local copy pdf
... Creation scientist. Jack Szostak is working to recreate a recipe that transformed chemistry into biology. ...
... Creation scientist. Jack Szostak is working to recreate a recipe that transformed chemistry into biology. ...
Chapter 17: Aldehydes and Ketones: Nucleophilic Addition to the
... • There will be two possible Wittig routes to an alkene. • Analyze the structure retrosynthetically, i.e., work the synthesis out backwards. • Disconnect (break the bond of the target that can be formed by a known reaction) the doubly bonded carbons. One becomes the aldehyde or ketone, the other th ...
... • There will be two possible Wittig routes to an alkene. • Analyze the structure retrosynthetically, i.e., work the synthesis out backwards. • Disconnect (break the bond of the target that can be formed by a known reaction) the doubly bonded carbons. One becomes the aldehyde or ketone, the other th ...
Enzymatic synthesis of bioactive compounds
... animals) but can also be obtained biotechnologically by fermentation and cell cultures or by enzymatic synthesis and modification of natural compounds. A cosmeceutical ingredient should possess an attractive property such as anti-oxidant, anti-inflammatory, skin whitening, anti-aging, anti-wrinkling ...
... animals) but can also be obtained biotechnologically by fermentation and cell cultures or by enzymatic synthesis and modification of natural compounds. A cosmeceutical ingredient should possess an attractive property such as anti-oxidant, anti-inflammatory, skin whitening, anti-aging, anti-wrinkling ...
Caboxylic acid Derivatives
... The acid catalyzed hydrolysis of an ester is simply the reverse reaction of the Fischer esterification. Addition of excess water drives the equilibrium towards the side of the acid and alcohol. The basic hydrolysis of esters is also known as saponification, and this does not involve the equilibrium ...
... The acid catalyzed hydrolysis of an ester is simply the reverse reaction of the Fischer esterification. Addition of excess water drives the equilibrium towards the side of the acid and alcohol. The basic hydrolysis of esters is also known as saponification, and this does not involve the equilibrium ...
Derivatization Reagents - Sigma
... Because the surface of laboratory glassware is slightly acidic, it can adsorb some analytes — particularly amines. In low level analyses, such losses can be significant. To prevent sample loss through adsorption, glassware used in low level analyses usually is silanized. Silanization masks the polar ...
... Because the surface of laboratory glassware is slightly acidic, it can adsorb some analytes — particularly amines. In low level analyses, such losses can be significant. To prevent sample loss through adsorption, glassware used in low level analyses usually is silanized. Silanization masks the polar ...
Atrial Natriuretic Peptides
... arterioles of renal glomeruli) Increase vascular permeability Inhibit the release and/or actions of several hormones and mediators including aldosterone, angiotensin II, endothelin and antidiuretic hormone (ADH) ...
... arterioles of renal glomeruli) Increase vascular permeability Inhibit the release and/or actions of several hormones and mediators including aldosterone, angiotensin II, endothelin and antidiuretic hormone (ADH) ...
NMR-BIO kits for large proteins labeling
... are optimized for the extraction of precise and long-range nOe distance restraints between methyl probes in perdeut erated proteins. Compared to standard 2-keto acids, NMR-Bio acetolact ate precursors increas e sensitivity by up to a factor of 4, allowing for the detection of structurally meaningful ...
... are optimized for the extraction of precise and long-range nOe distance restraints between methyl probes in perdeut erated proteins. Compared to standard 2-keto acids, NMR-Bio acetolact ate precursors increas e sensitivity by up to a factor of 4, allowing for the detection of structurally meaningful ...
2006_World of Chemis..
... 4. (6pts) Sketch a voltaic cell that uses the oxidation-reduction reaction Cu(s) + 2Ag+(aq Cu2+(aq) + 2Ag(s) ...
... 4. (6pts) Sketch a voltaic cell that uses the oxidation-reduction reaction Cu(s) + 2Ag+(aq Cu2+(aq) + 2Ag(s) ...
