Pharmacology Study Guide - Wright State University`s College of
... There is a bit of an overlap here with Principles of Pharmacology. These questions tend to be medication (or classification) specific. There are many medications on the test and many could be. As applicable, both brand and generic names are used. We recognize the attached grid is very lengthy, but h ...
... There is a bit of an overlap here with Principles of Pharmacology. These questions tend to be medication (or classification) specific. There are many medications on the test and many could be. As applicable, both brand and generic names are used. We recognize the attached grid is very lengthy, but h ...
Newer Antihistamines
... fexofenadine 180 mg, loratadine 10 mg, or chlorpheniramine 8 mg to 21 men (7 in each group). Before dosing and at 1, 3, 6, 9, and 24 hours after the first antihistamine dose as well as at 168, 192, and 216 hours after the first dose (ie, 12, 36, and 60 hours after the seventh and last consecutive da ...
... fexofenadine 180 mg, loratadine 10 mg, or chlorpheniramine 8 mg to 21 men (7 in each group). Before dosing and at 1, 3, 6, 9, and 24 hours after the first antihistamine dose as well as at 168, 192, and 216 hours after the first dose (ie, 12, 36, and 60 hours after the seventh and last consecutive da ...
Full Prescribing Information
... other opioid analgesics. ABSTRAL can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing ABSTRAL in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse or diversion. Because ...
... other opioid analgesics. ABSTRAL can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing ABSTRAL in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse or diversion. Because ...
Use of Plasma Octreotide Levels to Guide Sandostatin® LAR Dosing
... somatostatin analog available in the US for the treatment of neuroendocrine tumors. Some investigators believe that octreotide has both a suppressive effect on the growth of tumor cells in vitro and an antiproliferative or tumorostatic effect clinically. Octreotide growth inhibitory action in tumor ...
... somatostatin analog available in the US for the treatment of neuroendocrine tumors. Some investigators believe that octreotide has both a suppressive effect on the growth of tumor cells in vitro and an antiproliferative or tumorostatic effect clinically. Octreotide growth inhibitory action in tumor ...
Dose-Response Study of N,N-Dimethyltryptamine in Humans
... emphasizes the agonist or partial agonist properties of hallucinogens at serotonin (5-HT) receptors, specifically the 5-HT sub 2 [5,6], 5-HT1A [7], and 5-HT1C8 subtypes. N,N-dimethyltryptamine (DMT) is a prototypical indole hallucinogen, originally discovered in plants [9], but later found in lower ...
... emphasizes the agonist or partial agonist properties of hallucinogens at serotonin (5-HT) receptors, specifically the 5-HT sub 2 [5,6], 5-HT1A [7], and 5-HT1C8 subtypes. N,N-dimethyltryptamine (DMT) is a prototypical indole hallucinogen, originally discovered in plants [9], but later found in lower ...
Medroxyprogesterone at High Altitude. The Effects on Blood Gases
... acute mountain sickness (AMS). Design.—Two placebo-controlled trials during rapid ascent to high altitude. Participants.—In the first trial, 20 participants, and in the second trial, 24 participants. Setting.—During rapid ascent to 4680 m and on rapid ascent to 5200 m. Intervention.—In the first tri ...
... acute mountain sickness (AMS). Design.—Two placebo-controlled trials during rapid ascent to high altitude. Participants.—In the first trial, 20 participants, and in the second trial, 24 participants. Setting.—During rapid ascent to 4680 m and on rapid ascent to 5200 m. Intervention.—In the first tri ...
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... the overall analgesic profile of ULTRAM®. Analgesia in humans begins approximately within one hour after administration and reaches a peak in approximately two to three hours. Apart from analgesia, ULTRAM® administration may produce a constellation of symptoms (including dizziness, somnolence, nause ...
... the overall analgesic profile of ULTRAM®. Analgesia in humans begins approximately within one hour after administration and reaches a peak in approximately two to three hours. Apart from analgesia, ULTRAM® administration may produce a constellation of symptoms (including dizziness, somnolence, nause ...
Nonsurgical Treatment of Adenoidal Hypertrophy with Cefuroxime
... cardiorespiratory syndrome may necessitate urgent surgical removal of the adenoid (2,3). Lesser degrees of adenoidal hypertrophy complicated by chronic sinusitis, recurrent/chronic serous otitis media and/or significant obstructive symptoms are among other indications for surgical intervention (4). ...
... cardiorespiratory syndrome may necessitate urgent surgical removal of the adenoid (2,3). Lesser degrees of adenoidal hypertrophy complicated by chronic sinusitis, recurrent/chronic serous otitis media and/or significant obstructive symptoms are among other indications for surgical intervention (4). ...
