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Slides
Slides

... muscular system to effect bodily movement, and monitors the operation of internal organs like the heart and lungs by two-way signals. The brain and the spinal cord are generally referred to as the central nervous system, and the nerve network as the peripheral nervous system. The remainder of this l ...
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Advanced biomaterial strategies to transplant preformed micro
Advanced biomaterial strategies to transplant preformed micro

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bulbar pseudobulbar
bulbar pseudobulbar

... If a lesion occurs in the brain stem and damages both the nucleus of a cranial nerve and one side of the upper motor neurons of the pyramidal tract, a condition known as alternating hemiplegia may result. This involves paralysis of different structures on each side of the body. The lesion on the nu ...
Slide 1
Slide 1

... (listed on the left). The network is represented as a diagram of three neuronal systems (aminergic, reticular, and sensorimotor) that mediate REM sleep phenomena (depicted in tracings on the right). Postulated inhibitory connections are shown as red circles; postulated excitatory connections as gree ...
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Strategies for the Generation of Neuronal Diversity in the

... turned on in the floor plate, and at a time when cells are already specified to become motor neurons (Roelink et al., 1994). Indeed, there is evidence that some cells have already adopted a motor neuron identity before the floor plate has been specified (Yamada et al., 1993). While the presence of t ...
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chronic morphine exposure affects visual response latency of the

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introduction presentation - Sinoe Medical Association
introduction presentation - Sinoe Medical Association

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Ch 3 Biological Bases of Behavior

... • Tap your right finger when you see a command on a screen. It's a simple maneuver, yet carrying it out requires a vastly complicated series of actions. First, the image of the words on the screen (telling you to tap your finger) enters your eyes and strikes the retinas. The retinas then convert the ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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