Supplementary Notes - Word file
... from Upstate Biotechnology. Antibodies used in study: H2A, H2B, H4, H3-diMeK9, H3triMeK9, H3-AcK14, H4-meK20, tubulin, HDAC1, SAP30, and Sin3a (Upstate Biotechnology); H3, H3-diMeK4, H3-triMeK4, and H4-AcK8 (Abcam); Cyclin D1 and GST (Santa Cruz); Flag M5 (Sigma); ING2 1. Taqman Gene Expression Assa ...
... from Upstate Biotechnology. Antibodies used in study: H2A, H2B, H4, H3-diMeK9, H3triMeK9, H3-AcK14, H4-meK20, tubulin, HDAC1, SAP30, and Sin3a (Upstate Biotechnology); H3, H3-diMeK4, H3-triMeK4, and H4-AcK8 (Abcam); Cyclin D1 and GST (Santa Cruz); Flag M5 (Sigma); ING2 1. Taqman Gene Expression Assa ...
Ch-9-Carboxylic acids and their derivatives-corr2 - Home
... The Factors affecting acidity of carboxylic acids. The different ways to make carboxylic acids Salt formation reactions of carboxylic acids The nucleophilic substitution reactions at the carbonyl carbon and the specific products formed in each case. The chemistry of carboxylic acid derivatives ...
... The Factors affecting acidity of carboxylic acids. The different ways to make carboxylic acids Salt formation reactions of carboxylic acids The nucleophilic substitution reactions at the carbonyl carbon and the specific products formed in each case. The chemistry of carboxylic acid derivatives ...
Powerpoint slides - School of Engineering and Applied Science
... Much of the protein core comprises helices and sheets, folded into a threedimensional configuration: ...
... Much of the protein core comprises helices and sheets, folded into a threedimensional configuration: ...
Propolis (bee glue): an unusual mordant for gilding in Italian
... substances and beeswax. It is used by bees as a sealant and to protect the nest against microorganisms. Both Aristotle and Pliny give accounts of propolis – mentioning its medicinal properties. Interest in the material has revived for medical use and much work has been done on the chemical compositi ...
... substances and beeswax. It is used by bees as a sealant and to protect the nest against microorganisms. Both Aristotle and Pliny give accounts of propolis – mentioning its medicinal properties. Interest in the material has revived for medical use and much work has been done on the chemical compositi ...
List of Objectives for Chem52
... Name aromatic compounds (and their derivatives) by their IUPAC-accepted common names. You should know the structures of benzene, toluene, the xylenes, phenol, aniline, benzaldehyde, and benzoic acid. (See Table 15.1.) You should also know the structure of pyridine, pyrrole, and ...
... Name aromatic compounds (and their derivatives) by their IUPAC-accepted common names. You should know the structures of benzene, toluene, the xylenes, phenol, aniline, benzaldehyde, and benzoic acid. (See Table 15.1.) You should also know the structure of pyridine, pyrrole, and ...
ETHER
... are named as alkoxy derivatives of alkanes Always named in alphabetical order Can be symmetrical or unsymmetrical Example: diethyl ether is symmetrical Ethyl methyl ether is unsymmetrical ...
... are named as alkoxy derivatives of alkanes Always named in alphabetical order Can be symmetrical or unsymmetrical Example: diethyl ether is symmetrical Ethyl methyl ether is unsymmetrical ...
Lecture 9 Mass Spectrommetry Techniques
... Magnetic fields applied to trapping plates constrain the ions to move around in a circle in between the plates. The circular motion induces an alternating current. The frequency of the AC is related to the m/z ratio. ...
... Magnetic fields applied to trapping plates constrain the ions to move around in a circle in between the plates. The circular motion induces an alternating current. The frequency of the AC is related to the m/z ratio. ...
Stockholm University
... 7), are tolerated under the applied reaction conditions. The reactions involving substituted allylacetates provide the branched products with very high regioselectivity. The diastereoselectivity of the reaction is also very high. In many cases a single diastereomer was obtained (Entries 2, 6, 7 and ...
