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Canonical Neural Computation: A Summary and a Roadmap A
Canonical Neural Computation: A Summary and a Roadmap A

... enable the experimenter to control precisely information processing demands. Answering such questions is a challenge because it is difficult to differentiate among neural elements in behaving animals. We cannot visualize neurons in vivo as we can in the slice, because in order to ensure that the ani ...
What is EEG? Elana Zion
What is EEG? Elana Zion

... Advantages and Disadvantages of the Method EEG has two clear advantages for brain research. The first is characteristic of any electrical recording system—high precision time measurements. Changes in the brain’s electrical activity occur very quickly, and extremely high time resolution is required t ...
Martin D. Cassell and Robin L. Davisson Puspha Sinnayah, Timothy
Martin D. Cassell and Robin L. Davisson Puspha Sinnayah, Timothy

... promise for investigating genes involved in nervous system function and pathology, although its application for studying central neural regulation of cardiovascular function and disease has not been explored. Here, we report for the first time that recombination of loxP-flanked genes can be achieved ...
PDF
PDF

... 2005; Stott and Kirik, 2006). However, infectivity with retroviruses was revealed to be modest relative to other viral vectors, and this is probably the reason why their first use in the developing mammalian brain has been exploited for clonal analysis (Luskin et al., 1988; Price and Thurlow, 1988; ...
Retinal target cells of the centrifugal projection from the isthmo
Retinal target cells of the centrifugal projection from the isthmo

... cells, even though recent studies reporting many types of axon-bearing amacrine cells have expanded the definition of amacrine cells (Dacey, 1989; Sterling, 1998; Volgyi et al., 2001). Dendrites of neurons are generally sites for integration of input from more than one source. On the other hand, the ...
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SOMATOSENSORY SYSTEMS
SOMATOSENSORY SYSTEMS

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LTP
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... III and V (Fig.2A, C, E-G) and small-size cells in other layers (Fig.2A, C). None of the immunopositive cells showed lithostathine staining in their nuclei. Positive cells were numerous in parietal cortex and more abundant in frontal, occipital and temporal cortex. In the hippocampus, we essentially ...
The NTVA framework: Linking Cognition and Neuroscience
The NTVA framework: Linking Cognition and Neuroscience

... change in firing rates with a single stimulus in the receptive field. This finding can be explained by the pigeonholing mechanism (e.g., Treue & Trujillo, 1999) or by the presence of other stimuli in the receptive field than the one defined by the experimenter: Even though an experiment is designed ...
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... neuron. Myelin is not part of the structure of the neuron but consists of a thick layer mostly made up of lipids, present at regular intervals along the length of the axon. • Such fibers are called myelinated fibers. • The water-soluble ions carrying the current across the membrane cannot permeate t ...
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NERVOUS SYSTEM PHYSIOLOGY 5 (updated)

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Cellular Components of Nervous Tissue
Cellular Components of Nervous Tissue

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10.4. What follows from the fact that some neurons we consider

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Unit XIV: Regulation
Unit XIV: Regulation

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the potential for abuse: addiction

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Neural Networks – An Introduction
Neural Networks – An Introduction

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[pdf]
[pdf]

... ‘attention’. A variety of attention-related modulatory effects on neural processing across the visual system have been demonstrated, such as increases in baseline activity [1], increases in response gain of neurons that selectively respond to an attended feature or location [2,3], as well as shifts ...
Bridging Rate Coding and Temporal Spike Coding
Bridging Rate Coding and Temporal Spike Coding

... than the time required for temporal averaging of spike signals necessary for obtaining firing rates. Actually, precisely timed reproducible spiking has been experimentally observed with a precision of milliseconds [1], suggesting the importance of precise spike timing in information processing. The ...
Intrusion detection pattern recognition using an Artificial Neural
Intrusion detection pattern recognition using an Artificial Neural

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Chapter 16
Chapter 16

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Marshmallow Test: Executive Functioning in Children and Teens
Marshmallow Test: Executive Functioning in Children and Teens

... • Experience for the nervous system involves the activation of neural firing in response to a stimulus. When neurons become active, their connections to each other grow and supportive cells proliferate. This is how experience shapes neural structure. ...
Polarization theory of motivations, emotions and
Polarization theory of motivations, emotions and

... functions of sensory systems. The theory connects neurophysiological mechanisms of mental phenomena with the change of metabolic and functional state of perceptive neurons, which is reflected in the degree of polarization of a cell membrane. Key words: motivations, emotions, attention, polarization ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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