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Genetics 101 - hrsbstaff.ednet.ns.ca
Genetics 101 - hrsbstaff.ednet.ns.ca

... Some of these changes occur in cells of the body — such as in skin cells as a result of sun exposure — but are not passed on to children. Germline But other errors can occur in the DNA of cells that produce the eggs mutations are what cause diseases to and sperm. These are called germline mutations ...
UNIVERSITY COLLEGE LONDON THE UCL CANCER INSTITUTE
UNIVERSITY COLLEGE LONDON THE UCL CANCER INSTITUTE

... Our view of the regulatory genome has changed dramatically in recent years. We have expanded beyond classical models of gene control to appreciate that the spatial organization of the genome and the manner in which genes and regulatory elements are embedded therein has a critical role in facilitatin ...
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APS Science Curriculum Unit Planner

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rights reserved. AP Biology Living System and Genetic Information

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... gonads, differentiated gonads and the female default pathway to ovary development 5. Compare heterozygous and homozygous females for X-linked traits with hemizygous males 6. Examine colorblindness as example of an X-linked gene and compare its prevalence in males and females. 7. Compute the expected ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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