Lecture 24 - biologyofcancer.org
... They can target the pathways tumor cells use to curcumvent normal growth regulation and may inhibit signals that protect tumor cells from radiation damage thus acting as radiosensitizers. Therefore, an increased tumor cell response to radiation might be observed, despite of the lack of direct cytoto ...
... They can target the pathways tumor cells use to curcumvent normal growth regulation and may inhibit signals that protect tumor cells from radiation damage thus acting as radiosensitizers. Therefore, an increased tumor cell response to radiation might be observed, despite of the lack of direct cytoto ...
Red blood cell microrheological changes and drug transport efficiency
... 4. Conclusion: some probable molecular targets in RBCs for drug microrheological effect 4.1. Role of Ca2+ in red blood cell microrheology alteration The measurement of the total red cell calcium concentration has yielded values between 5 and 50 nM [22], while only a few percent of total red cell Ca2 ...
... 4. Conclusion: some probable molecular targets in RBCs for drug microrheological effect 4.1. Role of Ca2+ in red blood cell microrheology alteration The measurement of the total red cell calcium concentration has yielded values between 5 and 50 nM [22], while only a few percent of total red cell Ca2 ...
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... A variety of approaches have been implemented for the discovery of medicinal compounds, including the isolation of naturally occurring bioactive substances and the design and synthesis of new molecules with biological activity. Many compounds have been identified by these means, but the lack of sele ...
... A variety of approaches have been implemented for the discovery of medicinal compounds, including the isolation of naturally occurring bioactive substances and the design and synthesis of new molecules with biological activity. Many compounds have been identified by these means, but the lack of sele ...
Mesoderm induction in Xenopus laevis:responding
... related TGF-/J2 does induce muscle from isolated Xenopus animal pole regions (Rosa et al. 1988a). If, as suggested above, mesoderm is formed after culture of disaggregated blastomeres in a heap because their close proximity allows them to pass MIFs to each other, we should expect that culture of dis ...
... related TGF-/J2 does induce muscle from isolated Xenopus animal pole regions (Rosa et al. 1988a). If, as suggested above, mesoderm is formed after culture of disaggregated blastomeres in a heap because their close proximity allows them to pass MIFs to each other, we should expect that culture of dis ...
HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion
... cause any significant change in the in vitro phosphorylation by CK1δ (Fig. S2A). Taken together, our analysis identified residues Ser383 and Thr528 as the predominant CK1δ in vitro phosphorylation sites of human HIF-2α. The fact that these sites are also subjected to modification by the kinases pres ...
... cause any significant change in the in vitro phosphorylation by CK1δ (Fig. S2A). Taken together, our analysis identified residues Ser383 and Thr528 as the predominant CK1δ in vitro phosphorylation sites of human HIF-2α. The fact that these sites are also subjected to modification by the kinases pres ...
Spectroscopy and atomic force microscopy of biomass
... electron microscopy have been very important in analyzing lignocellulosic materials [13]. Indeed the conditions of operation of this type of techniques have long caused major drawbacks to their application in biology since they require the samples to be conductive, and the electron beam often damage ...
... electron microscopy have been very important in analyzing lignocellulosic materials [13]. Indeed the conditions of operation of this type of techniques have long caused major drawbacks to their application in biology since they require the samples to be conductive, and the electron beam often damage ...
GMS 6062 Pro Traf 02
... Pelham, H. R. 2001. Traffic through the Golgi apparatus, J Cell Biol 155, 1099-101. Paper: Martinez-Menarguez, J. A., Prekeris, R., Oorschot, V. M., Scheller, R., Slot, J. W., Geuze, H. J., and Klumperman, J. 2001. Peri-Golgi vesicles contain retrograde but not anterograde proteins consistent with t ...
... Pelham, H. R. 2001. Traffic through the Golgi apparatus, J Cell Biol 155, 1099-101. Paper: Martinez-Menarguez, J. A., Prekeris, R., Oorschot, V. M., Scheller, R., Slot, J. W., Geuze, H. J., and Klumperman, J. 2001. Peri-Golgi vesicles contain retrograde but not anterograde proteins consistent with t ...
MitoToxTM Mitochondrial toxicity application guide
... JC1 - mitochondrial membrane potential assay Kit The JC1 (ab113850) assay may be used to screen depolarization of mitochondria in cell lines. Depending on the microplate setup (see figure 2) either 3 or 4 compounds may be tested in triplicate dose response per plate. The kit uses tetraethylbenzimid ...
