A Novel Nuclear Pore Protein Nup82p Which
... Richardson et al., 1988). Concerning active nuclear import of proteins, which is NLS mediated and energy dependent, it was suggested that the central plug could serve as a transporter (Akey, 1992), whereas the channels between the spokes (Hinshaw et al., 1992) or between the transporter and the spok ...
... Richardson et al., 1988). Concerning active nuclear import of proteins, which is NLS mediated and energy dependent, it was suggested that the central plug could serve as a transporter (Akey, 1992), whereas the channels between the spokes (Hinshaw et al., 1992) or between the transporter and the spok ...
Ex vivo processing for maturation of Arabidopsis
... and gene families for all proteases are known. Arabidopsis encodes three KDEL CysEPs with homology to the RcCysEP, designated AtCEP1 (At5g50260), AtCEP2 (At3g48340) and AtCEP3 (At3g48350) that are expressed in tissues undergoing PCD. Determination of promoter activities using ß-glucuronidase as repo ...
... and gene families for all proteases are known. Arabidopsis encodes three KDEL CysEPs with homology to the RcCysEP, designated AtCEP1 (At5g50260), AtCEP2 (At3g48340) and AtCEP3 (At3g48350) that are expressed in tissues undergoing PCD. Determination of promoter activities using ß-glucuronidase as repo ...
Lineage Commitment During T cell Development
... The pre-Ta/b chain dimer promotes increased CD3 expression and induces a ligandindependent signal, perhaps because of constitutive localization to lipid rafts or constitutive dimerization (unusual preTalpha structure), that is responsible for maturation and probably shut off RAG expression and furth ...
... The pre-Ta/b chain dimer promotes increased CD3 expression and induces a ligandindependent signal, perhaps because of constitutive localization to lipid rafts or constitutive dimerization (unusual preTalpha structure), that is responsible for maturation and probably shut off RAG expression and furth ...
Chapter 3 PDF
... The variety of cell types found in living things is staggering. Your body alone is made of trillions of cells of many different shapes, sizes, and functions. They include long, thin nerve cells that transmit sensory information, as well as short, blocky skin cells that cover and protect the body. De ...
... The variety of cell types found in living things is staggering. Your body alone is made of trillions of cells of many different shapes, sizes, and functions. They include long, thin nerve cells that transmit sensory information, as well as short, blocky skin cells that cover and protect the body. De ...
Chapter 3 PDF
... The variety of cell types found in living things is staggering. Your body alone is made of trillions of cells of many different shapes, sizes, and functions. They include long, thin nerve cells that transmit sensory information, as well as short, blocky skin cells that cover and protect the body. De ...
... The variety of cell types found in living things is staggering. Your body alone is made of trillions of cells of many different shapes, sizes, and functions. They include long, thin nerve cells that transmit sensory information, as well as short, blocky skin cells that cover and protect the body. De ...
Imaging cytoskeletal filament organization at the molecular scale
... microtubules for successful cell division is not questioned, their precise organization and interaction with other proteins is still poorly understood. In particular, little is known about the functional contribution of septins, a family of proteins which was recently recognized as a novel component ...
... microtubules for successful cell division is not questioned, their precise organization and interaction with other proteins is still poorly understood. In particular, little is known about the functional contribution of septins, a family of proteins which was recently recognized as a novel component ...
medline:93194904
... The CD20(B1) encodes a B cell-specific protein involved in the regulation of human B cell proliferation and differentiation. Studies with 5' deletion CD20 promoter-CAT constructs have previously revealed two regions of the promoter between bases -186 and -280 and between bases -280 and -454 which co ...
... The CD20(B1) encodes a B cell-specific protein involved in the regulation of human B cell proliferation and differentiation. Studies with 5' deletion CD20 promoter-CAT constructs have previously revealed two regions of the promoter between bases -186 and -280 and between bases -280 and -454 which co ...
TMEM65 is a mitochondrial inner-membrane protein
... commonly observed in Leigh syndrome patients (Schapira, 2006; Huntsman et al., 2005). Mitochondrial disorder enhances anaerobic energy production, thus increasing the concentration of lactic acid in the blood and leading to acidosis. Elevated blood lactic acid concentration is seen also in French–Ca ...
... commonly observed in Leigh syndrome patients (Schapira, 2006; Huntsman et al., 2005). Mitochondrial disorder enhances anaerobic energy production, thus increasing the concentration of lactic acid in the blood and leading to acidosis. Elevated blood lactic acid concentration is seen also in French–Ca ...
The connection of cytoskeletal network with plasma membrane and
... between the integrins and the extracellular matrix is based on an Arg-Gly-Asp (RGD) motif (Ruoslahti and Pierschbacher 1987). In plants, no obvious integrin homologs exist and the cytoskeleton and cell wall continuum is also less clear. However, plant cells can respond to RGD peptides (Schindler et ...
