PRODUCT MONOGRAPH ACCUTANE™ ROCHE isotretinoin
... Pregnancy Tests: Female patients of childbearing potential must not be given ACCUTANE until pregnancy is excluded. The patient must have two negative pregnancy tests before starting ACCUTANE therapy with the first pregnancy test conducted at initial assessment when the patient is qualified for ACCUT ...
... Pregnancy Tests: Female patients of childbearing potential must not be given ACCUTANE until pregnancy is excluded. The patient must have two negative pregnancy tests before starting ACCUTANE therapy with the first pregnancy test conducted at initial assessment when the patient is qualified for ACCUT ...
HYZAAR® HYZAAR® DS
... The use of ARBs during the second and third trimesters is known to induce human fetotoxicity (decreased renal function; oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalemia). Infants with a history of in utero exposure to ARBs should be cl ...
... The use of ARBs during the second and third trimesters is known to induce human fetotoxicity (decreased renal function; oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalemia). Infants with a history of in utero exposure to ARBs should be cl ...
Listing proposed for C1-INH - Medical Services Advisory Committee
... Quantitative and functional protein assays are usually used to confirm a suspected diagnosis from clinical history. Serum levels of C4 may be sufficient to rule out HAE where clinical suspicion is low, while both C4 levels and C1-INH levels and function should be tested where the clinical suspicion ...
... Quantitative and functional protein assays are usually used to confirm a suspected diagnosis from clinical history. Serum levels of C4 may be sufficient to rule out HAE where clinical suspicion is low, while both C4 levels and C1-INH levels and function should be tested where the clinical suspicion ...
Prescribing Info - American Regent
... Drug stability and safety of acetylcysteine when mixed with other drugs in a nebulizer have not been established. Carcinogenesis, Mutagenesis, Impairment of Fertility: Carcinogenesis Carcinogenicity studies in laboratory animals have not been performed with acetylcysteine alone, nor with acetylcyste ...
... Drug stability and safety of acetylcysteine when mixed with other drugs in a nebulizer have not been established. Carcinogenesis, Mutagenesis, Impairment of Fertility: Carcinogenesis Carcinogenicity studies in laboratory animals have not been performed with acetylcysteine alone, nor with acetylcyste ...
Committee on Drugs 2001;108;1020 DOI: 10.1542/peds.108.4.1020
... among children with chronic illnesses, which should be considered in decisions to treat with acetaminophen.5,18 –21,30 – 40 Finally, clinical signs of liver disease, such as fever or abdominal pain, are often treated with acetaminophen. Whether hepatic injury from underlying conditions, such as vira ...
... among children with chronic illnesses, which should be considered in decisions to treat with acetaminophen.5,18 –21,30 – 40 Finally, clinical signs of liver disease, such as fever or abdominal pain, are often treated with acetaminophen. Whether hepatic injury from underlying conditions, such as vira ...
Bupropion Orion modified release tablet ENG SmPC
... The effect of bupropion on other medicinal products Although not metabolised by the CYP2D6 isoenzyme, bupropion and its main metabolite, hydroxybupropion inhibit the CYP2D6 pathway. Co-administration of bupropion and desipramine to healthy volunteers known to be extensive metabolisers of the CYP2D6 ...
... The effect of bupropion on other medicinal products Although not metabolised by the CYP2D6 isoenzyme, bupropion and its main metabolite, hydroxybupropion inhibit the CYP2D6 pathway. Co-administration of bupropion and desipramine to healthy volunteers known to be extensive metabolisers of the CYP2D6 ...
Abstract Ethnopharmacological relevance Achillea millefolium L
... disturbances (Andreatini et al., 2001, Carlini, 2003 and Mitte et al., 2005). Medicinal plants continue to have anxiolytic potential (Carlini, 2003 and Faustino et al., 2010). The elevated plus maze is likely the most frequently used animal model for studying anxiety and anxiolytic-like drugs (Caro ...
... disturbances (Andreatini et al., 2001, Carlini, 2003 and Mitte et al., 2005). Medicinal plants continue to have anxiolytic potential (Carlini, 2003 and Faustino et al., 2010). The elevated plus maze is likely the most frequently used animal model for studying anxiety and anxiolytic-like drugs (Caro ...
