Oxcarbazepine (TrileptalTM)
... greater patent life. The patent gives a company the sole right to sell the drug while the patent is in effect. When patents or other periods of exclusivity expire, manufacturers can apply to the FDA to sell generic versions. http://www.fda.gov/cder/ogd/ ...
... greater patent life. The patent gives a company the sole right to sell the drug while the patent is in effect. When patents or other periods of exclusivity expire, manufacturers can apply to the FDA to sell generic versions. http://www.fda.gov/cder/ogd/ ...
Reduction in Medication Errors: The Fentora Case Study
... It seems very likely that the bulk of the medication errors and subsequent patient injuries due to Fentora were related to incorrect prescriptions written by physicians. Given that 74% of the total medication errors reports may be classified as prescribing errors, the area of concern seems to be phy ...
... It seems very likely that the bulk of the medication errors and subsequent patient injuries due to Fentora were related to incorrect prescriptions written by physicians. Given that 74% of the total medication errors reports may be classified as prescribing errors, the area of concern seems to be phy ...
Modern Methods in Drug Discovery
... Historical development in Germany Until 1961 there was no comprehensive legislation regarding marketing of medical drugs in the former Federal Republic of Germany. Decisive for the new legislation was the so-called Contergan-scandal: The resonsible substance thalodomid (a sedative) did not show any ...
... Historical development in Germany Until 1961 there was no comprehensive legislation regarding marketing of medical drugs in the former Federal Republic of Germany. Decisive for the new legislation was the so-called Contergan-scandal: The resonsible substance thalodomid (a sedative) did not show any ...
FDA`s Efforts to Encourage Biomarker Development and Qualification
... Preferred Definitions and Conceptual Framework. Clin. Ther. Pharmacol. 2001;69:89-95. ...
... Preferred Definitions and Conceptual Framework. Clin. Ther. Pharmacol. 2001;69:89-95. ...
Oral Absorption and the Biopharmaceutics Classification
... diffusion is the most predominant pathway for drug absorption, while paracellular diffusion is usually absent when molecules are larger than approximately 200 Dalton (4). However, small hydrophilic molecules such as water can cross the intercellular space readily. Disease states may increase the cha ...
... diffusion is the most predominant pathway for drug absorption, while paracellular diffusion is usually absent when molecules are larger than approximately 200 Dalton (4). However, small hydrophilic molecules such as water can cross the intercellular space readily. Disease states may increase the cha ...
P h a rmaceutical industry is short ... drugs. Whereas in past decades about 50-60 new
... drugs. Whereas in past decades about 50-60 new drugs (new chemical entities, NCEs) were approved every year and introduced into therapy, this number declined significantly in the last few years, reaching its historical low in the year 2000 with 27 NCE’s, 2001 with 24 NCEs, and 2002 with only 18 NCEs ...
... drugs. Whereas in past decades about 50-60 new drugs (new chemical entities, NCEs) were approved every year and introduced into therapy, this number declined significantly in the last few years, reaching its historical low in the year 2000 with 27 NCE’s, 2001 with 24 NCEs, and 2002 with only 18 NCEs ...
учитесь читать аннотации к лекарственным препаратам
... DRUG 1. Therapeutic agent used in the prevention, diagnosis, treatment or cure of disease. 2. General term for any substance, stimulating or depressing, that can be habituated or addictive (produce dependence), especially a narcotic. ...
... DRUG 1. Therapeutic agent used in the prevention, diagnosis, treatment or cure of disease. 2. General term for any substance, stimulating or depressing, that can be habituated or addictive (produce dependence), especially a narcotic. ...
SAFETY OF ORAL IBUPROFEN ñ ANALYSIS OF DATA FROM THE
... Among the reported cases, the first one occurred due to medical error connected with the incorrect administration of IBUM Forte soft capsules 400 mg. A soft capsule is a pharmaceutical form, which encloses medicines in a relatively stable shell allowing them to be taken orally. It should be swallowe ...
