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Basic concepts of Pharmacology. Pharmacokinetics of drugs.
Basic concepts of Pharmacology. Pharmacokinetics of drugs.

... 6. The characteristic of direct and indirect, reversible and irreversible, main and adverse (side) action. 7. Dependence of action of drugs on external factors. A doze (definition, classification). a therapeutic index. 8. Dependence of action of drugs on physical and chemical properties (solubility, ...
EFFECT OF POLOXAMER 188 ON IN VITRO DISSOLUTION
EFFECT OF POLOXAMER 188 ON IN VITRO DISSOLUTION

... indicates the solvent properties of poloxamer 188 for the drug. Poloxamer 188 causes a decrease of interfacial tension between the drug and dissolution medium. These results could be explained that the reduction in crystallinity of drug led to a decrease of the energy required in the dissolving proc ...
NIOSH List of Hazardous Drugs - University of Kansas Medical Center
NIOSH List of Hazardous Drugs - University of Kansas Medical Center

... presented here, each organization should create its own list of drugs considered to be hazardous. This document presents guidance for making such a facility-specific list (see section entitled How to Generate your own List of Hazardous Drugs). Once this list is made, newly purchased drugs should be ...
Pharmaceutical and Medical Pharmaceutical and Medical
Pharmaceutical and Medical Pharmaceutical and Medical

... ages from birth to adolescence. Information in BNFC has been validated against emerging evidence, best practice guidelines, and advice from a network of clinical experts. The text is published under the authority of a Paediatric Formulary Committee. ...
American Geriatrics Society Updated Beers Criteria for - Geri-EM
American Geriatrics Society Updated Beers Criteria for - Geri-EM

... comes. Estimates from past studies in ambulatory and longterm care settings found that 27% of adverse drug events (ADEs) in primary care and 42% of ADEs in long-term care were preventable, with most problems occurring at the ordering and monitoring stages of care.1,2 In a study of the 2000/2001 Medi ...
Fast Dissolving Tablets- A Novel Approach
Fast Dissolving Tablets- A Novel Approach

... with ever increasing demand. Fast dissolving tablet (FDT) is one such type of an innovative and unique drug delivery system which is swiftly gaining much attention in the research field of rapid dissolving technology. Oral route is the most expedient and safest route of drug delivery because of wide ...
Pacemaker-ICD/Drug Interaction
Pacemaker-ICD/Drug Interaction

... cycle length; 5) change from sustained to nonsustained VT, resulting in inappropriate shock during nonsustained VT; 6) alternation in post-shock excitability, and 7) increase in pacing threshold.15 Regarding the alternations in DFT, ancillary antiarrhythmic drug therapy may have clinically significa ...
vocsigjan98
vocsigjan98

... potential routes in a specific dose form. • A drug is a static entity. It is associated with a set of appropriate routes by which that drug may be administered when being used to treat a patient • The actual route is part of the order HL7 Vocabulary SIG Meeting 1/13/98 ...
Synthetic cannabinoid case study – various brands | Male
Synthetic cannabinoid case study – various brands | Male

... NPS packaging is normally bright, colourful and appealing, although they can also be purchased in clear unmarked bags or wraps. The marketing of each category of drug can also follow common themes. For example cannabinoids often use brand names which describe the effect and may sound dark and sinist ...
causality assessment in drug induced liver injury
causality assessment in drug induced liver injury

... hepatic biochemical tests, may not be detected in today’s clinical trials. ...
DMID 01-553 FQ EBA Study Results
DMID 01-553 FQ EBA Study Results

... XE ...
American Geriatrics Society Updated Beers Criteria for
American Geriatrics Society Updated Beers Criteria for

... comes. Estimates from past studies in ambulatory and longterm care settings found that 27% of adverse drug events (ADEs) in primary care and 42% of ADEs in long-term care were preventable, with most problems occurring at the ordering and monitoring stages of care.1,2 In a study of the 2000/2001 Medi ...
Preferred Drug List - NYS Medicaid Pharmacy Prior Authorization
Preferred Drug List - NYS Medicaid Pharmacy Prior Authorization

... State law excludes Medicaid coverage of brand name drugs that have a Federal Food and Drug Administration (FDA) approved A-rated generic equivalent, unless a prior authorization is obtained. Drugs subject to the Preferred Drug Program (PDP), Clinical Drug Review Program (CDRP), and/or the Brand Less ...
Day 5 Session 1 OST june 13
Day 5 Session 1 OST june 13

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contaminantion in herbal drug and preparations
contaminantion in herbal drug and preparations

... integrate phytotherapy into their doctrines even though they are based on different cultural models. Pharmacist and physicians should be more aware about safety of herbal preparation as use of these preparations is increasing by patients day by day. Chemical compounds of herbal drugs could also be h ...
of  2011 Edition A DEA REsouRcE GuiDE
of 2011 Edition A DEA REsouRcE GuiDE

