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Innate Host Defenses - Interactive Physiology
Innate Host Defenses - Interactive Physiology

DOC - ADAM Interactive Anatomy
DOC - ADAM Interactive Anatomy

...  Phagocytes recognize invaders using receptors such as Toll-like receptors (TLRs) and the mannose receptor.  Binding of these receptors enhances phagocytosis and also causes secretion of chemicals that initiate adaptive immune responses. Page 9: Phagocytes: Killing Mechanisms  Phagocytes engulf p ...
Test-MID TERM (2-4-2012) Answer keys
Test-MID TERM (2-4-2012) Answer keys

... Responsible for antibody-mediated immunity (humoral immunity); a percentage of circulating B lymphocytes mature into plasma cells; plasma cells produce and secrete antibodies (immunoglobulins) which destroy antigens NK Cells (natural killer cells) Attack foreign cells and cells infected with viruses ...
Immunology for the Rheumatologist
Immunology for the Rheumatologist

... The cells of the innate immune system include neutrophils, eosinophils, basophils, NK (natural killer) cells, and the antigen-presenting cells. With regard to adaptive immunity there are CD4 positive T-helper cells, CD8 positive cytotoxic T cells, B cells and dendritic cells. When a microbe tries t ...
Module 12 Notes
Module 12 Notes

Immune
Immune

... – Bind to common antigens on many bacteria and plant proteins – Abundant in intestines and respiratory tract to keep out particles ...
final round - Sinoe Medical Association
final round - Sinoe Medical Association

Chapter 6 - Psychology
Chapter 6 - Psychology

... lymphatic system. They clean the lymph of bacteria and debris. lymphocytes - White blood cells found in lymph that are involved in the immune function. There are three types: (1) T-cells, (2) B-cells, and (3) natural killer cells. T-cells - Stem cells form in the bone marrow and travel to the thymus ...
Pathogenic Mechanisms of Uveitis
Pathogenic Mechanisms of Uveitis

... barrier also limits the immune response to the internal aspects of the eye, causing the eye to be considered an immune-privileged site. In cases of trauma or inflammation, these barriers can be disrupted, allowing blood products and cells to enter the eye. Flare, cell accumulations, and haze in the ...
Word version
Word version

... disease, or as a result of vaccination. Once an animal has produced a specific antibody, it can produce more antibodies of the same type rapidly in response to an infection. This is why there are some diseases that tend only to be seen clinically once in a lifetime. 2. Passive immunity This occurs w ...
The Immune system - Locust Trace Veterinary Assistant Program
The Immune system - Locust Trace Veterinary Assistant Program

Student factsheet for this topic
Student factsheet for this topic

... disease, or as a result of vaccination. Once an animal has produced a specific antibody, it can produce more antibodies of the same type rapidly in response to an infection. This is why there are some diseases that tend only to be seen clinically once in a lifetime. 2. Passive immunity This occurs w ...
millhouse integrative medical centre newsletter february march 2012
millhouse integrative medical centre newsletter february march 2012

... Flu vaccines have weaker versions or parts of the actual virus in them. These ‘parts’ are known as antigens which are like the virus’ finger prints. They are not strong enough to cause illness (most of the time) but are strong enough to activate an immune response. When a foreign body (bacteria or v ...
xCh7 immunity
xCh7 immunity

... Infected cells display viral antigens on their surface If a cytotoxic T cell recognizes a viral fragment there, it will destroy the infected cell Macrophages destroy the virus through phagocytosis and destroy infected cells to prevent further viral replication. ...
Supplementary Methods Quantification of Fg adsorption by
Supplementary Methods Quantification of Fg adsorption by

... For chondrogenesis, 200 000 cells were incubated in 500µL of medium (high glucose (4.5 g/L) DMEM supplemented with 50µg/mL ascorbic acid (Fluka), 40µg/mL L-proline (Sigma), 100µg/mL sodium pyruvate, 100µg/mL ITS culture supplement (BD Biosciences) and penicillin/streptomycin) without or with chondro ...


