MUCOADHESIVE EFFECT OF POLYETHYLENEOXIDE ON FAMOTIDINE NANOSUSPENSION PREPARED BY SOLVENT EVAPORATION METHOD
... Low oral bioavailability of poorly water‐soluble drugs poses a great challenge during drug development. Poorly water‐soluble compounds are difficult to develop as drug products using conventional formulation techniques and are frequently abandoned early in discovery. The aim of the ...
... Low oral bioavailability of poorly water‐soluble drugs poses a great challenge during drug development. Poorly water‐soluble compounds are difficult to develop as drug products using conventional formulation techniques and are frequently abandoned early in discovery. The aim of the ...
EVALUATION OF TAMARIND SEED POLYSACCHARIDE AS ABIODEGRADABLE CARRIER FOR COLON SPECIFIC DRUG DELIVERY
... therapeutically desirable, especially in the case of diseases which are affected by Circardian rythems2. Ulcerative colitis is currently treated with anti‐inflammatory medications such as sulfasalazine3. Enemas and suppositories are not effective for extensive proximal ulcer ...
... therapeutically desirable, especially in the case of diseases which are affected by Circardian rythems2. Ulcerative colitis is currently treated with anti‐inflammatory medications such as sulfasalazine3. Enemas and suppositories are not effective for extensive proximal ulcer ...
development and in vitro evaluation of buccoadhesive tablets
... of the rich blood supply and direct access to systemic circulation. The Buccal route is suitable for drugs, which are susceptible to acid hydrolysis in the stomach or which are extensively metabolized in the liver (first pass effect). Oral controlled release (CR) systems continue to be most popular ...
... of the rich blood supply and direct access to systemic circulation. The Buccal route is suitable for drugs, which are susceptible to acid hydrolysis in the stomach or which are extensively metabolized in the liver (first pass effect). Oral controlled release (CR) systems continue to be most popular ...
The Drug Treatment of Parkinson`s Disease
... Controlled release preparations of Madopar and Sinemet Controlled release preparations are recognised by the letters HBS or CR after the drug name. Madopar HBS and Sinemet CR release the drug over a four to six hour period and may result in more even levels of levodopa in the blood. If replacing sta ...
... Controlled release preparations of Madopar and Sinemet Controlled release preparations are recognised by the letters HBS or CR after the drug name. Madopar HBS and Sinemet CR release the drug over a four to six hour period and may result in more even levels of levodopa in the blood. If replacing sta ...
Introduction of new drugs and drug regimens for the management of
... clinical access programme to treat selected DR- TB patients with bedaquiline (BDQ) in March 2013. In October 2014, the MCC approved the use of bedaquiline for the treatment of MDR-TB. Already before bedaquiline was introduced, the NTP has identified the need for new drugs for the treatment of TB. Th ...
... clinical access programme to treat selected DR- TB patients with bedaquiline (BDQ) in March 2013. In October 2014, the MCC approved the use of bedaquiline for the treatment of MDR-TB. Already before bedaquiline was introduced, the NTP has identified the need for new drugs for the treatment of TB. Th ...
Multisource drug product
... Multisource drug product is a drug product that contains the same active drug substance in the same dosage form and is marketed by more than one pharmaceutical manufacturer. Single-source drug products are drug products for which the patent has not yet expired or has certain exclusivities so that on ...
... Multisource drug product is a drug product that contains the same active drug substance in the same dosage form and is marketed by more than one pharmaceutical manufacturer. Single-source drug products are drug products for which the patent has not yet expired or has certain exclusivities so that on ...
manuscript_rajeev k singla
... Impurities in pharmaceuticals are the unwanted chemicals that remain with the active pharmaceutical ingredients (APIs), or develop during formulation, or upon aging of both API and formulated APIs to medicines. The presence of these unwanted chemicals even in small amounts may influence the efficacy ...
... Impurities in pharmaceuticals are the unwanted chemicals that remain with the active pharmaceutical ingredients (APIs), or develop during formulation, or upon aging of both API and formulated APIs to medicines. The presence of these unwanted chemicals even in small amounts may influence the efficacy ...
Drug prescribing pattern of topical corticosteroids
... prescription, and use of drugs in a society as the drug utilization research, with particular stress on the consequences of medical, social, and economic aspects.[10] Such studies form the influential exploratory tools to determine the role of drugs in the society. They give rise to a strong sociome ...
... prescription, and use of drugs in a society as the drug utilization research, with particular stress on the consequences of medical, social, and economic aspects.[10] Such studies form the influential exploratory tools to determine the role of drugs in the society. They give rise to a strong sociome ...
NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) AND
... resources on behalf of their patients. These resources include not only interventions provided by themselves but also those offered by other health-related disciplines. Most patients presenting for physiotherapy treatment have received, or are are currently receiving, some form of pharmacotherapy of ...
... resources on behalf of their patients. These resources include not only interventions provided by themselves but also those offered by other health-related disciplines. Most patients presenting for physiotherapy treatment have received, or are are currently receiving, some form of pharmacotherapy of ...
P. aeruginosa
... be given 20 to 40 mg/kg/d up to a maximum of 1 g/d. Except for cefuroxime axetil, these drugs are not predictably active against penicillin-resistant pneumococci and should be used cautiously, if at all, to treat suspected or proved pneumococcal infections. Cefaclor is more susceptible to β-lactamas ...
... be given 20 to 40 mg/kg/d up to a maximum of 1 g/d. Except for cefuroxime axetil, these drugs are not predictably active against penicillin-resistant pneumococci and should be used cautiously, if at all, to treat suspected or proved pneumococcal infections. Cefaclor is more susceptible to β-lactamas ...
basic concepts and importance of various pharmacokinetic parameters
... Exercise increases cardiac output, but diverts blood flow away from the liver and could decrease the hepatic clearance of drugs. According to the degree of the hepatic extraction ratio, drugs may be classified as high, intermediate and low extracted drugs. In general, a highly-cleared drug is effici ...
... Exercise increases cardiac output, but diverts blood flow away from the liver and could decrease the hepatic clearance of drugs. According to the degree of the hepatic extraction ratio, drugs may be classified as high, intermediate and low extracted drugs. In general, a highly-cleared drug is effici ...
Extrapyramidal motor side-effects of first
... and sometimes in anticipation of such problems. To distinguish between patients receiving anticholinergic adjuncts in each study arm, the sample was stratified according to whether adjunctive medication was prescribed, effectively creating four treatment groups: (a) first-generation antipsychotic al ...
... and sometimes in anticipation of such problems. To distinguish between patients receiving anticholinergic adjuncts in each study arm, the sample was stratified according to whether adjunctive medication was prescribed, effectively creating four treatment groups: (a) first-generation antipsychotic al ...
karnataka, bengaluru
... of oral chewable tablets which suppressed the bitter taste of acetaminophen, often used as an antipyretic for infants. Corn starch/lactose, cacao butter and hard fat (Witepsol H-15) were used for matrix bases, and sucrose, cocoa powder and commercial bitter-masking powder mixture made from lecithin ...
... of oral chewable tablets which suppressed the bitter taste of acetaminophen, often used as an antipyretic for infants. Corn starch/lactose, cacao butter and hard fat (Witepsol H-15) were used for matrix bases, and sucrose, cocoa powder and commercial bitter-masking powder mixture made from lecithin ...
FORMULATION AND CHARACTERIZATION OF DRUG IN ADHESIVE TRANSDERMAL PATCHES Research Article
... The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug Diclofenac acid, Pressure Sensitive Adhesive (PSA) like acrylic adhesive by the solvent evaporation technique. Different concentrations of Labrasol, oleic acid and triacetin were used to enhance ...
... The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug Diclofenac acid, Pressure Sensitive Adhesive (PSA) like acrylic adhesive by the solvent evaporation technique. Different concentrations of Labrasol, oleic acid and triacetin were used to enhance ...
Chapter-7 Summary
... motion. After oral administration, SEDDS can maintain the poorly soluble drugs dissolved in the fine oil droplets when transiting through the GIT. Nanoemulsions have been reported to make the plasma concentration profiles and bioavailability of poorly soluble drugs more reproducible. Nanoemulsions h ...
... motion. After oral administration, SEDDS can maintain the poorly soluble drugs dissolved in the fine oil droplets when transiting through the GIT. Nanoemulsions have been reported to make the plasma concentration profiles and bioavailability of poorly soluble drugs more reproducible. Nanoemulsions h ...
ADULTERATION OF HERBAL MEDICINES AND DIETARY SUPPLEMENTS WITH UNDECLARED
... which are toxic for human health [4]. There is an emerging growing trend of marketing of dietary supplements or conventional foods or natural products with hidden drugs and harmful chemicals all over the world. Some under-developing countries have no specific rules and controlling system and authori ...
... which are toxic for human health [4]. There is an emerging growing trend of marketing of dietary supplements or conventional foods or natural products with hidden drugs and harmful chemicals all over the world. Some under-developing countries have no specific rules and controlling system and authori ...
false positive and false negative results in urine drug screening tests
... occurs, the binding of Ag and Ab may not be created. For example adding appropriate NaCl to urine environment may cause a false negative result (7, 8). All UDSTs used in labs have cut off levels. It is a level of substance in the system that is considered as a positive if the substance is revealed a ...
