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... International Journal of Pharmaceutical Sciences Review and Research Available online at www.globalresearchonline.net ...
Tetracyclines: History and Current Formulation Review
Tetracyclines: History and Current Formulation Review

... “cure or improvement was found in 22 percent in the doxycycline group and 18 percent in the group of patients treated with minocycline.”24 These results were not significantly different statistically, thereby concluding similar efficacy against acne. Other studies comparing doxycycline and minocycli ...
highlights of prescribing information
highlights of prescribing information

... zoster, chemical conjunctivitis, and corneal burn. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. 8 USE IN SPECIFIC POPULATIONS 8.1 Pregnancy Pre ...
Safety of allopurinol compared with other urate
Safety of allopurinol compared with other urate

... majority of adverse events were mild. Four patients in the febuxostat groups died (0.8 %) and none in the allopurinol group, although the investigators did not find any relation with the study drugs. There was, however, a higher number of withdraws with higher doses of febuxostat (120 mg) compared t ...
Re v. 07/14 5812 Lisinopril Tablets USP FULL PRESCRIBING
Re v. 07/14 5812 Lisinopril Tablets USP FULL PRESCRIBING

... Lisinopril tablets USP are indicated for the treatment of hypertension in adult patients and pediatric patients 6 years of age and older to lower blood pressure. Lowering blood pressure lowers the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These b ...
Candidate Gene Polymorphisms in Patients with Acetaminophen
Candidate Gene Polymorphisms in Patients with Acetaminophen

... used pain-relieving and fever-reducing drugs. Unfortunately, this drug is also one of the leading causes of acute liver failure (ALF) in this country, accounting for approximately half of all ALF cases identified by the Acute Liver Failure Study Group in the United States (Larson et al., 2005). In m ...
Amodiaquine for the treatment of uncomplicated falciparum malaria
Amodiaquine for the treatment of uncomplicated falciparum malaria

... In the mid 1980’s, reports of fatal adverse drug reactions (ADRs) were described in travellers using amodiaquine as prophylaxis 1, 2. Consequently, ParkeDavis (now Pfizer) modified the labelling and withdrew prophylaxis as an indication and the World Health Organization (WHO) prevented its use in ma ...
Editorial Response: Single Daily Dosing of Aminoglycosides
Editorial Response: Single Daily Dosing of Aminoglycosides

... monitoring goals are needed for patients who receive aminoglycosides via SDD. Some investigators (including Bailey et al.) have advocated obtaining a single serum drug concentration at least 6 hours after the initial dose of an aminoglycoside is given. Others have published a nomogram using a single ...
Adverse drug reactions in patients with gastroenterological diseases
Adverse drug reactions in patients with gastroenterological diseases

... the health of an older patient by causing an adverse drug reaction.3, 4 Additional factors reported to contribute to the risk of adverse reactions in the elderly are polypragmasy, drug±drug interactions, non-compliance and selfmedication.5±8 However, the results of epidemiological studies on the rel ...
1. name of the medicinal product
1. name of the medicinal product

... with caution in patients with active or quiescent pulmonary tuberculosis and fungal, viral or other infections of the airway. Appropriate treatment should be promptly instituted, if indicated. Rarely, Aesalfluca Forspiro may cause cardiac arrhythmias e.g. supraventricular tachycardia, extrasystoles ...
These highlights do not include all the information needed
These highlights do not include all the information needed

... of herpes labialis in the previous 12 months. The median age was 44 years (range 18 to 80 years), 72% were female, and 91% were Caucasian. Subjects were instructed to initiate treatment within 1 hour of noticing signs or symptoms and continue treatment for 5 days, with application of study medicati ...
analgesic agents - Magellan Health Services || TennCare Portal
analgesic agents - Magellan Health Services || TennCare Portal

... immunodeficiency virus (HIV) disease, anemia and neutropenia were the most significant adverse events observed. Pancytopenia, which was reversible in most instances after discontinuation of the drug, has been associated with zidovudine. ƒ Zidovudine carries a black box warning regarding the risk of ...
PREMEDICATION OF THE CHILD UNDERGOING SURGERY C. A
PREMEDICATION OF THE CHILD UNDERGOING SURGERY C. A