... JC1 - mitochondrial membrane potential assay Kit The JC1 (ab113850) assay may be used to screen depolarization of mitochondria in cell lines. Depending on the microplate setup (see figure 2) either 3 or 4 compounds may be tested in triplicate dose response per plate. The kit uses tetraethylbenzimid ...
Inhibition of active nuclear transport is an intrinsic trigger of
... vectors, which, after transfection into L. major cells, are maintained episomally and yield a constitutive expression of the recombinant protein; each protein was fused to the green fluorescent protein (GFP), either at the N- or the C-terminal end. The protein, LmjRan, was, in addition, expressed fu ...
... vectors, which, after transfection into L. major cells, are maintained episomally and yield a constitutive expression of the recombinant protein; each protein was fused to the green fluorescent protein (GFP), either at the N- or the C-terminal end. The protein, LmjRan, was, in addition, expressed fu ...
Mitosis and Polyploid Cell Formation
... for the genetic fidelity of the daughter cells. The first, DNA replica tion, correctly duplicates the genetic material and the second, mitosis, ensures that each daughter cell receives a complete set of chromo somes. These two phases are tightly coordinated such that the initia tion of one is depend ...
... for the genetic fidelity of the daughter cells. The first, DNA replica tion, correctly duplicates the genetic material and the second, mitosis, ensures that each daughter cell receives a complete set of chromo somes. These two phases are tightly coordinated such that the initia tion of one is depend ...
The A6B4 Integrin Can Regulate ErbB-3 Expression: Implications for
... Specifically, these studies identified key roles for a6h4 in the migration, invasion, and survival of carcinoma cells (7–9). Studies by several other laboratories have substantiated and extended these findings (10). In fact, there is now compelling evidence that a6h4 may actually be involved in the ...
... Specifically, these studies identified key roles for a6h4 in the migration, invasion, and survival of carcinoma cells (7–9). Studies by several other laboratories have substantiated and extended these findings (10). In fact, there is now compelling evidence that a6h4 may actually be involved in the ...
Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter
... Finally, studies in which zonal migration was disrupted failed to show alterations in cell division, GC size, or development of high-affinity anti-NP antibodies (Allen et al., 2004; Nie et al., 2004). Together with the initial short-term imaging studies, these physiologic experiments called into que ...
... Finally, studies in which zonal migration was disrupted failed to show alterations in cell division, GC size, or development of high-affinity anti-NP antibodies (Allen et al., 2004; Nie et al., 2004). Together with the initial short-term imaging studies, these physiologic experiments called into que ...
Transport Proteins
... and change shape to ________________________ the membrane – A transport protein ____________________________________ – Both channel and carrier proteins ___________________________ at which substances can pass through cell membranes. Concept 7.3: Passive transport is diffusion of a substance acros ...
... and change shape to ________________________ the membrane – A transport protein ____________________________________ – Both channel and carrier proteins ___________________________ at which substances can pass through cell membranes. Concept 7.3: Passive transport is diffusion of a substance acros ...
The Cell Cycle Notes from Pearson
... mitotic spindle. Are these regulatory proteins internal regulators or external regulators? ...
... mitotic spindle. Are these regulatory proteins internal regulators or external regulators? ...
NOBEL LECTURE: Yeast and Cancer
... variation in disease susceptibility. In the first two instances, yeast has told us something that is relevant to mankind. For the other two, it is too soon to tell. When I was finishing my graduate studies and thinking about what area of science to pick for my postdoctoral work, I wanted to study a ...
... variation in disease susceptibility. In the first two instances, yeast has told us something that is relevant to mankind. For the other two, it is too soon to tell. When I was finishing my graduate studies and thinking about what area of science to pick for my postdoctoral work, I wanted to study a ...
Comparative Study of Limbal Stem Cell Deficiency Diagnosis Methods
... MUC5AC, MUC5B, MUC6, and MUC19) molecules.6 –13 Goblet cells are intercalated between non-secretory epithelial cells in the conjunctival epithelium. Their function is to synthesize and secrete the gel-forming MUC5AC mucin into the tear film.13 Thus, the MUC5AC mucin that is only found in these cells ...
... MUC5AC, MUC5B, MUC6, and MUC19) molecules.6 –13 Goblet cells are intercalated between non-secretory epithelial cells in the conjunctival epithelium. Their function is to synthesize and secrete the gel-forming MUC5AC mucin into the tear film.13 Thus, the MUC5AC mucin that is only found in these cells ...
