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Vesicle traffic in the endomembrane system: a tale of COPs, Rabs
Vesicle traffic in the endomembrane system: a tale of COPs, Rabs

... depends on SNARE (soluble N-ethylmaleimide sensitive factor adaptor protein receptor) molecules [3•] in the vesicle (v-SNARE) and target (t-SNARE) membranes. The interaction of these proteins is regulated by a different class of small GTPases, belonging to the Rab/Ypt family, as well as by several o ...
Reversal of Multicellular-form Development in a
Reversal of Multicellular-form Development in a

... the transition from this early stage to the yeast phase. Multicellular form-development in wildtype cells can be reversed via budding in cells that are before an unidentified step in development, or by hyphal outgrowth in cells that are beyond that step (Oujezdsky et al., 1973). However, in this stu ...
Roseoloviruses manipulate host cell cycle - HHV
Roseoloviruses manipulate host cell cycle - HHV

... Summary of the findings and future directions It was shown that HHV-6 infection of T cells resulted in Rb degradation. The released E2F1 was associated with some cellular transcription as well as transcription of viral genes (Figure 1). The HHV-6 genome encodes a number of genes containing in their ...
CONTRIBUTION OF STEM CELLS AND DIFFERENTIATED CELLS
CONTRIBUTION OF STEM CELLS AND DIFFERENTIATED CELLS

PDF Copy - Brandon S. Russell, Ph.D.
PDF Copy - Brandon S. Russell, Ph.D.

ID helix-loop-helix proteins - Journal of Cell Science
ID helix-loop-helix proteins - Journal of Cell Science

... comprises >200 members, which have been identified in organisms from yeast to man (reviewed in Littlewood and Evan, 1995; Massari and Murre, 2000). In metazoa, HLH proteins function in the coordinate regulation of gene expression, orchestrating cell cycle control, cell lineage commitment and cell di ...
Grx5 Is a Mitochondrial Glutaredoxin Required for the
Grx5 Is a Mitochondrial Glutaredoxin Required for the

... Corresponding author. E-mail address: enric.herrero@cmb.udl.es. ...
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Attachment

... plastids, mitochondria, lysosomes, and Golgi complexes. Non-membrane-bound organelles, such as ribosomes and centrioles are also present in eukaryotic cells. Cells are small because as they get larger, their surface area to volume ratio becomes too small to bring in enough nutrients and get rid of e ...
Bottlenecks in Deriving Definitive Hematopoietic Stem Cells From
Bottlenecks in Deriving Definitive Hematopoietic Stem Cells From

... fate specification, as well as the potentially detrimental effects of an incorrect cellular milieu on their endogenous biology. Attempts to improve culture systems are hampered by significant gaps in our understanding of the origin, nature, and behavior of adult HSCs, as outlined below. ...
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Gastrulation in Drosophila: the logic and the cellular mechanisms
Gastrulation in Drosophila: the logic and the cellular mechanisms

... and later disperse into individual cells that spread out to form the germ layers by cell migration and rearrangement. The invagination of the mesoderm is heralded by subtle changes in the shapes of the most ventrally located blastoderm cells (Leptin and Grunewald, 1990; Sweeton et al., 1991). These ...
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... • 4.2 Discuss the types and functions of intercellular connections between epithelial cells. • 4.3 Describe the structure and function of ...
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... neoplasm of keratinocytes with many features one of which is the production of keratin.  SCC can be categorized histologically into in situ (intraepidermal) or invasive (penetrating the dermal-epidermal junction).  Some examples of in situ SCC include Bowen's disease and erythroplasia of Queyrat. ...
Reovirus for the treatment of acute myeloid leukaemia
Reovirus for the treatment of acute myeloid leukaemia

... Results: Cavatak demonstrated cytotoxic effects when administered to CLL cell lines but no effect against primary samples in monoculture. Interestingly, when primary CLL cells were incubated with CD40L-expressing mouse fibroblasts increased expression of both CD54 and CD55 was observed. The efficacy ...
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Epithelial Integrin O/6~4: Complete Primary Structure of and Variant

... important for the formation, maintenance, and repair of tissues as well as for other biological processes such as the metastasis of cancer cells. This interaction is mediated, in part, by a family of cell surface receptors called integrins (Hynes, 1987; Ruoslahti and Pierschbacher, 1987; Buck and Ho ...
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... _____ 33. Gland with ducts that carry secretions to target organ or location. _____ 34. Glands that secrete regulatory hormones directly into blood or lymph, no ducts. _____ 35. The more numerous of the two types of glands. _____ 36. Examples are the liver (produces bile), and pancreas (produces dig ...
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Multiscale View of Cytoskeletal Mechanoregulation of Cell and

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Tissue powerpoint File

... • 4.2 Discuss the types and functions of intercellular connections between epithelial cells. • 4.3 Describe the structure and function of ...
ESCV 2014 - Chromis Therapeutics
ESCV 2014 - Chromis Therapeutics

... constructed and characterized. An AD38 cell culture-generated HBV was used to infect HepG2/NTCP cells. The in vitro infection conditions had been optimized. An efficient HBV replication in the infected cells was confirmed with cell ELISA for several viral intracellular antigens (including HBsAg- Lar ...
(From the Section on Experimental Therapeutics, Laboratory of
(From the Section on Experimental Therapeutics, Laboratory of

... were of the same order of magnitude (Table II); and when the cells were grown on Cl*-labelled glutamic acid, both the glutamine and glutamic acid residues of the cell protein were found to have the same specific activity (13). Studies with other cells in primary culture will be necessary to determin ...
MS Cell Division, Reproduction, and Protein Synthesis
MS Cell Division, Reproduction, and Protein Synthesis

... enzyme breaks the bonds between the two DNA strands. Another enzyme pairs new, complementary nucleotides with those in the original chains. Two daughter DNA molecules form. Each contains one new chain and one original ...
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06. Euglena Notes

... Euglena are unicellular organisms classified into the Kingdom Protista. All euglena have chloroplasts and can make their own food by photosynthesis. They are not completely autotrophic (able to make their own food) though; euglena can also absorb food from their environment. Euglena usually live in ...
Lymphoid B cells induce NF-jB activation in high endothelial cells
Lymphoid B cells induce NF-jB activation in high endothelial cells

... functional features indicative of a permanently activated state which allows them to support high rates of lymphocyte extravasation not found in endothelial cells lining other vessels [reviewed in Girard and Springer (8)]. In contrast to the many reports on inflamed endothelium, the mechanisms invol ...
BiochemicalSociety A nnualSymposium No.77
BiochemicalSociety A nnualSymposium No.77

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Extracellular matrix



In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by cells that provides structural and biochemical support to the surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest.The plant ECM includes cell wall components, like cellulose, in addition to more complex signaling molecules. Some single-celled organisms adopt multicelluar biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances (EPS).
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