Supplementary Table 1
... (GM065997) to R.J.D. Supplementary Discussion for Table S2 Based on our findings with Gcn4, we propose a class of regulatory factors whose activity is required in a reaction, but whose subsequent turnover or removal promotes completion of the reaction or subsequent reaction cycles. Such ‘activation ...
... (GM065997) to R.J.D. Supplementary Discussion for Table S2 Based on our findings with Gcn4, we propose a class of regulatory factors whose activity is required in a reaction, but whose subsequent turnover or removal promotes completion of the reaction or subsequent reaction cycles. Such ‘activation ...
The enzymes of biotin dependent CO2 metabolism: What structures
... 2,25 and Bacillus thermodenitrificans pyruvate carboxylase26 all demonstrated conformations for the Bdomains somewhere between the closed and completely open forms. Recent molecular dynamics studies of E. coli biotin carboxylase suggest that the most stable position for the B-domain may not be in th ...
... 2,25 and Bacillus thermodenitrificans pyruvate carboxylase26 all demonstrated conformations for the Bdomains somewhere between the closed and completely open forms. Recent molecular dynamics studies of E. coli biotin carboxylase suggest that the most stable position for the B-domain may not be in th ...
Auxin: The Growth Hormone - Roberto Cezar | Fisiologista Vegetal
... plants have been derived from similar studies in animals. In animals the chemical messengers that mediate intercellular communication are called hormones. Hormones interact with specific cellular proteins called receptors. Most animal hormones are synthesized and secreted in one part of the body and ...
... plants have been derived from similar studies in animals. In animals the chemical messengers that mediate intercellular communication are called hormones. Hormones interact with specific cellular proteins called receptors. Most animal hormones are synthesized and secreted in one part of the body and ...
NIH Public Access
... stimulation [4] and NMDA receptor activation [25]. It was therefore predicted that the in situ neuronal mitochondria would reversibly accumulate Ca2+ in response to elevated [Ca2+]c [26]. Werth and Thayer [4] obtained evidence that mitochondria in cultured rat dorsal root ganglion neurons reversibly ...
... stimulation [4] and NMDA receptor activation [25]. It was therefore predicted that the in situ neuronal mitochondria would reversibly accumulate Ca2+ in response to elevated [Ca2+]c [26]. Werth and Thayer [4] obtained evidence that mitochondria in cultured rat dorsal root ganglion neurons reversibly ...
life cycle, cell wall and cell signal transduction
... 2002). The cell surface molecules that mediate this response have not been fully characterized. Major surface glycoprotein (MSG) expressed in the Pneumocystis cell wall has been shown to interact with fibronectin (Pottratz et al. 1991), but this is probably not the primary mechanism behind the cell ...
... 2002). The cell surface molecules that mediate this response have not been fully characterized. Major surface glycoprotein (MSG) expressed in the Pneumocystis cell wall has been shown to interact with fibronectin (Pottratz et al. 1991), but this is probably not the primary mechanism behind the cell ...
Myocyte Enhancer Factor 2 Transcription Factors in Heart
... alone could initiate skeletal myogenesis in a broad range of cell types in culture (Davis et al., 1987). MEF2 proteins were also identified during this time as essential regulators of skeletal muscle transcription, and as partners for MyoD and other myogenic bHLH proteins. In addition, it soon becam ...
... alone could initiate skeletal myogenesis in a broad range of cell types in culture (Davis et al., 1987). MEF2 proteins were also identified during this time as essential regulators of skeletal muscle transcription, and as partners for MyoD and other myogenic bHLH proteins. In addition, it soon becam ...
BAG1, a negative regulator of Hsp70 chaperone activity, uncouples
... was incubated with either Hsp70, or Hsp70 and BAG-1 in the presence or absence of ATP. In the absence of ATP, Hsp70 forms a stable complex with [125I]RCMLA, as detected in the native gel assay (Figure 2, lane 2), that rapidly dissociates upon addition of ATP (Figure 2, lanes 4–9). In striking contra ...
... was incubated with either Hsp70, or Hsp70 and BAG-1 in the presence or absence of ATP. In the absence of ATP, Hsp70 forms a stable complex with [125I]RCMLA, as detected in the native gel assay (Figure 2, lane 2), that rapidly dissociates upon addition of ATP (Figure 2, lanes 4–9). In striking contra ...
