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Equianalgesic Dosing It`s not just about the math
Equianalgesic Dosing It`s not just about the math

... Pt used the Oxycodone but also used about 40mg of IV PCA dilaudid PCA was stopped, oxycodone dosing was increased to 30-60mg q 3 ...
Clinical and experimental studies on theophylline
Clinical and experimental studies on theophylline

... Summary and Conclusion • These experimental studies show that theophylline-induced anxiety and tachycardia may be due to oxidative stress, and antioxidants may have protective role • Thus it could be speculated that treatment with antioxidants may be helpful in preventing such ADRs due to theophyll ...
Novel Anti-platelet Agents and Anticoagulants
Novel Anti-platelet Agents and Anticoagulants

... orthopaedic surgery. It is administered orally and commenced at a dose of 10mg once daily 6-10 hours post-operatively and continued for two weeks post knee replacement and five weeks post hip replacement. When used for prevention of stroke and systemic embolus in patients with AF, 20mg rivaroxaban o ...
Abstral - AZBlue
Abstral - AZBlue

... documentation of failure / ineffectiveness of concurrent use (each ingredient used at the same time) of individual generic components. When the drug in question is a low dose formulation, there must be documentation of failure / ineffectiveness of low dose generic formulation. Adverse Drug Event: Al ...
Use and monitoring of Low Molecular Weight Heparins
Use and monitoring of Low Molecular Weight Heparins

...  Refer to known patient allergies prior to prescribing Where the patient has been admitted to hospital in the past 100 days assume they have been given heparin (increased risk of HIT). HIT is rare after 14 days of treatment. If HIT is suspected, discuss with clinical Haematology Team at the acute t ...
Prescribing Information
Prescribing Information

... with OPSUMIT. Advise patients to contact their health care provider if they become pregnant or suspect they may be pregnant. Perform a pregnancy test if pregnancy is suspected for any reason. For positive pregnancy tests, counsel patients on the potential risk to the fetus [see Boxed Warning and Dos ...
National Prescribing Indicators 2015
National Prescribing Indicators 2015

... • ICS dose reduction should be considered every three months, decreasing the dose by approximately 25–50% each time. • NICE CG101 recommends that ICS should only be considered in combination with a long-acting beta-2 agonist in patients with stable chronic obstructive pulmonary disease who remain br ...
A REVIEW ABSTRACT - International Journal of Pharma and Bio
A REVIEW ABSTRACT - International Journal of Pharma and Bio

... decrease pain after surgery 16.Both submucosal and endo-alveolar administration of dexamethasone are effective in reducing postoperative sequelae of surgical removal of lower wisdom teeth.21 On the second postoperative day, facial edema showed a significant reduction in both dexamethasone 4mg and de ...
Pegin insert
Pegin insert

... (benzyl alcohol) which may be found in this product can infrequently cause serious problems (sometimes death) if given in large amounts (more than 100 milligrams per kilogram daily) to an infant during the first months of life (neonatal period). The risk is also greater with low birth weight infants ...
Presented at NICHD Conference on Nausea and Vomiting of
Presented at NICHD Conference on Nausea and Vomiting of

... and vomiting of pregnancy”. During the symposium many topics were discussed including the mechanism of nausea and vomiting associated with pregnancy and the old and the new innovative treatments that are and have been utilized to manage this clinical problem. The perspective on this subject ranges f ...
gau psychotropic medication guidelines
gau psychotropic medication guidelines

... mg/day every 3-4 days as needed. Usual max: 5-6 mg total/day. Start: Mild-10 to 20 mg 3 to 4 times daily. Severe-20-25 mg 3-4X daily. Usual max: 200 mg/day. Start (anxiety): 0.25 mg bid or tid. Usual max: 3 mg qday. Can ↑ dosage at HS to help with sleep. Start (panic d/o): 0.25 mg bid or tid then ↑ ...
fentanyl citrate lollipop, Fentora
fentanyl citrate lollipop, Fentora

... Oral/buccal transmucosal preparations of fentanyl citrate are only FDA approved in the management of breakthrough pain in patients with cancer who are already receiving and who are tolerant to around-the-clock opioid therapy. Patients considered opioid tolerant are those who are taking around-the-cl ...
LESCOL XL tablets
LESCOL XL tablets

