisil Singeldos cutaneous solution ENG SmPC
... in either species up to oral doses of about 100 mg/kg a day. At high oral doses, the liver and possibly also the kidneys were identified as potential target organs. In a two-year oral carcinogenicity study in mice, no neoplastic or other abnormal findings attributable to treatment were made up to do ...
... in either species up to oral doses of about 100 mg/kg a day. At high oral doses, the liver and possibly also the kidneys were identified as potential target organs. In a two-year oral carcinogenicity study in mice, no neoplastic or other abnormal findings attributable to treatment were made up to do ...
extensively metabolized by the liver. Tizanidine is
... Special precaution for use: In patients with renal insufficiency (creatinine clearance <25ml /min), it is recommended to start treatment at 2mg once daily. Dosage increases should be done in small steps according to tolerability and efficacy. if efficacy has to be improved, it is advisable to increa ...
... Special precaution for use: In patients with renal insufficiency (creatinine clearance <25ml /min), it is recommended to start treatment at 2mg once daily. Dosage increases should be done in small steps according to tolerability and efficacy. if efficacy has to be improved, it is advisable to increa ...
Alupent - Boehringer Ingelheim
... Carcinogenesis Long-term studies in mice and rats to evaluate the oral carcinogenic potential of metaproterenol sulfate have not been completed. Studies of metaproterenol sulfate have not been conducted to determine mutagenic potential or effect on fertility. Pregnancy TERATOGENIC EFFECTS: Pregnanc ...
... Carcinogenesis Long-term studies in mice and rats to evaluate the oral carcinogenic potential of metaproterenol sulfate have not been completed. Studies of metaproterenol sulfate have not been conducted to determine mutagenic potential or effect on fertility. Pregnancy TERATOGENIC EFFECTS: Pregnanc ...
Media Kit - Perosphere Inc.
... synthesize, and characterize a synthetic small molecule anticoagulant antidote (PER977). Blood was drawn from healthy human volunteers. Plasma was immediately collected and spiked with rivaroxaban or apixaban at 1x and 2x the therapeutic Cmax. Factor Xa activity was measured before and after PER977 ...
... synthesize, and characterize a synthetic small molecule anticoagulant antidote (PER977). Blood was drawn from healthy human volunteers. Plasma was immediately collected and spiked with rivaroxaban or apixaban at 1x and 2x the therapeutic Cmax. Factor Xa activity was measured before and after PER977 ...
Endocrine draft for consultation
... before initiating and during treatment. Prescribers should review patients after three to six months (and regularly thereafter) to ensure only patients who are benefiting from treatment continue Competact® (pioglitazone and metformin) should be reserved for patients with demonstrable compliance pr ...
... before initiating and during treatment. Prescribers should review patients after three to six months (and regularly thereafter) to ensure only patients who are benefiting from treatment continue Competact® (pioglitazone and metformin) should be reserved for patients with demonstrable compliance pr ...
Latanoprost Mylan eye drops, solution ENG SmPC
... intraocular pressure in man starts about three to four hours after administration and maximum effect is reached after eight to twelve hours. Pressure reduction is maintained for at least 24 hours. Studies in animals and man indicate that the main mechanism of action is increased uveoscleral outflow, ...
... intraocular pressure in man starts about three to four hours after administration and maximum effect is reached after eight to twelve hours. Pressure reduction is maintained for at least 24 hours. Studies in animals and man indicate that the main mechanism of action is increased uveoscleral outflow, ...
Lincocin®lincomycin hydrochloride tablets and
... with the individual animal. Levels are maintained above the in vitro minimum inhibitory concentration for most gram-positive organisms for six to eight hours following a therapeutic dose. Intravenous administration also provides very rapid absorption, but should be administered with normal saline or ...
... with the individual animal. Levels are maintained above the in vitro minimum inhibitory concentration for most gram-positive organisms for six to eight hours following a therapeutic dose. Intravenous administration also provides very rapid absorption, but should be administered with normal saline or ...
HiDAC (High Dose Cytarabine) for AML
... Relapsed disease post transplant. 3g/m2 is the standard dose. The dose may be reduced to 1.5g/m2 in elderly patients or those relapsed post transplant where 3g/m2 may not be tolerated. ...
... Relapsed disease post transplant. 3g/m2 is the standard dose. The dose may be reduced to 1.5g/m2 in elderly patients or those relapsed post transplant where 3g/m2 may not be tolerated. ...
LORazepam (lor-az-e-pam) - DavisPlus
... tion, mood, behavior) prior to and periodically throughout therapy. ...
... tion, mood, behavior) prior to and periodically throughout therapy. ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.