... prevent and contain infection in the most efficient way. Skin is the first line of defense against many pathogens. The digestive system is also a highly-guarded entry point. Once a breach does occur, various proteins and blood cells work in concert to stall and stop the infection. In general, immun ...
A fine Line
A fine Line

... or turn them off. They can trigger the formation of antibodies or cause a fever. “The function of an interleukin is always linked to its anatomical and cellular context,” specifies Korn. There are over thirty different interleukins. But that is not all – an interleukin’s effect will be quite differe ...
Slide_14
Slide_14

... Rare antigens in the thymus are also rare in 2º lympohoid organs, and usually insufficient to trigger an immune response. Some T cells will escape the tolerance, there could be a rare antigen, it leaves and gets out of he circulation. There are multiple cases we can use to get an autoimmune. In the ...
Measurement of the Innate Cellular Immune Responses of Hybrid
Measurement of the Innate Cellular Immune Responses of Hybrid

... surface of the pathogen to enhance ingestion by phagocytic cells, a process called opsonization. Lysozyme is a low molecular weight enzyme that breaks down the peptidoglycan layer of bacteria. Interferons are proteins produced by virus-infected cells that inhibit the replication of viral pathogens i ...
m5zn_6cef59fb9533e86
m5zn_6cef59fb9533e86

... MHC II found only on PM of B-cells, some T-cells & APCs  Display proteins derived from a phagocytized target  Exogenous antigen: foreign protein from outside the cell – presented to PM surface  Stimulates the CD4* cell population  form Helper T-cells (TH)  *formerly T4 cells ...
Characteristics of Bacteria Virulence
Characteristics of Bacteria Virulence

CLS 2215 Principles of Immunohematology
CLS 2215 Principles of Immunohematology

... is specific to an antigen present on the red blood cells of the fetus. • Fetal red cells become coated with the IgG alloantibody and undergo accelerated destruction both before and after birth. – Where does the baby get an antigen that is foreign to the Mom? ...
T cells
T cells

... • When a local response is not enough – system-wide response to infection – activated macrophages release interleukin-1 • triggers hypothalamus in brain to readjust body thermostat to raise body temperature ...
Lecture (5) Dr
Lecture (5) Dr

... infection. Second, the adaptive immune system is antigen specific and reacts only with the organism that induced the response. In contrast, the innate system is not antigen specific and reacts equally well to a variety of organisms. Finally, the adaptive immune system demonstrates immunological memo ...
ACQUIRED (SECONDARY) IMMUNODEFICIENCIES
ACQUIRED (SECONDARY) IMMUNODEFICIENCIES

... Pathogenesis of HIV Infection and AIDS  HIV disease begins with acute infection, which is only partly controlled by the adaptive immune response, and advances to chronic progressive infection of peripheral lymphoid tissues  Acute (early) infection is characterized by infection of memory CD4+ T c ...
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Phagocyte



Phagocytes are cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells. Their name comes from the Greek phagein, ""to eat"" or ""devour"", and ""-cyte"", the suffix in biology denoting ""cell"", from the Greek kutos, ""hollow vessel"". They are essential for fighting infections and for subsequent immunity. Phagocytes are important throughout the animal kingdom and are highly developed within vertebrates. One litre of human blood contains about six billion phagocytes. They were first discovered in 1882 by Ilya Ilyich Mechnikov while he was studying starfish larvae. Mechnikov was awarded the 1908 Nobel Prize in Physiology or Medicine for his discovery. Phagocytes occur in many species; some amoebae behave like macrophage phagocytes, which suggests that phagocytes appeared early in the evolution of life.Phagocytes of humans and other animals are called ""professional"" or ""non-professional"" depending on how effective they are at phagocytosis. The professional phagocytes include many types of white blood cells (such as neutrophils, monocytes, macrophages, mast cells, and dendritic cells). The main difference between professional and non-professional phagocytes is that the professional phagocytes have molecules called receptors on their surfaces that can detect harmful objects, such as bacteria, that are not normally found in the body. Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan.During an infection, chemical signals attract phagocytes to places where the pathogen has invaded the body. These chemicals may come from bacteria or from other phagocytes already present. The phagocytes move by a method called chemotaxis. When phagocytes come into contact with bacteria, the receptors on the phagocyte's surface will bind to them. This binding will lead to the engulfing of the bacteria by the phagocyte. Some phagocytes kill the ingested pathogen with oxidants and nitric oxide. After phagocytosis, macrophages and dendritic cells can also participate in antigen presentation, a process in which a phagocyte moves parts of the ingested material back to its surface. This material is then displayed to other cells of the immune system. Some phagocytes then travel to the body's lymph nodes and display the material to white blood cells called lymphocytes. This process is important in building immunity, and many pathogens have evolved methods to evade attacks by phagocytes.
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