a needle into the sub- and the dorsal funiculi. Preganglionic
... Neuronal Architecture of Spinal Gray Matter As ...
... Neuronal Architecture of Spinal Gray Matter As ...
Mammalian Models of CNS Regeneration - Wiley-VCH
... Although Nogo-66, MAG and OMgp lack sequence homology, a single cell-surface protein, NgR1 acts as a functional receptor for all three molecules (Fournier et al., 2001; Liu et al., 2002; Wang et al., 2002a). NgR1 is a GPI-linked cell-surface protein and requires LINGO-1 and either p75 or TROY for si ...
... Although Nogo-66, MAG and OMgp lack sequence homology, a single cell-surface protein, NgR1 acts as a functional receptor for all three molecules (Fournier et al., 2001; Liu et al., 2002; Wang et al., 2002a). NgR1 is a GPI-linked cell-surface protein and requires LINGO-1 and either p75 or TROY for si ...
L1CAM/Neuroglian controls the axon–axon interactions establishing
... (middle) regions of the MBs. neurons are marked by mCD8-GFP expression (c739-Gal4, green), and neurites of all MB are visualized by Dlg (magenta). Bottom panels show medial (side) views of 3D-surface rendered neurons. (B) In nrg14; P[nrg_wt] control animals, axons of all three MB neuron subtyp ...
... (middle) regions of the MBs. neurons are marked by mCD8-GFP expression (c739-Gal4, green), and neurites of all MB are visualized by Dlg (magenta). Bottom panels show medial (side) views of 3D-surface rendered neurons. (B) In nrg14; P[nrg_wt] control animals, axons of all three MB neuron subtyp ...
Shootin1 - The Journal of Cell Biology
... Recent studies have begun to define the signaling pathways involved in neuronal polarization. Esch et al. (1999) reported that the extracellular signals laminin and neuron-glia cell adhesion molecule can specify which neurite will become an axon. As effectors of spatial signals, rearrangements of th ...
... Recent studies have begun to define the signaling pathways involved in neuronal polarization. Esch et al. (1999) reported that the extracellular signals laminin and neuron-glia cell adhesion molecule can specify which neurite will become an axon. As effectors of spatial signals, rearrangements of th ...
Depolarization stimulates lamellipodia formation and
... according to Dotti et al. w10x. The distinction between filopodia and Žvery short. neurites or terminal segments was defined by length. Extensions longer than 0.7 m m and shorter than 5.1 m m were designated filopodia. Extensions equal to or longer than 5.1 m m were designated neurites if they emerg ...
... according to Dotti et al. w10x. The distinction between filopodia and Žvery short. neurites or terminal segments was defined by length. Extensions longer than 0.7 m m and shorter than 5.1 m m were designated filopodia. Extensions equal to or longer than 5.1 m m were designated neurites if they emerg ...
Mechanisms of cell migration in the nervous system
... glia (steps 1, 2, and 3), leaving a bifurcated axon behind. Pontine and other precerebellar neurons (purple) migrate tangentially in the marginal zone of the pons. Note that these migrations do not all occur at the same time. ...
... glia (steps 1, 2, and 3), leaving a bifurcated axon behind. Pontine and other precerebellar neurons (purple) migrate tangentially in the marginal zone of the pons. Note that these migrations do not all occur at the same time. ...
Septins promote dendrite and axon development by negatively
... Figure 1 | The core septin subunit SEPT7 is required for the growth of dendrites and axons of cerebrocortical neurons in vivo. (a) Representative immunofluorescence images of primary cerebrocortical neurons at div2 co-expressing GFP with control (left) or shRNA#1 against SEPT7 (right). Endogenous SEP ...
... Figure 1 | The core septin subunit SEPT7 is required for the growth of dendrites and axons of cerebrocortical neurons in vivo. (a) Representative immunofluorescence images of primary cerebrocortical neurons at div2 co-expressing GFP with control (left) or shRNA#1 against SEPT7 (right). Endogenous SEP ...
Formation of Neuronal Pathways in the lmaginal Discs of Drosophila
... information on pathway formation by peripheral pioneer neurons (Bate, 1976; Ho and Goodman, 1982; Bentley and Caudy, 1983a, b; Keshishian and Bentley, 1983a, b, c; Berlot and Goodman, 1984). It has been suggested that pioneer growth cones rely on at least two sources of guidance: (7) polarity along ...
... information on pathway formation by peripheral pioneer neurons (Bate, 1976; Ho and Goodman, 1982; Bentley and Caudy, 1983a, b; Keshishian and Bentley, 1983a, b, c; Berlot and Goodman, 1984). It has been suggested that pioneer growth cones rely on at least two sources of guidance: (7) polarity along ...
Neuronal RNA Localization and the Cytoskeleton
... stoichiometry, and structural organization differ from that of the perikarya. Of fundamental interest is identification of how the cytoskeletal composition of the growth cone differs from the perikarya, and the identification of mechanisms involved in this sorting and assembly. One mechanism to prov ...
... stoichiometry, and structural organization differ from that of the perikarya. Of fundamental interest is identification of how the cytoskeletal composition of the growth cone differs from the perikarya, and the identification of mechanisms involved in this sorting and assembly. One mechanism to prov ...
Spinal Cord
... with that dimension and that location is unlikely. The structure is adjacent to, but does not appear to be continuous with the adjacent disc. ...
... with that dimension and that location is unlikely. The structure is adjacent to, but does not appear to be continuous with the adjacent disc. ...
Netrin
Netrins are a class of proteins involved in axon guidance. They are named after the Sanskrit word ""netr"", which means ""one who guides."" Netrins are genetically conserved across nematode worms, fruit flies, frogs, mice, and humans. Structurally, netrin resembles the extracellular matrix protein laminin.Netrins are chemotropic; a growing axon will either move towards or away from a higher concentration of netrin. Though the detailed mechanism of axon guidance is not fully understood, it is known that netrin attraction is mediated through UNC-40/DCC cell surface receptors and repulsion is mediated through UNC-5 receptors. Netrins also act as growth factors, encouraging cell growth activities in target cells. Mice deficient in netrin fail to form the hippocampal comissure or the corpus callosum.A proposed model for netrin activity in the spinal column of developing human embryos is that netrins are released by the floor plate and then are picked up by receptor proteins embedded in the growth cones of axons belonging to neurons in the developing spinal column. The bodies of these neurons remain stationary while the axons follow a path defined by netrins, eventually connecting to neurons inside the embryonic brain by developing synapses. Research supports that new axons tend to follow previously traced pathways, rather than being guided by netrins or related chemotropic factors.