... between the integrins and the extracellular matrix is based on an Arg-Gly-Asp (RGD) motif (Ruoslahti and Pierschbacher 1987). In plants, no obvious integrin homologs exist and the cytoskeleton and cell wall continuum is also less clear. However, plant cells can respond to RGD peptides (Schindler et ...
View Full Page PDF
... 51). These proteins are not adhesins, but the loss of one of them is associated with the inability of M. pneumoniae to cytadhere, whereas its regain results in reversion to a cytadherence-positive phenotype (81). P40 and P90 were found to be surface proteins localized mainly at the tip organelle (Fi ...
... 51). These proteins are not adhesins, but the loss of one of them is associated with the inability of M. pneumoniae to cytadhere, whereas its regain results in reversion to a cytadherence-positive phenotype (81). P40 and P90 were found to be surface proteins localized mainly at the tip organelle (Fi ...
Supplementary Information (doc 1532K)
... Locomotor activity testing was performed on 3 consecutive days to allow for habituation to handling and injection (Day 1), collection of baseline activity data (Day 2) and collection of data after drug treatment (Day 3). RO 04-5595 HCl (Abcam) and (+)MA HCl (Sigma) were dissolved in sterile physiol ...
... Locomotor activity testing was performed on 3 consecutive days to allow for habituation to handling and injection (Day 1), collection of baseline activity data (Day 2) and collection of data after drug treatment (Day 3). RO 04-5595 HCl (Abcam) and (+)MA HCl (Sigma) were dissolved in sterile physiol ...
lecture i - Tripod.com
... - are either reversible or dissociable – or else you lose temporal specificity/resolution - TOXINS are not reversible – thus they decrease the number of active receptors Two types of receptors - ligand-gated ion channel – direct effect; rapid activation, not affected by voltage changes, but will aff ...
... - are either reversible or dissociable – or else you lose temporal specificity/resolution - TOXINS are not reversible – thus they decrease the number of active receptors Two types of receptors - ligand-gated ion channel – direct effect; rapid activation, not affected by voltage changes, but will aff ...
From Membrane to Cytoskeleton: Minireview
... extensive morphological changes necessary to establish functional connections. Extracellular cues function through surface receptors to control signaling pathways whose interplay results in the remodeling of the cytoskeleton and thereby changes in cell shape and motility. Past research has identifie ...
... extensive morphological changes necessary to establish functional connections. Extracellular cues function through surface receptors to control signaling pathways whose interplay results in the remodeling of the cytoskeleton and thereby changes in cell shape and motility. Past research has identifie ...
The role of Pex3p in early events of peroxisome biogenesis in
... In order to enable microscopical and biochemical distinction of ER-type membranes from other subcellular compartments, we fused the N-terminal 30 amino acids from the S. cerevisiae ER-located Hsp70 protein BiP to GFP. We showed before that this portion of BiP is sufficient to sort reporter proteins ...
... In order to enable microscopical and biochemical distinction of ER-type membranes from other subcellular compartments, we fused the N-terminal 30 amino acids from the S. cerevisiae ER-located Hsp70 protein BiP to GFP. We showed before that this portion of BiP is sufficient to sort reporter proteins ...
ch 3/4 ppt
... denaturation of a protein, in which it unravels and loses its shape. • High fevers (above 104º F) in humans can cause some proteins to denature. • Misfolded proteins are associated with – Alzheimer’s disease – Mad cow disease – Parkinson’s disease ...
... denaturation of a protein, in which it unravels and loses its shape. • High fevers (above 104º F) in humans can cause some proteins to denature. • Misfolded proteins are associated with – Alzheimer’s disease – Mad cow disease – Parkinson’s disease ...
Phosphoproteomics reveals extensive in vivo phosphorylation of
... mainly through RNA recognition motif (RRM) domains, sometimes with contributions of the RS domains. Protein interactions occur mainly through the RS domain and are regulated by phosphorylation. Phosphorylated SR proteins are recruited from sites of nuclear storage in speckles and are thought to stim ...
... mainly through RNA recognition motif (RRM) domains, sometimes with contributions of the RS domains. Protein interactions occur mainly through the RS domain and are regulated by phosphorylation. Phosphorylated SR proteins are recruited from sites of nuclear storage in speckles and are thought to stim ...
Lipid transfer and metabolism across the endolysosomal
... Lysosomes (vacuoles in yeast) represent the most important catabolic compartment of eukaryotic cells, containing a wide set of acidic hydrolases able to digest not only macromolecules (such as proteins, lipids, sugars, nucleic acids), but also entire organelles and pathogenic organisms [14,15]. A co ...
... Lysosomes (vacuoles in yeast) represent the most important catabolic compartment of eukaryotic cells, containing a wide set of acidic hydrolases able to digest not only macromolecules (such as proteins, lipids, sugars, nucleic acids), but also entire organelles and pathogenic organisms [14,15]. A co ...
