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Molecular Evolution and Non-extensive Statistics
Molecular Evolution and Non-extensive Statistics

... where pi is the ith spin momentum, Vij is the potential energy due to the interaction of spins i and j, rij is the distance between the relevant spins, and α is a positive exponent which is related to the range of interaction between the spins. The non-extensivity of the system can be inferred from ...
lecture25_DarkMatter..
lecture25_DarkMatter..

... 3. this union must be coherent, done separately for protein and RNA products, but it does not require that all the products necessarily share a common subsequence concisely summarized as a union of genomic sequences encoding a coherent set of ...
Note 7.1 - Gene to Protein
Note 7.1 - Gene to Protein

... during gene transcription. Precursor mRNA (pre-mRNA) – is the initial RNA transcription product. Transcription is the first step in protein synthesis. RNA polymerase is used to synthesize a RNA molecule, using complementary base pairs to one strand of a DNA molecule. The DNA template strand is read ...
Document
Document

... It has long been known that introduction of RNA into cells interferes with the function of the genes (3, 5). These effects have been proposed to result from the so called “antisense” mechanism that depends on hybridization between the exogenous RNA and endogenous messenger RNA transcripts thus block ...
Vocabulary From DNA to Proteins
Vocabulary From DNA to Proteins

... Double helix –the structure of DNA, composed of two strands of DNA that are held together by hydrogen bonds between complementary bases, shaped like a twisted ladder. Nitrogen base – Type of molecule that forms an important part of nucleic acid, composed of a nitrogen-containing ring structure. Hydr ...
Types of RNA
Types of RNA

... Sugar is ribose stranded Nitrogen bases are adenine, guanine, cytosine, and uracil ...
RNA Transcription
RNA Transcription

... The organization of eukaryotic genes is more complex than that of their bacterial counterparts. The majority of eukaryotic genes are made up of sequences that encode protein and thus are expressed (so-called exons) interspersed with intervening sequences (so-called introns) that do not code for pro ...
From Gene to Protein  I.
From Gene to Protein I.

... Introns and RNA splicing appear to have several functions. a. Some introns play a regulatory role in the cell. These introns contain sequences that control gene activity in some way. b. Splicing itself may regulate the passage of mRNA from the nucleus to the cytoplasm. c. One clear benefit of split ...
Document
Document

... spliced in several different ways , allowing a single gene to encode multiple proteins . This process is called alternative splicing . Splicing is usually performed by an RNA -protein complex called the spliceosome , but some RNA molecules are also capable of catalyzing their own splicing ( see ribo ...
Gene Expression
Gene Expression

... DNA in cells controls all sorts of things such as the color of your eyes, the color of your hair, and whether or not you can digest milk. These characteristics are called traits. DNA also controls your responses to stimuli in the environment to keep you alive. For example, when you are frightened, t ...
Lectures by Erin Barley Kathleen Fitzpatrick From Gene to Protein
Lectures by Erin Barley Kathleen Fitzpatrick From Gene to Protein

... RNA polymerase and the initiation of transcription • The completed assembly of transcription factors and RNA polymerase II bound to a promoter is called a transcription initiation complex • A promoter called a TATA box is crucial in forming the initiation complex in eukaryotes © 2011 Pearson Educati ...
Simulating Protein Synthesis and RNA Interference in the
Simulating Protein Synthesis and RNA Interference in the

... one end of the room 3) A second student will represent the Ribosome, responsible for making proteins from RNA instructions, and should be seated on the opposite end of the classroom with a set of pipe ...
gene_expression_info
gene_expression_info

... to form a clover leaf • It can attach to a specific aa in the cytoplasm • It can recognise the specific mRNA codon for the aa it carries ...
Saturday Study Session 2 Theme of the day: Information Transfer
Saturday Study Session 2 Theme of the day: Information Transfer

bio_ch08-5_transcript redo
bio_ch08-5_transcript redo

... You might consider it to be odd to describe the genetic as a punctuation of stop and start codes. The Latin word puctum means “point” and is derived form an older form meaning “to pierce or puncture.” Punctuation, in a general sense, signifies an interruption. The word punctuate can also be used to ...
Discovery of Introns
Discovery of Introns

