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composition changes with age of plaque
composition changes with age of plaque

... Conversion of lactic acid into less ionized acetic and propionic acids The pH rise factor in saliva (sialin) which is a basic peptide containing Arg. It accelerate glucose uptake by salivary organisms, increase acid production & the formation of CO2 & base. The effect is obvious at low sugar conc. A ...
``Biology of Cultured Cells``. In: Culture of Animal Cells, 5th Edition
``Biology of Cultured Cells``. In: Culture of Animal Cells, 5th Edition

... and collagen, which bind to them via a specific motif usually containing the arginine–glycine–aspartic acid (RGD) sequence [Yamada & Geiger, 1997]. Each integrin comprises one α and one β subunit, the extracellular domains of which are highly polymorphic, thus generating considerable diversity among ...
Red blood cells: proteomics, physiology and metabolism
Red blood cells: proteomics, physiology and metabolism

... further information regarding the proteins from which peptides were derived. e.g. molecular weight (MW) in the case of SDS-PAGE, or location when using membrane specific regimes. For SDS/PAGE fractionation, gels are typically sliced at known MW boundaries prior to in-gel proteolytic digestion and su ...
Thulashie Sivarajah
Thulashie Sivarajah

... other words, the objective of this research is to make effective inhibitors for kinase (Src) in order to prevent from cancers since mutagents in kinase or elevated level of kinase activity leads to cancers. Bivalent inhibitor is a peptide- based inhibitor, which is designed to simultaneously bind to ...
Inactivation of S-adenosylhomocysteine hydrolase intact cells
Inactivation of S-adenosylhomocysteine hydrolase intact cells

... pronounced in the hepatocytes (frcrn 50 to 3500 prol/l0 cells after 3 hours of exposure to ara-A). The cellular content of AdoMet increases slightly in liver cells, but remains lDlchanged in the cultured cells. Accumulation of intracellular MoHey leads to a marked egress of AdoHcy from the cells. Af ...
Synaptic Transmission 1
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... • For most CNS synapses at physiological [Ca2+]o, the binomial distribution, not the poisson one, should be used to analyze transmitter release. • To predict the distribution of outcomes using the binomial, we need to know more than simply m, alas. ...
SUMO Pathway Modulation of Regulatory Protein Binding
SUMO Pathway Modulation of Regulatory Protein Binding

... the cellular hub for the initial stages of ribosome assembly (Strunnikov et al. 2001; D’Amours et al. 2004; Panse et al. 2006; Takahashi et al. 2008; Srikumar et al. 2013b). To maintain robust ribosome production, cells have numerous ribosomal DNA (rDNA) copies, even though repeated DNA is prone to ...
Humic matter elicits proton and calcium fluxes and signaling
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... Protein kinases have also paramount importance in cell signal transduction [19,20]. They are responsible for the post-translational control of target proteins and act as critical regulators of various signaling cascades [19]. Furthermore, many plant receptors are endowed with protein kinase activity ...
Metabolic flux rewiring in mammalian cell cultures
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... of carbon, nitrogen, energy (ATP), and reductant (NADPH) to sustain their anabolic functions. Most CCLs, such as those used in industrial bioprocesses, rely heavily upon aerobic glycolysis to supply the energetic demands of cell growth, which involves rapid conversion of glucose to lactate even in t ...
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Nuclear pore interactions with the genome

... organization of the yeast nucleus. It is still unclear precisely how DNA zip codes promote interaction with the NPC. The transcription factor Put3 binds to the GRS I zip code in vivo and is required for its ability to target loci to the nuclear periphery [10] (Figure 1). Loss of Put3 blocks target ...
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In Silico Identification, Classification And Expression
In Silico Identification, Classification And Expression

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... entry according to a mechanism that appears to be conserved in its key elements in all higher eukaryotes. D-type cyclins are stimulated by mitogenic growth signals and, in common with all cyclins, form a kinase complex with a CDK subunit. A key phosphorylation target of D-cyclin kinases appears to b ...
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... 1. What are the components of the receptor complex? What is the ligand? The receptor complex is composed of LRP and Fzd. The ligand for Fzd is Wnt. 2. What is the molecular function of β-catenin itself? Apart from its role in adherens junctions, β-catenin is a transcriptional coactivator. β-catenin ...
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... Cytokine IFNγ and proliferation assays were conducted on 11 of these analogues with two analogues (4 & 5) showing comparable toxicity to ABC ...
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... Levels of Organization Lesson Essential Question(s): How do different types of cells develop from a single stem cell? How are cells organized to carry out the specialized functions of an organism? What are the five levels of organization of the human body? Vocabulary: Determination, Differentiation, ...
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... changed or packaged for storage. The Golgi apparatus does this. The golgi apparatus looks like a bunch of zip lock bags stacked on top of each other. Its kind of like the gift wrap department in Macy’s or J.C. Penny. You give the gift wrapper your present and they give it back nicely wrapped. The Go ...
Dynamic Localization of the DNA Replication
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... 2004). In addition, CDT1 and the MCM complex are actively exported from the nucleus during S phase, which prevents their association with replicated DNA (Tanaka and Diffley, 2002; Liku et al., 2005). After mitosis is complete, MCM is imported gradually back into the nucleus and reloaded onto the DNA ...
Acid – base balance - Masaryk University
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... All the known low molecular weight and water soluble biosynthetic intermediates possess groups that are essentially completely ionised at neutral pH’  pH-dependent ionisation (i.e. charge) serves to an efficient intracellular trapping of ionised compounds within the cell and its organelles ...
The Senses
The Senses

... is the most sensitive part of the eye. has many cones packed very close together. when you look at an object most of light falls here. is surrounded by rods (often you can see things in your peripheral vision without being able to identify its colour.) ...
Basic course, CDFD: Molecules of Life, 23-Aug-2007
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... Basic course, CDFD: Molecules of Life, 23-Aug-2007 ...
Proteinstruktur und
Proteinstruktur und

... since most signaling pathways are propagated via phosphorylation/ dephosphorylation • Acetylation (N-termini and Lys +42), often combined with removal of protein initial Met • Hydroxyprolination (Pro +16) stabilizes extra-cellular matrix on collagens • Ubiquitination (Lys +114) marks proteins for de ...
Genomic Tagging of the Anaphase-Promoting Complex Activator
Genomic Tagging of the Anaphase-Promoting Complex Activator

... protein whose main enzymatic activity is ubiquitylation of other proteins. Ubiquitylation is a process of covalent attachment of small, 76-amino acid, 8.5 kDa protein moieties called ubiquitin onto specific lysine residues of the target protein (17). Addition of only a couple of ubiquitin molecules ...
Characterization of the pH of Folate Receptor
Characterization of the pH of Folate Receptor

... equimolar quantities of folate-FITC (a pH-sensitive dye conjugate) and folate-rhodamine (a pH-insensitive dye conjugate) and then measured endosomal pH by quantitating the ratio of green (fluorescein) to red (rhodamine) fluorescence in each endocytic vesicle. By comparing this ratio to the same rati ...
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Signal transduction



Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.
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