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The dose-related effects of bolus esmolol on heart rate and blood
The dose-related effects of bolus esmolol on heart rate and blood

... other agents used in the studies ranged from lowdose narcotic to moderate-dose narcotic to no narcotic. Some studies used benzodiazepines, whereas others did not. Also, bolus administration vs infusion of esmolol was studied for effectiveness in decreasing heart rate and blood pressure during induct ...
Ethical Euthanasia and Short-Term Anesthesia of the Chick
Ethical Euthanasia and Short-Term Anesthesia of the Chick

... regulated by national legislation in most countries. If pentobarbital is not available, the use of other injectable anesthetic agents may be considered, such as a combination of ketamine and an alpha-2 agonist, i.e., medetomidine or xylazine. It must be noted that none of these is to be used as a mo ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... pharmacological actions; and decreased incidence of bradyarrythmias as an advantage 6.We used lower doses also because malignancy patients are already compromised as discussed previously. In this study we observed there was markedly decreased bleeding and better operative conditions thus increasing ...
Evidence-Based Perspectives on Contemporary Approaches to
Evidence-Based Perspectives on Contemporary Approaches to

... A minimally depressed level of consciousness produced by a pharmacologic method that retains the patient’s ability to independently and continuously maintain an airway and respond normally to tactile stimulation and verbal command. Although congnitive function may be modestly impaired, ventilatory a ...
Pediatric Sedation - McMaster Faculty of Health Sciences
Pediatric Sedation - McMaster Faculty of Health Sciences

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Position Paper on Procedural Sedation

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... 2. Amnesia – Patient doesn’t remember what happened just before, during, or right after surgery 3. Analgesia – Lack of pain and autonomic stability (generally go hand-in-hand) a. Intact autonomic responses can indicate pain or discomfort via changes in heart rate, BP, etc. 4. Muscle relaxation – Esp ...
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New Drugs and Techniques for Anesthesia
New Drugs and Techniques for Anesthesia

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PREMEDICATION OF THE CHILD UNDERGOING SURGERY C. A

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Anesthesia of Donkeys and Mules: How They Differ from Horses
Anesthesia of Donkeys and Mules: How They Differ from Horses

... tranquilizers. In my experience, this is also true for horses. If sedatives must be given by the intramuscular route, instead of intravenously, the dose should be doubled. The combination of xylazine-ketamine-guaifenesin, commonly referred to as “triple drip” can be used in donkeys, with some modifi ...
Novel Preoperative Pharmacologic Methods of Preventing
Novel Preoperative Pharmacologic Methods of Preventing

... lozenges containing amyl-m-cresol,18 and lozenges containing magnesium.19 The authors did not indicate if gargled solutions were swallowed after gargling. A group of researchers reported that the investigational drug was donated by the manufacturer.16 All sources9-19 were from authors practicing out ...
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History of general anesthesia



Attempts at producing a state of general anesthesia can be traced throughout recorded history in the writings of the ancient Sumerians, Babylonians, Assyrians, Egyptians, Greeks, Romans, Indians, and Chinese. During the Middle Ages, which correspond roughly to what is sometimes referred to as the Islamic Golden Age, scientists and other scholars made significant advances in science and medicine in the Muslim world and Eastern world, while their European counterparts also made important advances.The Renaissance saw significant advances in anatomy and surgical technique. However, despite all this progress, surgery remained a treatment of last resort. Largely because of the associated pain, many patients with surgical disorders chose certain death rather than undergo surgery. Although there has been a great deal of debate as to who deserves the most credit for the discovery of general anesthesia, it is generally agreed that certain scientific discoveries in the late 18th and early 19th centuries were critical to the eventual introduction and development of modern anesthetic techniques.Two ""quantum leaps"" occurred in the late 19th century, which together allowed the transition to modern surgery. An appreciation of the germ theory of disease led rapidly to the development and application of antiseptic techniques in surgery. Antisepsis, which soon gave way to asepsis, reduced the overall morbidity and mortality of surgery to a far more acceptable rate than in previous eras. Concurrent with these developments were the significant advances in pharmacology and physiology which led to the development of general anesthesia and the control of pain.In the 20th century, the safety and efficacy of general anesthesia was improved by the routine use of tracheal intubation and other advanced airway management techniques. Significant advances in monitoring and new anesthetic agents with improved pharmacokinetic and pharmacodynamic characteristics also contributed to this trend. Finally, standardized training programs for anesthesiologists and nurse anesthetists emerged during this period. And, of course, the increased application of economic and business administration principles to health care in the late 20th and early 21st centuries inevitably led to the introduction of management practices such as transfer pricing to improve the efficiency of anesthetists.
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