FEDEGOSO
... world. In Peru, the roots are considered a diuretic, and a decoction is made for fevers. The seeds are brewed into a coffee-like beverage for asthma, and a flower infusion is used for bronchitis in the Peruvian Amazon. In Brazil, the roots of fedegoso are considered a tonic, febrifuge, and diuretic; ...
... world. In Peru, the roots are considered a diuretic, and a decoction is made for fevers. The seeds are brewed into a coffee-like beverage for asthma, and a flower infusion is used for bronchitis in the Peruvian Amazon. In Brazil, the roots of fedegoso are considered a tonic, febrifuge, and diuretic; ...
Morphine Sulfate Extended-Release Tablets
... enterohepatic recycling. Because morphine is primarily metabolized to inactive metabolites, the effects of renal disease on morphine’s elimination are not likely to be pronounced. However, as with any drug, caution should be taken to guard against unanticipated accumulation if renal and/or hepatic f ...
... enterohepatic recycling. Because morphine is primarily metabolized to inactive metabolites, the effects of renal disease on morphine’s elimination are not likely to be pronounced. However, as with any drug, caution should be taken to guard against unanticipated accumulation if renal and/or hepatic f ...
PRESCRIBING INFORMATION AND CONSUMER
... In case severe, unexplained abdominal pain persists or worsens, or occurs together with symptoms like fever, nausea, vomiting, changes in bowel movements, abdominal tenderness, decreased blood pressure, fainting or blood in stool, medical advice should immediately be sought. Therapy should be discon ...
... In case severe, unexplained abdominal pain persists or worsens, or occurs together with symptoms like fever, nausea, vomiting, changes in bowel movements, abdominal tenderness, decreased blood pressure, fainting or blood in stool, medical advice should immediately be sought. Therapy should be discon ...
Xtram
... Drugs that reduce the seizure threshold - Tramadol can induce convulsions and increase the potential for selective serotonin re-uptake inhibitors, tricyclic antidepressants, antipsychotics and other seizure threshold lowering agents to cause convulsions. Use with MAO inhibitors - Tramadol should not ...
... Drugs that reduce the seizure threshold - Tramadol can induce convulsions and increase the potential for selective serotonin re-uptake inhibitors, tricyclic antidepressants, antipsychotics and other seizure threshold lowering agents to cause convulsions. Use with MAO inhibitors - Tramadol should not ...
Oral Cyclophosphamide Confounds the Relationship between
... systemic lupus erythematosus and can lead to chronic kidney disease or end stage renal failure [1, 2]. Clinical trials from ...
... systemic lupus erythematosus and can lead to chronic kidney disease or end stage renal failure [1, 2]. Clinical trials from ...
prevpac - Takeda
... the peak time from approximately two to 2.5 hours. Food also increases the clarithromycin peak plasma concentration by about 24%, but does not affect the extent of clarithromycin bioavailability. Food does not affect the onset of formation of the antimicrobially active metabolite, 14-OH clarithromyc ...
... the peak time from approximately two to 2.5 hours. Food also increases the clarithromycin peak plasma concentration by about 24%, but does not affect the extent of clarithromycin bioavailability. Food does not affect the onset of formation of the antimicrobially active metabolite, 14-OH clarithromyc ...
O F L O X A C IN O P H T H A L M IC S O L U T IO N U S P , 0 .3 %
... These dosages resulted in decreased fetal body weight and increased fetal mortality in rats and rabbits, respectively. Minor fetal skeletal variations were reported in rats receiving doses of 810 mg/kg/day. Ofloxacin has not been shown to be teratogenic at doses as high as 810 mg/kg/day and 160 mg/k ...
... These dosages resulted in decreased fetal body weight and increased fetal mortality in rats and rabbits, respectively. Minor fetal skeletal variations were reported in rats receiving doses of 810 mg/kg/day. Ofloxacin has not been shown to be teratogenic at doses as high as 810 mg/kg/day and 160 mg/k ...
Absorption, Metabolism, and Excretion of Paliperidone, a New
... Belgium). All participating subjects gave written informed consent before participation. Healthy Caucasian males aged between 40 and 63 years with a body mass index of 20 to 28 kg/m2 were enrolled in this single-center, single-dose, open-label study (study R076477-P01-103). Subjects were healthy on ...
