Ultrasound Assisted Synthesis of 5,9
... pheromones [1]. 5,9-Dimethylpentadecane (1) and 5,9-dimethylhexadecane (2) are known as the major and minor constituents, respectively, of the sex pheromone of Leucoptera coffeella, a pest of coffee trees [2]. Several ways of synthesizing 1 have been described. Stereoisomers of 1 were synthesized st ...
... pheromones [1]. 5,9-Dimethylpentadecane (1) and 5,9-dimethylhexadecane (2) are known as the major and minor constituents, respectively, of the sex pheromone of Leucoptera coffeella, a pest of coffee trees [2]. Several ways of synthesizing 1 have been described. Stereoisomers of 1 were synthesized st ...
05.Antibiotics of the aromatic and heterocyclic rows
... For the manifestation of biological activity of great importance is βlactam cycle, which is very unstable in acidic and alkaline environments. Penicillin is of the early era of antibiotics and because of its wide usage now 80-90 % strains of staphylococci developed resistance to it, producing the ...
... For the manifestation of biological activity of great importance is βlactam cycle, which is very unstable in acidic and alkaline environments. Penicillin is of the early era of antibiotics and because of its wide usage now 80-90 % strains of staphylococci developed resistance to it, producing the ...
... Dog and cat kidneys were supplied by the local official dog control center and rat, mouse, guinea pig and hamster kidneys from the animal breeding facility of our University. Analytical method. (rac)-methionine and (rac)-N-acetylmethionine were analyzed by HPLC using a Chirobiotic-T column (from Ast ...
The 2009 Nobel Prize in Chemistry and KEK`s Photon Factory
... moves out of the nucleus, into the main body of the cell. Here, a ribosome binds to the mRNA, decodes the genetic code on it, and uses the information in the mRNA to create a string of amino acids. This string of amino acids is a protein. Ribosomes consist of two subunits, unimaginatively named the ...
... moves out of the nucleus, into the main body of the cell. Here, a ribosome binds to the mRNA, decodes the genetic code on it, and uses the information in the mRNA to create a string of amino acids. This string of amino acids is a protein. Ribosomes consist of two subunits, unimaginatively named the ...
General shear stress
... body on which internal forces act. These internal forces arise as a reaction to external forces applied on the body. Because the loaded deformable body is assumed to behave as a continuum, these internal forces are distributed continuously within the volume of the material body, and result in deform ...
... body on which internal forces act. These internal forces arise as a reaction to external forces applied on the body. Because the loaded deformable body is assumed to behave as a continuum, these internal forces are distributed continuously within the volume of the material body, and result in deform ...
Metalloradicals
... R h(ttp)(C 7H 7) rearranged to give R h(ttp)(C H 2P h) quantitatively at 120 1C in 12 d (ttp = 5,10,15,20-tetratolylporphyrinato dianion).T his process is 1010 faster than for the organic analogue. M echanistic investigation suggests that a R hII(ttp)-catalyzed pathw ay is operating. C ycloheptatrie ...
... R h(ttp)(C 7H 7) rearranged to give R h(ttp)(C H 2P h) quantitatively at 120 1C in 12 d (ttp = 5,10,15,20-tetratolylporphyrinato dianion).T his process is 1010 faster than for the organic analogue. M echanistic investigation suggests that a R hII(ttp)-catalyzed pathw ay is operating. C ycloheptatrie ...
Chapter 17
... • The discovery of ribozymes rendered obsolete the belief that all biological catalysts were proteins ...
... • The discovery of ribozymes rendered obsolete the belief that all biological catalysts were proteins ...
penicillins
... 2. Sensitivity test 3. Follow-up the drug effect 4. Monitor antibiotic level to avoid toxicity. ...
... 2. Sensitivity test 3. Follow-up the drug effect 4. Monitor antibiotic level to avoid toxicity. ...