Plant Cells Contain Two Functionally Distinct
... barley lectin and sporamin colocalized in the same vacuole (Schroeder et al., 1993), and Matsuoka et al. (1995) suggested that the two biochemically defined pathways directed proteins to the same vacuolar compartment. However, an alternative hypothesis, consistent with identification of separate ale ...
... barley lectin and sporamin colocalized in the same vacuole (Schroeder et al., 1993), and Matsuoka et al. (1995) suggested that the two biochemically defined pathways directed proteins to the same vacuolar compartment. However, an alternative hypothesis, consistent with identification of separate ale ...
Full Text
... cryoembedded in Lowicryl K4M for immunogold labelling (Testillano et al., 1995a) Results showed that most of the cells which responded to the stress treatment were vacuolate microspores (Fig. 1a) indicating that this developmental stage is responsive for embryogenesis induction in barley. Vacuolate ...
... cryoembedded in Lowicryl K4M for immunogold labelling (Testillano et al., 1995a) Results showed that most of the cells which responded to the stress treatment were vacuolate microspores (Fig. 1a) indicating that this developmental stage is responsive for embryogenesis induction in barley. Vacuolate ...
Origin and shaping of the laterality organ in zebrafish - MPI
... these remarkably detailed studies, crucial questions remain concerning the cellular and molecular mechanisms that lead to DFC formation and the subsequent transformation of this cell group into a functional organ. In this study, we demonstrate that DFCs are formed by ingression of surface epithelial ...
... these remarkably detailed studies, crucial questions remain concerning the cellular and molecular mechanisms that lead to DFC formation and the subsequent transformation of this cell group into a functional organ. In this study, we demonstrate that DFCs are formed by ingression of surface epithelial ...
Why are cells so small
... 1. For this lab you and your team will compete against the other teams in class to see who can design the most efficiently sized cell. Your goal will be to have a cell that maximizes volume and mass while, at the same time, minimizing the amount of time it takes a liquid to diffuse throughout the c ...
... 1. For this lab you and your team will compete against the other teams in class to see who can design the most efficiently sized cell. Your goal will be to have a cell that maximizes volume and mass while, at the same time, minimizing the amount of time it takes a liquid to diffuse throughout the c ...
A fibroblast is a type of cell that synthesizes the extracellular matrix
... A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen (and fibrin), the structural framework (stroma) for animal tissues, and play a critical role in wound healing. They are the most common cells of connective tissue in animals. Fibroblasts and fibrocytes are two stat ...
... A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen (and fibrin), the structural framework (stroma) for animal tissues, and play a critical role in wound healing. They are the most common cells of connective tissue in animals. Fibroblasts and fibrocytes are two stat ...
CHAPTER 9 IMMUNOGLOBULIN BIOSYNTHESIS
... 4) Secretory IgA now has conventional S-piece (one portion of the Sp) covalently linked to its H-chain; the rest of the Sp molecule remains in the epithelial cell membrane (as Sf, or S-fragment) where it is internalized and degraded. 5) Only polymeric IgA (and to a slight extent IgM) is transported ...
... 4) Secretory IgA now has conventional S-piece (one portion of the Sp) covalently linked to its H-chain; the rest of the Sp molecule remains in the epithelial cell membrane (as Sf, or S-fragment) where it is internalized and degraded. 5) Only polymeric IgA (and to a slight extent IgM) is transported ...
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... with M-derived circular muscle fibers and with O- and Qderived progeny raised the possibility that cells from M, O and/or Q lineages may be required for fissure formation, and for the subsequent separation of ganglionic primordia. It has previously been shown that ganglia still form in Helobdella em ...
... with M-derived circular muscle fibers and with O- and Qderived progeny raised the possibility that cells from M, O and/or Q lineages may be required for fissure formation, and for the subsequent separation of ganglionic primordia. It has previously been shown that ganglia still form in Helobdella em ...
Endothelial Cell Changes as an Indicator for Upcoming Allograft
... Before their rejection episodes, eyes that later developed an allograft rejection showed a large and statistically significant difference in subjective scoring , endothelial cell density ,and hexagonality, compared to control eyes. This indicates that despite the absence of clinical signs of rejecti ...
... Before their rejection episodes, eyes that later developed an allograft rejection showed a large and statistically significant difference in subjective scoring , endothelial cell density ,and hexagonality, compared to control eyes. This indicates that despite the absence of clinical signs of rejecti ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.