PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION
... TRIALS). Prolonged heavy vaginal bleeding may occur and can be a sign of incomplete expulsion. Bleeding can lead to a significant decrease in hemoglobin levels and may necessitate a blood transfusion. Persistent bleeding should be monitored closely. The patient should have access to emergency medica ...
... TRIALS). Prolonged heavy vaginal bleeding may occur and can be a sign of incomplete expulsion. Bleeding can lead to a significant decrease in hemoglobin levels and may necessitate a blood transfusion. Persistent bleeding should be monitored closely. The patient should have access to emergency medica ...
Winter Newsletter December 2015
... accompanied by a similar decline in mortality and disease sequelae. All recommended vaccines are available to members of Gold Coast Health Plan (GCHP). The Plan has adopted the immunization recommendations of the Advisory Committee for Immunization Practices (ACIP) for its members (children and adul ...
... accompanied by a similar decline in mortality and disease sequelae. All recommended vaccines are available to members of Gold Coast Health Plan (GCHP). The Plan has adopted the immunization recommendations of the Advisory Committee for Immunization Practices (ACIP) for its members (children and adul ...
Adverse Reactions
... Pulmonary toxicity is both dose and age related, being more common in patients over 70 years of age and in those receiving over 400 units total dose. This toxicity, however, is unpredictable and has been seen in young patients receiving low doses ...
... Pulmonary toxicity is both dose and age related, being more common in patients over 70 years of age and in those receiving over 400 units total dose. This toxicity, however, is unpredictable and has been seen in young patients receiving low doses ...
Liposomal Amphotericin B Injection IP AMPHONEX
... Concurrent administration of AMPHONEX with other nephrotoxic agents such as cyclosporine, polymixin, tacrolimus and aminoglycosides may increase the risk of nephrotoxicity in some patients. Loop diuretics or thiazides and related diuretics have been reported to increase the risk of hypokalaemia when ...
... Concurrent administration of AMPHONEX with other nephrotoxic agents such as cyclosporine, polymixin, tacrolimus and aminoglycosides may increase the risk of nephrotoxicity in some patients. Loop diuretics or thiazides and related diuretics have been reported to increase the risk of hypokalaemia when ...
Ticagrelor versus Clopidogrel in Patients with Acute Coronary
... clopidogrel, prasugrel, another thienopyridine prodrug, has a more consistent and pronounced inhibitory effect on platelets,5,6 resulting in a lower risk of myocardial infarction and stent thrombosis, but is associated with a higher risk of major bleeding in patients with an acute coronary syndrome ...
... clopidogrel, prasugrel, another thienopyridine prodrug, has a more consistent and pronounced inhibitory effect on platelets,5,6 resulting in a lower risk of myocardial infarction and stent thrombosis, but is associated with a higher risk of major bleeding in patients with an acute coronary syndrome ...
Evaluation of Diuretic activity of aqueous and alcoholic rhizomes
... values are expressed as mean ± SEM. The values obtained for the parameters in case of the extract were compared with that of standard drug treated (fursemide) and control group by using ANOVA test followed by Dennetts test. The comparison made for the urine volume, concentration of electrolytes. P<0 ...
... values are expressed as mean ± SEM. The values obtained for the parameters in case of the extract were compared with that of standard drug treated (fursemide) and control group by using ANOVA test followed by Dennetts test. The comparison made for the urine volume, concentration of electrolytes. P<0 ...
Challenges and new discoveries in the treatment of
... Amphotericin B (deoxycholate) has been given to large numbers of patients with kala-azar that is clinically resistant to Pentostam and pentamidine. In Bihar, 99% of patients were cured with the standard regimen of 20 injections (1 mg/ kg/AD) of amphotericin B. Further studies showed that the duratio ...
... Amphotericin B (deoxycholate) has been given to large numbers of patients with kala-azar that is clinically resistant to Pentostam and pentamidine. In Bihar, 99% of patients were cured with the standard regimen of 20 injections (1 mg/ kg/AD) of amphotericin B. Further studies showed that the duratio ...
Product Monograph Template - Standard
... hazardous activities, particularly in the dose adjustment period, or until it has been established that they do not become drowsy, dizzy or develop muscle weakness. Dependence/Tolerance Physical and psychological dependence are known to occur in persons taking benzodiazepines. FRISIUM should not be ...
... hazardous activities, particularly in the dose adjustment period, or until it has been established that they do not become drowsy, dizzy or develop muscle weakness. Dependence/Tolerance Physical and psychological dependence are known to occur in persons taking benzodiazepines. FRISIUM should not be ...
