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CONCLUSIONS  133
CONCLUSIONS 133

... In addition to homodimerization, A2AR and dopamine D2 receptors (D2R) are able to form heterodimers. This heteromerization has been demonstrated in SH-SY5Y neuroblastoma cells stably transfected with the D2R. Stimulation of A2AR and/or D2R induces co-agregation and co-internalization of both recepto ...
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Signal transduction



Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.
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