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Amino Acids and Their Properties
Amino Acids and Their Properties

... Simple base matching (match/not) may work ok for closely related organisms ...
T. V. RajanBabu Chemistry, 730 Autumn 1997
T. V. RajanBabu Chemistry, 730 Autumn 1997

... Constitution, configuration and conformation Specifying stereochemistry - CIP notation, Fischer convention Chirality as a property of matter Enantiomeric relationships Enantiomeric excess (ee), optical activity - how to determine it Origin of chirality - asymmetric carbon atom, asymmetric heteroatom ...
Fig. 8.1. Amino acid structure
Fig. 8.1. Amino acid structure

730-2005 topics
730-2005 topics

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Week 7

... Objective: Students will use their knowledge of carbohydrates and their power of observations to test three known solutions to determine how mono, di and polysaccharides react to specific indicator test. Activity: Five minute exercise reviewing Activity: Complete lecture on Activity: Pre-lab the Car ...
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Organic Chemistry II
Organic Chemistry II

... An aldehyde or ketone can be converted to an acetal via acid-catalyzed formation of the hemiacetal and then acidcatalyzed elimination of water. This is followed by addition of the alcohol and loss of a proton  All steps are reversible. Be able to draw the mechanism of making an aldehyde from the ac ...
Deoksyribozymes active in the presence of cadmium ions and at low
Deoksyribozymes active in the presence of cadmium ions and at low

... presence Cd2+ ions were obtained. However, the obtained variants showed broader specificity and were active also with other metal ions. They exhibited the highest catalytic activity in the presence of Cd2+ ions and lower in the presence of Co2+, Mn2+ and Zn2+ions. This suggests that forming of an io ...
Slide 1 In this lesson, we will give you a general
Slide 1 In this lesson, we will give you a general

... The shape of a tetrahedron is given here. The compound on this PowerPoint is methane. ...
Critical Considerations for Analytical Similarity Assessment
Critical Considerations for Analytical Similarity Assessment

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1063-1069 - Australian Journal of Basic and Applied Sciences
1063-1069 - Australian Journal of Basic and Applied Sciences

Carboxylic Acid Derivatives 1. Background and Properties
Carboxylic Acid Derivatives 1. Background and Properties

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Grade 12 Chemistry LC2, Chapter 10 summary
Grade 12 Chemistry LC2, Chapter 10 summary

... properties: amines: basic, ammonia-like odor amides: neutral, most are solids uses: solvents, synthetic peptide hormones, fertilizer, nylon synthesis biological functions: in amino acids, peptide hormones, and proteins; distinctive odor of some cheeses examples: urea, putrescine, cadaverine, Nutrasw ...
Module 02.indd
Module 02.indd

... prevent loss of any volatile production reactant. The reaction mixture needs to be heated to speed up the reaction and refluxing is used to prevent loss of alcohol reactant. ...
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Chapter summaries

... appearance and high melting points. 4. Of the twenty amino acids found in proteins 19 have a common structure based around a central carbon, the C carbon, in which the amino, carboxyl, hydrogen and R group are arranged tetrahedrally. 5. An exception to this arrangement of atoms is proline. 6. The C ...
Lecture 31
Lecture 31

... coagulation likes basic amino acids such as K or R. As noted above most protcases are made with additional amino acids attached to their N-terminus (pro-proteins). To activate a protein such as chyrnotrypsin or trypsin, cleavage of the pro-protein occurs between residues 15 and 16 (F at P1) and give ...
File - Garbally Chemistry
File - Garbally Chemistry

... Halogenation reactions with alkanes involve replacement of one or all of the hydrogens in the alkane. These reactions may produce many products due to the high reactivity of the free radical species. The substitution reaction needs energy to be supplied before the reaction can proceed. Heating or sh ...
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... • The presence of a promoter sequence determines which strand of the DNA helix is the template. – Within the promoter is the starting point for the transcription of a gene. A DNA sequence called a TATA box is located near the start site. – The promoter also includes a binding site for RNA polymerase ...
Polymerization
Polymerization

Polymerization - WordPress.com
Polymerization - WordPress.com

... i. In other words, molecules with 2 functional groups can grow from both ends instead of just one end as in polyethylene. c. Formation of nylon – i. Hexanedioic acid (2 carboxylic acid groups) and 1,6 diaminohexane (2 amine groups) O HO OH ...
Defining the role of Histidyl tRNA Synthetase in the Zebrafish...  Aminoacyl tRNA synthetases are critical enzymes responsible for attaching specific
Defining the role of Histidyl tRNA Synthetase in the Zebrafish... Aminoacyl tRNA synthetases are critical enzymes responsible for attaching specific

... Aminoacyl tRNA synthetases are critical enzymes responsible for attaching specific amino acids to their appropriate tRNA molecules during protein synthesis. In humans, a point mutation in the gene for Histidine tRNA Synthetase (HARS) has been associated with Usher Syndrome Type 3b, a disease charact ...
Functional Assay for Botulinum Neurotoxin Type A
Functional Assay for Botulinum Neurotoxin Type A

... Multiple assays have been developed to detect botulinum toxin based solely on antigenic properties and/or enzymatic activity. Now with the recent identification of SV2c as the protein receptor for BTA1,2 new detection methods can be attempted that combine multiple steps of the disease process of bot ...
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MRSA brochure - Cook County Department of Public Health

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nmr.evilia.190303
nmr.evilia.190303

... In structure work, J coupling is critical to measuring the bond angles and dihedral angles between nuclei. The Karplus equation is used to calculate the dihedral angles for 3 bond or vicinal coupling: J = A + B cosq+ C cos2q Where A, B, C are coefficients that depend on the nuclei ...
Enhancing Antibacterial Efficacy using Protein Nanoparticles
Enhancing Antibacterial Efficacy using Protein Nanoparticles

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Bottromycin



Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from Streptomyces bottropensis. It has been shown to inhibit methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma. Bottromycin is structurally distinct from both vancomycin, a glycopeptide antibiotic, and methicillin, a beta-lactam antibiotic.Bottromycin binds to the A site of the ribosome and blocks the binding of aminoacyl-tRNA, therefore inhibiting bacterial protein synthesis. Although bottromycin exhibits antibacterial activity in vitro, it has not yet been developed as a clinical antibiotic, potentially due to its poor stability in blood plasma. To increase its stability in vivo, some bottromycin derivatives have been explored.The structure of bottromycin contains a macrocyclic amidine as well as a thiazole ring. The absolute stereochemistry at several chiral centers has been determined as of 2009. In 2012, a three-dimensional solution structure of bottromycin was published. The solution structure revealed that several methyl groups are on the same face of the structure.Bottromycin falls within the ribosomally synthesized and post-translationally modified peptide class of natural product.
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