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Cardiovascular drugs: some important interaction
Cardiovascular drugs: some important interaction

... • The most common mechanism of drug interaction • Competition occurs between the precipitant and object drug on the active site of the enzyme • Onset of interaction is rapid, occurring within hours • Non competitive mechanisms are existing less commonly • The enzyme inhibition is dose related • Reve ...
Tenesha Keyes - McMurry University
Tenesha Keyes - McMurry University

... intensified by hypnotic drugs. Suicidal tendencies may be present in such patients and protective measures may be required. Intentional over dosage is more common in these patients, and the least amount of drug that is feasible should be available to the patient at any one time (Roehrs 2002).” So if ...
業務核心
業務核心

... 4.A review of all significant deviations or non-conformances, their related investigations, and the effectiveness of resultant corrective and preventive ...
Drugs Used to Treat High Blood Pressure
Drugs Used to Treat High Blood Pressure

... as found in the study described above, an increased risk of cancer. It needs to be emphasized, however, that for those over 70 who have had previous cardiovascular disease, the use of statins may be beneficial. There are even questions as to whether elderly people who are hypertensive should have th ...
Maryland Corrections Sara Monnen
Maryland Corrections Sara Monnen

... (chemistry)) ...to see a marginally different version appear, using substances not covered in the original law. In the United States this problem was addressed in the Anti-Drug Abuse Act of 1986, which contained a Controlled Substance Analogue Enforcement Act (commonly called the Designer Drug Act), ...
movement disorders and ataxia
movement disorders and ataxia

... a. Acute: Bleed, infarct, toxins, drugs. Secondary edema may be life-threatening and require rapid neurosurgical intervention b. Subacute: Tumor, post-infectious cerebellitis, vasculitis, toxins, drugs. c. Chronic progressive: Alcoholism, Wilson's disease, drugs, toxins, Creutzfeldt-Jakob disease, h ...
designer drugs - Maryland Addictions Directors Council
designer drugs - Maryland Addictions Directors Council

... (chemistry)) ...to see a marginally different version appear, using substances not covered in the original law. In the United States this problem was addressed in the Anti-Drug Abuse Act of 1986, which contained a Controlled Substance Analogue Enforcement Act (commonly called the Designer Drug Act), ...
Antimycobacterials
Antimycobacterials

... to streptomycin develops readily, limiting its role as a single agent. Infections due to streptomycin-resistant organisms may be treated with kanamycin or amikacin (alternative second line drugs). Second line drugs 1. Ethionamide is a structural analog of INH and also blocks the synthesis of mycolic ...
Neuroleptics
Neuroleptics

... 1. Drugs with psychosedative action – they cause condition of psychomotor indifference (apathy, decreasing of moving activity, retarded emotions and wishes, disappearance of initiative) ...
Full Text Article
Full Text Article

... Bile acid sequestrants (e.g., colestipol [Colestid] and cholestyramine [Questran]) are generally not used in the treatment of hypercholesterolemia in patients with diabetes because they can raise TGs that may already be above target levels. DRUG INTERACTIONS IN HYPERTENSION As with dyslipidemia, the ...
Safety of ophthalmic drug therapy: focus on adverse efiects
Safety of ophthalmic drug therapy: focus on adverse efiects

... however do not require discontinuation of therapy. In the case of long-term treatment, the risk of side effects increases and has influence on the course of treatment. Sometimes it can be the reason for discontinuation of treatment, e.g. while taking preparations for the treatment of glaucoma (see T ...
Uppers, Downers, All Arounders, 7th Edition
Uppers, Downers, All Arounders, 7th Edition

... 2. Human brain chemistry can be affected by psychoactive drugs, behavioral addictions, and mental illness to induce an altered state of consciousness. If psychoactive drugs and behavioral addictions did not affect human brain chemistry in a desirable manner, they would not be used voluntarily. 3. Th ...
in the elderly
in the elderly

... treatment become more common. • Atypical presentation of diseases. • Expectations of both the family and the patient (people keep going to see the doctor until they get what they want). • There is no satisfactory doctor-patient relationship in time or in depth because of the crowded outpatient servi ...
Presentation - Chronice Myeloid Leukemia
Presentation - Chronice Myeloid Leukemia

... comparison with what we already use? AND cost effectiveness – how much more life or quality of life do we get for the extra money spent? A positive NICE appraisal has to be funded by the NHS: as the budget is fixed, something else has to be axed or delayed Main issue with NICE - too slow, so in 2007 ...
Protease inhibitors in chronic hepatitis C
Protease inhibitors in chronic hepatitis C

... The Canadian Liver Foundation (CLF) was the first organization in the world devoted to providing support for research and education into the causes, diagnoses, prevention and treatment of all liver disease. Through its chapters across the country, the CLF strives to promote liver health, improve pub ...
Overview of FDA`s Regulatory Framework for PET Drugs
Overview of FDA`s Regulatory Framework for PET Drugs

