HIGHLIGHTS OF PRESCRIBING INFORMATION These
... CONTRAVE (equivalent to bupropion doses of 360 mg/day). In these same studies, suicidal ideation was reported by 3 (0.20%) of 1,515 patients treated with placebo compared with 1 (0.03%) of 3,239 treated with CONTRAVE. Pooled analyses of short-term placebo-controlled trials of antidepressant drugs (s ...
... CONTRAVE (equivalent to bupropion doses of 360 mg/day). In these same studies, suicidal ideation was reported by 3 (0.20%) of 1,515 patients treated with placebo compared with 1 (0.03%) of 3,239 treated with CONTRAVE. Pooled analyses of short-term placebo-controlled trials of antidepressant drugs (s ...
ZYBAN (bupropion hydrochloride) Sustained-Release
... In many of these cases, a causal relationship to bupropion treatment is not certain, because depressed mood can be a symptom of nicotine withdrawal. However, some of the cases occurred in patients taking ZYBAN who continued to smoke. The risks of ZYBAN should be weighed against the benefits of its u ...
... In many of these cases, a causal relationship to bupropion treatment is not certain, because depressed mood can be a symptom of nicotine withdrawal. However, some of the cases occurred in patients taking ZYBAN who continued to smoke. The risks of ZYBAN should be weighed against the benefits of its u ...
Hydroxyzine Hydrochloride Injection, USP Hydroxyzine
... ability to render the disturbed patient more amenable to psychotherapy in long term treatment of the psychoneurotic and psychotic, although it should not be used as the sole treatment of psychosis or of clearly demonstrated cases of depression. Hydroxyzine is also useful in alleviating the manifesta ...
... ability to render the disturbed patient more amenable to psychotherapy in long term treatment of the psychoneurotic and psychotic, although it should not be used as the sole treatment of psychosis or of clearly demonstrated cases of depression. Hydroxyzine is also useful in alleviating the manifesta ...
Drug Treatment of Depression
... throughout pregnancy and during the first couple of months or so after the birth. Therefore, it is important to assess the potential adverse effects of medication on the foetus and on the neonate and child who may continue to be exposed via the breast milk. There is a diversity of opinion based on l ...
... throughout pregnancy and during the first couple of months or so after the birth. Therefore, it is important to assess the potential adverse effects of medication on the foetus and on the neonate and child who may continue to be exposed via the breast milk. There is a diversity of opinion based on l ...
Bactroban cream
... a mg/m2 basis and revealed no evidence of impaired fertility from mupirocin sodium. Pregnancy: Teratogenic Effects: Pregnancy Category B. Teratology studies have been performed in rats and rabbits with mupirocin administered subcutaneously at doses up to 78 and 154 times, respectively, a human topic ...
... a mg/m2 basis and revealed no evidence of impaired fertility from mupirocin sodium. Pregnancy: Teratogenic Effects: Pregnancy Category B. Teratology studies have been performed in rats and rabbits with mupirocin administered subcutaneously at doses up to 78 and 154 times, respectively, a human topic ...
Product Monograph
... The potential efficacy of Ebixa (memantine hydrochloride) as a treatment for the symptomatic management of moderate to severe Alzheimer’s disease was demonstrated by the results of 2 randomized, double-blind, placebo-controlled 6-month clinical studies. Both studies were conducted in patients with ...
... The potential efficacy of Ebixa (memantine hydrochloride) as a treatment for the symptomatic management of moderate to severe Alzheimer’s disease was demonstrated by the results of 2 randomized, double-blind, placebo-controlled 6-month clinical studies. Both studies were conducted in patients with ...
Off-label antibiotic use in children in three European countries
... Antibiotic prescriptions were evaluated for all inpatients in the neonatal intensive care units (NICUs) and the pediatric medical and surgical wards of two hospitals in UK (St George’s Hospital and Evelina Children’s Hospital in London), one in Italy (Department of Maternal and Pediatric Sciences of ...
... Antibiotic prescriptions were evaluated for all inpatients in the neonatal intensive care units (NICUs) and the pediatric medical and surgical wards of two hospitals in UK (St George’s Hospital and Evelina Children’s Hospital in London), one in Italy (Department of Maternal and Pediatric Sciences of ...
Prescribing Information
... exposure for subjects in the INTELENCE® arm and placebo arm was 52.3 and 51.0 weeks, respectively. Discontinuations due to adverse drug reactions (ADRs) were 5.2% in the INTELENCE® arm and 2.6% in the placebo arm. The most frequently reported ADR at least Grade 2 in severity was rash (10.0%). Steven ...
... exposure for subjects in the INTELENCE® arm and placebo arm was 52.3 and 51.0 weeks, respectively. Discontinuations due to adverse drug reactions (ADRs) were 5.2% in the INTELENCE® arm and 2.6% in the placebo arm. The most frequently reported ADR at least Grade 2 in severity was rash (10.0%). Steven ...
Acyclovir Tablets USP Acyclovir Tablets USP
... nephrotoxic agents since this may increase the risk of renal dysfunction and/or the risk of reversible central nervous system symptoms such as those that have been reported in patients treated with intravenous acyclovir. Adequate hydration should be maintained. ...
