committee for veterinary medicinal products
... calves. After oral administration in calves treated during the first hour of life 24% of the paromomycin sulphate was absorbed; the adsorption rate decreased constantly and was less than 1% at 30 days of age. Plasma peak concentrations were achieved between 2 and 6 hours irrespective of the age. The ...
... calves. After oral administration in calves treated during the first hour of life 24% of the paromomycin sulphate was absorbed; the adsorption rate decreased constantly and was less than 1% at 30 days of age. Plasma peak concentrations were achieved between 2 and 6 hours irrespective of the age. The ...
Comparison between a new once-daily,
... The aim of the present study was to evaluate whether bambuterol is suitable for once daily administration in asthmatic patients, with regard to the duration of its bronchodilating effect and its side effects, compared to terbutaline SR treatment twice daily. Patients and methods T wenty-five outpati ...
... The aim of the present study was to evaluate whether bambuterol is suitable for once daily administration in asthmatic patients, with regard to the duration of its bronchodilating effect and its side effects, compared to terbutaline SR treatment twice daily. Patients and methods T wenty-five outpati ...
The use of clozapine plasma levels in optimising therapy
... Centorrino et al (1995) found that there was no association between the degree of leucopenia caused by clozapine and clozapine or norclo zapine plasma levels. Clozapine serum levels are difficult to predict from the dose given and there are many factors which influence the serum level obtained. Shor ...
... Centorrino et al (1995) found that there was no association between the degree of leucopenia caused by clozapine and clozapine or norclo zapine plasma levels. Clozapine serum levels are difficult to predict from the dose given and there are many factors which influence the serum level obtained. Shor ...
CONCERTA Extended-Release Tablets PRODUCT INFORMATION
... Metabolism: In humans, methylphenidate is metabolised primarily by de-esterification to -phenylpiperidine acetic acid (PPAA) which has little or no pharmacologic activity. In adults the metabolism of CONCERTA once daily, as evaluated by metabolism to PPAA, is similar to that of methylphenidate thre ...
... Metabolism: In humans, methylphenidate is metabolised primarily by de-esterification to -phenylpiperidine acetic acid (PPAA) which has little or no pharmacologic activity. In adults the metabolism of CONCERTA once daily, as evaluated by metabolism to PPAA, is similar to that of methylphenidate thre ...
Managing Two Challenging Presentations of Acne
... account for a majority of pregnant patients with acne. Because of the anticipated low rate of systemic absorption and associated reduction of risks, topical agents would seem to be preferred for treatment of acne in pregnant women. However, it is essential to recognize that topical agents are not al ...
... account for a majority of pregnant patients with acne. Because of the anticipated low rate of systemic absorption and associated reduction of risks, topical agents would seem to be preferred for treatment of acne in pregnant women. However, it is essential to recognize that topical agents are not al ...
A New Look at the 5α-Reductase Inhibitor Finasteride
... prevention of prostate cancer in men. In The Prostate Cancer Prevention Trial, investigational use of finasteride as a chemopreventative agent showed that patients administered a dose of 5 mg per day (as is commonly prescribed for BPH) were 25% less likely to have developed prostate cancer at the en ...
... prevention of prostate cancer in men. In The Prostate Cancer Prevention Trial, investigational use of finasteride as a chemopreventative agent showed that patients administered a dose of 5 mg per day (as is commonly prescribed for BPH) were 25% less likely to have developed prostate cancer at the en ...
Homebrew equipoise 200mg/ml for Muscle Builing Boldenone
... drug (the undecylenate ester is only one carbon atom longer than decanoate), so that clinically injections would need to be repeated every three or four weeks. In the veterinary feild Equipoise is most commonly used on horses, exhibiting a pronounced effect on lean bodyweight, appetite and general d ...
... drug (the undecylenate ester is only one carbon atom longer than decanoate), so that clinically injections would need to be repeated every three or four weeks. In the veterinary feild Equipoise is most commonly used on horses, exhibiting a pronounced effect on lean bodyweight, appetite and general d ...
Rhophylac Coding Information
... Suppression of Rh Isoimmunization: The most common adverse reactions in the suppression of Rh isoimmunization with Rhophylac (*0.5% of patients) are nausea, dizziness, headache, injection-site pain, and malaise. Immune Thrombocytopenic Purpura: The most serious adverse reactions in patients receivin ...
... Suppression of Rh Isoimmunization: The most common adverse reactions in the suppression of Rh isoimmunization with Rhophylac (*0.5% of patients) are nausea, dizziness, headache, injection-site pain, and malaise. Immune Thrombocytopenic Purpura: The most serious adverse reactions in patients receivin ...