Walker GJA, Johnstone PW. Interventions for treating
... Patients who are first exposed to scabies often do not develop symptoms for several weeks. A well documented case report detailed the spread of scabies in a day care center, in which 21% of the staff and children were eventually infected. More than 570 family members of the children also became symp ...
... Patients who are first exposed to scabies often do not develop symptoms for several weeks. A well documented case report detailed the spread of scabies in a day care center, in which 21% of the staff and children were eventually infected. More than 570 family members of the children also became symp ...
BIOAVAILABILITY OF ORAL PROPOFOL IN HUMANS Victor
... the oxygen saturation of any volunteer. Discussion: The absorption of orally administered propofol is trivial. In 5 of 6 volunteers the propofol concentrations over the first hour were at or below the limits of quantitation. In one volunteer a trivial dose of 11 mg was absorbed following oral ingest ...
... the oxygen saturation of any volunteer. Discussion: The absorption of orally administered propofol is trivial. In 5 of 6 volunteers the propofol concentrations over the first hour were at or below the limits of quantitation. In one volunteer a trivial dose of 11 mg was absorbed following oral ingest ...
highlights of prescribing information
... PYLERA is contraindicated in patients who have taken disulfiram within the last two weeks. Psychotic reactions have been reported in alcoholic patients who are using metronidazole, a component of PYLERA, and disulfiram concurrently [see Drug Interactions (7.2)]. 4.3 Alcohol Alcoholic beverages or ot ...
... PYLERA is contraindicated in patients who have taken disulfiram within the last two weeks. Psychotic reactions have been reported in alcoholic patients who are using metronidazole, a component of PYLERA, and disulfiram concurrently [see Drug Interactions (7.2)]. 4.3 Alcohol Alcoholic beverages or ot ...
Cl = Vd x 0T693
... small single oral doses of propranolol is very small. However, as the single oral dose is increased above about 30 mg, the avid removal process becomes saturated and hepatic extraction falls, resulting in a larger fraction of an oral dose reaching the systemic circulation and a longer half-life, of ...
... small single oral doses of propranolol is very small. However, as the single oral dose is increased above about 30 mg, the avid removal process becomes saturated and hepatic extraction falls, resulting in a larger fraction of an oral dose reaching the systemic circulation and a longer half-life, of ...
ASCO 2011 NKTR-102 PopPK Poster
... proprietary polymer conjugation to improve the PK of its active metabolite SN38 resulting in significantly reduced Cmax and sustained exposure throughout the dosing interval. Methods: NKTR-102 was administered as a 90-min IV inf. to 94 pts: 76 pts at 58-245 mg/m2 wx3q4w, q14d or q21d, and 18 pts at ...
... proprietary polymer conjugation to improve the PK of its active metabolite SN38 resulting in significantly reduced Cmax and sustained exposure throughout the dosing interval. Methods: NKTR-102 was administered as a 90-min IV inf. to 94 pts: 76 pts at 58-245 mg/m2 wx3q4w, q14d or q21d, and 18 pts at ...
DICETEL PM
... syndrome were studied separately: pain, bowel disturbances and distension. Pinaverium bromide tablets were shown to be equivalent to the capsules; the tablet was however better tolerated. 16,35 In addition, the long-term safety and tolerance of the tablet at a dose of 3 tablets/day for a duration of ...
... syndrome were studied separately: pain, bowel disturbances and distension. Pinaverium bromide tablets were shown to be equivalent to the capsules; the tablet was however better tolerated. 16,35 In addition, the long-term safety and tolerance of the tablet at a dose of 3 tablets/day for a duration of ...
Autonomic Pharmacology
... in the respiratory tract these agents increase tracheobronchial secretions, bronchial tone and stimulate the carotid sinus and aortic body chemoreceptors in the eye they produce miosis, though, the ensuing fall in intraocular pressure may be preceded by a transient rise due to vasodilation & increas ...
... in the respiratory tract these agents increase tracheobronchial secretions, bronchial tone and stimulate the carotid sinus and aortic body chemoreceptors in the eye they produce miosis, though, the ensuing fall in intraocular pressure may be preceded by a transient rise due to vasodilation & increas ...
Slide
... when the highest dose in the study was less than ED95 the parameter estimates for EMAX, ED50, and N are poorly estimated with a high coefficient of variation and bias. However, within the range for which the data were available, the fit of the EMAX model to the data was quite good. Hence, care shoul ...
... when the highest dose in the study was less than ED95 the parameter estimates for EMAX, ED50, and N are poorly estimated with a high coefficient of variation and bias. However, within the range for which the data were available, the fit of the EMAX model to the data was quite good. Hence, care shoul ...
Allergy - Australian Medicines Handbook
... onset after IV exposure may be faster than after oral exposure). The risk or severity of anaphylactic reactions may be affected by other factors, such as exercise, infections, other diseases (eg asthma), drugs (eg NSAIDs), alcohol. There are no clinically relevant differences between anaphylactic re ...