... nephrotoxic agents since this may increase the risk of renal dysfunction and/or the risk of reversible central nervous system symptoms such as those that have been reported in patients treated with intravenous acyclovir. Adequate hydration should be maintained. ...
PrKETOTIFEN OPHTHALMIC SOLUTION
... The acute toxicity of ketotifen fumarate has been investigated in mice, rats and rabbits. Oral LD 50 values were 165 mg/kg, 360 mg/kg and 790 mg/kg in mice, rats and rabbits, respectively. Subchronic and chronic oral toxicity studies in rats and dogs demonstrated that the liver was a target organ fo ...
... The acute toxicity of ketotifen fumarate has been investigated in mice, rats and rabbits. Oral LD 50 values were 165 mg/kg, 360 mg/kg and 790 mg/kg in mice, rats and rabbits, respectively. Subchronic and chronic oral toxicity studies in rats and dogs demonstrated that the liver was a target organ fo ...
Metronidazole - American Academy of Veterinary Pharmacology
... Pregnancy/Reproduction Pregnancy—Metronidazole readily crosses the placenta and enters the fetal circulation.{R-1} No teratogenic effects were seen in the pups of rats that had received 250 mg per kg of body weight (mg/kg) a day for 1 to 12 days, or 100 mg/kg a day for 40 days. However, spermatogene ...
... Pregnancy/Reproduction Pregnancy—Metronidazole readily crosses the placenta and enters the fetal circulation.{R-1} No teratogenic effects were seen in the pups of rats that had received 250 mg per kg of body weight (mg/kg) a day for 1 to 12 days, or 100 mg/kg a day for 40 days. However, spermatogene ...
Rhophylac Coding Information
... ---------------------------------WARNINGS AND PRECAUTIONS--------------------------Both Indications (5.1) • IgA deficient patients with known antibodies to IgA are at greater risk of developing severe hypersensitivity and anaphylactic reactions (5.1.1). • Rhophylac is made from human blood; theref ...
... ---------------------------------WARNINGS AND PRECAUTIONS--------------------------Both Indications (5.1) • IgA deficient patients with known antibodies to IgA are at greater risk of developing severe hypersensitivity and anaphylactic reactions (5.1.1). • Rhophylac is made from human blood; theref ...
16. AL Dera HS. Protective Effect of Resveratrol Against Aluminium
... function in histopathological status after AlCl3 exposure associated with increased renal oxidative stress and inflammation suggesting strong pro-oxidant activity of AlCl3 in spite of its non-redox status 20. However, RES co-treatment with AlCl3to the rats showed significant improvement in all bioch ...
... function in histopathological status after AlCl3 exposure associated with increased renal oxidative stress and inflammation suggesting strong pro-oxidant activity of AlCl3 in spite of its non-redox status 20. However, RES co-treatment with AlCl3to the rats showed significant improvement in all bioch ...
news from chest - American College of Chest Physicians
... OPSUMIT® is an endothelin receptor antagonist (ERA) indicated for the treatment of pulmonary arterial hypertension (PAH, WHO Group I) to delay disease progression. Disease progression included: death, initiation of intravenous (IV) or subcutaneous prostanoids, or clinical worsening of PAH (decreased ...
... OPSUMIT® is an endothelin receptor antagonist (ERA) indicated for the treatment of pulmonary arterial hypertension (PAH, WHO Group I) to delay disease progression. Disease progression included: death, initiation of intravenous (IV) or subcutaneous prostanoids, or clinical worsening of PAH (decreased ...
OTHER DIURETICS
... are not filtered in sufficient concentrations to sites of action in the nephron. Loop diuretics can be substituted but high doses are often needed e.g. furosemide 80 mg twice daily. Where co-morbidities provide a compelling indication for a loop diuretic as part of the antihypertensive regimen e.g. ...
... are not filtered in sufficient concentrations to sites of action in the nephron. Loop diuretics can be substituted but high doses are often needed e.g. furosemide 80 mg twice daily. Where co-morbidities provide a compelling indication for a loop diuretic as part of the antihypertensive regimen e.g. ...
Product Monograph Template - Standard
... breast milk. However, other corticosteroids have been detected in human milk. Since there are no data from controlled trials on the use of AVAMYS® by nursing mothers, caution should be exercised when AVAMYS® is administered to a nursing woman. The use of fluticasone furoate in nursing mothers requir ...
... breast milk. However, other corticosteroids have been detected in human milk. Since there are no data from controlled trials on the use of AVAMYS® by nursing mothers, caution should be exercised when AVAMYS® is administered to a nursing woman. The use of fluticasone furoate in nursing mothers requir ...
Rare Adverse Effects of Human Immunoglobulin Therapy
... and injury to proximal renal tubules.26-28 There is now an FDA black box warning on IVIG products containing sucrose. Prevention and treatment include checking renal function prior to treatment, prehydration, avoiding volume depletion by diuretics, using slow infusion rates and limiting the IVIG dos ...
