Biological Activity of Withanolides
... above which the slope ~ the curve decreased . The ED50 was 33mglkg. Repeated administration of W A showed significant growth inhibitory and cytocidal effects on EAC. A total dose of 40 mg/kg. in 8 fraction (5 X 8mglkg. ) or a total dose of 60mg/kg. in 8 fraction (7 .5 X 8mglkg.) starting from 24 h. ...
... above which the slope ~ the curve decreased . The ED50 was 33mglkg. Repeated administration of W A showed significant growth inhibitory and cytocidal effects on EAC. A total dose of 40 mg/kg. in 8 fraction (5 X 8mglkg. ) or a total dose of 60mg/kg. in 8 fraction (7 .5 X 8mglkg.) starting from 24 h. ...
(l) seeds for central nervous system depressant activity
... Pachyrrhizus erosus is used as folk medicine in treatment of insomnia, we made an attempt to study its CNS depressant effect. The different activities studied were potentiation of pentobarbitone-induced sleep, test for locomotor activity, effect on muscle co-ordination, antiaggressive and antianxiet ...
... Pachyrrhizus erosus is used as folk medicine in treatment of insomnia, we made an attempt to study its CNS depressant effect. The different activities studied were potentiation of pentobarbitone-induced sleep, test for locomotor activity, effect on muscle co-ordination, antiaggressive and antianxiet ...
Prescribing Information
... approximately 170 mL/kg of body weight. Metabolism: Aspirin is rapidly hydrolyzed in the plasma to salicylic acid such that plasma levels of aspirin following DURLAZA administration are essentially undetectable 4-8 hours after dosing. In contrast to immediate release aspirin, measurable levels of sa ...
... approximately 170 mL/kg of body weight. Metabolism: Aspirin is rapidly hydrolyzed in the plasma to salicylic acid such that plasma levels of aspirin following DURLAZA administration are essentially undetectable 4-8 hours after dosing. In contrast to immediate release aspirin, measurable levels of sa ...
Medication Types
... Fentanyl is a strong opioid which is 100 times as potent as morphine. Morphine 10 mg is equivalent to fentanyl 100 micrograms. It is commonly used during operations by anaesthetists in the intravenous form. It has no active breakdown products and is relatively short acting. Fentanyl is commonly used ...
... Fentanyl is a strong opioid which is 100 times as potent as morphine. Morphine 10 mg is equivalent to fentanyl 100 micrograms. It is commonly used during operations by anaesthetists in the intravenous form. It has no active breakdown products and is relatively short acting. Fentanyl is commonly used ...
Hot Flashes - Indiana Pharmacists Alliance
... Estradiol 0.5 mg /norethindrone acetate 0.1 mg daily CEE 0.625 mg/medroxyprogesterone 2.5 mg daily Estradiol cream 0.1 mg/gm: 2 gm intravaginally once daily at bedtime ...
... Estradiol 0.5 mg /norethindrone acetate 0.1 mg daily CEE 0.625 mg/medroxyprogesterone 2.5 mg daily Estradiol cream 0.1 mg/gm: 2 gm intravaginally once daily at bedtime ...
Hot Flashes - Indiana Pharmacists Alliance
... Estradiol 0.5 mg /norethindrone acetate 0.1 mg daily CEE 0.625 mg/medroxyprogesterone 2.5 mg daily Estradiol cream 0.1 mg/gm: 2 gm intravaginally once daily at bedtime ...
... Estradiol 0.5 mg /norethindrone acetate 0.1 mg daily CEE 0.625 mg/medroxyprogesterone 2.5 mg daily Estradiol cream 0.1 mg/gm: 2 gm intravaginally once daily at bedtime ...
Rita Mannarino - Opioids for the Non
... * Pete is an ex-smoker, having quit about 12 years ago just prior to the birth of his first grandchild and after he started having issues with dyspnea for which he required the use of puffers ...
... * Pete is an ex-smoker, having quit about 12 years ago just prior to the birth of his first grandchild and after he started having issues with dyspnea for which he required the use of puffers ...
MIC - Physiologie et Thérapeutique Ecole Véto Toulouse (ENVT)
... by R. equi, based on in vitro activity data, pharmacokinetic studies, and retrospective studies. • The level of evidence for this recommendation is moderate, with no randomized controlled studies available to substantiate it. ...
