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Determine by Doctor
Determine by Doctor

... exceed 9 mg/L for this reason, many clinicians prefer to use a therapeutic range of approximately 4 to 8 mg/L the most common adverse effects associated with carbamazepine involve the central nervous system (CNS) nystagmus, ataxia , blurred vision, and drowsiness. In most patients, the ratio of carb ...
Co-trimoxazole (Systemic) 46067 AHFS Essentials ASHPI
Co-trimoxazole (Systemic) 46067 AHFS Essentials ASHPI

... 100 mg/kg of sulfamethoxazole daily in 3 or 4 divided doses. Usual duration is 14– 21 days. IV: Children ⱖ2 months of age: 15– 20 mg/kg of trimethoprim daily (as co-trimoxazole) in 3 or 4 equally divided doses. Usual duration is 14– 21 days. ⬎Primary Prophylaxis in Infants and Children Oral: 150 mg/ ...
Imovane (zopiclone)
Imovane (zopiclone)

... The principal metabolites are the N-oxide derivative (~12%), which has weak pharmacological activity in animals, and the N-desmethyl metabolite (~16%), which is pharmacologically inactive. Their apparent half-lives evaluated from the urinary data are approximately 4.5 and 7.4 hours, respectively. Bo ...
6 Acyclovir for Neonatal and Pediatric Viral Infections
6 Acyclovir for Neonatal and Pediatric Viral Infections

... been reproduced in the high-dose IV study6 and a study of oral acyclovir in 79 children less than 2 years of age.15 Elimination half-life in the oral study was found to decline sharply during the first month of life, from 10-15 hours at birth down to 2.5 hours at one month. Drug Interactions Acyclov ...
Calcium Channel Blockers 1997
Calcium Channel Blockers 1997

... as Adalat XLâ or newer CCBs such as felodipine ER offer a more gradual onset of effect and are preferred when CCBs are used for HTN.14,15 Although CCBs are effective and usually well tolerated, they should be used with caution. Given their uncertain long term efficacy, safety risks and higher cost ( ...
NSAIDs
NSAIDs

... The active ingredient of Willow bark , Salicin , which on hydrolysis yields salicylic acid , was later found in other natural sources. Acetyl salicylic acid was synthesized in 1853, but the drug was note used until 1899, when it is found to effective in arthritis. Because of its greater efficacy and ...
Anti-inflammatory and Analgesic Activity of Methanolic Extract of
Anti-inflammatory and Analgesic Activity of Methanolic Extract of

... Analgesics are drugs that selectively relieve pain by acting in the CNS or on peripheral pain mechanisms, without significantly altering consciousness. Analgesics relieve pain, without affecting its cause. Analgesics are divided into two groups, opioid analgesic and non-opioid analgesic [3]. The use ...
Trimethoprim - Barbary Coast Samoyed Club
Trimethoprim - Barbary Coast Samoyed Club

... susceptible to this toxicosis. A large majority of the animals in which idiosyncratic toxicosis occurs have had a previous exposure to a sulfonamide. Most cases involve a trimethoprim and sulfonamide combination. When sulfonamide therapy is discontinued, recovery generally occurs within 2 to 5 days. ...
invega sustenna
invega sustenna

... Absorption and Distribution: Due to its extremely low water solubility, paliperidone palmitate dissolves slowly after intramuscular injection before being hydrolyzed to paliperidone and absorbed into the systemic circulation. Following a single intramuscular dose, the plasma concentrations of palipe ...


... Erythromycin (and to a somewhat lesser extent clarithromycin) has the potential to inhibit the metabolism of any other drug taken concurrently that is metabolized by CYP3A4. A few documented interactions with erythro include cyclosporin (CYP3A4), carbamazepine (CYP3A4), and digoxin. Digoxin is a spe ...
Trends in the treatment of dermatophytosis 148
Trends in the treatment of dermatophytosis 148

... blood cells. It is extremely lipophilic and achieves high concentrations in fat, omentum, skin/nails and vaginal/cervical tissues [10]. Accumulation in skin is slow and antifungal therapeutically active high concentrations persist up to a month after the end of treatment [13]. The concentrations in ...
IMITREX® Tablets Tear Sheet
IMITREX® Tablets Tear Sheet

... after dosing. Associated symptoms such as nausea, photophobia, and phonophobia were also assessed. Maintenance of response was assessed for up to 24 hours postdose. A second dose of IMITREX Tablets or other medication was allowed 4 to 24 hours after the initial treatment for recurrent headache. Acet ...
The role of Mondia whitei in reproduction: a review of current evidence
The role of Mondia whitei in reproduction: a review of current evidence

