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ocena dokumentacji chemicznej, farmaceutycznej i biologicznej
ocena dokumentacji chemicznej, farmaceutycznej i biologicznej

... A formal interaction study investigating the potential of drug interaction between nitrendipine and anticonvulsants has not been performed. However, phenytoin, phenobarbitone and carbamazepine are known as potential inducers of the cytochrome P450 3A4 system. Furthermore, concomitant administration ...
aluminum hydroxide - DavisPlus
aluminum hydroxide - DavisPlus

... Tablets must be chewed thoroughly before swallowing to prevent their entering small intestine in undissolved form. Follow with a glass of water. Shake liquid preparations well before pouring. Follow administration with water to ensure passage into stomach. Liquid dosage forms are considered more eff ...
Hx - Palliative Care
Hx - Palliative Care

... Methylphenidate LA 54 mg/day increased from 36mg/day 2 weeks ago during midterm exams PE BP 124/80 HR 95 T37C oral Pain 6/10 Mild tenderness, no peritoneal signs, no guarding no rebound no acute appendicitis Labs Lipase WNL Hcg negative Lithium WNL CBC (WBC normal) urinalysis normal ERP ...
Antifungal Agents
Antifungal Agents

... but the propensity for inhibition of mammalian P450 appears to be low.  Similar to itraconazole in tits spectrum of action, having good activity against candida species.  More effective than itraconazole. ...
New oral anticoagulants in severe trauma patients: Enemy at the
New oral anticoagulants in severe trauma patients: Enemy at the

... regarded as a potentially reversible cause of mortality provided surgical damage control measures are adopted or coagulopathy associated to trauma is avoided.3,4 Nevertheless, if the patient is under the effects of some anticoagulant medication, the risk of bleeding increases---especially if anticoa ...
a55f476935070a0
a55f476935070a0

... Digoxin is an inotropic agent primarily used to treat CHF and atrial fibrillation. It is incompletely absorbed and once absorbed a substantial fraction is cleared by kidneys . in the acute care seting historically digoxin loading dose of = 1 mg/70 kg were administered before the initiation of the us ...
Pharmacogenetic and pharmacological treatment in psychiatric
Pharmacogenetic and pharmacological treatment in psychiatric

... Brief introduction: Psychiatric medications metabolized by cytochrome 2D6, may lead to different clinical response, according to patient genetic profiles. Literature’s data show that caucasian population is divided in 7% as poor metabolizer, 36% intermediate metabolizer, 50% extensive and 7% ultrara ...
Poster presentation
Poster presentation

... severe pneumonia or very severe disease (WHO defined) severe malnutrition other infectious conditions requiring antibiotics therapy clinically recognized congenital heart disease known or clinically recognized chronic systemic disorder history of repeated wheezing including physicians diagnosed asth ...
File
File

... – Aid mechanical removal directly or by disrupting components of plaque – Characteristics include: • agents with selective antibacterial activity • substantivity (retention in the mouth) • compatibility with dentifrice ingredients (toothpaste) • reduced adverse effects • non interference with natura ...
Digoxin – Loading Dose Guide (Adults)
Digoxin – Loading Dose Guide (Adults)

... Digoxin is indicated in the management of chronic cardiac failure. The therapeutic benefit of digoxin is greater in patients with ventricular dilatation. Digoxin is specifically indicated where cardiac failure is accompanied by atrial fibrillation. Digoxin is indicated in the management of certain s ...
codeine (koe-deen) - DavisPlus
codeine (koe-deen) - DavisPlus

... Before administering, clarify all ambiguous orders; have second practitioner independently check dose calculations and route of administration. High Alert: Do not confuse codeine with Lodine (etodolac). Explain therapeutic value of medication before administration to enhance the analgesic effect. Re ...
Trastuzumab
Trastuzumab