... onset after IV exposure may be faster than after oral exposure). The risk or severity of anaphylactic reactions may be affected by other factors, such as exercise, infections, other diseases (eg asthma), drugs (eg NSAIDs), alcohol. There are no clinically relevant differences between anaphylactic re ...
A Comparison of Oral Azithromycin with Topical Oxytetracycline
... recommends a single 1.0-g dose of oral azithromycin as an equivalent to 7 days of oral doxycycline therapy [11] . A trial of trachoma therapy in Gambia compared a single dose of azithromycin (20 mg/kg) in 97 subjects to twice daily topical tetracycline for 6 weeks in 97 subjects, 10 of whom also rec ...
... recommends a single 1.0-g dose of oral azithromycin as an equivalent to 7 days of oral doxycycline therapy [11] . A trial of trachoma therapy in Gambia compared a single dose of azithromycin (20 mg/kg) in 97 subjects to twice daily topical tetracycline for 6 weeks in 97 subjects, 10 of whom also rec ...
SPIRIVA® 18 microgram, inhalation powder, hard capsule
... bromide inhalation powder has been used concomitantly with other drugs without clinical evidence of drug interactions. These include sympathomimetic bronchodilators, methylxanthines, oral and inhaled steroids, commonly used in the treatment of COPD. The co-administration of tiotropium bromide with o ...
... bromide inhalation powder has been used concomitantly with other drugs without clinical evidence of drug interactions. These include sympathomimetic bronchodilators, methylxanthines, oral and inhaled steroids, commonly used in the treatment of COPD. The co-administration of tiotropium bromide with o ...
DRUG NAME - BC Cancer Agency
... should be considered when other hepatotoxic drugs are being used, or when there is pre-existing liver disease. Mercaptopurine should be discontinued with the onset of clinical jaundice, hepatomegaly, anorexia with tenderness in the right hypochondrium, deterioration in liver function tests, toxic he ...
... should be considered when other hepatotoxic drugs are being used, or when there is pre-existing liver disease. Mercaptopurine should be discontinued with the onset of clinical jaundice, hepatomegaly, anorexia with tenderness in the right hypochondrium, deterioration in liver function tests, toxic he ...
domperidone domperidone
... drug is effective for treating such conditions as gastroparesis and gastroesophageal reflux but appears to have little physiologic effect on the colon or in colonic motility disorders. 7 Domperidone has not yet been approved for use in the United States, and there is little clinical experience with ...
... drug is effective for treating such conditions as gastroparesis and gastroesophageal reflux but appears to have little physiologic effect on the colon or in colonic motility disorders. 7 Domperidone has not yet been approved for use in the United States, and there is little clinical experience with ...
IDWeek 2015_Dalbavancin Poster #786_Van Anglen et al
... (53%) received other intravenous antibiotics (IVABs) prior to treatment with DAL for a median of 5 days. Eighty seven pts (83%) received 2 doses of DAL, one week apart. Six pts (6%) received more than 2 doses. Infusions were administered by peripheral intravenous catheter in 84 pts (80%). Among 81 p ...
... (53%) received other intravenous antibiotics (IVABs) prior to treatment with DAL for a median of 5 days. Eighty seven pts (83%) received 2 doses of DAL, one week apart. Six pts (6%) received more than 2 doses. Infusions were administered by peripheral intravenous catheter in 84 pts (80%). Among 81 p ...
Nasacort AQ (troamcinolone acetonide)
... The recommended starting dose of NASACORT AQ (triamcinolone acetonide aqueous nasal spray) is 220 mcg as two sprays in each nostril once daily. It is always desirable to titrate an individual patient to the minimum effective dose to reduce the possibility of side effects. Therefore, when the maximum ...
... The recommended starting dose of NASACORT AQ (triamcinolone acetonide aqueous nasal spray) is 220 mcg as two sprays in each nostril once daily. It is always desirable to titrate an individual patient to the minimum effective dose to reduce the possibility of side effects. Therefore, when the maximum ...
Pharmacokinetics
... warfarin, benzodiapzepines, sumatriptan. Fatal reactions: MAOI's. > sertraline levels: cimetidine, warfarin, other highly protein bound drugs. Altered lithium levels: lithium. Sertraline in contraindicated with pimozide. Potentiation of SSRI, serotonin syndrome: St. John's Wort, SAM-e; do not use to ...
... warfarin, benzodiapzepines, sumatriptan. Fatal reactions: MAOI's. > sertraline levels: cimetidine, warfarin, other highly protein bound drugs. Altered lithium levels: lithium. Sertraline in contraindicated with pimozide. Potentiation of SSRI, serotonin syndrome: St. John's Wort, SAM-e; do not use to ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.