... by R. equi, based on in vitro activity data, pharmacokinetic studies, and retrospective studies. • The level of evidence for this recommendation is moderate, with no randomized controlled studies available to substantiate it. ...
The Use of Methadone in Palliative Medicine
... When switching from a strong opioid other than morphine, the total equivalent daily dose of morphine is used. If there has been recent rapid escalation of the pre-switch opioid dose, calculate the initial dose of methadone using the pre-escalation dose of the opioid. The use of a loading dose ...
... When switching from a strong opioid other than morphine, the total equivalent daily dose of morphine is used. If there has been recent rapid escalation of the pre-switch opioid dose, calculate the initial dose of methadone using the pre-escalation dose of the opioid. The use of a loading dose ...
Oral Dosing of Encochleated Amphotericin B (CAmB
... causes tissue levels to increase to 4-40x the MIC. Conclusions: In Candida-infected mice, orally administered CAmB is taken up from the GI tract resulting in significant tissue concentrations above the MIC level. Contrary to DAmB, concentrations of AmB from CAmB accumulate rapidly in the tissues wit ...
... causes tissue levels to increase to 4-40x the MIC. Conclusions: In Candida-infected mice, orally administered CAmB is taken up from the GI tract resulting in significant tissue concentrations above the MIC level. Contrary to DAmB, concentrations of AmB from CAmB accumulate rapidly in the tissues wit ...
Full Prescribing Information
... Palmar-plantar erythrodysesthesia syndrome (PPES) occurred in 42% of patients treated with CABOMETYX and in 6% of patients treated with everolimus. Grade 3 PPES occurred in 8.2% of CABOMETYX-treated patients and in <1% of everolimus-treated patients. Withhold CABOMETYX in patients who develop intole ...
... Palmar-plantar erythrodysesthesia syndrome (PPES) occurred in 42% of patients treated with CABOMETYX and in 6% of patients treated with everolimus. Grade 3 PPES occurred in 8.2% of CABOMETYX-treated patients and in <1% of everolimus-treated patients. Withhold CABOMETYX in patients who develop intole ...
drug name: anastrozole
... clastogenic in in vitro and in vivo chromosome tests. Fertility: No information found. ...
... clastogenic in in vitro and in vivo chromosome tests. Fertility: No information found. ...
Nature`s
... USA; roots and rhizomes used History Used by Native Americans for women’s health problems and a variety of other uses; A component of Lydia Pinkham’s elixir, In Europe a special black cohosh extract has been used since the 1950s for symptoms of menopause and PMS Chemistry Contains phytosterin, ...
... USA; roots and rhizomes used History Used by Native Americans for women’s health problems and a variety of other uses; A component of Lydia Pinkham’s elixir, In Europe a special black cohosh extract has been used since the 1950s for symptoms of menopause and PMS Chemistry Contains phytosterin, ...
Product Monograph
... intravenous infusion lasting at least two hours. BONEFOS should not be mixed with other intravenous infusions. No other drugs or nutrients should be added to the diluted infusion solution (see DOSAGE AND ADMINISTRATION). BONEFOS (clodronate disodium) should NOT be given as a bolus injection since ra ...
... intravenous infusion lasting at least two hours. BONEFOS should not be mixed with other intravenous infusions. No other drugs or nutrients should be added to the diluted infusion solution (see DOSAGE AND ADMINISTRATION). BONEFOS (clodronate disodium) should NOT be given as a bolus injection since ra ...
Pharmacology/Therapeutics I Block V Lectures 2012
... and D4 as well as prostaglandins, resulting in reductions in leukocyte chemotaxis, bronchiolar smooth muscle contraction, vascular permeability and airway mucus secretion. ...
... and D4 as well as prostaglandins, resulting in reductions in leukocyte chemotaxis, bronchiolar smooth muscle contraction, vascular permeability and airway mucus secretion. ...
The Top 6 June specials 2015
... paraesthesia (particularly of the scalp), urinary retention or urgency, and supine hypertension. The longer-term efficacy and safety of midodrine has not been assessed in the RCTs, nor has its effect on activities of daily living. Midodrine acts as an alpha adrenergic receptor agonist. It stimulates ...
