digoxin - DavisPlus
... ing therapy. Notify health care professional before giving dose if patient is hypokalemic. Hypokalemia, hypomagnesemia, or hypercalcemia may make the patient more susceptible to digitalis toxicity. Pedi: Neonates may have falsely elevated serum digoxin concentrations due to a naturally occurring sub ...
... ing therapy. Notify health care professional before giving dose if patient is hypokalemic. Hypokalemia, hypomagnesemia, or hypercalcemia may make the patient more susceptible to digitalis toxicity. Pedi: Neonates may have falsely elevated serum digoxin concentrations due to a naturally occurring sub ...
Guide to steroids (and other drugs)
... Injecting is dangerous, and there is no way to completely remove its risk. We’d urge everyone to consider trying to set realistic goals, and achieve them through training and diet. Steroids are usually injected, because taking tablets is less effective, and may cause liver damage. However, injecting ...
... Injecting is dangerous, and there is no way to completely remove its risk. We’d urge everyone to consider trying to set realistic goals, and achieve them through training and diet. Steroids are usually injected, because taking tablets is less effective, and may cause liver damage. However, injecting ...
1. NAME OF THE MEDICINAL PRODUCT Dompicare 20 mg, film
... In patients with severe renal impairment (GFR <30 ml/min/1.73 m2) the elimination half-life of domperidone was increased from 7.4 to 20.8 hours, but plasma drug levels were lower than in healthy volunteers, see sections 4.2, 4.4. 5.3. Preclinical safety data Electrophysiological in vitro and in vivo ...
... In patients with severe renal impairment (GFR <30 ml/min/1.73 m2) the elimination half-life of domperidone was increased from 7.4 to 20.8 hours, but plasma drug levels were lower than in healthy volunteers, see sections 4.2, 4.4. 5.3. Preclinical safety data Electrophysiological in vitro and in vivo ...
prescribing information
... approximately 19 hours (13% to 15% CV). The mean Cmax for sumatriptan when given as TREXIMET is similar to that of sumatriptan when given as IMITREX® (sumatriptan succinate) Tablets 100 mg alone. The median sumatriptan Tmax is only slightly different (1 hour for TREXIMET and 1.5 hours for IMITREX). ...
... approximately 19 hours (13% to 15% CV). The mean Cmax for sumatriptan when given as TREXIMET is similar to that of sumatriptan when given as IMITREX® (sumatriptan succinate) Tablets 100 mg alone. The median sumatriptan Tmax is only slightly different (1 hour for TREXIMET and 1.5 hours for IMITREX). ...
NOACs versus warfarin for stroke prevention in patients with AF: a
... not this contributes to gastrointestinal bleeding is unclear. RE-LY did note significantly more dyspepsia in both dabigatran doses than warfarin, which was the most likely adverse reaction leading to discontinuation of the study drug and contributed to the approximate 5% higher discontinuation of dab ...
... not this contributes to gastrointestinal bleeding is unclear. RE-LY did note significantly more dyspepsia in both dabigatran doses than warfarin, which was the most likely adverse reaction leading to discontinuation of the study drug and contributed to the approximate 5% higher discontinuation of dab ...
Role of azathioprine in preventing recurrences in a patient of
... complete abstinence while on therapy. After 5 days of this treatment, there was no fever and the joints pain were alleviated. The ENL lesions also started healing, with complete relief in 2 weeks. Prednisolone was reduced by 10 mg every week and then stopped after 4 weeks while thalidomide was reduc ...
... complete abstinence while on therapy. After 5 days of this treatment, there was no fever and the joints pain were alleviated. The ENL lesions also started healing, with complete relief in 2 weeks. Prednisolone was reduced by 10 mg every week and then stopped after 4 weeks while thalidomide was reduc ...
Anabolic Steroids hardcore info
... and swabs and a safe place to dispose of your used injecting equipment. It is a totally anonymous and confidential service with friendly staff who can provide you with sound advice and information about safer ways to inject. Increasingly many of the services now offer advice and health care to stero ...
... and swabs and a safe place to dispose of your used injecting equipment. It is a totally anonymous and confidential service with friendly staff who can provide you with sound advice and information about safer ways to inject. Increasingly many of the services now offer advice and health care to stero ...
SediationAnalgesiaNursingMgt
... It is within the scope of practice of registered nurses to administer medications for the purpose of induction of conscious (procedural) sedation for short-term therapeutic, diagnostic or surgical procedures. ...
... It is within the scope of practice of registered nurses to administer medications for the purpose of induction of conscious (procedural) sedation for short-term therapeutic, diagnostic or surgical procedures. ...
Corticosteroids in sports-related injuries: Friend or Foe
... Increased intraocular pressure has been reported in pediatric populations,28 patients over the age of 40 and those with a history of glaucoma.29 Sub-capsular cataract formation has been strongly associated with prednisolone administration and may be related to covalent binding between glucocorticoid ...
