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Osteoprosis
Osteoprosis

Optimizing Chemotherapeutic Dose
Optimizing Chemotherapeutic Dose

... RESULTS and CONCLUSION: The time point of maximum impact of treatment is when the absolute value of the ratio of growth rates (perturbed/control) is greatest as determined by methods of calculus. For all dose levels analyzed this point averaged from 8.3-10.1 days into therapy, with the impact of tre ...
Schizophrenia II - Psychiatry Training
Schizophrenia II - Psychiatry Training

... – Prolactin elevation and extrapyramidal side effects (EPS) were characteristic side effect (e.g. haloperidol) – EPS: parkinsonism, akathisia, dystonia; were thought to be inextricably linked with antipsychotic efficacy ...
211 Aerosolized Robinul
211 Aerosolized Robinul

... The effectiveness and duration of robinul should be evaluated after the first dose, and after the first 24 hours of therapy. Robinul is to be administered as infrequently as possible. Limited clinical experience at SFGH has demonstrated effective control of secretions with q day treatments. Bronchod ...
amoxicillin (a-mox-i-sill-in) - DavisPlus
amoxicillin (a-mox-i-sill-in) - DavisPlus

... Most Infections ...
Anti-anemics
Anti-anemics

... associated with cancer or the therapy of cancer – MOA: Stimulates proliferation and maturation of red blood cells. – Pharmacokinetics: Route of administration: i.v., s.c. Hematocrit should be monitored to determined appropriate dose. – Side effects: Aggravation of hypertension. Thrombosis. ...
PACKAGE LEAFLET ALMAGEL A ATC code:AO2A B O2
PACKAGE LEAFLET ALMAGEL A ATC code:AO2A B O2

... Almagel A should not be used in combination with sulphonamides since their action is antagonized. Preferably, other drugs should be taken 1-2 hours before or after almagel A ingestion. The preparation contains sorbitol which permits its administration in diabetic patients as well. Usage longer than ...
Apo-Amoxycillin Capsules
Apo-Amoxycillin Capsules

... clinical use since 1972 and its suitability in human pregnancy has been well documented in clinical studies. Amoxycillin may be used in pregnancy when the potential benefits outweigh the potential risks associated with treatment. Category A: Drugs which have been taken by a large number of pregnant ...
Management of overdose and poisoning
Management of overdose and poisoning

... At the end of NAC infusion, a blood sample should be taken for determination of the INR, plasma creatinine and ALT. If any is abnormal or the patient is symptomatic, further monitoring is required and advice sought from the NPIS Patients with normal INR, plasma creatinine and ALT and who are asympto ...
A Case Study of Osteochemonecrosis
A Case Study of Osteochemonecrosis

... Surgery mentioned that the treatment duration of ONJ and the route of administration of bisphosphonate have an important role in the proliferation of the lesion. The intravenous form of bisphosphonate is especially concerned but also the oral form associated to invasive dental surgery that can contr ...
Lopinavir/Ritonavir solution (Kaletra)
Lopinavir/Ritonavir solution (Kaletra)

... scheduled dose, skip the missed dose and take your next dose at the usual time. Do not take two doses at the same time. Missed doses (especially if just one drug in the combination) may lead to the virus becoming resistant to all of the antiretroviral drugs that you are taking, reducing or eliminati ...
anadrol®-50 - Meda Pharmaceuticals
anadrol®-50 - Meda Pharmaceuticals

... The following conditions have been reported in patients receiving androgenic anabolic steroids as a general class of drugs: Peliosis hepatis, a condition in which liver and sometimes splenic tissue is replaced with blood-filled cysts, has been reported in patients receiving androgenic anabolic stero ...
Drug Information Sheet("Kusuri-no-Shiori") Internal Revised: 12
Drug Information Sheet("Kusuri-no-Shiori") Internal Revised: 12

... details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment. ...
PACKAGE LEAFLET TINIDAZOL ATC code
PACKAGE LEAFLET TINIDAZOL ATC code

... Antabus reaction (red colour of skin, tachycardia) is manifested when alcohol or alcohol-containing drugs have been used. It enhances the activity of the coumarin anticoagulants - the tendency for bleeding is augmented. Adaptation of the anticoagulant dose is needed during the treatment and 8 days a ...
Opioid Presentation (updated) [Compatibility Mode]
Opioid Presentation (updated) [Compatibility Mode]

... Term was originally used for drugs that produced sleep like state (narcosis), then for drugs (usually from opium) that both produced pain relief and sleep like state, it is no longer a medically useful term because it has been hi jacked into legal circles and is now often used to include many other ...
1315_Ansell_EB4E2
1315_Ansell_EB4E2

... • Thrombotic events occurred in five patients between 2-24 days after idarucizumab administration. None of these patients were receiving antithrombotic therapy at the time of their event. • 26 deaths, which appear to have been related to reason for emergency admission to the hospital and/or to co-mo ...
narcotics - The Podiatry Institute
narcotics - The Podiatry Institute

... applied to any drug that induced sleep, was for a number of years used to refer to morphine-like analgesics. Today, the term narcotic is no longer useful in a pharmacological context. With the advent of mixed agonist-antagonists, some of which do not suppress morphine-like physical dependence, and w ...
Carbamazepine VS Oxcarbazepine
Carbamazepine VS Oxcarbazepine

... • This drug does not use the liver cytochrome system and therefore does not result in such widespread drug interactions and is generally better tolerated. • However, be remembered that, given the chemical similarity of these drugs, allergic cross-reactions between the two drugs can occur ...
Symptom Relief
Symptom Relief

... in platelet aggregation the blood does not form clots as easily. The changes to the blood cell from ASA are irreversible, though the cell only lives from 5 to 7 days. ...
(PK) of LOXO-101 During the First-in-Human
(PK) of LOXO-101 During the First-in-Human

... dosing, the AUC between 0 and 12 hours was calculated by log-linear extrapolation of the measured concentrations at 6 and 8 hours through 12 hours. The extrapolated AUC was 9% of the AUC in all cases. For BID dosing, AUC0-24 was calculated as 2 x AUC0-12. ...
SPECTAZOLE (econazole nitrate 1%) Cream For Topical Use Only DESCRIPTION: 631-11-331-1
SPECTAZOLE (econazole nitrate 1%) Cream For Topical Use Only DESCRIPTION: 631-11-331-1

... Fertility (Reproduction): Oral administration of econazole nitrate in rats has been reported to produce prolonged gestation. Intravaginal administration in humans has not shown prolonged gestation or other adverse reproductive effects attributable to econazole nitrate therapy. Pregnancy: Pregnancy C ...
Alkylating Agents
Alkylating Agents

... Distribution Rapid and extensive to tissues. ...
47 CONSUMER INFORMATION DIFLUCAN
47 CONSUMER INFORMATION DIFLUCAN

... Usual dose: Take DIFLUCAN only as directed by your doctor. Overdose: In case of drug overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms. Missed Dose: If a dose of this medication has been missed, it ...
ONS Congress 2016
ONS Congress 2016

... • There is not sufficient evidence to say whether these interventions are effective or not ...
Pharmacokinetics
Pharmacokinetics

... • A small change in dose can produce a big change in plasma concentration • Rare except if elimination process is saturated (can occur with TCAs) ...
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Dydrogesterone



Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.
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