RNA Structure and the Versatility of RNA
... acid sequence of proteins. It does this by carrying an amino acid to the protein synthetic machinery of a cell (ribosome) as directed by a three-nucleotide sequence (codon) in a messenger RNA (mRNA). As such, tRNAs are a necessary component of translation, the biological synthesis of new proteins ac ...
... acid sequence of proteins. It does this by carrying an amino acid to the protein synthetic machinery of a cell (ribosome) as directed by a three-nucleotide sequence (codon) in a messenger RNA (mRNA). As such, tRNAs are a necessary component of translation, the biological synthesis of new proteins ac ...
生物核磁共振波谱学NMR in Biological Science 闫永彬博士Yong
... Nucleic acids structure X-ray crystallography and NMR Nucleic acids structure NMR structures of large proteins and protein complexes Protein-DNA interactions from NMR In vivo NMR studies structure-based drug design from NMR Protein dynamics from NMR NMR and membrane proteins Para ...
... Nucleic acids structure X-ray crystallography and NMR Nucleic acids structure NMR structures of large proteins and protein complexes Protein-DNA interactions from NMR In vivo NMR studies structure-based drug design from NMR Protein dynamics from NMR NMR and membrane proteins Para ...
16.2: Structure and Bonding in Ethers and Epoxides
... 16.1: Nomenclature of Ethers, Epoxides, and Sulfides (Please read) 16.2: Structure and Bonding in Ethers and Epoxides The ether oxygen is sp3-hybridized and tetrahedral. In general, the C-O bonds of ethers have low reactivity. 16.3: Physical Properties of Ethers The O-H group of alcohols act as both ...
... 16.1: Nomenclature of Ethers, Epoxides, and Sulfides (Please read) 16.2: Structure and Bonding in Ethers and Epoxides The ether oxygen is sp3-hybridized and tetrahedral. In general, the C-O bonds of ethers have low reactivity. 16.3: Physical Properties of Ethers The O-H group of alcohols act as both ...
A-level Chemistry Question paper Unit 4 - Further Physical
... (iii) State and explain which of the two routes to propylamine, by nucleophilic substitution or by reduction, gives the less pure product. Draw the structure of a compound formed as an impurity. Route giving the less pure product ...................................................................... ...
... (iii) State and explain which of the two routes to propylamine, by nucleophilic substitution or by reduction, gives the less pure product. Draw the structure of a compound formed as an impurity. Route giving the less pure product ...................................................................... ...
Renin Precursor Synthesis and Renin
... gel electrophoresis. In both assay systems renin was synthesized with a molecular weight of 50 000, which is 10 OOO greater than the fully enzymatic active mol. wt. 40000 renin (Poulsen et al., 1979b). Control experiments demonstrated that it was displaced from the antibody by pure submaxillary reni ...
... gel electrophoresis. In both assay systems renin was synthesized with a molecular weight of 50 000, which is 10 OOO greater than the fully enzymatic active mol. wt. 40000 renin (Poulsen et al., 1979b). Control experiments demonstrated that it was displaced from the antibody by pure submaxillary reni ...
Snímek 1
... groups come together and lose a small molecule such as H2O or HCl. In this method, any two reactive molecules can combine, so that monomer is not necessarily added to the end of a growing chain. ...
... groups come together and lose a small molecule such as H2O or HCl. In this method, any two reactive molecules can combine, so that monomer is not necessarily added to the end of a growing chain. ...
Summer Internship project
... (iii) Which metabolic pathways are they utilizing? According to our preliminary data, there is good correspondence between the amount of total RNA isolated and the abundance of living microorganisms in a sample. In contrast to relatively stable DNA that can persist in the environment for a long time ...
... (iii) Which metabolic pathways are they utilizing? According to our preliminary data, there is good correspondence between the amount of total RNA isolated and the abundance of living microorganisms in a sample. In contrast to relatively stable DNA that can persist in the environment for a long time ...
42(5): 551-557. 2010 Insecticidal activities of essential oils from
... method. The insecticidal properties of L. cubeba were evaluated under laboratory conditions. The results showed that the essential oil of L. cubeba strongly repelled Sitophilus zeamais and Tribolium castaneum even at low concentrations, but its repellency was more marked toward T. castaneum. Of inte ...
