OLMESARTAN MEDOXOMIL/HYDROCHLOROTHIAZIDE 20/12
... Olmesartan medoxomil is a potent, orally active, selective angiotensin II receptor (type AT1) antagonist. Angiotensin II is the primary pressor agent of the reninangiotensin system with effects that include vasoconstriction, stimulation of the synthesis and release of aldosterone, cardiac stimulatio ...
... Olmesartan medoxomil is a potent, orally active, selective angiotensin II receptor (type AT1) antagonist. Angiotensin II is the primary pressor agent of the reninangiotensin system with effects that include vasoconstriction, stimulation of the synthesis and release of aldosterone, cardiac stimulatio ...
The Impact of Nalmefene on Side Effects Due to Intrathecal
... Compared with groups of patients given parentally or orally administered analgesics for postoperative pain control, those who received intrathecal morphine had improved analgesic satisfaction scores, ambulated earlier, and were discharged earlier from the hospital.1-6 When administered intrathecally ...
... Compared with groups of patients given parentally or orally administered analgesics for postoperative pain control, those who received intrathecal morphine had improved analgesic satisfaction scores, ambulated earlier, and were discharged earlier from the hospital.1-6 When administered intrathecally ...
Vascular Medicine
... treatment group (CCUS Adjudication Committee, University Hospital Carl Gustav Carus, Dresden, Germany). A score reflecting the burden of leg vein thrombus was defined a priori and was analogous to the venography score described by Marder et al.17 It included all affected proximal and distal vein seg ...
... treatment group (CCUS Adjudication Committee, University Hospital Carl Gustav Carus, Dresden, Germany). A score reflecting the burden of leg vein thrombus was defined a priori and was analogous to the venography score described by Marder et al.17 It included all affected proximal and distal vein seg ...
Clinical Toxicology: Part I. Diagnosis and Management of Common Drug Overdosage EY
... and cardiac arrhythmias, the most important aspects in the management of a poisoned patient is the maintenance of the patient’s airway, ventilation and circulation, while the drug is excreted. The diagnosis and management of common drug overdoses (e.g sedative, hypnotic, psychoactive, neuroleptic, a ...
... and cardiac arrhythmias, the most important aspects in the management of a poisoned patient is the maintenance of the patient’s airway, ventilation and circulation, while the drug is excreted. The diagnosis and management of common drug overdoses (e.g sedative, hypnotic, psychoactive, neuroleptic, a ...
Central Nervous System Depressant, Analgesic and Antidiarrheal
... used. The number of times a rat passed through the hole from one chamber to other was counted for a period of 3 min at 0, 30, 60, 90 and 120 min after oral administration of normal saline (10 ml/kg), experimental crude extracts (at dose of 200 mg/kg and 300 mg/kg) and diazepam as standard drug (1 mg ...
... used. The number of times a rat passed through the hole from one chamber to other was counted for a period of 3 min at 0, 30, 60, 90 and 120 min after oral administration of normal saline (10 ml/kg), experimental crude extracts (at dose of 200 mg/kg and 300 mg/kg) and diazepam as standard drug (1 mg ...
Carbamazepine
... Limitations of Gabapentin In Bipolar Disorders • Not effective as monotherapy in treatmentresistant rapid cycling • Not effective as primary add-on antimanic agent • Possible use for associated anxiety/insomnia ...
... Limitations of Gabapentin In Bipolar Disorders • Not effective as monotherapy in treatmentresistant rapid cycling • Not effective as primary add-on antimanic agent • Possible use for associated anxiety/insomnia ...
of administration (injection, oral or inhalation), BDP and its
... systemically available inhaled corticosteroids. After withdrawal from systemic corticosteroids, a number of months are required for recovery of hypothalamic-pituitaryadrenal (HPA) function. Patients who have been previously maintained on 20 mg or more per day of prednisone (or its equivalent) may be ...
... systemically available inhaled corticosteroids. After withdrawal from systemic corticosteroids, a number of months are required for recovery of hypothalamic-pituitaryadrenal (HPA) function. Patients who have been previously maintained on 20 mg or more per day of prednisone (or its equivalent) may be ...
Bromide
... compared with chloride, which is present at 18 980 mg/l to over 23 000 mg/l (Al-Mutaz, 2000). Freshwater concentrations range typically from a trace to about 0.5 mg/l. Bromide and chloride are always present in body fluids in animals in steady state at levels dependent upon intake, and both are excr ...
... compared with chloride, which is present at 18 980 mg/l to over 23 000 mg/l (Al-Mutaz, 2000). Freshwater concentrations range typically from a trace to about 0.5 mg/l. Bromide and chloride are always present in body fluids in animals in steady state at levels dependent upon intake, and both are excr ...