... Among the reported cases, the first one occurred due to medical error connected with the incorrect administration of IBUM Forte soft capsules 400 mg. A soft capsule is a pharmaceutical form, which encloses medicines in a relatively stable shell allowing them to be taken orally. It should be swallowe ...
Rise of Hallucinogen Use
... with the drug on themselves, other academics, local artists, and students. Leary was dismissed from Harvard for promoting LSD, but he continued to advocate its use as a positive mind-altering experience and identified psychedelics as part of a countercultural or lifestyle choice. Although nonmedical ...
... with the drug on themselves, other academics, local artists, and students. Leary was dismissed from Harvard for promoting LSD, but he continued to advocate its use as a positive mind-altering experience and identified psychedelics as part of a countercultural or lifestyle choice. Although nonmedical ...
PREPARATION AND SOLID STATE CHARACTERIZATION OF SIMVASTATIN
... correlation with results already reported [25]. It is suggested that these dissolution behaviors of all processed particles might be due to the amorphous nature. The dissolution profile obtained in the study clearly gives indication about the enhancement of solubility of the pure drug by using this ...
... correlation with results already reported [25]. It is suggested that these dissolution behaviors of all processed particles might be due to the amorphous nature. The dissolution profile obtained in the study clearly gives indication about the enhancement of solubility of the pure drug by using this ...
parasympathomimetic drugs
... Longer DOA as compared to ACh Therapeutic uses: given SC for the relief of paroxysmal atrial tachycardia ...
... Longer DOA as compared to ACh Therapeutic uses: given SC for the relief of paroxysmal atrial tachycardia ...
Formulation, Development and Characterization of Emulgel of
... delivery of piroxicam. Emulgel formulations of piroxicam were prepared using three types of gelling agents: Carbopol 934, Xanthan gum and HPMCK15M. Based on solubility studies Tween-80 and Span-80 as emulsifiers and propylene glycol as co-surfactant were selected for preparation of emulgel. The pers ...
... delivery of piroxicam. Emulgel formulations of piroxicam were prepared using three types of gelling agents: Carbopol 934, Xanthan gum and HPMCK15M. Based on solubility studies Tween-80 and Span-80 as emulsifiers and propylene glycol as co-surfactant were selected for preparation of emulgel. The pers ...
strategies to improve free drug tolerance in anti-drug
... Immunogenicity of biopharmaceutical products is a major concern in clinical and preclinical studies since it can lead to potentially serious side effects, loss of efficacy, and changes in drug exposure, complicating the interpretation of toxicity, pharmacokinetic (PK) and pharmacodynamic (PD) data1. ...
... Immunogenicity of biopharmaceutical products is a major concern in clinical and preclinical studies since it can lead to potentially serious side effects, loss of efficacy, and changes in drug exposure, complicating the interpretation of toxicity, pharmacokinetic (PK) and pharmacodynamic (PD) data1. ...
Drugs and the Drug Laws: Historical and Cultural Contexts
... alternative subcultures, hated minority groups and foreign enemies.22 An “us versus them” mentality frames the public debate, eventually singling out certain psychoactive substances more for their perceived relationship to unpopular social groups than for any deleterious effects of the drugs themse ...
... alternative subcultures, hated minority groups and foreign enemies.22 An “us versus them” mentality frames the public debate, eventually singling out certain psychoactive substances more for their perceived relationship to unpopular social groups than for any deleterious effects of the drugs themse ...
Enhancement of dissolution rate of poorly water
... dissolution properties of water-insoluble agents was investigated using diclofenac sodium as the model drug. Several formulations of liquisolid compacts having different drug concentration (40% to 60% w/w) and with varying ratios of carrier to coat (i.e., different R values, ranging from 5 to 15) we ...
... dissolution properties of water-insoluble agents was investigated using diclofenac sodium as the model drug. Several formulations of liquisolid compacts having different drug concentration (40% to 60% w/w) and with varying ratios of carrier to coat (i.e., different R values, ranging from 5 to 15) we ...