... paraesthesia (particularly of the scalp), urinary retention or urgency, and supine hypertension. The longer-term efficacy and safety of midodrine has not been assessed in the RCTs, nor has its effect on activities of daily living. Midodrine acts as an alpha adrenergic receptor agonist. It stimulates ...
Drugs for Bronchial Asthma, Antitussives, Expectorants
... Its use decline due to serious cardiac side effects. ...
... Its use decline due to serious cardiac side effects. ...
Evidence-Based Perspectives on Contemporary Approaches to
... • Combination of nitrous and oral agents “may produce minimal, moderate or deep sedation or general anesthesia” • “Supplemental dosing is a single additional dose” for “prolonged procedures” and “should not exceed ½ the initial dose” (not until the “clinical half-life of the initial dose has ...
... • Combination of nitrous and oral agents “may produce minimal, moderate or deep sedation or general anesthesia” • “Supplemental dosing is a single additional dose” for “prolonged procedures” and “should not exceed ½ the initial dose” (not until the “clinical half-life of the initial dose has ...
lycopene in the management of oral submucous fibrosis
... antioxidants when used in combination with intralesional steroids to treat OSF. The improvement in mouth opening observed in our study can be attributed to two reasons: 1. Lycopene exerts its antiinflammatory action by increasing the lymphocyte resistance to stress [12], inhibition of pivotal pro-in ...
... antioxidants when used in combination with intralesional steroids to treat OSF. The improvement in mouth opening observed in our study can be attributed to two reasons: 1. Lycopene exerts its antiinflammatory action by increasing the lymphocyte resistance to stress [12], inhibition of pivotal pro-in ...
FLOXAPEN PRODUCT INFORMATION (flucloxacillin sodium
... Antibiotic associated pseudomembranous colitis has been reported with many antibiotics including flucloxacillin. A toxin produced with Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosi ...
... Antibiotic associated pseudomembranous colitis has been reported with many antibiotics including flucloxacillin. A toxin produced with Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosi ...
ADHD in a College Population - American College Health Association
... ✴ DA transporter blockade; NE transporter blockade ✴ d–isomer has greater pharmacologic activity than the l– isomer ‣ Majority of MPH products exist as 50/50 mixture • One exception: dexmethylphenidate (Focalin®) ...
... ✴ DA transporter blockade; NE transporter blockade ✴ d–isomer has greater pharmacologic activity than the l– isomer ‣ Majority of MPH products exist as 50/50 mixture • One exception: dexmethylphenidate (Focalin®) ...
Ipravent pressurised inhalation, solution ENG SmPC
... As patients with cystic fibrosis may be prone to gastrointestinal motility disturbances, ipratropium bromide, as with other anticholinergics, should be used with caution in these patients. There have been isolated reports of ocular complications (i.e. reversible accommodation disorder, mydriasis, in ...
... As patients with cystic fibrosis may be prone to gastrointestinal motility disturbances, ipratropium bromide, as with other anticholinergics, should be used with caution in these patients. There have been isolated reports of ocular complications (i.e. reversible accommodation disorder, mydriasis, in ...
Scenario 4: Choice of hormone replacement therapy (HRT)
... extensive first-pass metabolism in the liver. However, newer HRT preparations usually contain either a readily degradable oestradiol or conjugated equine oestrogens. Amongst the progestogens, norethisterone derivatives have more of an effect on liver metabolism than do the progesterone derivatives [ ...
... extensive first-pass metabolism in the liver. However, newer HRT preparations usually contain either a readily degradable oestradiol or conjugated equine oestrogens. Amongst the progestogens, norethisterone derivatives have more of an effect on liver metabolism than do the progesterone derivatives [ ...
PRODUCT INFORMATION DIFFLAM FORTE ANTI
... Benzydamine is an anti-inflammatory analgesic agent structurally unrelated to the steroid group. Benzydamine differs chemically from other non-steroidal antiinflammatory agents in that it is a base rather than an acid. Animal models show that, when administered systemically, benzydamine is effective ...
... Benzydamine is an anti-inflammatory analgesic agent structurally unrelated to the steroid group. Benzydamine differs chemically from other non-steroidal antiinflammatory agents in that it is a base rather than an acid. Animal models show that, when administered systemically, benzydamine is effective ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.