A comparison of the cardiovascular ... formoterol, salbutamol and fenoterol
... of fenoterol's greater effect on the heart. The most likely explanation for these findings is that fenoterol has greater intrinsic cardiac beta 1-receptor activity than formoterol, as its inotropic and chronotropic effects are considerably greater than formoterol, at doses that result in similar sys ...
... of fenoterol's greater effect on the heart. The most likely explanation for these findings is that fenoterol has greater intrinsic cardiac beta 1-receptor activity than formoterol, as its inotropic and chronotropic effects are considerably greater than formoterol, at doses that result in similar sys ...
AVELOX PRODUCT INFORMATION
... patients). In a single oral dose study in patients with stable chronic liver cirrhosis, concentrations of moxifloxacin were reduced by approximately 23% while concentrations of the sulphate metabolite were increased almost four-fold. No dosage adjustment for mild to moderate hepatic impairment is re ...
... patients). In a single oral dose study in patients with stable chronic liver cirrhosis, concentrations of moxifloxacin were reduced by approximately 23% while concentrations of the sulphate metabolite were increased almost four-fold. No dosage adjustment for mild to moderate hepatic impairment is re ...
Oral midazolam – grapefruit juice drug interaction
... midazolam by 35%, leading to the possibility of excessive sedation.4,5,7 The ramifications of these findings for pediatric dentists are significant. Excessive sedation can result from the administration of midazolam with grapefruit juice. This is due to the increased peak plasma levels and the prolo ...
... midazolam by 35%, leading to the possibility of excessive sedation.4,5,7 The ramifications of these findings for pediatric dentists are significant. Excessive sedation can result from the administration of midazolam with grapefruit juice. This is due to the increased peak plasma levels and the prolo ...
Tramadol - Clinician`s Brief
... In humans, tramadol-mediated analgesia is produced primarily by its metabolite, O-desmethyltramadol (ODT; ie, M1 metabolite).4 ODT, a high-affinity mu-receptor agonist, is 200 times more potent than tramadol and inhibits serotonin and norepinephrine reuptake.3,5 The metabolite is minimal in dogs and ...
... In humans, tramadol-mediated analgesia is produced primarily by its metabolite, O-desmethyltramadol (ODT; ie, M1 metabolite).4 ODT, a high-affinity mu-receptor agonist, is 200 times more potent than tramadol and inhibits serotonin and norepinephrine reuptake.3,5 The metabolite is minimal in dogs and ...
Product Monograph
... Pregnant Women: The safety of SALAGEN tablets has not been established in human pregnancy. There are no known human data for the effects of pilocarpine on fetal survival and development. Studies in animals have shown reproductive toxicity (see TOXICOLOGY). SALAGEN tablets should be used in pregnancy ...
... Pregnant Women: The safety of SALAGEN tablets has not been established in human pregnancy. There are no known human data for the effects of pilocarpine on fetal survival and development. Studies in animals have shown reproductive toxicity (see TOXICOLOGY). SALAGEN tablets should be used in pregnancy ...
STADOL NS®
... (see PRECAUTIONS: Labor and Delivery and Nursing Mothers). Butorphanol is extensively metabolized in the liver. Metabolism is qualitatively and quantitatively similar following intravenous, intramuscular, or nasal administration. Oral bioavailability is only 5–17% because of extensive first-pass met ...
... (see PRECAUTIONS: Labor and Delivery and Nursing Mothers). Butorphanol is extensively metabolized in the liver. Metabolism is qualitatively and quantitatively similar following intravenous, intramuscular, or nasal administration. Oral bioavailability is only 5–17% because of extensive first-pass met ...
The Muscarinic Receptor Agonist Xanomeline Has an Antipsychotic
... were tested alone to ascertain their effects on the startle response and PPI. In this study, all compounds were administered 30 min before rats were placed in the startle chambers, except pilocarpine, which was administered 20 min pretest. Study 2 assessed the ability of haloperidol (n ⫽ 8), pilocar ...
... were tested alone to ascertain their effects on the startle response and PPI. In this study, all compounds were administered 30 min before rats were placed in the startle chambers, except pilocarpine, which was administered 20 min pretest. Study 2 assessed the ability of haloperidol (n ⫽ 8), pilocar ...
Practical Guidelines for Clinicians Who Treat Patients With
... For the initial control of VT and fibrillation, therapy is always initiated in the hospital except in patients who already have an ICD, in whom amiodarone therapy can be initiated on an outpatient basis. In the management of patients with atrial fibrillation, loading and maintenance doses can be muc ...
... For the initial control of VT and fibrillation, therapy is always initiated in the hospital except in patients who already have an ICD, in whom amiodarone therapy can be initiated on an outpatient basis. In the management of patients with atrial fibrillation, loading and maintenance doses can be muc ...