Silkis - Galderma
... are present. If the serum calcium level becomes elevated, calcitriol therapy should be discontinued and the serum calcium level monitored in these patients until it returns to normal. Due to the potential effect of Vitamin D and its metabolites on calcium metabolism, substances that may increase the ...
... are present. If the serum calcium level becomes elevated, calcitriol therapy should be discontinued and the serum calcium level monitored in these patients until it returns to normal. Due to the potential effect of Vitamin D and its metabolites on calcium metabolism, substances that may increase the ...
Drug Treatment of Depression
... throughout pregnancy and during the first couple of months or so after the birth. Therefore, it is important to assess the potential adverse effects of medication on the foetus and on the neonate and child who may continue to be exposed via the breast milk. There is a diversity of opinion based on l ...
... throughout pregnancy and during the first couple of months or so after the birth. Therefore, it is important to assess the potential adverse effects of medication on the foetus and on the neonate and child who may continue to be exposed via the breast milk. There is a diversity of opinion based on l ...
Cyclomen (danazol)
... appear to be ethisterone and 17-hydroxymethylethisterone. The mean plasma elimination half-life of danazol is in the order of 24 hours. Bioavailability studies indicate that blood levels do not increase proportionally with increases in the administered dose. When the dose of Cyclomen is doubled the ...
... appear to be ethisterone and 17-hydroxymethylethisterone. The mean plasma elimination half-life of danazol is in the order of 24 hours. Bioavailability studies indicate that blood levels do not increase proportionally with increases in the administered dose. When the dose of Cyclomen is doubled the ...
Efavirenz-Central Nervous System Side Effects
... Prevention and management of side effects from drugs used to manage HIV and AIDS remain a challenge to clinicians, patients, drug regulators, researchers, government, health care workers, family members and all those affected. Acute and long term side effects, mild to severe (sometimes fatal) reacti ...
... Prevention and management of side effects from drugs used to manage HIV and AIDS remain a challenge to clinicians, patients, drug regulators, researchers, government, health care workers, family members and all those affected. Acute and long term side effects, mild to severe (sometimes fatal) reacti ...
The use of transdermal fentanyl in the treatment of
... Results from clinical study in UK show that the ratings of patients and investigators are similar, 85% patients and 86% investigators rated the treatment as good or excellent (16) In a large study, from October 1996 to February 1998 transdermal treatment was documented for 1005 patients (506 men and ...
... Results from clinical study in UK show that the ratings of patients and investigators are similar, 85% patients and 86% investigators rated the treatment as good or excellent (16) In a large study, from October 1996 to February 1998 transdermal treatment was documented for 1005 patients (506 men and ...
Product Monograph - AstraZeneca Canada
... and is unlikely to be of clinical benefit in patients with bleeding. Since co-administration of BRILINTA with desmopressin did not decrease template bleeding time, desmopressin is unlikely to be effective in managing clinical bleeding events. Antifibrinolytic therapy (aminocaproic acid or tranexamic ...
... and is unlikely to be of clinical benefit in patients with bleeding. Since co-administration of BRILINTA with desmopressin did not decrease template bleeding time, desmopressin is unlikely to be effective in managing clinical bleeding events. Antifibrinolytic therapy (aminocaproic acid or tranexamic ...
In Vivo and In Vitro Antimalarial Activity of 4Nerolidylcatechol
... doses of 500, 100 and 20 mg/kg (orally administered) in P. berghei‐infected Swiss rats and found that P. peltatum extract was inactive and P. umbellatum extract presented moderate activity (parasitemia reduced by 66%, 55% and 28%, respectively). In a follow‐up study, Amorim et al. (1988) administere ...
... doses of 500, 100 and 20 mg/kg (orally administered) in P. berghei‐infected Swiss rats and found that P. peltatum extract was inactive and P. umbellatum extract presented moderate activity (parasitemia reduced by 66%, 55% and 28%, respectively). In a follow‐up study, Amorim et al. (1988) administere ...
xtram plus
... tramadol, leading to altered tramadol exposure. Potential for Tramadol to Affect Other Drugs In vitro studies indicate that tramadol is unlikely to inhibit the CYP3A4-mediated metabolism of other drugs when tramadol is administered concomitantly at therapeutic doses. Tramadol does not appear to indu ...
