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Profile Documents Logout
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m/z
m/z

... • Exercise 1: Protein cleavage/digestion 1. Go to http://www.expasy.ch/tools/peptidecutter/ 2. In the box, enter ALBU_HUMAN (this is the swissprot name of human serum albumin) - you can also choose a different protein if you like. Sequences and swissprot codes can for example be found in the swisspr ...
Slide 1
Slide 1

(SREBP 1c) is strongly expressed in MIN6 beta cells
(SREBP 1c) is strongly expressed in MIN6 beta cells

... Protein Kinase B (PKB, also known as Akt) is an important signalling molecule which has been shown to become activated in response to many stimuli, including insulin, growth factors and a variety of survival promoting agents. The signalling pathway by which insulin activates PKB has been well charac ...
From Genes to Proteins - Yale Center for Teaching and Learning
From Genes to Proteins - Yale Center for Teaching and Learning

... a) In the sequence of amino acids b) In the sequence of nucleotides c) In the sequence of covalent bonds d) In the sequence of phosphate groups ...
document
document

... These tend to be liquid at room temp., such as olive oil and canola oil. Unsaturated fats are generally considered to be healthier when used in moderation. ...
Worked Example 19.1
Worked Example 19.1

Essential Nutrients
Essential Nutrients

... be polar because they have a negatively charged head (phosphate) and a positively charged tail (2 fatty acids). ...
- International Journal of Applied Research in Natural
- International Journal of Applied Research in Natural

... considered for publication in your journal [International Journal of Applied Research in Natural Products]. ...
Macromolecules
Macromolecules

... 9. _________________fatty acids contain all of the __________________ they can hold. There are no carbon to carbon ________________bonds in saturated fatty acids. Saturated fatty acids are typical of _________________ fats and are believed to cause blockage of ___________________ which can lead to s ...
View Full PDF - Biochemical Society Transactions
View Full PDF - Biochemical Society Transactions

... Academic Press, New York, Sun Francisco and London, 1977, p p . 720, €39.05 ...
Organic Chemistry chapter 2
Organic Chemistry chapter 2

... • A polysaccharide like cellulose (on the right) is many monosaccharides linked together. ...
EXAM 1 LINK
EXAM 1 LINK

... 34) Upon chemical analysis, a particular polypeptide was found to contain 100 amino acids. How many peptide bonds are present in this protein? 35) Which bonds are created during the formation of the primary structure of a protein? 36) What maintains the secondary structure of a protein? 37) Which ty ...
NOSOCOMIAL ANTIBIOTIC RESISTANT ORGANISMS
NOSOCOMIAL ANTIBIOTIC RESISTANT ORGANISMS

... Risk factors for VRE infection Severe illness  Treatment with multiple antibiotics  Abdominal or cardiac surgery  Devices used in invasive procedures  Age  ICU  Prolonged or repeated hospital stays ...
Information Flow
Information Flow

... tRNA at the P site and the formation of a peptide bond between that amino acid and the amino acid attached to the tRNA at the A site. i The Th enzyme that h is i part off the h ribosome ...
Supramolecular Factories Inspired by Processive Enzymes
Supramolecular Factories Inspired by Processive Enzymes

... threaded with a long molecule or polymer. Recognizing the similarity in architecture between processive enzymes and rotaxanes, Nolte and co-workers created the first catalytically active rotaxane system in 2003.1 In this system, a polybutadiene polymer is threaded through a macrocycle containing a m ...
171392_ProteinSyn
171392_ProteinSyn

PART III. PROTEIN SYNTHESIS SATISFIES: How DNA Makes It A
PART III. PROTEIN SYNTHESIS SATISFIES: How DNA Makes It A

... 3. SET UP: Place the "Nuclear Membrane" strip vertically on the middle of your desk. Take the original (white) DNA molecule used in the REPLICATION kit, and place it to the right of the "membrane", along with all the blue mRNA (messenger-RNA) nucleotides scattered next to it. This represents the con ...
Central Dogma WebQuest - Life Science
Central Dogma WebQuest - Life Science

... 3. In a eukaryotic cell, transcription occurs in the nucleus, and translation occurs in the ______________. 4. Write the functions of the following forms of RNA: mRNA: ___________________________________________________________________________ tRNA: __________________________________________________ ...
DNA to Protein Name____________ Period______ DNA Location
DNA to Protein Name____________ Period______ DNA Location

... 1. DNA is contained in the nucleus of eukaryotes (plants/animals) 2. DNA mRNA The DNA message gets copied into mRNA. This is called transcription. 3. The mRNA leaves nucleus and sticks to ribosomes. (The ribosomes can be floating in cytoplasm (free) or stuck to rough endoplasmic reticulum.) 4. Ribo ...
Genetics Practice Questions C 1. Describe transcription
Genetics Practice Questions C 1. Describe transcription

... 6. The genetic code is universal, unambiguous, and redundant. Explain what this means and why it is important. ・Universality・・・・All known living things have the same genetic code. ...
Explanation of Scaffold`s Display Options - Proteome Software
Explanation of Scaffold`s Display Options - Proteome Software

... question. This number is the number of assigned spectra for this protein divided by the total spectra in the sample (as seen in the Load Data View). Assigned spectra: This is the number of spectra which Protein Prophet assigns to the protein in question.The peptides represented by these spectra may ...
File
File

... – The ribosome helps form a polypeptide bond between the amino acids. – The ribosome pulls the mRNA strand the length of one codon. ...
12-3 RNA and Protein Synthesis
12-3 RNA and Protein Synthesis

... Translation Step 2 • mRNA binds to the ribosome. tRNA attaches • Anticodons on the tRNA line up with codons on mRNA The other end of the tRNA is an amino acid ...
Gene Activity - Haiku Learning
Gene Activity - Haiku Learning

... Gene unzips and exposes unpaired bases Serves as template for mRNA formation Loose RNA nucleotides bind to exposed DNA bases using the C=G & A=U rule When entire gene is transcribed into mRNA, result is an mRNA transcript of the gene The base sequence in the mRNA is complementary to the base se ...
polymerisation
polymerisation

... Physical ...
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Bottromycin



Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from Streptomyces bottropensis. It has been shown to inhibit methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma. Bottromycin is structurally distinct from both vancomycin, a glycopeptide antibiotic, and methicillin, a beta-lactam antibiotic.Bottromycin binds to the A site of the ribosome and blocks the binding of aminoacyl-tRNA, therefore inhibiting bacterial protein synthesis. Although bottromycin exhibits antibacterial activity in vitro, it has not yet been developed as a clinical antibiotic, potentially due to its poor stability in blood plasma. To increase its stability in vivo, some bottromycin derivatives have been explored.The structure of bottromycin contains a macrocyclic amidine as well as a thiazole ring. The absolute stereochemistry at several chiral centers has been determined as of 2009. In 2012, a three-dimensional solution structure of bottromycin was published. The solution structure revealed that several methyl groups are on the same face of the structure.Bottromycin falls within the ribosomally synthesized and post-translationally modified peptide class of natural product.
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