... method. The insecticidal properties of L. cubeba were evaluated under laboratory conditions. The results showed that the essential oil of L. cubeba strongly repelled Sitophilus zeamais and Tribolium castaneum even at low concentrations, but its repellency was more marked toward T. castaneum. Of inte ...
Protocol
... 2. Prepare serial dilutions of RNA standard (0 to 1 g/mL): 2.1 Prepare a 100 μg/mL stock solution of RNA in DEPC treated water. 2.2 Add 10 μL of 100 μg /mL RNA stock solution (from Step 2.1) to 490 L of Assay buffer (Component B) to have 2 μg/mL RNA solution, and then perform 1:2 serial dilutions ...
... 2. Prepare serial dilutions of RNA standard (0 to 1 g/mL): 2.1 Prepare a 100 μg/mL stock solution of RNA in DEPC treated water. 2.2 Add 10 μL of 100 μg /mL RNA stock solution (from Step 2.1) to 490 L of Assay buffer (Component B) to have 2 μg/mL RNA solution, and then perform 1:2 serial dilutions ...
Coupling Coherence Distinguishes Structure Sensitivity in Protein
... rates occurs in the small C multiple-pathway regime. Because small C values have been computed in nonheme proteins as well, we can further explore the correlation between small C values and exponential distance decay. Previous theoretical analysis of the blue-copper protein azurin indicates that all ...
... rates occurs in the small C multiple-pathway regime. Because small C values have been computed in nonheme proteins as well, we can further explore the correlation between small C values and exponential distance decay. Previous theoretical analysis of the blue-copper protein azurin indicates that all ...
1. Pam matrices
... acids. All the data being used in PAM were come from sequence alignments that are closely related proteins, which involved more than 85% amino acid that are identity of one another. Besides, PAM matrix is also based on global sequence alignment being calculated by observed the dissimilarity in close ...
... acids. All the data being used in PAM were come from sequence alignments that are closely related proteins, which involved more than 85% amino acid that are identity of one another. Besides, PAM matrix is also based on global sequence alignment being calculated by observed the dissimilarity in close ...
Chapter 18
... Carboxylic acid derivatives will react similar to ketones and aldehydes in that the first step is reaction of the nucleophile with the electrophilic carbonyl carbon ...
... Carboxylic acid derivatives will react similar to ketones and aldehydes in that the first step is reaction of the nucleophile with the electrophilic carbonyl carbon ...
Antibiotics
... Common forms of antibiotic misuse include excessive use of prophylactic antibiotics in travelers, failure to take into account the patient's weight and history of prior antibiotic use when prescribing, since both can strongly affect the efficacy of an antibiotic prescription, failure to take the en ...
... Common forms of antibiotic misuse include excessive use of prophylactic antibiotics in travelers, failure to take into account the patient's weight and history of prior antibiotic use when prescribing, since both can strongly affect the efficacy of an antibiotic prescription, failure to take the en ...
Bottromycin
Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from Streptomyces bottropensis. It has been shown to inhibit methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma. Bottromycin is structurally distinct from both vancomycin, a glycopeptide antibiotic, and methicillin, a beta-lactam antibiotic.Bottromycin binds to the A site of the ribosome and blocks the binding of aminoacyl-tRNA, therefore inhibiting bacterial protein synthesis. Although bottromycin exhibits antibacterial activity in vitro, it has not yet been developed as a clinical antibiotic, potentially due to its poor stability in blood plasma. To increase its stability in vivo, some bottromycin derivatives have been explored.The structure of bottromycin contains a macrocyclic amidine as well as a thiazole ring. The absolute stereochemistry at several chiral centers has been determined as of 2009. In 2012, a three-dimensional solution structure of bottromycin was published. The solution structure revealed that several methyl groups are on the same face of the structure.Bottromycin falls within the ribosomally synthesized and post-translationally modified peptide class of natural product.