... Increased intraocular pressure has been reported in pediatric populations,28 patients over the age of 40 and those with a history of glaucoma.29 Sub-capsular cataract formation has been strongly associated with prednisolone administration and may be related to covalent binding between glucocorticoid ...
leucovorin - Cancer Care Ontario
... Leucovorin is not to be administered for the treatment of pernicious anemia or other megaloblastic anemias where vitamin B12 is deficient. Hematologic remission may occur while neurologic manifestations continue to progress. It is contraindicated for intrathecal use. The oral formulation contains l ...
... Leucovorin is not to be administered for the treatment of pernicious anemia or other megaloblastic anemias where vitamin B12 is deficient. Hematologic remission may occur while neurologic manifestations continue to progress. It is contraindicated for intrathecal use. The oral formulation contains l ...
ANTIVIRAL AGENTS pharm
... Oral bioavailability of acyclovir ranges from 10% - 30% and decreases with increasing dose. Peak plasma concentrations average 0.4 to 0.8 µgm/l after 200mg and 1.6µg/ml 800mg doses. Following intravenous administration, peak plasma concentration average 9.8 µg/ml after 5mg/kg per 8 hrs and 20.7µg/ml ...
... Oral bioavailability of acyclovir ranges from 10% - 30% and decreases with increasing dose. Peak plasma concentrations average 0.4 to 0.8 µgm/l after 200mg and 1.6µg/ml 800mg doses. Following intravenous administration, peak plasma concentration average 9.8 µg/ml after 5mg/kg per 8 hrs and 20.7µg/ml ...
Clinical pearls
... o Diminished bronchoprotective effect? Place in therapy: moderate and severe persistant asthma Clinical pearls o Not to be used to treat acute symptoms or exacerbations Should NEVER take o Tolerance? down regulation of B2 receptors from chronic use more than one puff of o NOT MONOTHERAPY SMART s ...
... o Diminished bronchoprotective effect? Place in therapy: moderate and severe persistant asthma Clinical pearls o Not to be used to treat acute symptoms or exacerbations Should NEVER take o Tolerance? down regulation of B2 receptors from chronic use more than one puff of o NOT MONOTHERAPY SMART s ...
MAR 2 ( ZuO6 Memorandum
... daily dosage for its Diosrnin 95 Complex is 600 mg, while the recommended daily dosage for Nutratech's 90 formulation is 500 mg. Both dosage levels axe well within the levels tested repeatedly in the studies that FDA has already reviewed as part of Nutratech's submission. In fact, as noted herein, m ...
... daily dosage for its Diosrnin 95 Complex is 600 mg, while the recommended daily dosage for Nutratech's 90 formulation is 500 mg. Both dosage levels axe well within the levels tested repeatedly in the studies that FDA has already reviewed as part of Nutratech's submission. In fact, as noted herein, m ...
evidence based pharmaco- clinical studies on ashwagandha
... better stress tolerance in rats. These results indicated a significant increase in plasma corticosterone level, phagocyte index, and avidity index in control rats, whereas these levels were near normal in WS rats subjected to the same test.14 Reduction in tumor incidence significantly (tumor inciden ...
... better stress tolerance in rats. These results indicated a significant increase in plasma corticosterone level, phagocyte index, and avidity index in control rats, whereas these levels were near normal in WS rats subjected to the same test.14 Reduction in tumor incidence significantly (tumor inciden ...
[Product Monograph Template
... Churg-Strauss syndrome, a condition which is often treated with systemic corticosteroid therapy. These events have been reported as occurring both with and without steroid withdrawal or reduction. Physicians should be alert to eosinophilia, vasculitic rash, arthralgia, worsening pulmonary symptoms, ...
... Churg-Strauss syndrome, a condition which is often treated with systemic corticosteroid therapy. These events have been reported as occurring both with and without steroid withdrawal or reduction. Physicians should be alert to eosinophilia, vasculitic rash, arthralgia, worsening pulmonary symptoms, ...
Document
... Belongs to family of analogs of ATP Display high affinity for P2Y12 receptor Potent inhibitor of ADP-induced aggregation of human washed platelets (PIC509.4 with 30 mol/L ADP) Does not require conversion to an active metabolite Immediately active after IV infusion Half-life of 3 to 6 min ...
... Belongs to family of analogs of ATP Display high affinity for P2Y12 receptor Potent inhibitor of ADP-induced aggregation of human washed platelets (PIC509.4 with 30 mol/L ADP) Does not require conversion to an active metabolite Immediately active after IV infusion Half-life of 3 to 6 min ...
Administration
... appropriate agent (the latter agent should be continued as clinically indicated). A second dose MAY be given after a 24-hour interval if there is no clinical improvement, and providing the renal function has not become impaired. In this case, it is not necessary to check the serum level of gentamici ...