Glycopyrronium (as bromide) - Therapeutic Goods Administration
... the exposure to the parent drug. Since in vitro studies did not show lung metabolism and M9 was of minor importance in the circulation (about 4% of parent drug Cmax and AUC) after i.v. administration, it is assumed that M9 is formed from the swallowed dose fraction of orally inhaled glycopyrronium b ...
... the exposure to the parent drug. Since in vitro studies did not show lung metabolism and M9 was of minor importance in the circulation (about 4% of parent drug Cmax and AUC) after i.v. administration, it is assumed that M9 is formed from the swallowed dose fraction of orally inhaled glycopyrronium b ...
Glucosine 625 mg film-coated tablet ENG SmPC
... Data on possible drug interactions with glucosamine is limited. Increased effect of coumarin anticoagulants (e.g. warfarin) during concomitant treatment with glucosamine has been reported in the post–marketing experience. Patients treated with coumarin anticoagulants should therefore be monitored cl ...
... Data on possible drug interactions with glucosamine is limited. Increased effect of coumarin anticoagulants (e.g. warfarin) during concomitant treatment with glucosamine has been reported in the post–marketing experience. Patients treated with coumarin anticoagulants should therefore be monitored cl ...
Product Monograph Template - Standard
... MS•IR should not be consumed with alcohol as it may increase the chance of experiencing dangerous side effects, including death (see CONTRAINDICATIONS and ADVERSE REACTIONS, Sedation, and DRUG INTERACTIONS). Severe pain antagonizes the subjective and respiratory depressant actions of opioid analgesi ...
... MS•IR should not be consumed with alcohol as it may increase the chance of experiencing dangerous side effects, including death (see CONTRAINDICATIONS and ADVERSE REACTIONS, Sedation, and DRUG INTERACTIONS). Severe pain antagonizes the subjective and respiratory depressant actions of opioid analgesi ...
Prescribing Information - Novartis Pharmaceuticals Corporation
... patients with severe congestive heart failure), treatment with ACE inhibitors and angiotensin receptor antagonists has been associated with oliguria, progressive azotemia and, rarely, acute renal failure and death. Closely monitor serum creatinine, and down-titrate or interrupt ENTRESTO in patients ...
... patients with severe congestive heart failure), treatment with ACE inhibitors and angiotensin receptor antagonists has been associated with oliguria, progressive azotemia and, rarely, acute renal failure and death. Closely monitor serum creatinine, and down-titrate or interrupt ENTRESTO in patients ...
How I treat anticoagulated patients undergoing an elective
... antagonist (VKA), such as warfarin, is a common but complex clinical problem, affecting an estimated 250 000 patients per year in North America alone or approximately 1 in 10 patients on chronic VKA.1 It is well established that continuing oral anticoagulation is associated with an increased risk of ...
... antagonist (VKA), such as warfarin, is a common but complex clinical problem, affecting an estimated 250 000 patients per year in North America alone or approximately 1 in 10 patients on chronic VKA.1 It is well established that continuing oral anticoagulation is associated with an increased risk of ...
How I treat anticoagulated patients undergoing an elective
... antagonist (VKA), such as warfarin, is a common but complex clinical problem, affecting an estimated 250 000 patients per year in North America alone or approximately 1 in 10 patients on chronic VKA.1 It is well established that continuing oral anticoagulation is associated with an increased risk of ...
... antagonist (VKA), such as warfarin, is a common but complex clinical problem, affecting an estimated 250 000 patients per year in North America alone or approximately 1 in 10 patients on chronic VKA.1 It is well established that continuing oral anticoagulation is associated with an increased risk of ...
Overview of Oral Modified-Release Opioid Products for
... There is considerable individual variability in the analgesic response to opioids and the development of ADEs.15 Patients who experience insufficient analgesia or excessive ADEs with one opioid are often switched to another in an effort to improve clinical response. Clinicians refer to equianalgesic ...
... There is considerable individual variability in the analgesic response to opioids and the development of ADEs.15 Patients who experience insufficient analgesia or excessive ADEs with one opioid are often switched to another in an effort to improve clinical response. Clinicians refer to equianalgesic ...
Meta-analysis of Oral Triptan Therapy for Migraine: Number Needed
... Nonetheless, nearly all triptan trials use comparable protocols. We therefore assumed, for the sake of analysis, that all placebocontrolled studies not involving direct comparison of triptans were fundamentally comparable.22 We used the clinical endpoint of pain free at 2 hours as the indicator of e ...
... Nonetheless, nearly all triptan trials use comparable protocols. We therefore assumed, for the sake of analysis, that all placebocontrolled studies not involving direct comparison of triptans were fundamentally comparable.22 We used the clinical endpoint of pain free at 2 hours as the indicator of e ...
