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Enzyme POGIL-PCR
Enzyme POGIL-PCR

... PCR is a technique where millions of copies of a specific segment of DNA can be made from one original copy. IN this method, the target DNA molecule is subjected to temperatures over 95° C to make the double-stranded DNA separate. The temperature is then lowered slightly to allow primers to anneal b ...
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... only one of the strands of the double-stranded RNA. From these observations it has been concluded that the genome of the bluetongue virus is transcribed into a single-stranded RNA which functions as a messenger in the synthesis of viral-specific proteins (Huismans, 1970). The question which immediat ...
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Biology for Bioinformatics - NIU Department of Biological

... In prokaryotes, transcription and translation are essentially simultaneous: translation of the messenger RNA starts before transcription is completed. In eukaryotes, transcription occurs in the nucleus (where the DNA is), and translation occurs in the cytoplasm. This de-coupling of transcription and ...
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Polyadenylation



Polyadenylation is the addition of a poly(A) tail to a messenger RNA The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In eukaryotes, polyadenylation is part of the process that produces mature messenger RNA (mRNA) for translation. It, therefore, forms part of the larger process of gene expression.The process of polyadenylation begins as the transcription of a gene finishes, or terminates. The 3'-most segment of the newly made pre-mRNA is first cleaved off by a set of proteins; these proteins then synthesize the poly(A) tail at the RNA's 3' end. In some genes, these proteins may add a poly(A) tail at any one of several possible sites. Therefore, polyadenylation can produce more than one transcript from a single gene (alternative polyadenylation), similar to alternative splicing.The poly(A) tail is important for the nuclear export, translation, and stability of mRNA. The tail is shortened over time, and, when it is short enough, the mRNA is enzymatically degraded. However, in a few cell types, mRNAs with short poly(A) tails are stored for later activation by re-polyadenylation in the cytosol. In contrast, when polyadenylation occurs in bacteria, it promotes RNA degradation. This is also sometimes the case for eukaryotic non-coding RNAs.mRNA molecules in both prokaryotes and eukaryotes have polyadenylated 3'-ends, with the prokaryotic poly(A) tails generally shorter and less mRNA molecules polyadenylated.
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