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PPTX - Bonham Chemistry
PPTX - Bonham Chemistry

... in the liver and kidneys • Gluconeogenesis is similar to glycolysis (but is not a reversal) • Different in the three regulatory steps of glycolysis: – hexokinase – PFK-1 ...
Chapter 1 - Origin of Vertebrate Limb Muscle
Chapter 1 - Origin of Vertebrate Limb Muscle

... of the animal (reviewed in Biressi et al., 2007a; Stockdale, 1992). Of intense interest is understanding how these different phases of muscle arise. Because differentiated muscle is postmitotic, muscle is generated from myogenic progenitors and committed myoblasts, which proliferate and differentiat ...
Fatty acid transport proteins: a current view of a
Fatty acid transport proteins: a current view of a

... metabolites – glucose and LCFAs – from storage to utilizing organs. The differential distribution of glucose among organs is facilitated by tissue-specific expression of a family of different glucose transporters, in addition to different abilities to respond to insulin changes34. The mechanisms by ...
The Trp64Arg β3 -adrenergic receptor amino acid
The Trp64Arg β3 -adrenergic receptor amino acid

... The β3-adrenergic receptor ( β3AR) plays a critical role in lipid metabolism, and thus alterations in its function may be involved in the metabolic syndrome. Indeed, we have found previously that the Trp64Arg amino acid variant of the β3AR is associated with hypertension and higher serum triacylglyc ...
Metabolism
Metabolism

... Fast twitch muscle fibers utilize the first of the two mechanisms described above almost exclusively. Very heavily exercising muscle can use this pathway as the sole source of ATP synthesis for a short period of time. This probably evolved in humans as a defense mechanism, but is now used by athlete ...
Understanding the acetylome: translating targeted
Understanding the acetylome: translating targeted

... the TCA cycle and glyoxylate pathways when citrate is in abundance. Immunoprecipitation followed by pan-acetyllysine immunoblotting demonstrated that GapA, AceA, and AceK are hyperacetylated in the ⌬CobB strain, concomitant with increased glycolytic flux, whereas differential deacetylation was obser ...
Diabetes and Mitochondria
Diabetes and Mitochondria

... which can conduct a series of caspase reaction and subsequent activation then demolished the cell apoptosis. Insulin resistance was defined as a diminished responsive ability of cells or tissues in normal physiological insulin concentrations. Genetic and environmental factors, including aging, obesi ...
GLYCOGENOLYSIS AND GLYCOLYSIS IN MUSCLE
GLYCOGENOLYSIS AND GLYCOLYSIS IN MUSCLE

... muscles during contraction—require insulin in order to take in glucose. The unique mechanism by which muscles take up glucose during exercise is currently being studied (Chapter 9). Nerve and brain tissues usually consume large amounts of glucose; the liver also usually takes up large amounts even i ...
"Amino Acids of the 21st Century" (7) –The
"Amino Acids of the 21st Century" (7) –The

... +/- 5 mg/dl) and frequent fatigue. Rapid recovery from muscle soreness and lower back pain was particularly desirable for this group. Comparisons of hematological parameters before and after ingestion of the amino acid mixture (AVP) (Figure 3) showed that TC levels increased to 191 mg/dl. Increases ...
Creatine Monohydrate - National Drug Strategy
Creatine Monohydrate - National Drug Strategy

... Apart from this main benefit of 'supplying energy to the muscles', some believe that creatine can have additional effects: o Increasing the volume of muscles (by pulling water molecules into muscle cells) o Neutralisation of lactic acid build-up (acting as a 'buffer') o Protein-synthesis (increasing ...
Intermediary Metabolism Intermediary Metabolism
Intermediary Metabolism Intermediary Metabolism

... protein synthesis glucose uptake glycogen synthesis ...
Predicted Effects of Metacarpal Shortening on Interosseous Muscle
Predicted Effects of Metacarpal Shortening on Interosseous Muscle

... 2 mm to as much as 10 mm has been deemed acceptable in the literature. We examined the effect of metacarpal shortening on interosseous muscle architecture and predicted force production capacity based on the standard muscle length-tension curve (commonly known as the Blix curve). Methods: The dorsal ...
Citric Acid Cycle Regulation
Citric Acid Cycle Regulation

... Step 5 of glycolysis converts NAD+ to NADH (G3P to G1,3BP) For next round of glycolysis to occur need NADH converted to NAD+ for use in step 5. How cells (muscle especially) accomplish this? Pyruvate (Py), the end product of glycolysis, is converted to lactate. At the same time NADH is converted to ...
Animal Systems
Animal Systems

