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STING Millennium: a web-based suite of programs
STING Millennium: a web-based suite of programs

... rows indicate the secondary structure according to the annotations in PDB, DSSP and Stride, respectively. Another five rows are displayed color coded according to: temperature factor, relative entropy, accessibility in complex, accessibility in isolation and dihedral angles. His_57 and parameters be ...
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... basis. Antibiotic resistance is conveyed to all physicians through a hospital antibiogram every 6 months. The antibiotics on restricted use are told to the physicians. Definitions ...
Alcohols I Reading: Wade chapter 10, sections 10-1- 10
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... In each case, hydrogen gas is given off as a by-product; because of the high acidity of phenols, phenoxides may be formed by treatment of phenol with sodium hydroxide: OH ...
A Biocatalytic Henry Reaction-The Hydroxynitrile Lyase from Hevea
A Biocatalytic Henry Reaction-The Hydroxynitrile Lyase from Hevea

... ethene, was detected as the only by-product. By comparing optical rotation data of the product with literature values the absolute configuration of the product was determined to be S,[5] which is in agreement with the known stereopreference of HbHNL in cyanohydrin reactions. Although the nitroaldol ...
The Effects of Ozone on Compounds in Epicuticular Waxes in Plant
The Effects of Ozone on Compounds in Epicuticular Waxes in Plant

... quercetin, ferulic acid and methyl decanoate were chosen to be representative of compounds found in epicuticular waxes. Each standard was individually exposed to excess amounts of ozone and reacted in a Teflon bottle for a prolonged period prior to analysis. Both the standard and the ozonized produc ...
Photoremovable Protecting Groups
Photoremovable Protecting Groups

... literature on a topic. Several good reviews on photoremovable protecting groups have appeared since this topic was reviewed in 1993 (e.g., Adams and Tsien3 and Corrie and Trentham4). Notable among the more recent reviews are those by Wirz,5 Bochet,6 and Givens.7 A volume of Methods in Enzymology dev ...
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PowerPoint 演示文稿

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United  States  Patent Dolphin  et al.
United States Patent Dolphin et al.

... where A, D, R1 through R6 and Sl through S4 are described above, to form an osmate ester at the [:l,r:l'position; and b. reducing the osmate ester to form the corresponding 13,B'-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin of formula (1). Three methods of making the dem ...
عرض تقديمي من PowerPoint
عرض تقديمي من PowerPoint

... Heterocyclic analogues of Cyclopropane All three membered rings have one major property in common- a strained ring which confers great reactivity on the compounds in comparison with their openchain analogues. ...
Molecular orbital approach to substituent effects in amine
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... and bulk diffusion of P. Our results for D M M P decomposition on a-Fe2039 show that it is active for D M M P decomposition but deactivates as phosphate forms. Unlike Mo, Pt does not readily form a stable bulk oxide. Thus, removal of P can occur only when gas-phase oxygen is present to drive the for ...
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Thermo Scientific Solutions for Quantitative

... a powerful, more-flexible alternative to time- and resourceintensive, enzyme-linked immunosorbent assays (ELISAs). Targeted quantitation is frequently applied to large sample sets to validate putative biomarkers identified in earlier discovery experiments or to analyze wide-scale changes in biologic ...
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Chem 322 - Exam #3 - Spring 2003
Chem 322 - Exam #3 - Spring 2003

... with 4 moles of nitric acid to produce a nitrate tetraester, pentaerythritol tetranitrate,” to get at the structure of compound C. You would need to recall that when esters form from alcohols and acids, the acid loses an OH, the alcohol loses an H, and the ester bond forms. If you were less astute, ...
Unit 4 Chemical Kinetics and Chemical Equilibrium
Unit 4 Chemical Kinetics and Chemical Equilibrium

...  Asymmetric reagents such as H-X add to a C=C so that the proton adds to the carbon (in the double bond) that already has the greater number of hydrogen atoms.  “The rich get richer” ...
Chapter 12. Aldehydes, Ketones and Carboxylic Acids
Chapter 12. Aldehydes, Ketones and Carboxylic Acids

... 1. Aliphatic carboxylic acids up to nine carbon atoms are colourless liquids at room temperature with unpleasant odours. The higher acids are wax like solids. 2. The lower carboxylic acids are freely miscible with water due to the presence of intermolecular hydrogen bonding with H2O molecules. Howev ...
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Document

... Self-cleavage of the RNA molecules • The regulation of glmS gene(glutamine-fructose-6phosphate amidotransferase)in B. subtilis is by associated activity of ribozyme and riboswitches. • In this case the 5’ UTR of glmS binds with gluosamin6-phosphate, product of GlmS activity and start acting as ribo ...
CHM-373 American Women in Science and Society
CHM-373 American Women in Science and Society

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Chapter 16 Aldehydes and Ketones I. Nucleophilic Addition to

... reagents result in formation of a tetrahedral alkoxide intermediate l The carbonyl π electrons shift to oxygen to give the alkoxide l The carbonyl carbon changes from trigonal planar to ...
1012_4th Exam_1020619 - NTOU-Chem
1012_4th Exam_1020619 - NTOU-Chem

... 35) What are heterocyclic compounds? A) They are cyclic compounds in which carbon ring is connected to another ring not containing carbon atoms B) They are cyclic compounds in which two or more carbon rings are connected with C-C bons (for example biphenyl) C) They are cyclic compounds in which one ...
Dr. Peter John M.Phil, PhD Assistant Professor
Dr. Peter John M.Phil, PhD Assistant Professor

LNA-PNA Comparison4
LNA-PNA Comparison4

... PNA and LNA probes contributes in many areas of applications like antigene and antisense therapeutics, SNP genotyping assays, Fluorescent insitu hybridization etc. Apart from the applications there are certain drawbacks where LNA probes are preferred over PNA probes- firstly, PNA resembles closely o ...
New liquid absorbents for the removal of CO2 from gas
New liquid absorbents for the removal of CO2 from gas

... highly selective, posses a high absorption capacity, present as low cost as possible and not be harmful to the environment. Standard absorption technologies for trapping of CO2 and acid gases in general using primary amines and amino alcohols as efficient sorption media are limited for this purpose ...
Crossing borders to bind proteins—a new concept in protein
Crossing borders to bind proteins—a new concept in protein

... Proteins that have reached the status of biomarkers have frequently been well investigated and the literature is rich in small organic molecules designed to bind important biomarkers, but with affinities and selectivities insufficient for biomedical applications. They are excellent starting points f ...
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Bottromycin



Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from Streptomyces bottropensis. It has been shown to inhibit methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma. Bottromycin is structurally distinct from both vancomycin, a glycopeptide antibiotic, and methicillin, a beta-lactam antibiotic.Bottromycin binds to the A site of the ribosome and blocks the binding of aminoacyl-tRNA, therefore inhibiting bacterial protein synthesis. Although bottromycin exhibits antibacterial activity in vitro, it has not yet been developed as a clinical antibiotic, potentially due to its poor stability in blood plasma. To increase its stability in vivo, some bottromycin derivatives have been explored.The structure of bottromycin contains a macrocyclic amidine as well as a thiazole ring. The absolute stereochemistry at several chiral centers has been determined as of 2009. In 2012, a three-dimensional solution structure of bottromycin was published. The solution structure revealed that several methyl groups are on the same face of the structure.Bottromycin falls within the ribosomally synthesized and post-translationally modified peptide class of natural product.
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