AusPAR Lenvatinib mesilate - Therapeutic Goods Administration
... External beam radiation may be useful in patients with metastatic DTC that is refractory to radioiodine or in patients whose tumours do not concentrate radioiodine. Management of persistent or recurrent disease (minimal versus extensive) is also discussed. A subset of patients has radioiodine negati ...
... External beam radiation may be useful in patients with metastatic DTC that is refractory to radioiodine or in patients whose tumours do not concentrate radioiodine. Management of persistent or recurrent disease (minimal versus extensive) is also discussed. A subset of patients has radioiodine negati ...
How Much Tylenol is Too Much Tylenol
... time standby remedy has been Tylenol (Acetaminophen, APAP; N-Acetyl-PAminophenol). This medication is marketed not only for its medicinal quality, but for NOT causing stomach upset and risks of stomach ulceration; this medicine is noted for being well tolerated. With this quality, it seems obvious t ...
... time standby remedy has been Tylenol (Acetaminophen, APAP; N-Acetyl-PAminophenol). This medication is marketed not only for its medicinal quality, but for NOT causing stomach upset and risks of stomach ulceration; this medicine is noted for being well tolerated. With this quality, it seems obvious t ...
New Medicine Assessment – Spironolactone in Acne
... 58% of people taking 200 mg of spironolactone, when assessed double blind by the investigators using photographic means, compared to 21% improvement in the placebo group. The results from the two groups were pooled and reported a reduction in lesion counts from 37.8 ± 5.8 to 12.9 ± 3.3 in the spiron ...
... 58% of people taking 200 mg of spironolactone, when assessed double blind by the investigators using photographic means, compared to 21% improvement in the placebo group. The results from the two groups were pooled and reported a reduction in lesion counts from 37.8 ± 5.8 to 12.9 ± 3.3 in the spiron ...
DUROGESIC Transdermal System
... patients, respectively. DUROGESIC patches were applied at 72 hours intervals. The results of these trials demonstrated that satisfactory analgesia was achieved when doses were titrated to effective levels. Patients also preferred DUROGESIC over their previous analgesic, such as, oral sustained relea ...
... patients, respectively. DUROGESIC patches were applied at 72 hours intervals. The results of these trials demonstrated that satisfactory analgesia was achieved when doses were titrated to effective levels. Patients also preferred DUROGESIC over their previous analgesic, such as, oral sustained relea ...
Product Monograph - AstraZeneca Canada
... whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Pediatrics (6 to 17 years of age): In utero exposure: Infants with a history of in utero exposure to ARBs should be closely observed for hypotension, oliguria, and hyperkalemia. ...
... whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Pediatrics (6 to 17 years of age): In utero exposure: Infants with a history of in utero exposure to ARBs should be closely observed for hypotension, oliguria, and hyperkalemia. ...
intravenous paracetamol
... Reported errors include incorrect dose in adults with high or low body mass index; accidental overdose in children associated with use of 100ml-vials; 10-fold drug calculation errors; confusion between dose volume in millilitres and dose of drug in milligrams; errors when setting up infusion pumps; ...
... Reported errors include incorrect dose in adults with high or low body mass index; accidental overdose in children associated with use of 100ml-vials; 10-fold drug calculation errors; confusion between dose volume in millilitres and dose of drug in milligrams; errors when setting up infusion pumps; ...
Answers Small Group II
... dose was within the normal therapeutic range (10-20 mg/L), however, the patient has been complaining of nausea, insomnia, and nervousness. Calculate a new maintenance infusion of theophylline to reduce the serum concentration to 12 mg/L. ...
... dose was within the normal therapeutic range (10-20 mg/L), however, the patient has been complaining of nausea, insomnia, and nervousness. Calculate a new maintenance infusion of theophylline to reduce the serum concentration to 12 mg/L. ...
An Exploratory Human Laboratory Experiment Evaluating Vaporized
... analgesia, psychoactive and cognitive effects as recommended by previous investigators 23, 46. Participants inhaled four puffs after baseline data were obtained (Figure 1). They then inhaled ...
... analgesia, psychoactive and cognitive effects as recommended by previous investigators 23, 46. Participants inhaled four puffs after baseline data were obtained (Figure 1). They then inhaled ...
Prescribing information
... by the CYP450 2D6 isozyme include the following drug classes: tricyclic antidepressants, selective serotonin reuptake inhibitors, beta-blockers, antiarrhythmics class 1C (e.g., flecainide and propafenone) and monoamine oxidase inhibitors Type B. Coadministration of Lamisil (terbinafine hydrochloride ...
... by the CYP450 2D6 isozyme include the following drug classes: tricyclic antidepressants, selective serotonin reuptake inhibitors, beta-blockers, antiarrhythmics class 1C (e.g., flecainide and propafenone) and monoamine oxidase inhibitors Type B. Coadministration of Lamisil (terbinafine hydrochloride ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.