PATELLIN1/2 interact with CVL1 and CVP2 to regulate vascular
... distinguished into microdomains due to the levels of unsaturation in their fatty acid tails, adding an extra layer of specificity in PI-target binding (Heilmann, 2016a). These binding events can impact the localization and catalytic activity of proteins (Cullen et al., 2001; Itoh and Takenawa, 2002) ...
... distinguished into microdomains due to the levels of unsaturation in their fatty acid tails, adding an extra layer of specificity in PI-target binding (Heilmann, 2016a). These binding events can impact the localization and catalytic activity of proteins (Cullen et al., 2001; Itoh and Takenawa, 2002) ...
The Presynaptic Microtubule Cytoskeleton in Physiological and
... cytoskeleton in a highly regulated manner, where depolarization induces calcium-dependent phosphorylation of Synapsin by CaMKII in residues S566 and S603, which ultimately results in a dramatic decrease in Synapsin–actin interaction (Huttner and Greengard, 1979; Bähler et al., 1989; Cesca et al., 20 ...
... cytoskeleton in a highly regulated manner, where depolarization induces calcium-dependent phosphorylation of Synapsin by CaMKII in residues S566 and S603, which ultimately results in a dramatic decrease in Synapsin–actin interaction (Huttner and Greengard, 1979; Bähler et al., 1989; Cesca et al., 20 ...
Posttranslational Modification of MDM2
... presumably because its association with p53 cannot be weakened by ser17 phosphorylation. These data are in keeping with the notion that phosphorylation of ser17 regulates MDM2p53 association in a cellular context, but this has yet to be demonstrated. Similarly, it will be of considerable interest to ...
... presumably because its association with p53 cannot be weakened by ser17 phosphorylation. These data are in keeping with the notion that phosphorylation of ser17 regulates MDM2p53 association in a cellular context, but this has yet to be demonstrated. Similarly, it will be of considerable interest to ...
The role of homocysteine in endothelial dysfunction
... In the walls blood of vessels, NO contributes to the regulation of systemic blood flow and pressure by activating intracellular signaling pathways that modulate calcium levels in VSMC resulting in vasodilation. Homocysteine is known to decrease vascular function by the oxidative depletion of biologi ...
... In the walls blood of vessels, NO contributes to the regulation of systemic blood flow and pressure by activating intracellular signaling pathways that modulate calcium levels in VSMC resulting in vasodilation. Homocysteine is known to decrease vascular function by the oxidative depletion of biologi ...
Algal and cyanobacterial responses to fluoride
... effect and thus stimulates growth. 2. Single most important barrier to fluoride is the cell envelope (cell wall + cell membrane). Cellulosic cell wall of eukaryotic algae is much tougher than the gram-negative type cyanobacterial cell wall that offers more susceptible sites for direct F action. 3. T ...
... effect and thus stimulates growth. 2. Single most important barrier to fluoride is the cell envelope (cell wall + cell membrane). Cellulosic cell wall of eukaryotic algae is much tougher than the gram-negative type cyanobacterial cell wall that offers more susceptible sites for direct F action. 3. T ...
The PINK1 p.I368N mutation affects protein stability and ubiquitin
... Background: Mutations in PINK1 and PARKIN are the most common causes of recessive early-onset Parkinson’s disease (EOPD). Together, the mitochondrial ubiquitin (Ub) kinase PINK1 and the cytosolic E3 Ub ligase PARKIN direct a complex regulated, sequential mitochondrial quality control. Thereby, damag ...
... Background: Mutations in PINK1 and PARKIN are the most common causes of recessive early-onset Parkinson’s disease (EOPD). Together, the mitochondrial ubiquitin (Ub) kinase PINK1 and the cytosolic E3 Ub ligase PARKIN direct a complex regulated, sequential mitochondrial quality control. Thereby, damag ...
The cell biology of major histocompatibility complex class
... with MHC I molecules and facilitates peptide loading (30). Interaction of ERp57 with both tapasin and calreticulin may strengthen the individually weak interactions that exist between these chaperones and MHC I molecules. However, all might not be quite so simple: Zhang et al. showed that ERp57 requ ...
... with MHC I molecules and facilitates peptide loading (30). Interaction of ERp57 with both tapasin and calreticulin may strengthen the individually weak interactions that exist between these chaperones and MHC I molecules. However, all might not be quite so simple: Zhang et al. showed that ERp57 requ ...
