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Biology 340 Molecular Biology Lecture
Biology 340 Molecular Biology Lecture

... binding sites for three regulatory protein in a short span of DNA. These include RNA polymerase, lac repressor and another protein, CAP=catabolite activator protein which also functions in lac regulation along with cAMP. ...
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RNA Synthesis (Transcription)

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3D structures of RNA

... of protein three-dimensional structures would grow, starting with the first protein in 1960, as indicated by the above exponential growth function. On 27 March 2001 there were 12,123 3D protein structures in the PDB: Dickerson’s formula predicts 12,066 (within 0.5% -- not a bad prediction)! ...
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... Several types of neurodegenerative diseases were described, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), prion disease, and Parkinson’s disease (PD). Since the potential treatment strategies of these disorders might be more successful in the ...
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1 How-to-guide for accessing big data Franziska Denk 1. Go to http

... Kilobase per Million mapped reads), it is a normalised measure of gene expression. It takes into account the length of the transcript (“per kilobase”) and the overall number of reads (“per million mapped reads”) to create a number that can be compared across samples within an experiment. It is impor ...
I. The Emerging Role of Genetics and Genomics in Medicine
I. The Emerging Role of Genetics and Genomics in Medicine

... I. The Emerging Role of Genetics and Genomics in Medicine A. Genetics is ____________________________________________________________ B. Genes are _____________________________________________________________ C. Chromosomes are ______________________________________________________ D. A gene’s nucle ...
Sec on 9 - Small World Initiative
Sec on 9 - Small World Initiative

... •  A  phylogene$c  tree  is  a  structure  in  which  species  are   arranged  on  branches  that  link  them  according  to  their   rela$onship  and/or  evolu$onary  descent.     •  Gene$c  distance  is  the  number  of  muta$on/evolu$ona ...
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SCI 30 UA CH 2 Review Questions
SCI 30 UA CH 2 Review Questions

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Protein Synthesis – Level 1

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research description

... for development of a healthy immune response, and is, to some degree, genetically determined. The human microbiota has been attracting tremendous interest and since there is increasing evidence supporting the involvement of the gut microbiota in several human diseases: from inflammatory bowel diseas ...
A Novel Estrogen-Inducible Gene Expression System for Plants
A Novel Estrogen-Inducible Gene Expression System for Plants

... Technology Summary In basic plant biology research and biotechnological applications, it is highly desirable to express genes in a controllable fashion. The development of transgenic techniques has allowed researchers to introduce homologous or heterologous genes into plants, with modified functions ...
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Genetic Technology

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Chromomere - aqinfo.com

... Chromomere  Bead like projections – along entire length of polytene chromosome  Heavier stained than inter-chromomeric regions  Clear in dipteran salivary gland chromosome as dark bands  Genes are located within chromomere  One chromomere – single gene  Evidence – local coiling of continuous D ...
The Spurious Foundation of Genetic Engineering
The Spurious Foundation of Genetic Engineering

... kinds of nucleotides, strung together in each gene in a particular linear order of sequence. Segments of DNA comprise the genes that, through a series of molecular processes, give rise to each of our inherited traits. Guided by Crick's theory, the Human Genome Project was intended to identify and en ...
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ppt - Sol Genomics Network

... - 500 high quality tomato genes - statistical models on codon usage and splice sites of Arabidopsis will be used  Second round training: - 2000 high quality tomato genes - Build a tomato-only version of EuGene Approx. 150 BACs needed for first round training ...
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... 15. A nasal spray containing copies of the normal gene that is defective in persons with cystic fibrosis has been used on a trial basis. It is hoped that the cells in the lungs will take in the healthy gene from the spray and produce normal mucus. This is an attempt at __________________________. Ge ...
A Statistical Approach to Literature
A Statistical Approach to Literature

... • Each gene is annotated by a set of GO terms • The importance of any term wrt the gene list is measured by the number of genes that are associated with this term • Need to correct for the uneven distribution of GO terms: a hypergeometric test ...
Gene_March_2005 - Buffalo Ontology Site
Gene_March_2005 - Buffalo Ontology Site

... Part I: The Human Genome Project Completed in 2003 Goals: – identify all the approximately 20,000-25,000 genes in human DNA, – determine the sequences of the 3 billion chemical base pairs that make up human DNA, – store this information in databases, – improve tools for data analysis, – transfer re ...
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Laboratory #11: Molecular genetics simulations

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... AT GGA AGT ATT TAA AGC GCC ACC TAT TGG GAT ATA AG… G S I STOP Together with the complementary strand there are 6 possible reading frames. In nature usually only one of these is translated into a protein. Open reading frame (ORF): interval of DNA sequence without stop codons. Eukaryotic genes can be ...
pGLO2011 Wilkes
pGLO2011 Wilkes

... short segments of DNA containing a foreign or modified gene to living cells. Transformation- the uptake and expression of DNA by a living cell is the limiting factor in the genetic engineering of any species. Genes can be cut from human, animal, or plant DNA and placed inside bacteria. For example, ...
CH 6.3-6.5 Mendelian Genetics Class Notes
CH 6.3-6.5 Mendelian Genetics Class Notes

... What does this cell division do to chromosome #? - Maintains the same/identical chromosome # What part inside a nucleus carries ones traits? – Chromosomes What makes up a chromosome? – DNA and histones What is the study of how traits are passed from parents to offspring? - Genetics What is the name ...
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Artificial gene synthesis

Artificial gene synthesis is a method in synthetic biology that is used to create artificial genes in the laboratory. Currently based on solid-phase DNA synthesis, it differs from molecular cloning and polymerase chain reaction (PCR) in that the user does not have to begin with preexisting DNA sequences. Therefore, it is possible to make a completely synthetic double-stranded DNA molecule with no apparent limits on either nucleotide sequence or size. The method has been used to generate functional bacterial or yeast chromosomes containing approximately one million base pairs. Recent research also suggests the possibility of creating novel nucleobase pairs in addition to the two base pairs in nature, which could greatly expand the possibility of expanding the genetic code.Synthesis of the first complete gene, a yeast tRNA, was demonstrated by Har Gobind Khorana and coworkers in 1972. Synthesis of the first peptide- and protein-coding genes was performed in the laboratories of Herbert Boyer and Alexander Markham, respectively.Commercial gene synthesis services are now available from numerous companies worldwide, some of which have built their business model around this task. Current gene synthesis approaches are most often based on a combination of organic chemistry and molecular biological techniques and entire genes may be synthesized ""de novo"", without the need for precursor template DNA. Gene synthesis has become an important tool in many fields of recombinant DNA technology including heterologous gene expression, vaccine development, gene therapy and molecular engineering. The synthesis of nucleic acid sequences is often more economical than classical cloning and mutagenesis procedures.
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