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The Cerebral Cortex
The Cerebral Cortex

... receptor are both ligand and voltage gated – In order to open it needs to be both depolarized and in the presence of glutamate, and Ca++ will influx and cause the cellular machinery to manufacture more AMPA glutamate receptors that require only glutamate to cause depolarization ...
Neurotransmitters & Synapses - IB
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The Nervous System: Neural Tissue
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Neurons and Circuits - UT Computer Science
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Neural Control - Del Mar College
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Neuroembryology II_UniTsNeurosciAY1415_06a

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Chapter 12 - Mesa Community College
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Chapter 11: Fundamentals of the Nervous System and Nervous Tissue
Chapter 11: Fundamentals of the Nervous System and Nervous Tissue

... Na+ and Cl- ions more numerous outside Small amounts of K+ move to the outside through leakage (nongated) channels with anions following (cannot diffuse through the membrane and get stuck at the membrane) Note: there are more K+ leakage channels than Na+ leakage channels The inside of the cell has a ...
here - CNC
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... The Portuguese Neuroscientist António Egas Moniz (1874-1955) had an important role in uncovering the roles of difFerent brain regions and how they interact. He was awarded the Nobel Prize in Physiology and Medicine in 1949. ...
Chater 2 - Study Guide
Chater 2 - Study Guide

... cell body to the axon to the dendrites. dendrites to the axon to the cell body. axon to the cell body to the dendrites. dendrites to the cell body to the axon. axon to the dendrites to the cell body. ...
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Synaptic gating



Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation).Bistable neurons have the ability to oscillate between a hyperpolarized (down state) and a depolarized (up state) resting membrane potential without firing an action potential. These neurons can thus be referred to as up/down neurons. According to one model, this ability is linked to the presence of NMDA and AMPA glutamate receptors. External stimulation of the NMDA receptors is responsible for moving the neuron from the down state to the up state, while the stimulation of AMPA receptors allows the neuron to reach and surpass the threshold potential. Neurons that have this bistable ability have the potential to be gated because outside gatekeeper neurons can modulate the membrane potential of the gated neuron by selectively shifting them from the up state to the down state. Such mechanisms have been observed in the nucleus accumbens, with gatekeepers originating in the cortex, thalamus and basal ganglia.
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