... 7), are tolerated under the applied reaction conditions. The reactions involving substituted allylacetates provide the branched products with very high regioselectivity. The diastereoselectivity of the reaction is also very high. In many cases a single diastereomer was obtained (Entries 2, 6, 7 and ...
Phenylketonuria Phenylketonuria
... Blood is collected by heel-prick onto a piece of blotter-paper (Guthrie card); The blood is then placed on a culture dish which contains a species of bacteria which require phenylalanine for growth In normal children’s blood there isnt enough phenylalanine to support growth. Other blood tests may al ...
... Blood is collected by heel-prick onto a piece of blotter-paper (Guthrie card); The blood is then placed on a culture dish which contains a species of bacteria which require phenylalanine for growth In normal children’s blood there isnt enough phenylalanine to support growth. Other blood tests may al ...
Distribution of Prolyl Oligopeptidase in Human
... energy difference between the cis and the trans conformation, so that a larger percentage of X-Pro bonds supports the cis conformation rather than the ail-trans conformation. On account of these factors, peptide bonds involving proline are seldom cleaved by classical serine endopeptidases, since the ...
... energy difference between the cis and the trans conformation, so that a larger percentage of X-Pro bonds supports the cis conformation rather than the ail-trans conformation. On account of these factors, peptide bonds involving proline are seldom cleaved by classical serine endopeptidases, since the ...
Chapter 15 Carboxylic Acids and Esters
... USEFUL CARBOXYLIC ACID SALTS (continued) • A mixture of sodium citrate and citric acid is widely used as a buffer to control pH. • The buffer can be found in: • Jelly • Ice cream • Candy • Whipped cream • Medicines • Human blood for transfusions (also an anticoagulant) ...
... USEFUL CARBOXYLIC ACID SALTS (continued) • A mixture of sodium citrate and citric acid is widely used as a buffer to control pH. • The buffer can be found in: • Jelly • Ice cream • Candy • Whipped cream • Medicines • Human blood for transfusions (also an anticoagulant) ...
Carboxylic Acid Derivatives and Nucleophilic Acyl Substitution
... Conversion of Carboxylic Acids into Acid Anhydrides • Heat cyclic dicarboxylic acids that can form fiveor six-membered rings • Acyclic anhydrides are not generally formed this way - they are usually made from acid chlorides and carboxylic acids ...
... Conversion of Carboxylic Acids into Acid Anhydrides • Heat cyclic dicarboxylic acids that can form fiveor six-membered rings • Acyclic anhydrides are not generally formed this way - they are usually made from acid chlorides and carboxylic acids ...
Vancomycin monitoring : One or Two Serum level?
... Diffuse well into pleural, pericardial, synovial and ascitic fluid Penetration into CSF is not reliable or predictable, therapeutic concentrations may be reached in patients with a acute meningitis ...
... Diffuse well into pleural, pericardial, synovial and ascitic fluid Penetration into CSF is not reliable or predictable, therapeutic concentrations may be reached in patients with a acute meningitis ...
Bottromycin
Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from Streptomyces bottropensis. It has been shown to inhibit methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma. Bottromycin is structurally distinct from both vancomycin, a glycopeptide antibiotic, and methicillin, a beta-lactam antibiotic.Bottromycin binds to the A site of the ribosome and blocks the binding of aminoacyl-tRNA, therefore inhibiting bacterial protein synthesis. Although bottromycin exhibits antibacterial activity in vitro, it has not yet been developed as a clinical antibiotic, potentially due to its poor stability in blood plasma. To increase its stability in vivo, some bottromycin derivatives have been explored.The structure of bottromycin contains a macrocyclic amidine as well as a thiazole ring. The absolute stereochemistry at several chiral centers has been determined as of 2009. In 2012, a three-dimensional solution structure of bottromycin was published. The solution structure revealed that several methyl groups are on the same face of the structure.Bottromycin falls within the ribosomally synthesized and post-translationally modified peptide class of natural product.