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Discovering spatial working memory fields in prefrontal cortex
Discovering spatial working memory fields in prefrontal cortex

... disrupted in error trials when the cue was in a neuron’s memory field and the monkey made a wrong saccadic response, indicating that neuronal mnemonic activity could predict the animal’s behavioral outcome. A second salient finding was that neurons in each hemifield of the prefrontal cortex prefer s ...
The Nervous System
The Nervous System

... • Brain tissue supplied with oxygen from that blood source dies • Loss of some functions or death may result • Hemiplegia–One-sided paralysis • Aphasis–Damage to speech center in left hemisphere • Transischemia-attack (TIA)–temporary brain ischemia (restriction of blood flow) • Warning signs for mor ...
What do Babies See? By Dr. Lin Day, Baby Sensory. When a baby
What do Babies See? By Dr. Lin Day, Baby Sensory. When a baby

... The ability to see has fascinated scientists for decades. In the 19th century, examination of the eye was made possible by the microscope. Further research showed that the rod cells were insensitive to colour, while the cone cells responded to colour. It was also found that the rod cells could not f ...
VIEW PDF - Glaucoma Today
VIEW PDF - Glaucoma Today

... monkey stained with Nissl, the majority of neurons are arranged in six layers, indicated by numbers (A). Immunostaining for CaMKII-alpha of the control lateral geniculate nucleus shows CaMKII-alpha neurons between layers 1 and 2, between layers 2 and 3, and below layer 1 (layer S) as well as additio ...
The Visual System: The Nature of Light
The Visual System: The Nature of Light

... • The point at which the optic nerve travels through the retina to exit the eye (Optic Disk) • There are no rods and cones at this point, so there is a small blind spot in vision. (do demo on page 174) • We don’t notice our blind spot because each eye compensates for the other or your brain “fills i ...
Practice Questions for Neuro Anatomy Exam 1 Which of the
Practice Questions for Neuro Anatomy Exam 1 Which of the

... signal is descending from CNS to the body? a. Ventral root b. Dorsal root c. Afferent ...
PDF - Center for Neural Science
PDF - Center for Neural Science

... behaviors. That a cortical area exhibits a new type of behavior does not necessarily mean that the circuit must possess unique biological machineries completely different from those of other areas. Hence, persistent activity may be generated in the PFC when the strength of recurrent excitation (medi ...
Slide 1
Slide 1

... Voluntary movement • Voluntary movements are organized in cortex • Sensory feed back – Visual information – Proprioceptive information – Sounds and somatosensory information ...
Microscopic study of cell division in the cerebral cortex of adult
Microscopic study of cell division in the cerebral cortex of adult

... from different neurons. Dispersed around the neurons are tremendous number of neuroglial cells, i.e., astrocytes and oligodendrocytes. They offer structural support, nutritional supply to neighboring neurons, the maintenance of local homeostasis and formation of myelin sheath around nerve fibers. Su ...
Ciccarelli SG Chapter 2
Ciccarelli SG Chapter 2

... the spinal cord. Afferent (sensory) neurons send information from our senses to the spinal cord. For example, sensory neurons would relay information about a sharp pain in your finger. Efferent (motor) neurons send commands from the spinal cord to our muscles, such as a command to pull your finger b ...
On the computational architecture of the neocortex
On the computational architecture of the neocortex

... from an area with one sort of concern to another. A persistent theme is to distinguish lower cortical areas, with direct sensory or motor connections from higher ones which are associating information from lower areas, so that information moves first from lower, more sensory areas to higher, more co ...
Is this a brain which I see before me? Modeling human neural
Is this a brain which I see before me? Modeling human neural

... in human early neuroectodermal cells is essential to terminate the expression of pluripotent genes and to initiate expression of neural genes such as SOX1 and SOX2. This is in contrast to the situation observed in the mouse, where Sox1 is the earliest marker gene expressed during neural commitment, ...
12-1 Test Bank Huether and McCance: Understanding
12-1 Test Bank Huether and McCance: Understanding

