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Correlated neuronal activity and the flow of neural information
Correlated neuronal activity and the flow of neural information

... Low frequency oscillation of fMRI signal and spontaneous activity at rest • When a long MRI time series data are analyzed in terms of frequency distribution, one can see the oscillation power is largely in the low frequency region, far below respiration rate. There are some peaks at 0.1Hz or at a l ...
LiuPoster - Department of Mathematics
LiuPoster - Department of Mathematics

... rat barrel cortex, the region of the somatosensory cortex that corresponds to whisker deflections. Whisker deflections first stimulate a specific group of neurons in the thalamus which send input to the barrel cortex. The barrel cortex is then able to detect synchrony levels in the thalamic neurons ...
short communication - Deep Blue
short communication - Deep Blue

... 1969). Direct connections between sensory fibers and stomatogastric elements within the ganglion have not yet been demonstrated, however (see Orlov, 1927). Although the changes described here in stomatogastric output associated with feeding could be explained in terms of a peripheral reflex involvin ...
unit 6 - nervous system / special senses
unit 6 - nervous system / special senses

... The cerebellum is a fascinating brain part that communicates with the brain and spinal cord. It helps to integrate and analyze information from the spinal cord and the cerebrum and is able to send impulses to further stimulate or inhibit skeletal muscles at appropriate times to cause movement of bod ...
10 - Computing and Cybernetics in the Soviet Union.pptx
10 - Computing and Cybernetics in the Soviet Union.pptx

... John von Neumann ...
1 - davis.k12.ut.us
1 - davis.k12.ut.us

... The cerebellum is a fascinating brain part that communicates with the brain and spinal cord. It helps to integrate and analyze information from the spinal cord and the cerebrum and is able to send impulses to further stimulate or inhibit skeletal muscles at appropriate times to cause movement of bod ...
Text S1.
Text S1.

... stimulation, while 60 of these (except corner electrodes CR11, CR18, CR81 and CR88) were used for recording (Figure S1-1B). In real MEAs, electrode CR15 is the large ground electrode and is not used for recording/stimulation (not shown in Figure S1-1A). In the simulated network, each electrode recor ...
Answer Key Chapter 28 - Scarsdale Public Schools
Answer Key Chapter 28 - Scarsdale Public Schools

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Brain Uncoupling Protein 2: Uncoupled Neuronal Mitochondria
Brain Uncoupling Protein 2: Uncoupled Neuronal Mitochondria

... sodium phosphate buffer (PB), pH 7.4. Brains were dissected, and 3-mmthick coronal blocks were post-fixed for an additional 1–2 hr. Thirty- or 50-mm-thick sections were cut on a vibratome. Sections were rinsed in 1% sodium borohydride in PB for 15 min to eliminate unbound aldehydes. For the mitochon ...
Interneuron Transplantation as a Treatment for
Interneuron Transplantation as a Treatment for

... During forebrain development, neural progenitors born in the dorsal telencephalon use radial glia as scaffolds and migrate along radial glial fibers to reach their final cortical destinations (Gotz and Huttner 2005; Molyneaux et al. 2007). In contrast, cortical interneurons are ventrally born, migra ...
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11Cranial nerve 8 (Vestibulo-cochlear)

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Neurophysiological foundations of sleep, arousal, awareness and
Neurophysiological foundations of sleep, arousal, awareness and

... the REM phase, the brain is isolated from motor neurons and does not respond to external stimuli, while the EEG is desynchronised, similar to the state of brain cortical arousal. In the mid-1930s, the first isolated brain samples were obtained in animal studies with precise separation of the respect ...
Why Neurons Cannot be Detectors: Shifting Paradigms from Sherlock Holmes... Elvis Presley? Nancy A. Salay ()
Why Neurons Cannot be Detectors: Shifting Paradigms from Sherlock Holmes... Elvis Presley? Nancy A. Salay ()

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Melting the Iceberg
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Contraction Properties of VLSI Cooperative Competitive Neural
Contraction Properties of VLSI Cooperative Competitive Neural

... Cooperative Competitive Networks (CCNs), which are an abstract representation of the cooperative-competitive connectivity observed in cortex. This specific type of network is believed to play a major role in shaping cortical responses and selecting the relevant signal among distractors and noise. In ...
Lateral prefrontal cortex
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neural control and coordination

... movements, balance of the body, functioning of vital involuntary organs (e.g., lungs, heart, kidneys, etc.), thermoregulation, hunger and thirst, circadian (24-hour) rhythms of our body, activities of several endocrine glands and human behaviour. It is also the site for processing of vision, hearing ...
Volitional enhancement of firing synchrony and oscillation by
Volitional enhancement of firing synchrony and oscillation by

... or excitation caused by reward delivery. Analysis of the firing rates and synchrony of individual neurons and neuron pairs during the conditioning revealed that the firing rates and synchrony of some but not all neurons and neuron pairs increased in each group of neighboring neurons (Figures 5, 6). ...
Neural networks.
Neural networks.

... Neural networks are adaptive statistical models based on an analogy with the structure of the brain. They are adaptive because they can learn to estimate the parameters of some population using a small number of exemplars (one or a few) at a time. They do not differ essentially from standard statist ...
The Biological Perspective - Virgil Zeigler-Hill
The Biological Perspective - Virgil Zeigler-Hill

... The Neural Impulse: The Action Potential  After the firing of an action potential, the membrane that allows sodium into the cell closes  It takes time before the neuron can fire again The absolute refractory period is the minimum length of time after an action potential during which another acti ...
Lecture 07 Part A - Artificial Neural Networks
Lecture 07 Part A - Artificial Neural Networks

... • A neuron only fires if its input signal exceeds a certain amount (the threshold) in a short time period. • Synapses play role in formation of memory – Two neurons are strengthened when both neurons are active at the same time – The strength of connection is thought to result in the storage of info ...
The Schizophrenic Brain: A Broken Hermeneutic
The Schizophrenic Brain: A Broken Hermeneutic

... exponents, fractal dimensions, entropies etc.) to characterize neurological categories are now well-known [18], the application of dynamic systems theory brought a breath of fresh air to the methodology of processing of neural signals. Schizophrenic symptoms may occur due to impairment in coupling o ...
Purkinje cells
Purkinje cells

...  The indirect pathway takes a detour from the striatum, (GABA) first to the external segment of the globus pallidus (GABA) and then to the subthalamic nucleus (Glu), before finally reaching the internal segment of the globus pallidus or the substantia nigra pars reticulata. The isgp and the snpr pr ...
PDF
PDF

... ter-type layer were more weakly correlated, while neurons within different eye-specific layers had the weakest, but still significant, correlations. If each retina independently generates spontaneous bursts of activity, there should be essentially no correlation between the patterns of spontaneous a ...
Receptor Theory and Biological Constraints on Value
Receptor Theory and Biological Constraints on Value

... To the degree that mental constructs of value become physically instantiated in the brain, Equation 2 describes how this transformation might occur (with certain assumptions). Under either interpretation, the utility may be that of a certain event or the value assigned to a lottery, in which case it ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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