... although oral ketamine has been reported to reduce emergence delirium. Co-administration of benzodiazepines or subsequent administration of general anesthetic agents reduces the incidence of hallucinations to approximately 4%53. Recovery of patients who have received ketamine in a quiet environment ...
20-Drug-Therapy-Diuretic-Therapy
20-Drug-Therapy-Diuretic-Therapy

... 2). The relation between the rate at which the diuretic is excreted and the response to it is the same in patients with renal insufficiency as it is in normal subjects.50,51 Thus, the remaining nephrons in patients with renal insufficiency retain their responsiveness to the diuretic; the problem is ...
Prescribing Information
Prescribing Information

... evidence of raltegravir and/or elvitegravir resistance received TIVICAY 50 mg twice daily with the current failing background regimen for 7 days and with optimized background therapy from Day 8. The rate of adverse events leading to discontinuation was 4% of subjects at Week 48. Treatment-emergent A ...
Neotigason - Actavis think smart medicine
Neotigason - Actavis think smart medicine

... In diabetics, retinoids can either improve or worsen glucose tolerance. Blood sugar levels must therefore be checked more frequently than usual in the early stages of treatment. Paediatric use Skeletal changes in premature epiphysial ossification are seen in young animals treated with etretinate. Th ...
0.9% Sodium Chloride Injection, USP
0.9% Sodium Chloride Injection, USP

... determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in the responses between elderly and younger patients. When selecting the type of infusion solution and the volume/rate of infusion for a geriatric patient, one should ...
Amlodipin Accord 10 mg tablets
Amlodipin Accord 10 mg tablets

... patients have shown that amlodipine does not lead to clinical deterioration as measured by exercise tolerance, left ventricular ejection fraction and clinical symptomatology. A placebo-controlled study (PRAISE) designed to evaluate patients in NYHA Class III-IV heart failure receiving digoxin, diure ...
New Anticoagulants For Stroke Prevention in AF Atrial Fibrillation
New Anticoagulants For Stroke Prevention in AF Atrial Fibrillation

... • Avoid use with PgP inducers (rifampin) • If CrCl 30-50 and dronedarone – consider 75 mg bid ...
Information sheet : Bisphosphonates in Surgical and Implant Dentistry
Information sheet : Bisphosphonates in Surgical and Implant Dentistry

... patient and observe wound healing and any adverse effects for a two-month period of time. Antimicrobial rinses such as chlorohexidine should be recommended twice per day during this two-month observation period. Dental infections should be treated as quickly as possible after diagnosis; e.g. endodon ...
Subsys Prescribing Information
Subsys Prescribing Information

... fentanyl products that result in clinically important differences in the extent of absorption of fentanyl that could result in fatal overdose [see Dosage and Administration (2.1), Warnings and Precautions (5.5)].  When prescribing, do not convert patients on a mcg per mcg basis from any other fenta ...
QT variability during initial exposure to sotalol: experience based on
QT variability during initial exposure to sotalol: experience based on

... Clinical predictors of DQTc ≥ 48 h among sotalol-exposed patients are depicted in Figure 3 and listed in Supplementary material online, Table S4. Female gender was associated with an increase in DQTc as was age (7.1 ms for female gender, CI: 0.8 –14.1, and 2.3 ms per 5 year increase in age, CI: 0.2 ...
The Family Practice Newsletter
The Family Practice Newsletter

... furthering this problem. In the US alone, this primarily affects the utilization of albuterol inhalers, of which 52 million prescriptions are filled annually. However, all inhalers which contain CFCs are affected by this ruling. HFA inhalers will not only be more expensive, but the new devices may b ...
S A M P L E   C H...
S A M P L E C H...

... headaches, tachycardia or essential tremor. However, beta-blockers are not as effective as angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs) or diuretics as initial therapy for primary prevention of cardiovascular events in patients over the age of 60 years. In addition, they ...
G U I D E L I N E S ... ADVISORY  COMMITTEE Scope
G U I D E L I N E S ... ADVISORY COMMITTEE Scope

... Re-examine child if he/she is not improving within 48 to 72 hours. If perforation occurs, this is not a serious complication as this generally heals without intervention. Water and objects such as cotton tip swabs should be kept out of the ear canal. There is no need to refer to an otolaryngo ...
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Ofloxacin



Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.
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