... The Lipoprotein and Coronary Atherosclerosis Study (LCAS) In the Lipoprotein and Coronary Atherosclerosis Study (LCAS), the effect of fluvastatin therapy on coronary atherosclerosis in patients with mild to moderately elevated LDL cholesterol levels (3.0 - 4.9 mmol/L (115 – 190 mg/dL)) and documente ...
Local New Medicine Treatment Protocol Template
Local New Medicine Treatment Protocol Template

...  The use of activated charcoal to reduce absorption in case of rivaroxaban overdose may be considered.  Should a bleeding complication arise in a patient receiving rivaroxaban, the next dose of rivaroxaban should be delayed or treatment discontinued as clinically appropriate - rivaroxaban has a ha ...
Ketamine Parenteral and Oral Dose Recommendations
Ketamine Parenteral and Oral Dose Recommendations

... o Inhibits glutamate binding to NMDA-R receptor; activity at norepinephrine, serotonin, and muscarinic cholinergic, kappa opioid, and voltage-sensitive calcium channel receptors • Pharmacokinetics o Lipophilic; Crosses blood brain barrier o Protein binding: 47% o Onset of action: 1-5 mi ...
Hydrofluoroalkane-134a Beclomethasone
Hydrofluoroalkane-134a Beclomethasone

... This was a 12-week, placebo-controlled, parallel-group, randomized, blinded, multicenter study. The study population included nonsmoking adults, aged 18 to 65 years, with at least moderate asthma who were symptomatic despite current treatment with bronchodilators and inhaled steroid of 0 to 400 mg/d ...
Methylergonovine Maleate Injection, USP (0.2 mg/ml)
Methylergonovine Maleate Injection, USP (0.2 mg/ml)

... should not be coadministered with methylergonovine. Examples of some of the more potent CYP 3A4 inhibitors include macrolide antibiotics (e.g., erythromycin, troleandomycin, clarithromycin), HIV protease or reverse transcriptase inhibitors (e.g., ritonavir, indinavir, nelfinavir, delavirdine) or azo ...
Epilim Chrono
Epilim Chrono

... Liver function should be measured before and then periodically monitored during the first 6 months of therapy, especially in those who seem most at risk, and those with a prior history of liver disease. Amongst usual investigations, tests which reflect protein synthesis, particularly prothrombin rat ...
DIM-Evail - Designs for Health
DIM-Evail - Designs for Health

... Can DIM be Taken with Medications? DIM is safe when taken with Tamoxifen, birth control pills and other herbs such as St. John’s Wort that affect cytochrome p450 enzymes. Because of its effects on CYP enzymes, I3C, however, should not be taken with any of these. I3C blocks ovulation, can interfere w ...
MIFLONIDE
MIFLONIDE

... have clinically significant alteration in drug exposure (see section 11 Clinical pharmacology). Paediatrics (6 years and above) Due to the absence of clinical experience in children under 6 years of age, Miflonide should not be used in this age group. Treatment of children with mild asthma may be in ...
use
use

... USA; roots and rhizomes used History  Used by Native Americans for women’s health problems and a variety of other uses; A component of Lydia Pinkham’s elixir,  In Europe a special black cohosh extract has been used since the 1950s for symptoms of menopause and PMS Chemistry  Contains phytosterin, ...
Product
Product

... USA; roots and rhizomes used History  Used by Native Americans for women’s health problems and a variety of other uses; A component of Lydia Pinkham’s elixir,  In Europe a special black cohosh extract has been used since the 1950s for symptoms of menopause and PMS Chemistry  Contains phytosterin, ...
I. 	 . Chemical Physical  Information A. 	 Synonyms:
I. . Chemical Physical Information A. Synonyms:

... measured by the activated thrCIIIboplastin time assay. Elmiron reduced thrCIIIbin generation, impaired the generation of ...
Update on Oral anticoagulation therapy
Update on Oral anticoagulation therapy

... require routine laboratory monitoring of their anticoagulant effect.5,6,14,15,52 A significant disadvantage of NOACs is the lack of a specific reversal agent (see below) and in addition, there are concerns regarding the risks of bleeding in an unselected population as distinct from a clinical trial ...
azopt - Vision Institute of Canada
azopt - Vision Institute of Canada

... capsules of brinzolamide twice per day for up to 32 weeks. This regimen provided a higher rate of systemic drug input than topical ocular administration of AZOPT™ (Brinzolamide Ophthalmic Suspension) 1% dosed to both eyes three times per day, and allowed more rapid saturation of systemic CA-II and a ...
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Dydrogesterone



Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.
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