... T antigen at all! The expected deletion of an interior segment of the T antigen does not occur. If these antigen proteins reflect their genes, this doesn’t make any sense at all, as both t and T are read from the same nucleotides in the same reading frame (see chapter 13). How can it be a deletion a ...
Lecture 9b (2/18/13) "How to Make Proteins"
Lecture 9b (2/18/13) "How to Make Proteins"

... amino acids. When a ribosome finishes reading a mRNA, these two subunits split apart. ...
[pdf]
[pdf]

... RNase H is a sequence-nonspecific endonuclease that cleaves RNA strands in RNA–DNA hybrids. It is a member of a superfamily of nucleotidyl transferases that includes transposase and Holliday junction resolvase, and the enzymes of this family have important roles in many processes. However, little is ...
HOW ARE PROTEINS MADE?
HOW ARE PROTEINS MADE?

... What is the maximum number of amino acids that could be coded for by this section of mRNA? ...
Transcription and Translation
Transcription and Translation

... DNA sequence has coding regions (exons) and noncoding regions (introns) Introns must be removed before primary transcript is mRNA and can leave nucleus ...
LUCA - University of Washington
LUCA - University of Washington

... more complicated RNA machinery in their cells than bacteria and archaea do? And if, as Poole and his colleagues say, all these RNA devices are indeed molecular "living fossils" left over from a different world, then it seems unlikely that eukaryotes would have invented all this machinery to complica ...
The On’s and Off’s of Gene Expression
The On’s and Off’s of Gene Expression

... • Expression of the lac genes is regulated. – The genes are expressed only if lactose is in the growth medium. – The genes are not expressed if glucose is ...
Chap2 DNA RNA and Protein
Chap2 DNA RNA and Protein

...  subunit: promoter specificity. In E. coli, the  factor (e.g. 70, 32) is essential for initiation, it’s released when RNA chain reaches 8-9 nt. ...
Force vs. Velocity Profiles for Single Molecules of RNAP
Force vs. Velocity Profiles for Single Molecules of RNAP

... sequential substrates that are in rapid equilibrium and located at adjacent physical sites along the DNA The rate of enzyme progress is proportional to the relative occupancy of the forward and reaward sites, p+ and pδ is identified as d, the physical distance between the forward and reaward sites o ...
Chapter 10 Protein Synthesis
Chapter 10 Protein Synthesis

... 7. What enzyme makes RNA? 8. What type of RNA does it make? 9. After Tx, are Introns or Exons removed from the mRNA? 10. What do you call the 3-Nucleotide sequences that code for an amino acid? 11. How many codons are there? ...
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Polyadenylation



Polyadenylation is the addition of a poly(A) tail to a messenger RNA The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In eukaryotes, polyadenylation is part of the process that produces mature messenger RNA (mRNA) for translation. It, therefore, forms part of the larger process of gene expression.The process of polyadenylation begins as the transcription of a gene finishes, or terminates. The 3'-most segment of the newly made pre-mRNA is first cleaved off by a set of proteins; these proteins then synthesize the poly(A) tail at the RNA's 3' end. In some genes, these proteins may add a poly(A) tail at any one of several possible sites. Therefore, polyadenylation can produce more than one transcript from a single gene (alternative polyadenylation), similar to alternative splicing.The poly(A) tail is important for the nuclear export, translation, and stability of mRNA. The tail is shortened over time, and, when it is short enough, the mRNA is enzymatically degraded. However, in a few cell types, mRNAs with short poly(A) tails are stored for later activation by re-polyadenylation in the cytosol. In contrast, when polyadenylation occurs in bacteria, it promotes RNA degradation. This is also sometimes the case for eukaryotic non-coding RNAs.mRNA molecules in both prokaryotes and eukaryotes have polyadenylated 3'-ends, with the prokaryotic poly(A) tails generally shorter and less mRNA molecules polyadenylated.
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