... occurs, the binding of Ag and Ab may not be created. For example adding appropriate NaCl to urine environment may cause a false negative result (7, 8). All UDSTs used in labs have cut off levels. It is a level of substance in the system that is considered as a positive if the substance is revealed a ...
Adrenergic_antagonists
... It produces arterial & venous dilation. So it decreases BP, so it is used for the treatment of hypertension It causes less tachycardia than non–selective vasodilators (because it doesn’t act on α2 receptors) It precipitates less angina & cardiac arrhythmia It may increase HDL / cholesterol ratio. HD ...
... It produces arterial & venous dilation. So it decreases BP, so it is used for the treatment of hypertension It causes less tachycardia than non–selective vasodilators (because it doesn’t act on α2 receptors) It precipitates less angina & cardiac arrhythmia It may increase HDL / cholesterol ratio. HD ...
Anticholinergic drugs
... SCh is rapidly hydrolyzed by plasma pseudocholinesterase to succinylmonocholine and then to succinic acid and choline (the action lasts 3–5 min). Some patients (1:3000) have genetically determined abnormality (low affinity for SCh) or deficiency of pseudocholinesterase. In these patients SCh causes ...
... SCh is rapidly hydrolyzed by plasma pseudocholinesterase to succinylmonocholine and then to succinic acid and choline (the action lasts 3–5 min). Some patients (1:3000) have genetically determined abnormality (low affinity for SCh) or deficiency of pseudocholinesterase. In these patients SCh causes ...
Slide 1
... SCh is rapidly hydrolyzed by plasma pseudocholinesterase to succinylmonocholine and then to succinic acid and choline (the action lasts 3–5 min). Some patients (1:3000) have genetically determined abnormality (low affinity for SCh) or deficiency of pseudocholinesterase. In these patients SCh causes ...
... SCh is rapidly hydrolyzed by plasma pseudocholinesterase to succinylmonocholine and then to succinic acid and choline (the action lasts 3–5 min). Some patients (1:3000) have genetically determined abnormality (low affinity for SCh) or deficiency of pseudocholinesterase. In these patients SCh causes ...
Pharmaceutical Applications of Ispaghula Husk
... with plasma LDL cholesterol levels and coronary heart disease risk. Intake of dietary fibers known to lower the concentration of LDL in plasma is considered to be highly beneficial. Psyllium intake has consistently shown significant reductions in plasma LDL cholesterol levels ranging from 10 to 24%. ...
... with plasma LDL cholesterol levels and coronary heart disease risk. Intake of dietary fibers known to lower the concentration of LDL in plasma is considered to be highly beneficial. Psyllium intake has consistently shown significant reductions in plasma LDL cholesterol levels ranging from 10 to 24%. ...
issa`s guide to the regulation of antibacterial hand soaps
... Products eligible for the review: Only products having the same formulation, labeling and dosage as those that existed in the marketplace on or before December 4, 1975 are eligible for the Drug Review. All hand sanitizers included in the Review require a water rinse followed by drying except: "insta ...
... Products eligible for the review: Only products having the same formulation, labeling and dosage as those that existed in the marketplace on or before December 4, 1975 are eligible for the Drug Review. All hand sanitizers included in the Review require a water rinse followed by drying except: "insta ...
RSPT 1410 Common Respiratory Drugs
... DNA in the sputum • the change in sputum viscosity is dose dependent – greater reduction occurs at higher concentrations of the drug ...
... DNA in the sputum • the change in sputum viscosity is dose dependent – greater reduction occurs at higher concentrations of the drug ...
Cyclodextrins as Sustained
... DE--CD and retarded by complexation with -CD. Complexation with DE--CD also led to a better dissolution of TNG from the ointment base, giving better percutaneous absorption. -CD retarded drug release because of its hydrophilic character, which led to decreased solubility of the drug in the ointm ...
... DE--CD and retarded by complexation with -CD. Complexation with DE--CD also led to a better dissolution of TNG from the ointment base, giving better percutaneous absorption. -CD retarded drug release because of its hydrophilic character, which led to decreased solubility of the drug in the ointm ...
Sedative–hypnotic and Anxiolytic Drugs
... absorbed by this route. Since the benzodiazepines are weak bases, they are less ionized in the relatively alkaline environment of the small intestine, and therefore, most of their absorption takes place at this site. For emergency treatment of seizures or when used in anesthesia, the benzodiazepines ...
... absorbed by this route. Since the benzodiazepines are weak bases, they are less ionized in the relatively alkaline environment of the small intestine, and therefore, most of their absorption takes place at this site. For emergency treatment of seizures or when used in anesthesia, the benzodiazepines ...