... The hypothalamus functions to maintain a constant internal environment and instinctive behavioral patterns. It is the hypothalamus, not the thalamus, that maintains homeostasis. The thalamus serves also as a relay center for information from the basal ganglia and cerebellum to the appropriate motor ...
Is this a brain which I see before me? Modeling human neural
Is this a brain which I see before me? Modeling human neural

... in human early neuroectodermal cells is essential to terminate the expression of pluripotent genes and to initiate expression of neural genes such as SOX1 and SOX2. This is in contrast to the situation observed in the mouse, where Sox1 is the earliest marker gene expressed during neural commitment, ...
Current advances and pressing problems in studies of stopping
Current advances and pressing problems in studies of stopping

... choice response tasks accomplished with any effector system. The stop-signal task enables powerful, translational research because it can be studied with humans, monkeys, and even rats, employing behavioral [4!!,5,6], neurochemical [7], neurophysiological [8!!,9!!], electrophysiological [10,11], mag ...
Nervous System
Nervous System

... conditions such as Downs Syndrome and Fetal Alcohol Syndrome c. lab animals who have received stimulation as infants show more dendritic branching C. Axon (term comes from Greek word meaning axis) 1. single fiber that is thicker and longer than dendrites 2. axon may have many branches at its end 3. ...
Social defeat stress, sensitization, and intravenous cocaine self
Social defeat stress, sensitization, and intravenous cocaine self

... Repeated social defeat increases Fos expression in mesocorticolimbic system – In VTA, prelimbic and infralimbic cortical ...
1 Spiking Neurons
1 Spiking Neurons

... input, however, is hardly stationary, but often changing on a fast time scale. For example, even when viewing a static image, we perform saccades, rapid changes of the direction of gaze. The retinal photo receptors receive therefore every few hundred milliseconds a new input. Despite its shortcoming ...
here
here

... Nerve
impulses
are
transmitted
along
an
individual
neuron
by
means
of
an
action
potential.

Since
these
 signals
must
be
transmitted
not
only
along
a
single
neuron,
but
from
one
neuron
to
another,
or
from
a
 neuron
to
an
effector,
there
must
be
a
means
of
passing
the
signal
from
one
neuron
to
anothe ...
ling411-11 - Rice University
ling411-11 - Rice University

...  Cats and monkeys don’t have language  Therefore language must have unique properties of its structural representation in the cortex  Answer: Yes, language is different, but ...
Zoology Assignment - Wikimedia Commons
Zoology Assignment - Wikimedia Commons

... Proprioceptors (proprius, one’s self + receptor), commonly called “stretch receptors,” are internal sense organs that respond to mechanically induced changes caused by stretching, compression, bending, or tension. These receptors give an animal information about the movement of its body parts and th ...
Neurons of the Central Complex of the Locust Schistocerca gregaria
Neurons of the Central Complex of the Locust Schistocerca gregaria

... anesthetized by cooling and were waxed anterior uppermost to a metal holder. The heads of the locusts were immobilized by a wax–rosin mixture, and their legs were removed. For intracellular recordings from the central protocerebrum, a small window was cut into the head capsule between the two compou ...
Spinal Cord
Spinal Cord

... 3) Others: Transmit information between different levels of brain and spinal cord. ...
Slide () - Anesthesiology - American Society of Anesthesiologists
Slide () - Anesthesiology - American Society of Anesthesiologists

... Myelinating oligodendrocytes at a midrostrocaudal level: All panels are stained immunochemically with antibodies to myelin basic protein (MBP). A presents an overview showing different stages of myelination at a midrostrocaudal level of a control brain. In the cerebrocortical mantel, and in the tran ...
EN Sokolov`s Neural Model of Stimuli as Neuro
EN Sokolov`s Neural Model of Stimuli as Neuro

... generates commands from the center to the periphery of the body and is responsible for their execution. The modulating system comprises nerve cells associated with the processing of information that circulates between the neural networks that make up the afferent and effector subsystems of the conc ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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