... tramadol, leading to altered tramadol exposure. Potential for Tramadol to Affect Other Drugs In vitro studies indicate that tramadol is unlikely to inhibit the CYP3A4-mediated metabolism of other drugs when tramadol is administered concomitantly at therapeutic doses. Tramadol does not appear to indu ...
Full Product Information
... In a clinical trial designed to assess iris pigmentation over five years, there was no evidence of adverse consequences due to increased pigmentation even when administration of latanoprost continued. These results are consistent with post-marketing clinical experience since 1996. In addition, IOP r ...
... In a clinical trial designed to assess iris pigmentation over five years, there was no evidence of adverse consequences due to increased pigmentation even when administration of latanoprost continued. These results are consistent with post-marketing clinical experience since 1996. In addition, IOP r ...
Chloral hydrate has general CNS depressant effects believed to be
... is prolonged in children (10 hours), preterm neonates (37 hours) and term neonates (28 hours). Trichloroethanol is 70 to 80% bound to plasma proteins and is widely distributed to all body tissues including CSF, breast milk and placenta. The half-life of trichloroacetic acid is longer, up to 100 hour ...
... is prolonged in children (10 hours), preterm neonates (37 hours) and term neonates (28 hours). Trichloroethanol is 70 to 80% bound to plasma proteins and is widely distributed to all body tissues including CSF, breast milk and placenta. The half-life of trichloroacetic acid is longer, up to 100 hour ...
irinotecan - Cancer Care Ontario
... religation of the single-strand breaks in the DNA molecule. The drug and its active metabolite are believed to exert their cytotoxic effects during the S-phase of cell cycle. ...
... religation of the single-strand breaks in the DNA molecule. The drug and its active metabolite are believed to exert their cytotoxic effects during the S-phase of cell cycle. ...
variceal bleeding and ascites
... for use in Canada, was administered before endoscopic treatment and was found to result in fewer blood transfusions and better control of bleeding than endoscopic treatment alone.54 No major toxic effects and practically no complications are associated with the use of somatostatin or its analogues. ...
... for use in Canada, was administered before endoscopic treatment and was found to result in fewer blood transfusions and better control of bleeding than endoscopic treatment alone.54 No major toxic effects and practically no complications are associated with the use of somatostatin or its analogues. ...
Department for Transport - Over-the
... Each class of drug was reviewed individually. We looked at its structure and function, pharmacokinetics, sedating properties and its effect on performance. Although some of the drugs reviewed do not usually cause sedation at the recommended dose, if taken above the recommended dose then sedation is ...
... Each class of drug was reviewed individually. We looked at its structure and function, pharmacokinetics, sedating properties and its effect on performance. Although some of the drugs reviewed do not usually cause sedation at the recommended dose, if taken above the recommended dose then sedation is ...
Octroflex solution for injection ENG SmPC
... regulation. Post-prandial glucose tolerance may be impaired and, in some instances, the state of persistent hyperglycaemia may be induced as a result of chronic administration. Hypoglycaemia has also been reported. In patients with insulinomas, octreotide, because of its greater relative potency in ...
... regulation. Post-prandial glucose tolerance may be impaired and, in some instances, the state of persistent hyperglycaemia may be induced as a result of chronic administration. Hypoglycaemia has also been reported. In patients with insulinomas, octreotide, because of its greater relative potency in ...
Maintenance therapy with zuclopenthixol decanoate: associations
... using the lowest effective dose approach are well established (Burnett et al. 1993; Gerlach 1995; Kane et al. 1998). One important aspect in this approach is to minimise disabling side effects of antipsychotic treatment. In this context, the pharmacokinetic and pharmacogenetic properties may be impo ...
... using the lowest effective dose approach are well established (Burnett et al. 1993; Gerlach 1995; Kane et al. 1998). One important aspect in this approach is to minimise disabling side effects of antipsychotic treatment. In this context, the pharmacokinetic and pharmacogenetic properties may be impo ...
Extract from Clinical Evaluation Report: Fentanyl citrate
... Comment: The potential advantages of Abstral are acknowledged. On the other hand, one of the advantages of Actiq – particularly during initial dose titration – is that the product can be removed from the mouth if signs of excessive opioid effects appear. This is less feasible with a rapidly-disinteg ...
... Comment: The potential advantages of Abstral are acknowledged. On the other hand, one of the advantages of Actiq – particularly during initial dose titration – is that the product can be removed from the mouth if signs of excessive opioid effects appear. This is less feasible with a rapidly-disinteg ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.