The Neuromuscular Junction
... chemically regulated ion channel (purple). Note that as the acetylcholine falls off the receptor, the ion channel on the receptor closes, preventing further flow of sodium and potassium ions. 2. The acetylcholine binds to the enzyme acetylcholinesterase (aqua-colored). 3. The acetylcholinesterase br ...
... chemically regulated ion channel (purple). Note that as the acetylcholine falls off the receptor, the ion channel on the receptor closes, preventing further flow of sodium and potassium ions. 2. The acetylcholine binds to the enzyme acetylcholinesterase (aqua-colored). 3. The acetylcholinesterase br ...
Theranostics Using C-Arm X-Ray Imaging to Guide Local Reporter
... semi-permeable membrane to protect cells from immune rejection by blocking antibodies yet permitting the diffusion of nutrients, cytokines, and waste products. Recently, it has been demonstrated that the addition of a contrast agent to this biocompatible coating may enable cell tracking by MR, ultra ...
... semi-permeable membrane to protect cells from immune rejection by blocking antibodies yet permitting the diffusion of nutrients, cytokines, and waste products. Recently, it has been demonstrated that the addition of a contrast agent to this biocompatible coating may enable cell tracking by MR, ultra ...
Gene Section BTK (Bruton agammaglobulinemia tyrosine kinase) Atlas of Genetics and Cytogenetics
... Mutations in BTK gene that cause XLA The BTK mutations that have been identified in XLA patients compromise BTK function either through gross structural changes (such as deletions or altered protein folding) or through specific loss of functionally relevant residues. Strikingly, none of the found un ...
... Mutations in BTK gene that cause XLA The BTK mutations that have been identified in XLA patients compromise BTK function either through gross structural changes (such as deletions or altered protein folding) or through specific loss of functionally relevant residues. Strikingly, none of the found un ...
Journal of Medical Microbiology
... A pool of heparan sulphate-binding proteins (HSBPs) from Helicobacter pylori culture supernates was obtained by sequential ammonium sulphate precipitation and af®nity chromatography on heparin-Sepharose. The chromatographic procedure yielded one major fraction that contained proteins with heparan su ...
... A pool of heparan sulphate-binding proteins (HSBPs) from Helicobacter pylori culture supernates was obtained by sequential ammonium sulphate precipitation and af®nity chromatography on heparin-Sepharose. The chromatographic procedure yielded one major fraction that contained proteins with heparan su ...
Regional Specialization of the Membrane of Retinal Glial Cells and
... cell membrane (arrows) following a [K+l0increase in the inner plexiform layer. In this situation, the local [K+l0increase is attenuated, but only at the expense of raising [K’],, in other retinal layers. Because K+ conductance is principally localized in the endfoot process of Miiller cells, the act ...
... cell membrane (arrows) following a [K+l0increase in the inner plexiform layer. In this situation, the local [K+l0increase is attenuated, but only at the expense of raising [K’],, in other retinal layers. Because K+ conductance is principally localized in the endfoot process of Miiller cells, the act ...
ESCV 2014 - Chromis Therapeutics
... Compound cytotoxicity was determined in parallel, using cells in same 96-well plates. The antiviral activity and cytotoxicity of the identified hits was further evaluated at multiple concentrations, and the EC50 and CC50 values were determined. As a result, at least five distinct chemistry series of ...
... Compound cytotoxicity was determined in parallel, using cells in same 96-well plates. The antiviral activity and cytotoxicity of the identified hits was further evaluated at multiple concentrations, and the EC50 and CC50 values were determined. As a result, at least five distinct chemistry series of ...
Regulation of translation initiation following stress
... (reviewed by Hinnebusch, 1994). GCN2 is activated in response to nutrient deprivation, a condition that causes the accumulation of uncharged-tRNAs (reviewed by Hinnebusch, 1994). It has been reported that phosphorylation of eIF2 (Ser51 of a subunit) inhibits eIF2B such that eIF2B can no longer catal ...
... (reviewed by Hinnebusch, 1994). GCN2 is activated in response to nutrient deprivation, a condition that causes the accumulation of uncharged-tRNAs (reviewed by Hinnebusch, 1994). It has been reported that phosphorylation of eIF2 (Ser51 of a subunit) inhibits eIF2B such that eIF2B can no longer catal ...
Tracheary Element Differentiation Uses a Novel Mechanism
... to identify and distinguish central morphological or molecular PCD events from confounding concurrent developmental events, and no basal PCD machinery has yet been identified in plants analogous to the well-defined caspase pathway for apoptosis in animals (Cohen, 1997). Although the evolutionary rel ...
... to identify and distinguish central morphological or molecular PCD events from confounding concurrent developmental events, and no basal PCD machinery has yet been identified in plants analogous to the well-defined caspase pathway for apoptosis in animals (Cohen, 1997). Although the evolutionary rel ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.