Clinical condition / indication(s) for use
... (GSL) and Pharmacy (P) medicines, and supply in prisons only of complete packs of the smallest available pack size of some GSL medicines to clients, by registered nurses employed by Worcestershire Health and Care NHS Trust. This policy enables a registered nurse to administer an agreed list of medic ...
... (GSL) and Pharmacy (P) medicines, and supply in prisons only of complete packs of the smallest available pack size of some GSL medicines to clients, by registered nurses employed by Worcestershire Health and Care NHS Trust. This policy enables a registered nurse to administer an agreed list of medic ...
Benzodiazepines: A Model for Central Nervous System
... • Short-acting BZDs – Consider tapering with the same drug – Most research involves alprazolam withdrawal • Original strategy: taper at a rate of 1mg q 3 days; however, many individuals taking the drug for longer than 12 weeks could not tolerate this strategy • More currently, taper at rate of 0.5mg ...
... • Short-acting BZDs – Consider tapering with the same drug – Most research involves alprazolam withdrawal • Original strategy: taper at a rate of 1mg q 3 days; however, many individuals taking the drug for longer than 12 weeks could not tolerate this strategy • More currently, taper at rate of 0.5mg ...
Presentation - Poorly water soluble substances: challenges
... • neurotoxic, adverse CNS effects, children below 6 years more susceptible, effects on developing brain! (prematures, neonates, infants) • exposure should be assessed as potential blood level after ingestion • CNS effects reported already at 0.01 g/L • What is a safe level after single dose/over tre ...
... • neurotoxic, adverse CNS effects, children below 6 years more susceptible, effects on developing brain! (prematures, neonates, infants) • exposure should be assessed as potential blood level after ingestion • CNS effects reported already at 0.01 g/L • What is a safe level after single dose/over tre ...
Intravenous Agents - RAH
... the combination of low clearance and large volume of distribution results in the relatively long elimination half-life, ie. most of the drug is in the tissues rather than plasma and thus is not available for hepatic elimination with larger or repeated doses, recovery is slow as there is accumulation ...
... the combination of low clearance and large volume of distribution results in the relatively long elimination half-life, ie. most of the drug is in the tissues rather than plasma and thus is not available for hepatic elimination with larger or repeated doses, recovery is slow as there is accumulation ...
North of England Cancer Network Palliative Care Guidelines
... If YES, prescribe Haloperidol 1.5-3mg daily by s-c injection (syringe driver if preferred) Also prescribe Cyclizine 50mg prn s-c, maximum 150mg/24hrs If NO, prescribe Cyclizine 150mg/24hrs via syringe driver Also prescribe Haloperidol 1.5mg s-c prn, maximum 3 doses in 24hrs If anxiolytic/sedative ef ...
... If YES, prescribe Haloperidol 1.5-3mg daily by s-c injection (syringe driver if preferred) Also prescribe Cyclizine 50mg prn s-c, maximum 150mg/24hrs If NO, prescribe Cyclizine 150mg/24hrs via syringe driver Also prescribe Haloperidol 1.5mg s-c prn, maximum 3 doses in 24hrs If anxiolytic/sedative ef ...
LUPRON DEPOT® 7.5 mg (leuprolide acetate for depot suspension)
... LUPRON DEPOT. Reports of anaphylactic reactions to GnRH agonist analogs have been reported in the medical literature. 2. All formulations of LUPRON DEPOT are contraindicated in women who are or may become pregnant while receiving the drug. LUPRON DEPOT may cause fetal harm when administered to a pre ...
... LUPRON DEPOT. Reports of anaphylactic reactions to GnRH agonist analogs have been reported in the medical literature. 2. All formulations of LUPRON DEPOT are contraindicated in women who are or may become pregnant while receiving the drug. LUPRON DEPOT may cause fetal harm when administered to a pre ...
NESCN Palliative Care Guidelines Guidance Sheets (v2June15)
... If 2 or more rescue doses are needed in 24 hours, start a syringe driver with morphine (or other opioid) and continue the patch(es). The morphine (or other opioid) dose in the syringe driver should equal the total rescue doses given in previous 24 hours up to a maximum of 50% of the existing regular ...
... If 2 or more rescue doses are needed in 24 hours, start a syringe driver with morphine (or other opioid) and continue the patch(es). The morphine (or other opioid) dose in the syringe driver should equal the total rescue doses given in previous 24 hours up to a maximum of 50% of the existing regular ...
Heart Listen - Men`s Health Network
... INFORMED OF THE POTENTIAL HAZARDS. If the patient becomes pregnant while taking this drug, therapy should be discontinued immediately and the patient apprised of the potential hazard to the fetus. WARNINGS Liver Enzymes HMG-CoA reductase inhibitors, like some other lipidlowering therapies, have been ...
... INFORMED OF THE POTENTIAL HAZARDS. If the patient becomes pregnant while taking this drug, therapy should be discontinued immediately and the patient apprised of the potential hazard to the fetus. WARNINGS Liver Enzymes HMG-CoA reductase inhibitors, like some other lipidlowering therapies, have been ...