... and injury to proximal renal tubules.26-28 There is now an FDA black box warning on IVIG products containing sucrose. Prevention and treatment include checking renal function prior to treatment, prehydration, avoiding volume depletion by diuretics, using slow infusion rates and limiting the IVIG dos ...
famotidine injection - Boehringer Ingelheim
... one to three hours. Duration of inhibition of secretion by doses of 20 and 40 mg was 10 to 12 hours. After intravenous administration, the maximum effect was achieved within 30 minutes. Single intravenous doses of 10 and 20 mg inhibited nocturnal secretion for a period of 10 to 12 hours. The 20 mg d ...
... one to three hours. Duration of inhibition of secretion by doses of 20 and 40 mg was 10 to 12 hours. After intravenous administration, the maximum effect was achieved within 30 minutes. Single intravenous doses of 10 and 20 mg inhibited nocturnal secretion for a period of 10 to 12 hours. The 20 mg d ...
and Paul J. Seligman, MD, MPH
... of a non-selective NSAID and a proton pump inhibitor). Valdecoxib is associated with an increased rate of serious and potentially lifethreatening skin reactions (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme) compared to other COX-2 selective agents and is the only ...
... of a non-selective NSAID and a proton pump inhibitor). Valdecoxib is associated with an increased rate of serious and potentially lifethreatening skin reactions (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme) compared to other COX-2 selective agents and is the only ...
Pharmacokinetics of cefotaxime during continuous and intermittent infusion in critically ill patients
... Parenteral beta-lactam antibiotics such as cefotaxime, a broad-spectrum cephalosporin antibiotic, are widely used in various patients groups including critically ill patients with suspected or proven infections with micro-organisms susceptible to cefotaxime. As is the case in all beta-lactam antibio ...
... Parenteral beta-lactam antibiotics such as cefotaxime, a broad-spectrum cephalosporin antibiotic, are widely used in various patients groups including critically ill patients with suspected or proven infections with micro-organisms susceptible to cefotaxime. As is the case in all beta-lactam antibio ...
North of England Cancer Network Palliative Care Guidelines
... Patients already taking an oral anti-emetic who reach the last days of life should have the antiemetic continued by the sub-cutaneous route to ensure on-going symptom control. This will require a drug change (Domperidone to Metoclopramide; Prochlorperazine to Cyclizine). New onset nausea/vomiting in ...
... Patients already taking an oral anti-emetic who reach the last days of life should have the antiemetic continued by the sub-cutaneous route to ensure on-going symptom control. This will require a drug change (Domperidone to Metoclopramide; Prochlorperazine to Cyclizine). New onset nausea/vomiting in ...
NESCN Palliative Care Guidelines Guidance Sheets (v2June15)
... Patients already taking an oral anti-emetic who reach the last days of life should have the antiemetic continued by the sub-cutaneous route to ensure on-going symptom control. This will require a drug change (Domperidone to Metoclopramide; Prochlorperazine to Cyclizine). New onset nausea/vomiting in ...
... Patients already taking an oral anti-emetic who reach the last days of life should have the antiemetic continued by the sub-cutaneous route to ensure on-going symptom control. This will require a drug change (Domperidone to Metoclopramide; Prochlorperazine to Cyclizine). New onset nausea/vomiting in ...
paracetamol, diphenhydramine hydrochloride
... Dose should not be repeated more frequently than four hour intervals. Not more than 4 doses should be taken in 24 hours. Dosage should not be continued for more than three days without consulting a doctor. Care is advised in the administration of paracetamol to patients with severe renal or severe h ...
... Dose should not be repeated more frequently than four hour intervals. Not more than 4 doses should be taken in 24 hours. Dosage should not be continued for more than three days without consulting a doctor. Care is advised in the administration of paracetamol to patients with severe renal or severe h ...
VRS-317
... ago (6) and a sustained-release rhGH (7–10) was approved for children but later withdrawn from distribution because of difficulties with manufacturing of the product. Since then, studies have been performed with a variety of modified rhGH molecules that may be suitable for weekly administration (11– ...
... ago (6) and a sustained-release rhGH (7–10) was approved for children but later withdrawn from distribution because of difficulties with manufacturing of the product. Since then, studies have been performed with a variety of modified rhGH molecules that may be suitable for weekly administration (11– ...
niaspan - Sunovion Pharmaceuticals Canada Inc.
... in the simvastatin plus NIASPAN FCT group and 15 (0.9%) in the simvastatin plus placebo group, a non-statistically significant result (HR 1.79, [95%CI = 0.95-3.36], p=0.071). The ontreatment ischemic stroke events were 19 for the simvastatin plus NIASPAN FCT group and 15 for the simvastatin plus pla ...
... in the simvastatin plus NIASPAN FCT group and 15 (0.9%) in the simvastatin plus placebo group, a non-statistically significant result (HR 1.79, [95%CI = 0.95-3.36], p=0.071). The ontreatment ischemic stroke events were 19 for the simvastatin plus NIASPAN FCT group and 15 for the simvastatin plus pla ...
Ofloxacin
Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.