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Supplemental Text Box 1 The Neurobiology of Arousal The defense
Supplemental Text Box 1 The Neurobiology of Arousal The defense

... increases in the gut, muscles, and skin, raising perfusion pressure and blood flow to the brain and the heart. Increased blood flow to the muscles will occur later, once skeletal muscles become active (e.g., via flight or fight). Temperature increases, and digestive activity, including intestinal pe ...
THE CELLULAR BASIS OF LIFE UNIT TWO
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... carry the motor and sensory messages that enable us to move and receive stimuli from the world around us. Neurons in our brains let us decipher all this information and make decisions accordingly. Unlike other cells in our bodies, neurons do not replace themselves when they die. We are born with all ...
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6.5 Nerves, Hormones and Homeostasis part 1

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Specific Projection of the Sensory Crypt Cells in
Specific Projection of the Sensory Crypt Cells in

... to the medial bundle of the medial olfactory tract mediating alarm reaction (Hamdani et al., 2001; Hamdani and Døving, 2002). Congruently, crypt neurons were labeled only by DiI injections into two specific ventral sites in catfish (Hansen et al., 2003). These findings, further, indicate that in the ...
Connectionist Models: Basics
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PDF

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Request pdf

... T o be regarded as specialized types of nerve cells are the receptor cells that are found at the first stage of any sensory system. T h e receptor can be defined as a neuron in which the generator potential is produced not by synaptic action but by particular environmental stimuli such as pressure, ...
No Slide Title
No Slide Title

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Chapter 11: Nervous System

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Name________________________ Midterm #1 Biology 3330, Fall
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a Tool for Relating Neuronal Form to Function

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Nerve Cells and Nervous Systems - ReadingSample - Beck-Shop

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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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