... data and make a final decision whether to propose that a drug or other substance should be removed or controlled and into which schedule it should be placed. If a drug does not have a potential for abuse, it cannot be controlled. Although the term “potential for abuse” is not defined in the CSA, the ...
Content and Format of an Investigational New Drug (IND) Application
Content and Format of an Investigational New Drug (IND) Application

... the investigational drug has been obtained, and are intended to gather the additional information about effectiveness and safety that is needed to evaluate the overall benefit-to-risk relationship of the drug and to provide an adequate basis for product labeling. Phase 3 studies usually include fro ...
Pharmacology - The Carter Center
Pharmacology - The Carter Center

... Pharmacology is a medical science that forms a backbone of the medical profession as drugs form the corner stone of therapy in human diseases. Therefore, it is of utmost importance to describe the pharmacological basis of therapeutics in order to maximize the benefits and minimize the risks of drugs ...
Will They Turn You into a Zombie? - Center for Applied Behavioral
Will They Turn You into a Zombie? - Center for Applied Behavioral

... Human Exposure Calls to U.S. Poison Centers  on Synthetic Cannabinoids and Cathinones and  the Effect of Federal Regulations The Effect of Federal Controls on Synthetic  Cannabis Calls to Poison Centers ...
9294 Steroids CE 8x11
9294 Steroids CE 8x11

... before the survey. ■ Some possible side effects from steroid use include acne, baldness, and oily skin. More severe side effects include mood swings, increased aggressiveness, enlarged heart, liver problems, and renal failure. ■ Athletes have been known to abuse anabolic steroids since the 1950’s. ■ ...
Dosage Form Design: Pharmaceutical and Formulation
Dosage Form Design: Pharmaceutical and Formulation

... If the medication is intended for systemic use and oral administration is desired, tablets and/or capsules are usually prepared because they are easily handled by the patient and are most convenient in the self-administration of medication. If a drug substance has application in an emergency in whic ...
oral bioavailability and first-pass effects
oral bioavailability and first-pass effects

... Eq. 14 is experimentally preferable to eq. 13 in that a peripheral vein is more accessible than the hepatic vein. Moreover, the evaluation of FS would entail only one additional treatment, Dia,n, rather than two, Dia,n and Div,h. Total body clearance, CL or CL9, may be calculated from serum, plasma, ...
Preventing Occupational Exposure to Antineoplastic and Other
Preventing Occupational Exposure to Antineoplastic and Other

... for defining hazardous drugs and (2) posting a list of the hazardous drugs to ensure worker safety. Institutions may wish to compare their lists to the sample listing in this document or on the NIOSH Web site. It is not likely that every health care provider or facility will use all drugs that have ...
pharmacy technician certification examination content outline......
pharmacy technician certification examination content outline......

... It is very important for technicians to know when to answer a patient’s question and when to refer the patient to the pharmacist. Technicians SHOULD NOT interpret a patient-specific question or provide information that may require professional judgment. The technician is not the one to tell the pati ...
A summary of the health harms of drugs
A summary of the health harms of drugs

... Withdrawal syndrome with delirium; an acute psychotic state occurring during the withdrawal phase in people with alcohol dependence. Characterised by confusion, disorientation, paranoid ideation, delusions, illusions, hallucinations, restlessness, distractibility, tremor, sweating, tachycardia and h ...
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Orphan drug

An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.In the US and EU it is easier to gain marketing approval for an orphan drug, and there may be other financial incentives, such as extended exclusivity periods, all intended to encourage the development of drugs which might otherwise lack a sufficient profit motive. The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries, and has resulted in medical breakthroughs that may not have otherwise been achieved due to the economics of drug research and development.According to Thomson Reuters in their 2012 publication ""The Economic Power of Orphan Drugs"", there has been increased investing in orphan drug Research and Development partly due to the U. S. Orphan Drug Act (ODA) 1983 and similar Acts in other regions of the world and also driven by ""high-profile philanthropic funding."" The period between 2001 to 2011 was the ""most productive period in the history of orphan drug development, in terms of average annual orphan drug designations and orphan drug approvals."" For the same decade the compound annual growth rate (CAGR) of the orphan drugs was an ""impressive 25.8 percent, compared to only 20.1 percent for a matched control group of non-orphan drugs."" By 2012 the market for orphan drugs was worth USD$637 million compared to the USD$638 million matched control group of non-orphan drugs, Thomson Reuters.By 2012, ""the revenue-generating potential of orphan drugs [was] as great as for non-orphan drugs, even though patient populations for rare diseases are significantly smaller. Moreover, we suggest that orphan drugs have greater profitability when considered in the full context of developmental drivers including government financial incentives, smaller clinical trial sizes, shorter clinical trial times and higher rates of regulatory success.""
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