... PET Drugs-IND and RDRC • Producers of investigational PET drugs (IND) and research PET drugs (RDRC): – Option to follow the requirements in part 212 or to produce PET drugs in accordance with USP Chapter <823> ‘‘Radiopharmaceuticals for Positron Emission ...
THE ROLE OF LIPIDS IN DRUG ABSORPTION THROUGH THE GIT
THE ROLE OF LIPIDS IN DRUG ABSORPTION THROUGH THE GIT

... and Muller, 2007). LN can also be composed of PPL, which are used as surfactants surfacing the nanoparticles and stabilizing them in aqueous dispersions. LN are characterized by a solid matrix revealing high physicochemical stability, including the possibility to achieve controlled release and also ...
IJBCP International Journal of Basic & Clinical
IJBCP International Journal of Basic & Clinical

... blood transfusion. Frequency of PCV was according to severity of anemia and response to transfusion. For prompt and satisfactory response oral iron was started after PCV (Table 4). These findings are similar to other studies in United States (72%),22 Switzerland (65%),23 West Nepal (72%)24 and Egypt ...
drug-food interactions and role of pharmacist
drug-food interactions and role of pharmacist

... time foods and the medications are taken also play an important role. Avoidance of drug interactions does not necessarily mean avoiding drugs or foods. In the case of tetracycline and dairy products, these should simply be taken at different times; rather than eliminating one or the other from the d ...
Flamel Technologies to be Included in NASDAQ Biotech Index
Flamel Technologies to be Included in NASDAQ Biotech Index

... About Flamel Technologies - Flamel Technologies SA's (NASDAQ: FLML) business model is to blend highvalue internally developed products with its leading drug delivery capabilities. The Company markets Bloxiverz® (neostigmine methylsulfate) and Vazculep™ (phenylephrine hydrochloride) in the US and lic ...
Rx Side Effects: New Plaquenil Guidelines and More
Rx Side Effects: New Plaquenil Guidelines and More

... Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use, a ...
Triple C Fast Facts - Oregon Trail District
Triple C Fast Facts - Oregon Trail District

... young adults are the principal abusers of dextromethorphan and Triple C. Usually stocked on open shelves, Triple C is susceptible to shoplifting, which has caused some stores to place it behind the counter. Its accessibility and relatively low price make it particularly attractive to young people, e ...
Process Pharmacology: A Pharmacological Data Science Approach
Process Pharmacology: A Pharmacological Data Science Approach

... the GO knowledgebase (http://www.geneontology.org/6). Genes are annotated to a controlled vocabulary of GO terms (categories) providing a canonical description of their known biological functions.7,8 These are subdivided into molecular functions, cellular components, and biological processes. Relati ...
Mixed reviews for a stage-fright remedy
Mixed reviews for a stage-fright remedy

... amateur pianist, noted that beta blockers are inexpensive and relatively safe, and that they affect only physical, not cognitive, anxiety. "There's very little downside except whatever number you do on yourself about taking the drugs." But now that the drugs have established themselves as a seeming ...
6. Danesh A, Chen X, Davies MC, Roberts CJ, Sanders
6. Danesh A, Chen X, Davies MC, Roberts CJ, Sanders

... HCl3 (Shows polymorphism) etc. depends on their polymorphic forms. A particular polymorph shows more activity than other polymorphs of the same drug. Sometimes one of the polymorphs of the same drugs shows toxic effects. Polymorphism affects various kinds of physical and chemical properties dependin ...
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Orphan drug

An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.In the US and EU it is easier to gain marketing approval for an orphan drug, and there may be other financial incentives, such as extended exclusivity periods, all intended to encourage the development of drugs which might otherwise lack a sufficient profit motive. The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries, and has resulted in medical breakthroughs that may not have otherwise been achieved due to the economics of drug research and development.According to Thomson Reuters in their 2012 publication ""The Economic Power of Orphan Drugs"", there has been increased investing in orphan drug Research and Development partly due to the U. S. Orphan Drug Act (ODA) 1983 and similar Acts in other regions of the world and also driven by ""high-profile philanthropic funding."" The period between 2001 to 2011 was the ""most productive period in the history of orphan drug development, in terms of average annual orphan drug designations and orphan drug approvals."" For the same decade the compound annual growth rate (CAGR) of the orphan drugs was an ""impressive 25.8 percent, compared to only 20.1 percent for a matched control group of non-orphan drugs."" By 2012 the market for orphan drugs was worth USD$637 million compared to the USD$638 million matched control group of non-orphan drugs, Thomson Reuters.By 2012, ""the revenue-generating potential of orphan drugs [was] as great as for non-orphan drugs, even though patient populations for rare diseases are significantly smaller. Moreover, we suggest that orphan drugs have greater profitability when considered in the full context of developmental drivers including government financial incentives, smaller clinical trial sizes, shorter clinical trial times and higher rates of regulatory success.""
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