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No Slide Title
No Slide Title

... Unwinding, base pairing, joining, replication ...
INBREEDING Definition
INBREEDING Definition

... Heterosis and Out-breeding depression  Heterosis is strong in F1 generation and weak in F2-F3  Out-breeding is weak in F1 and Strong in F2 and F3 ...
21.2  Different cell types result from differential gene expression... Cells have equivalent genomes (genes are the same) AP Biology
21.2 Different cell types result from differential gene expression... Cells have equivalent genomes (genes are the same) AP Biology

Method S1 Data source and processing methods of the 11 genomic
Method S1 Data source and processing methods of the 11 genomic

... Phenotypic sementic similarity: Mouse phenotypic data was retrieved from Mammalian Phenotype Browser. A method in terms of Smallest Shared Mammalian Phenotypes was used to measure the correlation of gene pairs sharing the similar phenotypic data. Smallest Shared Mammalian Phenotypes is based on the ...
Genetic terms, punnett squares
Genetic terms, punnett squares

The plant cell that is responsible for asexual reproduction is called
The plant cell that is responsible for asexual reproduction is called

... chromosomes, how many would each the sperm and the egg have? ...
Unit 2 - Molecular and genetic factors in disease
Unit 2 - Molecular and genetic factors in disease

... inactivation is random ,  This can have a bearing on the expression of diseases which are due to mutations in genes on the X chromosome as either the normal or the mutant gene may be inactivated. ...
Cell-cell fusion assay
Cell-cell fusion assay

... T7 Polymerase is one of a group of very active phage polymerases, that use a short double-stranded promoter sequence to initiate transcription at a specific base in the template, and then transcribe single or double stranded DNA with good fidelity until the end of the DNA bottom strand is reached; ...
Obesity caused BBC tumors to form at a faster rate compared to lean
Obesity caused BBC tumors to form at a faster rate compared to lean

... • Some gene expression profiles increase with increasing arsenic exposure and some gene expression profiles decrease with decreased arsenic exposure • These changes suggest that prenatal arsenic exposure does affect a baby’s gene expression profile ...
Genetics and genomics in wildlife studies: Implications for
Genetics and genomics in wildlife studies: Implications for

... sticklebacks. His data showed how selection repeatedly targeted similar genomic regions associated with phenotypic adaptations to these aquatic environments showing how genomes might be shaped by ecological factors. As an alternative to genome-wide scans, a focus on a more restricted set of candidat ...
Enteric bacteria as model systems
Enteric bacteria as model systems

...  The drug resistance genes could be cloned and the regions flanking the insertion sequenced. This could provide the DNA sequence of the raf genes.  These days, complete genome sequences are available, so we need only determine a small region of sequence adjacent to our insertion, and gather the re ...
Lecture Chpt. 16 DNA 1
Lecture Chpt. 16 DNA 1

... Something from the dead cells, caused the good cells to change into bad ...
Concept 14.4: Microevolution is a change in a population`s gene pool.
Concept 14.4: Microevolution is a change in a population`s gene pool.

... House sparrows adapting to climate in North America ...
Παρουσίαση του PowerPoint
Παρουσίαση του PowerPoint

... GR is already known in hematologic malignancies; however its role is not yet elucidated in BC. GR has previously been mentioned to participate in the oncogenesis of bladder cancer, yet its role is still obscure. The HCCS gene is located on the X chromosome and to date, there are no reports linking i ...
nature v. nurture
nature v. nurture

... predispositions for lots of diseases, like diabetes, cancer and heart disease." Human cells have tens of thousands of genes inside them, each with its own job, such as producing energy or overseeing cell division. But only certain genes are active at any given time or in any cell type while the rest ...
Immunogenetics 1
Immunogenetics 1

Repetitive DNA and next-generation sequencing
Repetitive DNA and next-generation sequencing

... De novo assembly---strategies ...
Ligation and Transformation
Ligation and Transformation

... plasmid; colonies floresce green (+pGLO) ...
Tetrad Genetics
Tetrad Genetics

... 1982: “P-elements”: Rubin, Kidwell, and Bingham demonstrate that the “P” cytotype is due to transposable elements. But, why are wild females protected? Hmmm... (notice how the use of italics creates suspense) 1982: Spradling and Rubin clone the P-element and demonstrate that it can be used to genera ...
Genetics and Heredity
Genetics and Heredity

... mucus production. Both genes are defected (recessive). Scientist insert working copies of gene into harmless viruses. The engineered viruses can be sprayed into the lungs of the patients. • Gene therapy works in hemophilia by using DNA as the drug and viruses as the deliverer. A virus containing the ...
talk_DNAEditing
talk_DNAEditing

... RETRO: violating the central dogma! 4. Insertion into new genomic locations, increasing the number of genomic copies of the sequence. • Mobile elements are like double edge sword. ...
DNA Repilication and Transmission
DNA Repilication and Transmission

... Chromosomes are strands of DNA. There are two types: autosomes and sex chromosomes (allosomes). The autosomes occur as homologous pairs, but only a female’s allosomes are homologous. The chromosomes of a person constitute one’s karyotype. ...
Intro to Genetics PowerPoint Notes
Intro to Genetics PowerPoint Notes

12GeneEvol
12GeneEvol

... A. a mobile DNA element that can also reproduce as a virus. B. an old-fashion transposon that is no longer in popular among geneticists. C. a transposable element that passes through an RNA stage. D. a transposable element that cuts and moves the DNA from one site to another. True or false 1. In hig ...
Genetics & Heredity Unit Review
Genetics & Heredity Unit Review

... make-up. (Which alleles does it have? Example: TT or Tt or tt) Allele - one form of a gene. Each gene is controlled by 2 alleles. Dominant allele - it is more “powerful” and can mask/hide a recessive allele. Example: “Tall” stems are controlled by the dominant allele (shown with a capital “T”). Rece ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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