... Belgium). All participating subjects gave written informed consent before participation. Healthy Caucasian males aged between 40 and 63 years with a body mass index of 20 to 28 kg/m2 were enrolled in this single-center, single-dose, open-label study (study R076477-P01-103). Subjects were healthy on ...
Nystatin - E
... statements regarding the paediatric use of nystatin. Teofarma produces Nilstat (Nystatin). 100.000 IU/ml oral solution and has provided a very short critical expert overview. MEDA is responsible for “Nystatin Lederle Tropfen, 100.000 IU/ml, oral solution”, “Nystatin Lederle Filmtabletten, 500,000 I. ...
... statements regarding the paediatric use of nystatin. Teofarma produces Nilstat (Nystatin). 100.000 IU/ml oral solution and has provided a very short critical expert overview. MEDA is responsible for “Nystatin Lederle Tropfen, 100.000 IU/ml, oral solution”, “Nystatin Lederle Filmtabletten, 500,000 I. ...
SCIENTIFIC DISCUSSION 1. Introduction Fungal infections have
... (R,R,S,S) enantiomer. Three polymorphic forms of posaconazole have been observed during development, but the synthetic process is designed to constantly produce form I. Moreover, the crystal form is controlled as part of the drug substance specification and there has been no evidence of polymorphic ...
... (R,R,S,S) enantiomer. Three polymorphic forms of posaconazole have been observed during development, but the synthetic process is designed to constantly produce form I. Moreover, the crystal form is controlled as part of the drug substance specification and there has been no evidence of polymorphic ...
Product Monograph
... Fluconazole should be administered with caution to patients with liver dysfunction. Hepatic injury: DIFLUCAN (fluconazole) has been associated with rare cases of serious hepatic toxicity, including fatalities, primarily in patients with serious underlying medical conditions. In cases of fluconazole- ...
... Fluconazole should be administered with caution to patients with liver dysfunction. Hepatic injury: DIFLUCAN (fluconazole) has been associated with rare cases of serious hepatic toxicity, including fatalities, primarily in patients with serious underlying medical conditions. In cases of fluconazole- ...
Product Monograph - Ask Novartis Pharma
... In a dose-response study in patients with Parkinson’s disease, the maximal effect was obtained with a single dose of 200 mg entacapone. Doses of entacapone greater than 200 mg did not further improve the bioavailability of levodopa. Studies in healthy volunteers and in patients with Parkinson’s dise ...
... In a dose-response study in patients with Parkinson’s disease, the maximal effect was obtained with a single dose of 200 mg entacapone. Doses of entacapone greater than 200 mg did not further improve the bioavailability of levodopa. Studies in healthy volunteers and in patients with Parkinson’s dise ...
Evaluation of 22 SIN List 2.0 substances according to
... in humans or animal species living in the environment or when there is evidence from animal studies, possibly supplemented with other information, to provide a strong presumption that the substance has the capacity to cause ED effects in humans or animals living in the environment. The animal studie ...
... in humans or animal species living in the environment or when there is evidence from animal studies, possibly supplemented with other information, to provide a strong presumption that the substance has the capacity to cause ED effects in humans or animals living in the environment. The animal studie ...
The pharmacokinetics and metabolism of ivermectin in domestic
... this helps to optimise clinical efficacy. Ivermectin is probably one of the most widely used antiparasitic drugs worldwide, and its efficacy is well established. However, the pharmacokinetic parameters of ivermectin vary extensively and in accordance with many factors that can all influence the drug’s pl ...
... this helps to optimise clinical efficacy. Ivermectin is probably one of the most widely used antiparasitic drugs worldwide, and its efficacy is well established. However, the pharmacokinetic parameters of ivermectin vary extensively and in accordance with many factors that can all influence the drug’s pl ...
Prescribing Information
... interferon alfa with or without ribavirin. Discontinue TRIZIVIR as medically appropriate and consider dose reduction or discontinuation of interferon alfa, ribavirin, or both. (5.6) • Exacerbation of anemia has been reported in HIV-1/HCV co-infected patients receiving ribavirin and zidovudine. Coadm ...
... interferon alfa with or without ribavirin. Discontinue TRIZIVIR as medically appropriate and consider dose reduction or discontinuation of interferon alfa, ribavirin, or both. (5.6) • Exacerbation of anemia has been reported in HIV-1/HCV co-infected patients receiving ribavirin and zidovudine. Coadm ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.