Aspirin/Dipyridamole
... Metabolism: rapidly hydrolyzed in plasma to salicylic acid which is then conjugated in the liver to minor metabolites; conjugation is saturable Excretion: clearance is through the kidneys and decreases at higher concentrations Dipyridamole Absorption: readily but variable absorption from the GI trac ...
... Metabolism: rapidly hydrolyzed in plasma to salicylic acid which is then conjugated in the liver to minor metabolites; conjugation is saturable Excretion: clearance is through the kidneys and decreases at higher concentrations Dipyridamole Absorption: readily but variable absorption from the GI trac ...
Pocket Guide - Cancer Care Ontario
... options if agitation develops – particularly in cases where patient, family and staff safety may become threatened. Benzodiazepines may paradoxically excite some patients and should be avoided unless the source of delirium is alcohol or sedative drug withdrawal, or when severe agitation is not con ...
... options if agitation develops – particularly in cases where patient, family and staff safety may become threatened. Benzodiazepines may paradoxically excite some patients and should be avoided unless the source of delirium is alcohol or sedative drug withdrawal, or when severe agitation is not con ...
Prescribing Information
... The number of subjects (n=10) ≥65 years old treated with CLARINEX-D 12 HOUR Extended Release Tablets was too limited to make any formal statistical comparison regarding the efficacy or safety of this drug product in this age group, or to determine whether they respond differently from younger subjec ...
... The number of subjects (n=10) ≥65 years old treated with CLARINEX-D 12 HOUR Extended Release Tablets was too limited to make any formal statistical comparison regarding the efficacy or safety of this drug product in this age group, or to determine whether they respond differently from younger subjec ...
WHO Analgesic Ladder: Step 3 Methadone
... in the first days of treatment. Home visits may not be necessary and telephone calls may be adequate if the ...
... in the first days of treatment. Home visits may not be necessary and telephone calls may be adequate if the ...
Methadone
... First dose similar to MS dose effect Effect within about 30 min after oral administration Metabolism slow AND variable from patient to patient (No active Metabs) Lipid soluble, and protein binding: enters tissues and builds up over time Half life 10-75 hrs ...
... First dose similar to MS dose effect Effect within about 30 min after oral administration Metabolism slow AND variable from patient to patient (No active Metabs) Lipid soluble, and protein binding: enters tissues and builds up over time Half life 10-75 hrs ...
Levofloxacin 0.5% Eye Drops
... No teratogenic effect was observed when rabbits were dosed orally as high as 50 mg/kg/day, which corresponds to approximately 400 times the highest recommended maximum human ophthalmic dose, or when dosed intravenously as high as 25 mg/kg/day, corresponding to approximately 200 times the highest rec ...
... No teratogenic effect was observed when rabbits were dosed orally as high as 50 mg/kg/day, which corresponds to approximately 400 times the highest recommended maximum human ophthalmic dose, or when dosed intravenously as high as 25 mg/kg/day, corresponding to approximately 200 times the highest rec ...
O A
... ensure bio-availability of acetic acid, a period of 5 min was given to each animal following which period the number of writhing times was counted for 10 min. 1.6 Statistical analysis: Experimental values are expressed as mean ± SEM. Independent Sample t-test was carried out for statistical comparis ...
... ensure bio-availability of acetic acid, a period of 5 min was given to each animal following which period the number of writhing times was counted for 10 min. 1.6 Statistical analysis: Experimental values are expressed as mean ± SEM. Independent Sample t-test was carried out for statistical comparis ...
Pentazocine - e-SAFE
... This is mainly found with the l-isomer and in equipotent doses to that seen with morphine. Care is required in patients with impaired respiratory drive. Transient apnoea may occur in the neonate following its use in labour. Raised intracranial pressure Pentazocine increases intracranial fluid pressu ...
... This is mainly found with the l-isomer and in equipotent doses to that seen with morphine. Care is required in patients with impaired respiratory drive. Transient apnoea may occur in the neonate following its use in labour. Raised intracranial pressure Pentazocine increases intracranial fluid pressu ...
UKMi - Wolverhampton Formulary
... 48 hours after initiation of transdermal fentanyl or up-titration of the dose (11). Healthcare professionals should ensure patients and caregivers are aware of signs and symptoms of fentanyl overdose –i.e. trouble breathing or shallow breathing; tiredness; extreme sleepiness or sedation; inability t ...
... 48 hours after initiation of transdermal fentanyl or up-titration of the dose (11). Healthcare professionals should ensure patients and caregivers are aware of signs and symptoms of fentanyl overdose –i.e. trouble breathing or shallow breathing; tiredness; extreme sleepiness or sedation; inability t ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.