Reassessing Bioavailability of Silymarin
... The aim of this technique is to encage silymarin into liposomal structures to make it more effective, safe, and targeted to liver cells. Liposomes are spherical, self-enclosed structures with a lipid bilayer (ranging from some nanometers to several micrometers) that possess a unique amphiphilic char ...
... The aim of this technique is to encage silymarin into liposomal structures to make it more effective, safe, and targeted to liver cells. Liposomes are spherical, self-enclosed structures with a lipid bilayer (ranging from some nanometers to several micrometers) that possess a unique amphiphilic char ...
Oncobiguanides: Paracelsus’ law and nonconventional routes
... assume the real possibility that the antitumoral activity of metformin can be attributed to its many direct actions on target cancer cells as shown in vitro, we should then consider that, in certain contexts, short-term exposure to higher doses of biguanides could have clinical use in oncology. Thus ...
... assume the real possibility that the antitumoral activity of metformin can be attributed to its many direct actions on target cancer cells as shown in vitro, we should then consider that, in certain contexts, short-term exposure to higher doses of biguanides could have clinical use in oncology. Thus ...
Brilinta - PI
... In PLATO, a >50% increase in serum creatinine levels was observed in 7.4% of patients receiving BRILINTA 90 mg compared to 5.9% of patients receiving clopidogrel. The increases typically did not progress with ongoing treatment and often decreased with continued therapy. Evidence of reversibility upo ...
... In PLATO, a >50% increase in serum creatinine levels was observed in 7.4% of patients receiving BRILINTA 90 mg compared to 5.9% of patients receiving clopidogrel. The increases typically did not progress with ongoing treatment and often decreased with continued therapy. Evidence of reversibility upo ...
to our motrin information package
... aggregation, but is not used therapeutically for this action since it is a minor and reversible effect. Adverse effects Ibuprofen appears to have the lowest incidence of gastrointestinal adverse drug reactions (ADRs) of all the non-selective NSAIDs. However, this only holds true at lower doses of ib ...
... aggregation, but is not used therapeutically for this action since it is a minor and reversible effect. Adverse effects Ibuprofen appears to have the lowest incidence of gastrointestinal adverse drug reactions (ADRs) of all the non-selective NSAIDs. However, this only holds true at lower doses of ib ...
Version 1
... the AUC of oral oxycodone. On average, the AUC was approximately 50% lower (range 37-57%). Rifampicin, a CYP3A4 inducer, administered as 600 mg once-daily for seven days, reduced the AUC of oral oxycodone. On average, the AUC was approximately 86% lower Drugs that inhibit CYP2D6 activity, such as ...
... the AUC of oral oxycodone. On average, the AUC was approximately 50% lower (range 37-57%). Rifampicin, a CYP3A4 inducer, administered as 600 mg once-daily for seven days, reduced the AUC of oral oxycodone. On average, the AUC was approximately 86% lower Drugs that inhibit CYP2D6 activity, such as ...
nausea and vomiting - KSU Faculty Member websites
... connected to the emetic center via nucleus tractus solitarius and its also contains afferent fibers which terminate at the CTZ. Because of its location within the area postrema , the CTZ is exposed to both cerebrospinal fluid and the systemic circulation thus; substances circulating in both fluids c ...
... connected to the emetic center via nucleus tractus solitarius and its also contains afferent fibers which terminate at the CTZ. Because of its location within the area postrema , the CTZ is exposed to both cerebrospinal fluid and the systemic circulation thus; substances circulating in both fluids c ...
1: gastro-intestinal system
... ‘Dry as a bone, blind as a bat, red as a beet, hot as a hare, mad as a hatter.’ The muscarinic receptors in salivary glands are very responsive to antimuscarinics and inhibition of salivation occurs at lower doses than required for other antimuscarinic effects.4 In some patients, a reduction in exce ...
... ‘Dry as a bone, blind as a bat, red as a beet, hot as a hare, mad as a hatter.’ The muscarinic receptors in salivary glands are very responsive to antimuscarinics and inhibition of salivation occurs at lower doses than required for other antimuscarinic effects.4 In some patients, a reduction in exce ...
Eulexin Manufacturer`s Data Sheet for Physicians
... tritium-labeled flutamide to human volunteers showed that the drug is rapidly and completely absorbed. Following a single 250 mg oral dose to normal adult volunteers, the biologically active alpha-hydroxylated metabolite reaches maximum plasma concentrations in about 2 hours, indicating that it is r ...
... tritium-labeled flutamide to human volunteers showed that the drug is rapidly and completely absorbed. Following a single 250 mg oral dose to normal adult volunteers, the biologically active alpha-hydroxylated metabolite reaches maximum plasma concentrations in about 2 hours, indicating that it is r ...
Drugs for Bacterial Infections
... - These medications do not halt the progression of Parkinson’s disease (PD): however, they do offer symptomatic relief from dyskinesias (e.g., bradykinesis, resting tremors, and muscle rigidity). - Levodopa may be used as a first-line medication for PD treatment - Pramipexole (Mirapex) is used as mo ...