... Trastuzumab therapy should be stopped immediately in patients who develop clinically significant congestive heart failure. When trastuzumab is used in the adjuvant setting, cardiac function should be assessed every 6 months for at least 2 years following the completion of therapy. Carefully monitor ...
Doctor Leaflet Mesulid 100 mg caplets
Doctor Leaflet Mesulid 100 mg caplets

... pre- and postimplantation loss and in embryonic-fetal mortality. Furthermore, an increased incidence of various malformations, including the cardiovascular one, has been reported in animals to which inhibitors of prostaglandin synthesis were administered during the period of organogenesis. Studies i ...
SINAREST-LEVO TABLETS
SINAREST-LEVO TABLETS

... Levocetirizine is an orally active and selective H1-receptor antagonist. It is the Renantiomer of cetirizine, a racemic compound with antihistaminic properties. Mechanism of Action In vitro studies have revealed that levocetirizine has an affinity for the human H1receptor, that is 2-fold higher than ...
Opportunistic Infections
Opportunistic Infections

... • Start therapy early (success is related to severity of the disease at the time of initiation of therapy). • Therapy is individualized (to reflect the immune deficit, tolerance of specific drugs, geographic location and the medical ...
Medical treatment for vertigo - ORL
Medical treatment for vertigo - ORL

... An overview of the medical treatment options currently available for vertigo in Belgium is given. The pharmacological properties, contra-indications, side-effects and dosage are discussed for each drug. For more detailed information we refer to textbooks on pharmacology.1-3 1. Acute unilateral vesti ...
balance - Ortho Molecular Products
balance - Ortho Molecular Products

... (8, 20 and 30 mg) over 3 menstrual cycles. Symptom severity was assessed by patients using scales for irritability, mood alteration, anger, headaches, bloating and breast fullness. They found that the treatment was well tolerated and improvement in total symptom score in the 20 mg group was signific ...
YAZ® and YASMIN - James A. Simon, MD
YAZ® and YASMIN - James A. Simon, MD

... statistically significant difference between the thromboembolism risk caused by pills with drospirenone and those with other progestogens. According to a Danish study, the risk for levonorgestrel (used in both studies for the basis of comparison) was 5.8 in 10,000 women per year, as compared to 7.8 ...
Allergy and Immunology Review Corner: Chapter 87 of
Allergy and Immunology Review Corner: Chapter 87 of

... In studies in volunteers inoculated a with rhinoviruses, some first-generation H1antihistamines such as chlorpheniramine and clemastine have been reported to reduce symptoms during colds, due in part to their antimuscarinic, anticholinergic actions. In this model, loratadine, desloratadine, and othe ...
vancomycin (van-koe-mye-sin) - DavisPlus
vancomycin (van-koe-mye-sin) - DavisPlus

... ● Lab Test Considerations: Monitor for casts, albumin, or cells in the urine or ...
complementary and alternative therapies
complementary and alternative therapies

... have other forms of complementary and alternative medicine (CAM). Surveys estimate that some 60 million Americans now use some form of CAM--from Gingko biloba (10.8 million) to St. John’s wort (7.5 million). Today, nearly one-third of the population has tried an herbal product, and $3.5 billion was ...
Migraine drug table
Migraine drug table

... q 8 hrs p.r.n. intractable headaches up to 5 doses; see protocol. 6 mg subcutaneously (adults) Can repeat in 1 hr 25 mg p.o. Nasal spray Effective even after headache is well established Not approved in kids 15-60 mg IM ...
PRODUCT INFORMATION CECLOR® (cefaclor monohydrate)
PRODUCT INFORMATION CECLOR® (cefaclor monohydrate)

... Antibiotic associated pseudomembranous colitis has been reported with many antibiotics including cefaclor. A toxin produced with Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in ...
The Pharmacological Management of Hypertension
The Pharmacological Management of Hypertension

... All patients should have at least an annual review of care ...
New Anesthesia Drugs Already here or on the Horizion
New Anesthesia Drugs Already here or on the Horizion

... Expensive ; Expensive; Expensive; Expensive ...
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Dydrogesterone



Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.
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