... appropriate agent (the latter agent should be continued as clinically indicated). A second dose MAY be given after a 24-hour interval if there is no clinical improvement, and providing the renal function has not become impaired. In this case, it is not necessary to check the serum level of gentamici ...
NEWER ANTIPLATELETS
... Belongs to family of analogs of ATP Display high affinity for P2Y12 receptor Potent inhibitor of ADP-induced aggregation of human washed platelets (PIC509.4 with 30 mol/L ADP) Does not require conversion to an active metabolite Immediately active after IV infusion Half-life of 3 to 6 min ...
... Belongs to family of analogs of ATP Display high affinity for P2Y12 receptor Potent inhibitor of ADP-induced aggregation of human washed platelets (PIC509.4 with 30 mol/L ADP) Does not require conversion to an active metabolite Immediately active after IV infusion Half-life of 3 to 6 min ...
Gentamicin – Therapeutic drug monitoring
... interval if there is no clinical improvement, and providing the renal function has not become impaired. In this case, it is not necessary to check the serum level of gentamicin before giving the second dose. Should once-daily gentamicin be required for more than two doses, this should be guided by s ...
... interval if there is no clinical improvement, and providing the renal function has not become impaired. In this case, it is not necessary to check the serum level of gentamicin before giving the second dose. Should once-daily gentamicin be required for more than two doses, this should be guided by s ...
Comparison of the Circulating Metabolite Profile of PF
... Metabolite Identification in Hepatocytes. Stock solutions of unlabeled PF-04991532 were prepared in 10% dimethyl sulfoxide and 90% acetonitrile. The final concentration of dimethyl sulfoxide and acetonitrile in the incubation mixtures were 0.1 and 0.9%, respectively. Williams E media was prepared by ...
... Metabolite Identification in Hepatocytes. Stock solutions of unlabeled PF-04991532 were prepared in 10% dimethyl sulfoxide and 90% acetonitrile. The final concentration of dimethyl sulfoxide and acetonitrile in the incubation mixtures were 0.1 and 0.9%, respectively. Williams E media was prepared by ...
Topical Corticosteroids: Making Sense of the Options
... patients.9 Indeed, their retrospective case control study found that cataract patients younger than 65 with an axial length of > 29.0 mm had a 35-fold increased risk of having steroid-induced IOP spike to over 34 mmHg.9 Patients with any of these risk factors for elevated IOP during corticosteroid t ...
... patients.9 Indeed, their retrospective case control study found that cataract patients younger than 65 with an axial length of > 29.0 mm had a 35-fold increased risk of having steroid-induced IOP spike to over 34 mmHg.9 Patients with any of these risk factors for elevated IOP during corticosteroid t ...
Timoptic-XE® timolol maleate ophthalmic gel forming solution
... Beta-adrenergic receptor blockade in the bronchi and bronchioles results in increased airway resistance from unopposed parasympathetic activity. Such an effect in patients with asthma or other bronchospastic conditions is potentially dangerous. Pharmacokinetics In a study of plasma drug concentratio ...
... Beta-adrenergic receptor blockade in the bronchi and bronchioles results in increased airway resistance from unopposed parasympathetic activity. Such an effect in patients with asthma or other bronchospastic conditions is potentially dangerous. Pharmacokinetics In a study of plasma drug concentratio ...
REFERENCE GUIDE FOR THE PHARMACY
... specifically written for the preparation of NAPLEX® and Canadian Qualifying Exams. It contains over 1200 questions with answers and complete explanations. The exam puts more stress on trade names of drugs and therefore most questions have been formatted by using trade names instead of generic names. ...
... specifically written for the preparation of NAPLEX® and Canadian Qualifying Exams. It contains over 1200 questions with answers and complete explanations. The exam puts more stress on trade names of drugs and therefore most questions have been formatted by using trade names instead of generic names. ...
goline
... As with other ergot derivatives, Cabergoline should not be used in women with preeclampsia or postpartum hypertension. A single dose of 0.25 mg of Cabergoline should not be exceeded in nursing women treated for suppression of established lactation to avoid potential postural hypotension. Treatment o ...
... As with other ergot derivatives, Cabergoline should not be used in women with preeclampsia or postpartum hypertension. A single dose of 0.25 mg of Cabergoline should not be exceeded in nursing women treated for suppression of established lactation to avoid potential postural hypotension. Treatment o ...
Dianabol
... dianabol is normally used in a mass building stack to jumpstart gains in muscle mass and strength as well as to improve pumps. • The norm is to use a dose of 15-40 mg a day for a period of 46 weeks for this purpose. • Dianabol should not be used for more than eight weeks at the absolute maximum and ...
... dianabol is normally used in a mass building stack to jumpstart gains in muscle mass and strength as well as to improve pumps. • The norm is to use a dose of 15-40 mg a day for a period of 46 weeks for this purpose. • Dianabol should not be used for more than eight weeks at the absolute maximum and ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.