... - These medications do not halt the progression of Parkinson’s disease (PD): however, they do offer symptomatic relief from dyskinesias (e.g., bradykinesis, resting tremors, and muscle rigidity). - Levodopa may be used as a first-line medication for PD treatment - Pramipexole (Mirapex) is used as mo ...
Slide 1
... If you don’t know the true relationship between dose and toxicity, how do you estimate the MTD? – Use the actual data from the study to estimate the dose-toxicity curve – Borrow data from other experiences What is the target dose of interest? – Dose that has 25% toxicity What is the proposed dose-to ...
... If you don’t know the true relationship between dose and toxicity, how do you estimate the MTD? – Use the actual data from the study to estimate the dose-toxicity curve – Borrow data from other experiences What is the target dose of interest? – Dose that has 25% toxicity What is the proposed dose-to ...
DRUG PROFILES Structural formula of Losartan
... Losartan and its active metabolite are highly bound to plasma proteins, primarily albumin, with plasma free fractions of 1.3% and 0.2%, respectively. Plasma protein binding is constant over the concentration range achieved with recommended doses. Studies in rats indicate that Losartan crosses the bl ...
... Losartan and its active metabolite are highly bound to plasma proteins, primarily albumin, with plasma free fractions of 1.3% and 0.2%, respectively. Plasma protein binding is constant over the concentration range achieved with recommended doses. Studies in rats indicate that Losartan crosses the bl ...
new zealand data sheet
... medicines which have been taken by a large number of pregnant women and women of childbearing age without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the foetus having been observed. Animal studies with amoxicillin have shown no teratogenic ef ...
... medicines which have been taken by a large number of pregnant women and women of childbearing age without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the foetus having been observed. Animal studies with amoxicillin have shown no teratogenic ef ...
Fentanyl citrate - Therapeutic Goods Administration
... sublingual route, there was a slight differences seen in absorption parameters (slower absorption in females and lower Cmax) which did not affect overall plasma exposure and bioavailability. Bioavailability for the sublingual route was predictably3 greater than the oral route at 73% for 0.01 mg/kg, ...
... sublingual route, there was a slight differences seen in absorption parameters (slower absorption in females and lower Cmax) which did not affect overall plasma exposure and bioavailability. Bioavailability for the sublingual route was predictably3 greater than the oral route at 73% for 0.01 mg/kg, ...
Antimicrobial Therapy
... The extrapolation of pharmacokinetic data to untested species is complicated by the fact that there may be differences in the way that even individuals and closely related species absorb and excrete antimicrobial drugs.15 For example, the aminoglycosides are excreted unchanged by the kidney, and the ...
... The extrapolation of pharmacokinetic data to untested species is complicated by the fact that there may be differences in the way that even individuals and closely related species absorb and excrete antimicrobial drugs.15 For example, the aminoglycosides are excreted unchanged by the kidney, and the ...
Full Prescribing Information
... Methylergonovine maleate acts directly on the smooth muscle of the uterus and increases the tone, rate, and amplitude of rhythmic contractions. Thus, it induces a rapid and sustained tetanic uterotonic effect which shortens the third stage of labor and reduces blood loss. The onset of action after i ...
... Methylergonovine maleate acts directly on the smooth muscle of the uterus and increases the tone, rate, and amplitude of rhythmic contractions. Thus, it induces a rapid and sustained tetanic uterotonic effect which shortens the third stage of labor and reduces blood loss. The onset of action after i ...
Sebastiania chamaelea Research Article N.YASODAMMA*, K.S.SHANTHI SREE, C.ALEKHYA
... astringent and used as a remedy for diarrhea by the herbalists. Hence antidiarrhoel activity of leaf extracts was carried out. Methods: Acute toxicity studies were carried out as per OECD guidelines up to 3000mg/kg b.w, observed for 14 days. Antidiarrhoel studies by castor oil induced fecal defecati ...
... astringent and used as a remedy for diarrhea by the herbalists. Hence antidiarrhoel activity of leaf extracts was carried out. Methods: Acute toxicity studies were carried out as per OECD guidelines up to 3000mg/kg b.w, observed for 14 days. Antidiarrhoel studies by castor oil induced fecal defecati ...
Med-Psych Drug-Drug Interactions Update Triptans
... ciprofloxacin (Cipro威), and grapefruit juice] would potentially increase plasma levels of the triptans and may worsen side effects/toxicity. Verapamil, a moderate inhibitor of 3A4, and fluoxetine, a moderate inhibitor of both 3A4 and 2D6, both caused a moderate increase in Cmax and AUC of almotripan ...
... ciprofloxacin (Cipro威), and grapefruit juice] would potentially increase plasma levels of the triptans and may worsen side effects/toxicity. Verapamil, a moderate inhibitor of 3A4, and fluoxetine, a moderate inhibitor of both 3A4 and 2D6, both caused a moderate increase in Cmax and AUC of almotripan ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.