Curriculum Vitae
... parahaemolyticus calR mutants Erin Voelschow: Developing the fruit fly as a model system for Vibrio parahaemolyticus pathogenesis Fall 2009 Aimee Villard: Determining divalent cation specificity of calciumregulated genes in Vibrio parahaemolyticus Heather Nelson: Investigating phenotypes of V. parah ...
... parahaemolyticus calR mutants Erin Voelschow: Developing the fruit fly as a model system for Vibrio parahaemolyticus pathogenesis Fall 2009 Aimee Villard: Determining divalent cation specificity of calciumregulated genes in Vibrio parahaemolyticus Heather Nelson: Investigating phenotypes of V. parah ...
npr review - Olivamine
... can be upregulated or downregulated depending upon the target. Included among these molecular targets are transcription factors, enzymes, inflammatory mediators, protein kinases, drug resistance proteins, cell-cycle regulatory proteins, adhesion molecules, growth factors, receptors, cell-survival pr ...
... can be upregulated or downregulated depending upon the target. Included among these molecular targets are transcription factors, enzymes, inflammatory mediators, protein kinases, drug resistance proteins, cell-cycle regulatory proteins, adhesion molecules, growth factors, receptors, cell-survival pr ...
Brain glycine receptors as a common target for alcohol and
... PREFACE ...........................................................................................................................10 ...
... PREFACE ...........................................................................................................................10 ...
Bacterial ribosome requires multiple L12 dimers for efficient initiation
... hinges were proposed to form the core dimer (12). However, this model failed to justify the strong dimer interaction in L12 dimer, had no functional relevance and was contradicted by an NMR structure where both the hinges were seen in fully extended form (9,11). Thus it is now universally accepted t ...
... hinges were proposed to form the core dimer (12). However, this model failed to justify the strong dimer interaction in L12 dimer, had no functional relevance and was contradicted by an NMR structure where both the hinges were seen in fully extended form (9,11). Thus it is now universally accepted t ...
Glutamine and the bowel
... For amino sugar synthesis ： 1. glutamine may be one factor in the maintenance of mucosal structure, especially the maintenance of tight junction. (Panigrahi et al. 1997) 2. a precursor for N-acetylglucosamine and N-acetylglactosamine synthesis, glutamine could play a critical role in intestinal muci ...
... For amino sugar synthesis ： 1. glutamine may be one factor in the maintenance of mucosal structure, especially the maintenance of tight junction. (Panigrahi et al. 1997) 2. a precursor for N-acetylglucosamine and N-acetylglactosamine synthesis, glutamine could play a critical role in intestinal muci ...
Cenp-A Presence in Drosophila - Institute of Molecular Life Sciences
... chromosomes. These information strings are precisely transmitted to daughter cells during mitotic and meiotic cell divisions, but only if the centromere, a specialized chromosomal region, is functional. The centromere region within chromosomes of many species—including humans and the fly Drosophila ...
... chromosomes. These information strings are precisely transmitted to daughter cells during mitotic and meiotic cell divisions, but only if the centromere, a specialized chromosomal region, is functional. The centromere region within chromosomes of many species—including humans and the fly Drosophila ...
two types of titin interactions lead to an asymmetrical sorting of actinin
... C-terminal domain of α-actinin therefore appears not to be the sole protein interaction that controls the sarcomeric sorting of the molecule. Rather, a second Z-disk-specific binding site could be predicted from these observations, which should be important for the correct assembly of the Z-disk. In ...
... C-terminal domain of α-actinin therefore appears not to be the sole protein interaction that controls the sarcomeric sorting of the molecule. Rather, a second Z-disk-specific binding site could be predicted from these observations, which should be important for the correct assembly of the Z-disk. In ...
Control of Leaf and Vein Development by Auxin
... (C ) In primary morphogenesis, leaves grow predominantly via cell division to acquire their shape and vascular pattern. Auxin activity maxima at the margins of the leaf correlate with sites of lateral vein (orange, LV) formation and positions of serration development. Marginal veins (yellow, MV) eme ...
... (C ) In primary morphogenesis, leaves grow predominantly via cell division to acquire their shape and vascular pattern. Auxin activity maxima at the margins of the leaf correlate with sites of lateral vein (orange, LV) formation and positions of serration development. Marginal veins (yellow, MV) eme ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.