... consists of thin sheets of tightly packed cells that covers surfaces and lines internal organs which protects what it covers. ________________ consists of cells and fibres held together by non-living material called the matrix. It acts to support the organism. ____________________ consists of long b ...
part_4_cellular_respiration_stations
part_4_cellular_respiration_stations

... Anaerobic respiration is very inefficient as it only produces 2 ATP molecules per glucose. The process of anaerobic respiration only occurs in the cytoplasm, not in the mitochondria. ...
Specialised training
Specialised training

... D. Competitive phase – refinement of skills/ maintenance of fitness levels/quality rather than quantity/relevant examples of training modifications E. Tapering/peaking – preparation for specific competition/mainly skill focus F. Transition phase – active rest/out of season recovery period ...
Interleukin-6 in Sepsis and Capillary Leakage Syndrome - Labor
Interleukin-6 in Sepsis and Capillary Leakage Syndrome - Labor

... current understanding of sepsis, bacterial components activate innate immune responses via pattern-recognition receptors that stimulate signaling pathways, thereby leading to activation of NF-kB and the release of cytokines, alarming the organism and coordinating appropriate defense mechanisms. The ...
Biochemistry Ch 33 597-624 [4-20
Biochemistry Ch 33 597-624 [4-20

... -in addition to stimulating synthesis and release of LPL, insulin stimulates glucose metabolism in adipose and leads to activation of PFK-1 by activating kinase activity of PFK-2, which increased F-2,6-BP -insulin also stimulates dephosphorylation of pyruvate dehydrogenase so that pyruvate produced ...
Desmin Is Essential for the Tensile Strength and
Desmin Is Essential for the Tensile Strength and

... desmin. Muscle maturation also occurred on time, and a normal muscle fiber phenotype was seen in all muscles. However, as early as 2 wk after birth, we found that there were ultrastructural modifications in myofibril organization, necrosis, and focal regeneration. These modifications were prominent ...
Lecture 9-lea
Lecture 9-lea

... • Describe where glycolysis occurs • Explain the importance of glycolysis • Describe all the reactions of glycolysis particularly the 3 irreversible reactions, the formation of ATP and the NAD requiring reaction. • Identify the key regulated step • Explain the distinction between anaerobic and aerob ...
intermediary metabolism
intermediary metabolism

... metabolic fuels for energy supply or as precursors in the biosynthesis of compounds required by the cell for maintenance or growth are interrelated and well coordinated. This interrelation of metabolism could be considered at the following levels: A. The flow of key metabolites between different met ...
PFK-2
PFK-2

... low levels of glucose. But is quickly saturated. • Glucokinase is found in liver and b-cells of pancreas • Glucokinase allows liver to respond to blood glucose levels • It has a high Km, so it does not become saturated till very high levels of glucose are reached • At low glucose levels, very little ...
赣南医学院教案
赣南医学院教案

... then turn into ketone bodies by ketogenesis. Ketogenesis only occurs in liver, but the enzymes that are required by utilization of ketone bodies are absent from the liver. Therefore, the liver is a net producer of ketone bodies. ...
Mad Scientist Muscle - Home
Mad Scientist Muscle - Home

... When you begin the program, you gradually accumulate workload and training volume, moving more and more towards overtraining. This training "on the edge" is where the REAL results are - you won't get anywhere if you stay too far away from it! At the end of the "accumulation" phase, you've hit Overtr ...
Eating increases oxidative damage in a reptile
Eating increases oxidative damage in a reptile

... neutralized by an organism’s antioxidant capabilities (Costantini et al., 2010). Because oxidative damage is associated with an array of biological functions (e.g. ornamentation, hibernation, immune function and reproductive effort; Costantini et al., 2010), it may be a universal constraint in life ...
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Myokine

A myokine is one of several hundred cytokines or other small proteins (~5–20 kDa) and proteoglycan peptides that are produced and released by muscle cells (myocytes) in response to muscular contractions. They have autocrine, paracrine and/or endocrine effects; their systemic effects occur at picomolar concentrations.Receptors for myokines are found on muscle, fat, liver, pancreas, bone, heart, immune, and brain cells. The location of these receptors explain the fact that myokines have multiple functions. Foremost, they are involved in exercise-associated metabolic changes, as well as in the metabolic changes following training adaptation. They also participate in tissue regeneration and repair, maintenance of healthy bodily functioning, immunomodulation; and cell signaling, expression and differentiation.
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