A Review: Stereochemical consideration and eudismic ratio in chiral
... superior in-vivo properties and clinical trials were conducted to determine the safety and efficacy of (S)-citalopram and (R)-fluoxetine. In case of citalopram, the S-enantiomer is primarily responsible for antagonism of serotonin reuptake while the (R)- enantiomer is 30 fold less potent. [16] In cl ...
... superior in-vivo properties and clinical trials were conducted to determine the safety and efficacy of (S)-citalopram and (R)-fluoxetine. In case of citalopram, the S-enantiomer is primarily responsible for antagonism of serotonin reuptake while the (R)- enantiomer is 30 fold less potent. [16] In cl ...
The First Amendment And Off-Label Promotion
... drug for a particular indication or indications in patients with the disease or condition. “Phase III” trials, are intended to gather additional information about effectiveness and safety that is needed to evaluate the overall benefit-risk relationship of the drug.5 Many drugs, like chemotherapy for ...
... drug for a particular indication or indications in patients with the disease or condition. “Phase III” trials, are intended to gather additional information about effectiveness and safety that is needed to evaluate the overall benefit-risk relationship of the drug.5 Many drugs, like chemotherapy for ...
Scope And Significance Of Floating Drug Delivery System
... on the natural physiology of the gastrointestinal tract and those that are designed to overcome it. Approaches such as size or floatation, which rely on delayed emptying from the stomach, depend on the normal physiological duration of the fed state of 4-8 h, following a meal and rather reproducible ...
... on the natural physiology of the gastrointestinal tract and those that are designed to overcome it. Approaches such as size or floatation, which rely on delayed emptying from the stomach, depend on the normal physiological duration of the fed state of 4-8 h, following a meal and rather reproducible ...
Fruit Juice Interactions - Drug Interactions by Hansten and Horn
... The Table lists drugs that are susceptible to grapefruit juice–induced inhibition of their first-pass metabolism and that may produce increased toxicity when administered with adequate amounts of grapefruit juice. In addition to being CYP3A4 substrates, each of these drugs has relatively low bioavai ...
... The Table lists drugs that are susceptible to grapefruit juice–induced inhibition of their first-pass metabolism and that may produce increased toxicity when administered with adequate amounts of grapefruit juice. In addition to being CYP3A4 substrates, each of these drugs has relatively low bioavai ...
Heads Up: Real News About Drugs and Your Body
... to get high or feel good at a party. Or they want to use them to help them study, lose weight, or for pain relief. We’ve already discussed some of the reasons not to use stimulants to study or painkillers without a prescription. But as far as getting high—my advice is that there are many things that ...
... to get high or feel good at a party. Or they want to use them to help them study, lose weight, or for pain relief. We’ve already discussed some of the reasons not to use stimulants to study or painkillers without a prescription. But as far as getting high—my advice is that there are many things that ...
A REVIEW ON BIOAVAILABILITY AND BIOEQUIVALENCE TRIALS AND ITS NECESSITY
... circulation following multiple dosing at steady state. Tmax It is the time required to achieve maximum drug concentration in systemic circulation. AUC 0t ...
... circulation following multiple dosing at steady state. Tmax It is the time required to achieve maximum drug concentration in systemic circulation. AUC 0t ...
Omnicare Diabetes Health Management Program
... “Multiple medications of the same pharmacological class/category or any medication that substantially duplicates a particular effect of another medication that the individual is taking.” “Duplicate therapy is generally not indicated, unless current clinical standards of practice and documented c ...
... “Multiple medications of the same pharmacological class/category or any medication that substantially duplicates a particular effect of another medication that the individual is taking.” “Duplicate therapy is generally not indicated, unless current clinical standards of practice and documented c ...
L-35 Drugs and Medicines
... earliest attempts at this, involved use of various plants. The knowledge was based on experience and was handed on from generation to generation. It is being used even today. In an attempt to conquer pain and disease, a large number of synthetic chemicals have been discovered. The chemicals used as ...
... earliest attempts at this, involved use of various plants. The knowledge was based on experience and was handed on from generation to generation. It is being used even today. In an attempt to conquer pain and disease, a large number of synthetic chemicals have been discovered. The chemicals used as ...