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Cisplatin- Etoposide
Cisplatin- Etoposide

... Orally for 1 day only †† Refer to ASWCS Individual Drug Guidelines for specific recommendations when administering Cisplatin (Section A3.2) In patients with swallowing difficulties, Day 3 Etoposide can be given intravenously rather than orally (at a dose of 100mg/m2) ...
Neonatal Abstinence Syndrome (Assessment of neonatal
Neonatal Abstinence Syndrome (Assessment of neonatal

... AAP guidelines illustrate oral morphine and methadone as first-line therapies based on current evidence and practice in the United States. Clonidine is also suggested as adjunctive therapy based on new literature illustrating its efficacy (Hudak & Tan, 2012). This is a change from AAP (1998) recomme ...
A Review of Hormone Replacement Therapy for
A Review of Hormone Replacement Therapy for

... Sweden.5 The study also demonstrated a risk reduction of 6% for every year of use of HRT.5 The protective benefits of HRT were largely lost within 5 years of cessation of therapy. The method of drug administration did not matter: both transdermal and oral estrogen conferred equal benefit. HRT (estro ...
Triptans - Stort Physio
Triptans - Stort Physio

... more severe, disabling, and longer lasting than other migraine. Frovatriptan designed as a preventative migraine medication with a long lasting effect and a low risk of adverse events. The pooled results of 3 RCTs assessed 346 women with migraine (187 classified as menstrual) ...
Serex Film Coated Tablets 25-100-200-300 mg, 30 tablets
Serex Film Coated Tablets 25-100-200-300 mg, 30 tablets

... for deterioration in glucose table. Quetiapine may cause dizziness, tachycardia and sometimes hypotension accompanied by syncope, especially in dose increasing period at the start of treatment. As in with other antipsychotics, quetiapine also should be used carefully in patients that have seizures o ...
The modern management of gout
The modern management of gout

... generally well tolerated, although regular LFT monitoring is essential ...
Intentional low-molecular-weight heparin overdose: a case report
Intentional low-molecular-weight heparin overdose: a case report

... and hanged herself. She is heterozygous for the factor V Leiden mutation and had a pulmonary embolus 2.5 years prior to this admission. She had been prescribed enoxaparin 1 mg/kg (80 mg) Q 12 h by her primary provider. In the ED, central venous access was attempted in her bilateral femoral veins. An ...
Casodex drug insert
Casodex drug insert

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Full Prescribing Information

... base exhibited evidence of maternal toxicity including decreased body weight gain and/or body weight loss and a concomitant decrease in food consumption during the first week of dosing. No teratogenic or embryo-fetal effects were observed at doses equivalent to up to 22.5 mg/kg per day rolapitant f ...
shared care management of parkinson`s disease
shared care management of parkinson`s disease

... patients with PD. Patients not infrequently complain of aching and stiffness leading to orthopaedic or rheumatological referral. Medication with dopaminergic drugs can result in motor side effects such as dyskinesias. These can be observed early in the disease course in some patients, but are more t ...
Neuromodulation for Failed Back Surgery
Neuromodulation for Failed Back Surgery

... a number of inconsistencies in the data which could have been overlooked using only pain ratings and patient satisfaction data. No one treatment emerged as the most effective across all of the disease specific and generic measures. Although generally “satisfied” with treatment, patients continued to ...
the Agrylin
the Agrylin

... in the study. Episodes of increased pulse and decreased systolic or diastolic blood pressure beyond the normal ranges in the absence of clinical symptoms were observed. Adverse events that had been reported in these pediatric patients prior to ...


... of the lesions (7). It has also been studied in other presentations such as oral patches, tablets or adhesive films. Meng et al. (7) observed no significant differences in efficacy between the application of amlexanox in patch or tablet form, though patients appear to prefer the former presentation. ...
A 35 Year-Old Woman with Spontaneous Iliac Artery Rupture
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... I thought 2000 mg was the max? • White lies: up to 4000 mg/day is safe • Found in many OTC meds • Accidental overdose is too common • READ ALL LABELS ...
582 Antihistamines
582 Antihistamines

... eye drops equivalent to 0.025% ketotifen, in children from 3 years of age. Asthma. Results of studies on the effectiveness of ketotifen in the treatment of asthma (p.1108) have been conflicting; although some have found it effective in reducing symptoms1-4 and in enabling a reduction in use of other ...
Selexipag for the treatment of pulmonary arterial hypertension
Selexipag for the treatment of pulmonary arterial hypertension

... in patients with World Health Organization functional class (FC) II or III disease. The recommended initial selexipag dosage is 200 mg twice daily. Like prostanoid analogs, selexipag has a dose-dependent adverse-effect profile that includes nausea, vomiting, diarrhea, headache, and musculoskeletal p ...
Principles of Analgesic Use in the Treatment of Acute Pain
Principles of Analgesic Use in the Treatment of Acute Pain

... both topical diclofenac preparations? In 2005, the US Food and Drug Administration (FDA) required the addition of a black box warning to the product label of all cyclooxygenase-2 (COX-2) selective and nonselective nonsteroidal anti-inflammatory drug (NSAID) products, regardless of their method of ad ...
CSP Octreotide
CSP Octreotide

... experience, data on a limited number of exposed pregnancies have been reported in patients with acromegaly, however, in half of the cases the pregnancy outcomes are unknown. Most women were exposed to octreotide during the first trimester of pregnancy at doses ranging from 100 to 300 micrograms/day ...
Exelon - DavisPlus
Exelon - DavisPlus

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PACKAGE INSERT TEMPLATE FOR ACETYLSALICYLIC ACID
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... Acetylsalicylic acid is rapidly hydrolyzed in the plasma to salicylic acid such that plasma levels of Acetylsalicylic acid are essentially undetectable 1-2 hours after dosing. Salicylic acid is primarily conjugated in the liver to form salicyluric acid, a phenolic glucuronide, an acyl glucuronide, a ...
Ampisid
Ampisid

... set. Co-administration of ampicillin with oral contraceptives and estrogen-containing agents can decrease the effects of these drugs. Probenecid delays renal secretions of ampicillin and sulbactam and prolongs half-lives of both of these agents. ...
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Proteus, Klebsiella, E. coli

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... becomes evident within 12 to 48 hours.1,2 Our laboratory was unable to culture C minutissimum from our patients. Inquiry revealed that an improper culture medium had been used in each case. Erythromycin is the treatment of choice for erythrasma. One gram in divided doses is usually given daily for 5 ...
Pharmacological effects and Clinical efficacy
Pharmacological effects and Clinical efficacy

...  Because of narrow therapeutic window of theophylline , and the fact that t1/2 is highly variable between patients, especially smokers, care must be taken.  The usual does is 125-250mg is adults, three times daily , and half of that in children. ...
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Dydrogesterone



Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.
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