... action. This increased sperm density observed in the cauda epididymis of the treated rats confirmed the androgenic effect of Mondia whitei. The findings of this study suggested that Mondia whitei possesses sex-stimulant property thus supporting its traditional use as an aphrodisiac. ...
EVALUATION OF ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC POTENTIAL OF SWERTIA CORYMBOSA Research Article
EVALUATION OF ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC POTENTIAL OF SWERTIA CORYMBOSA Research Article

... myeloperoxidase) are used as markers of inflammation [1]. Study of inflammation with carrageenan as a phlogistic agent has revealed increased vascular permeability, formation of exudate and a large number of cellular infiltrates a polymorphonuclear leukocyte [2]. Tumor necrosis factor alpha (TNF-α), ...
The biochemical effects of ivermectin on reproductive hormones and
The biochemical effects of ivermectin on reproductive hormones and

... viewpoints about the effects of IVM on animal reproduction are prevalent among scientists. Namely, some researchers feel that IVM has dangerous and hazardous effects on reproduction (COUSENS et al., 1997). Others feel that IVM can have beneficial effects on reproductive efficiency in animals (LANKAS ...
Product Information: Rifaximin
Product Information: Rifaximin

... should be instituted as clinically indicated. Use with P-glycoprotein inhibitors Caution should be exercised when concomitant use of rifaximin and a P-glycoprotein inhibitor such as ciclosporin is needed (see ‘Interactions with other medicines’). Effects on fertility There were no effects on fertili ...
View Product Information
View Product Information

... impair absorption and should not be given to patients taking doxycycline. Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin. Because the tetracyclines have been shown to depress plasma pro ...
- Boehringer Ingelheim (Canada)
- Boehringer Ingelheim (Canada)

... setting. Home based treatment can be recommended in exceptional cases (severe symptoms or experienced patients requiring higher doses) when a low dose rapid acting beta-agonist bronchodilator has been insufficient in providing relief after consultation with an experienced physician. Administration s ...
Zolpidem Vitabalans film
Zolpidem Vitabalans film

... and pharmacodynamics were not significantly modified. The clinical relevance of these results is unknown. When zolpidem was administered with ketoconazole, a potent CYP3A4 inhibitor, zolpidem’s elimination half-life was prolonged, total exposure to zolpidem (AUC) was increased by 83%, and the appare ...
Update in 2015: Novel Oral Anticoagulant (NOAC
Update in 2015: Novel Oral Anticoagulant (NOAC

... (Pradaxa®),  edoxaban  (Savaysa®),  and  rivaroxaban  (Xarelto®)  that  are  FDA  approved  for  treatment  of   (VTE).       Each  has  demonstrated  efficacy  in  the  prevention  of  recurrence  in  the  treatment  of  acute  VTE  comp ...
Haldol/Haldol Decanoate (haloperidol)
Haldol/Haldol Decanoate (haloperidol)

... Haldol is less sedating than the lower-potency antipsychotics, but it induces bothersome side effects called extrapyramidal symptoms. These are neurological disturbances caused by antipsychotics (or a neurological disorder) in the area of the brain that controls motor coordination. Haldol is more li ...
checs medications list and possible side effects
checs medications list and possible side effects

... Dilantin IV must be delivered at less than 1ml/minute to prevent dysrhythmias, hypotension. Additive effects may occur with other central nervous system depressants. NOTE The following drugs should not be used together as they may cause excessive drowsiness: Ambien, Benadryl, Claritin, Compazine, Di ...
Piroxicam Capsules USP, 10 mg 100 count
Piroxicam Capsules USP, 10 mg 100 count

... ulceration, and perforation of the stomach, small intestine, or large intestine, which can be fatal. These serious adverse events can occur at any time, with or without warning symptoms, in patients treated with NSAIDs. Only one in five patients, who develop a serious upper GI adverse event on NSAID ...
Fife Minor Ailments Service Formulary
Fife Minor Ailments Service Formulary

... This document has been developed to: >> Provide a formulary list which complies with the Fife Joint Formulary >> Provide a list of medicines for which there is an evidence base >> Provide guidance to facilitate consistency of prescribing choices >> Provide a smaller range of medicines, allowing pres ...
Fentanyl Buccal Lozenges (Actiq®)
Fentanyl Buccal Lozenges (Actiq®)

... concomitant use may cause severe hypotension due to additive blood pressure-lowering effects ...
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Dydrogesterone



Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.
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