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The Central Visual System
The Central Visual System

... From Single Neurons to Perception From Photoreceptors to Grandmother Cells Grandmother cells: Face-selective neurons in area IT? Probably not: Perception is not based on the activity of individual, higher order cells Parallel Processing and Perception Groups of cortical areas contribute to the perc ...
Structural and functional architecture of respiratory networks in the
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... particular the respiratory CPG, including the mechanisms underlying the circuit dynamic reconfiguration under different conditions represents a central and challenging problem in neuroscience. Indeed, breathing is a dynamically mutable motor behaviour that not only performs a vital homeostatic funct ...
Correlation between auditory threshold and the auditory brainstem
Correlation between auditory threshold and the auditory brainstem

... After hypoxic-ischemic (HI) injury, diverse mechanisms produce cell damage [31], perinatal brain is especially susceptible to energy failure (decrease of ATP levels), cellular excitotoxicity and oxidative stress which can in turn promote cellular death [32,33], as we can see in Fig 4. Neurons are th ...
Voltage-Dependent Switching of Sensorimotor Integration by a
Voltage-Dependent Switching of Sensorimotor Integration by a

... specific pyloric network neurons, including the LP neuron, for several tens of seconds (Fig. 1 A, compare simultaneously recorded LP and PD neuron traces). Moreover, as seen in Figure 1 A–C, repeated sensory nerve stimulation (at 20 sec intervals) elicited successive episodes of LP neuron burst inac ...
Neuroscience: the Science of the Brain
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The Nervous System

... living human brains—and showing an astonishing level of detail about learning, emotions, and memory. Chief among these harmless techniques is functional magnetic resonance imaging, or fMRI. Regular MRI shows the location of soft tissue; fMRI tracks the movement of glucose through the brain. Because ...
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... There appear to be at least two stages in learning SR rules, the first being driven by the instruction and the second driven by actual or possibly mentally simulated practice. The first uses a network of PFC, PM and PPC areas (Ruge and Wolfensteller, 2009; Cole et al, 2010; Brass et al., 2009). The ...
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Nervous System I - Union County College
Nervous System I - Union County College

... • Resting or Membrane Potential: a small difference in voltage across the cell membrane; the cell is normally negatively charged. – This allows the neuron to be ready to respond more quickly than it could if it were electrically neutral. – Think about a car battery. It retains a charge so that the c ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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